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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila willistoni (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 32NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GK18290
OrganismiDrosophila willistoni (Fruit fly)
Taxonomic identifieri7260 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007798 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0013152 Dwil\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545001 – 254Alcohol dehydrogenaseAdd BLAST254

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi7260.FBpp0247433

Structurei

3D structure databases

ProteinModelPortaliQ05114
SMRiQ05114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169 Eukaryota
COG1028 LUCA
InParanoidiQ05114
KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiQ05114

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q05114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTNKNIIF VAGLGGIGLD TSRELVKRDL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTTPLTE TTKLLKTIFA QLKTVDVLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG LVNTTTAILD FWDKRKGGPG GVICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAVVS FTQSIAKLAN VTGVTAFTVN PGITKTTLVH KFNSWLDVET
210 220 230 240 250
RVAEKLLEHP TQTTLACAQN FVKAIELNKN GAIWKLDLGT LEPIEWTKHW

DSGI
Length:254
Mass (Da):27,620
Last modified:October 1, 1996 - v2
Checksum:iC20FDF95E89D6E16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41N → K in AAF72724 (Ref. 6) Curated1
Sequence conflicti73K → N in AAF72724 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti57V → I in strain: 0811.4. 2 Publications1
Natural varianti77T → A in strain: 0811.0 and Lima. 2 Publications1
Natural varianti138S → P in strain: Manaus I. 2 Publications1
Natural varianti194S → P in strain: Manaus III. 2 Publications1
Natural varianti213T → A in strain: Cano Mora and Atlixco. 2 Publications1
Natural varianti225I → T in strain: A57. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08648 Genomic DNA Translation: AAA91100.1
U95251 Genomic DNA Translation: AAD00777.1
U95252 Genomic DNA Translation: AAD00778.1
U95253 Genomic DNA Translation: AAD00779.1
U95254 Genomic DNA Translation: AAD00780.1
U95255 Genomic DNA Translation: AAD00781.1
U95256 Genomic DNA Translation: AAD00782.1
U95257 Genomic DNA Translation: AAD00783.1
U95258 Genomic DNA Translation: AAD00784.1
U95259 Genomic DNA Translation: AAD00785.1
U95260 Genomic DNA Translation: AAD00786.1
U95261 Genomic DNA Translation: AAD00787.1
U95262 Genomic DNA Translation: AAD00788.1
U95263 Genomic DNA Translation: AAD00789.1
U95264 Genomic DNA Translation: AAD00790.1
U95265 Genomic DNA Translation: AAD00791.1
U95266 Genomic DNA Translation: AAD00792.1
U95267 Genomic DNA Translation: AAD00793.1
CH963913 Genomic DNA Translation: EDW77442.1
AF264082 Genomic DNA Translation: AAF72724.1
RefSeqiXP_002066456.1, XM_002066420.2
XP_015033661.1, XM_015178175.1

Genome annotation databases

EnsemblMetazoaiFBtr0248941; FBpp0247433; FBgn0013152
FBtr0417483; FBpp0375647; FBgn0013152
GeneIDi6643501
KEGGidwi:Dwil_GK18290

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADH_DROWI
AccessioniPrimary (citable) accession number: Q05114
Secondary accession number(s): B4MZ46
, Q9NG34, Q9TVL4, Q9TW33, Q9TY28, Q9TY29, Q9TY30, Q9TY31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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