Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-protein ligase E3A

Gene

UBE3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates (PubMed:10373495, PubMed:16772533, PubMed:19204938, PubMed:19233847, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24273172, PubMed:24728990). Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B (PubMed:10373495, PubMed:19204938, PubMed:19325566, PubMed:19591933, PubMed:22645313, PubMed:24728990). Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins (PubMed:19233847). Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). Acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation (PubMed:16772533). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (By similarity). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533).By similarity9 Publications
(Microbial infection) Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses.1 Publication

Miscellaneous

A cysteine residue is required for ubiquitin-thioester formation.

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei843Glycyl thioester intermediate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri44 – 83C4-type; atypical1 PublicationAdd BLAST40

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • transcription coactivator activity Source: Ensembl
  • ubiquitin protein ligase activity Source: CACAO
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  • androgen receptor signaling pathway Source: Ensembl
  • brain development Source: ProtInc
  • ovarian follicle development Source: Ensembl
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  • positive regulation of protein ubiquitination Source: CACAO
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • progesterone receptor signaling pathway Source: UniProtKB
  • prostate gland growth Source: Ensembl
  • protein autoubiquitination Source: FlyBase
  • protein K48-linked ubiquitination Source: UniProtKB
  • proteolysis Source: ProtInc
  • regulation of circadian rhythm Source: UniProtKB
  • regulation of ubiquitin-dependent protein catabolic process Source: UniProtKB
  • response to progesterone Source: UniProtKB
  • rhythmic process Source: UniProtKB-KW
  • sperm entry Source: Ensembl
  • ubiquitin-dependent protein catabolic process Source: ProtInc
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionTransferase
Biological processBiological rhythms, Host-virus interaction, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.3.2.B9 2681
6.3.2.19 2681
ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ05086
UniPathwayiUPA00143

Protein family/group databases

MoonDBiQ05086 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-protein ligase E3A (EC:2.3.2.261 Publication)
Alternative name(s):
E6AP ubiquitin-protein ligase1 Publication
HECT-type ubiquitin transferase E3A
Human papillomavirus E6-associated protein1 Publication
Oncogenic protein-associated protein E6-AP1 Publication
Renal carcinoma antigen NY-REN-54
Gene namesi
Name:UBE3AImported
Synonyms:E6AP1 Publication, EPVE6AP1 Publication, HPVE6A1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000114062.17
HGNCiHGNC:12496 UBE3A
MIMi601623 gene
neXtProtiNX_Q05086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Involvement in diseasei

Angelman syndrome (AS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodevelopmental disorder characterized by severe motor and intellectual retardation, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, open-mouthed expression revealing the tongue.
See also OMIM:105830
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073196129T → K in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781241Ensembl.1
Natural variantiVAR_073199235D → V in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587780581Ensembl.1
Natural variantiVAR_073200260L → H in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587780582Ensembl.1
Natural variantiVAR_073201260L → Q in AS; unknown pathological significance. 1 Publication1
Natural variantiVAR_073202286L → W in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587780583Ensembl.1
Natural variantiVAR_073205458L → P in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781242Ensembl.1
Natural variantiVAR_073206481P → L in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587780584Ensembl.1
Natural variantiVAR_073207500R → P in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781243Ensembl.1
Natural variantiVAR_073209568G → R in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781233Ensembl.1
Natural variantiVAR_073210589M → K in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781244Ensembl.1
Natural variantiVAR_073211607E → Q in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781235Ensembl.1
Natural variantiVAR_073214679T → I in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781236Ensembl.1
Natural variantiVAR_073216713F → C in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781237Ensembl.1
Natural variantiVAR_008144826I → II in AS. 1 Publication1
Natural variantiVAR_073218850P → L in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781239Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi750F → D: Disrupt trimer formation, 50-fold reduction in E3 ligase activity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi7337
GeneReviewsiUBE3A
MalaCardsiUBE3A
MIMi105830 phenotype
OpenTargetsiENSG00000114062
Orphaneti72 Angelman syndrome
PharmGKBiPA37144

Polymorphism and mutation databases

BioMutaiUBE3A
DMDMi215274240

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001949801 – 875Ubiquitin-protein ligase E3AAdd BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218PhosphoserineCombined sources1
Modified residuei659Phosphotyrosine; by ABL11 Publication1

Post-translational modificationi

Phosphorylation at Tyr-659 by ABL1 impairs E3 ligase activity and protects p53/TP53 from degradation in (HPV)-infected cells.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ05086
MaxQBiQ05086
PaxDbiQ05086
PeptideAtlasiQ05086
PRIDEiQ05086
ProteomicsDBi58306
58307 [Q05086-2]
58308 [Q05086-3]

PTM databases

iPTMnetiQ05086
PhosphoSitePlusiQ05086

Expressioni

Gene expression databases

BgeeiENSG00000114062
ExpressionAtlasiQ05086 baseline and differential
GenevisibleiQ05086 HS

Organism-specific databases

HPAiCAB009723
HPA039410
HPA040380

Interactioni

Subunit structurei

The active form is probably a homotrimer. Binds UBQLN1 and UBQLN2. Interacts with the 26S proteasome. Interacts with BPY2. Interacts with HIF1AN, MAPK6 AND NEURL4; interaction with MAPK6 may be mediated by NEURL4. Interacts with the proteasomal subunit PSMD4. Interacts with ESR1 and WBP2 (PubMed:16772533, PubMed:21642474). Interacts with ARNTL/BMAL1 (PubMed:24728990). Interacts with ARC (By similarity).By similarity9 Publications
(Microbial infection) Interacts with HCV core protein and targets it to degradation.1 Publication
(Microbial infection) Interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53/TP53 tumor-suppressor protein for ubiquitin-mediated proteolysis.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113185, 193 interactors
CORUMiQ05086
DIPiDIP-6002N
IntActiQ05086, 173 interactors
MINTiQ05086
STRINGi9606.ENSP00000381045

Structurei

Secondary structure

1875
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 41Combined sources15
Helixi65 – 78Combined sources14
Helixi407 – 413Combined sources7
Beta strandi525 – 527Combined sources3
Beta strandi529 – 531Combined sources3
Helixi532 – 545Combined sources14
Helixi548 – 552Combined sources5
Beta strandi557 – 559Combined sources3
Helixi569 – 582Combined sources14
Helixi585 – 587Combined sources3
Beta strandi589 – 592Combined sources4
Turni594 – 596Combined sources3
Beta strandi599 – 601Combined sources3
Helixi609 – 624Combined sources16
Helixi635 – 641Combined sources7
Helixi648 – 654Combined sources7
Helixi656 – 667Combined sources12
Helixi672 – 675Combined sources4
Beta strandi679 – 684Combined sources6
Turni687 – 689Combined sources3
Beta strandi692 – 697Combined sources6
Turni698 – 702Combined sources5
Turni707 – 709Combined sources3
Helixi710 – 722Combined sources13
Helixi727 – 741Combined sources15
Beta strandi742 – 744Combined sources3
Helixi753 – 760Combined sources8
Turni768 – 770Combined sources3
Beta strandi775 – 779Combined sources5
Helixi785 – 795Combined sources11
Helixi799 – 809Combined sources11
Beta strandi810 – 815Combined sources6
Helixi820 – 823Combined sources4
Beta strandi826 – 833Combined sources8
Beta strandi839 – 841Combined sources3
Helixi842 – 844Combined sources3
Beta strandi846 – 851Combined sources6
Helixi855 – 868Combined sources14

3D structure databases

ProteinModelPortaliQ05086
SMRiQ05086
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05086

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini776 – 875HECTPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni401 – 418E6-bindingAdd BLAST18
Regioni418 – 517Interaction with HCV core proteinAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi394 – 399Asp/Glu-rich (acidic)6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri44 – 83C4-type; atypical1 PublicationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0941 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00910000144004
HOVERGENiHBG059326
InParanoidiQ05086
KOiK10587
OMAiDTDHNEE
OrthoDBiEOG091G01LV
PhylomeDBiQ05086
TreeFamiTF315189

Family and domain databases

CDDicd00078 HECTc, 1 hit
InterProiView protein in InterPro
IPR032353 AZUL
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR017134 UBE3A
PfamiView protein in Pfam
PF16558 AZUL, 1 hit
PF00632 HECT, 1 hit
PIRSFiPIRSF037201 Ubiquitin-protein_ligase_E6-AP, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform II (identifier: Q05086-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKLHQCYWK SGEPQSDDIE ASRMKRAAAK HLIERYYHQL TEGCGNEACT
60 70 80 90 100
NEFCASCPTF LRMDNNAAAI KALELYKINA KLCDPHPSKK GASSAYLENS
110 120 130 140 150
KGAPNNSCSE IKMNKKGARI DFKDVTYLTE EKVYEILELC REREDYSPLI
160 170 180 190 200
RVIGRVFSSA EALVQSFRKV KQHTKEELKS LQAKDEDKDE DEKEKAACSA
210 220 230 240 250
AAMEEDSEAS SSRIGDSSQG DNNLQKLGPD DVSVDIDAIR RVYTRLLSNE
260 270 280 290 300
KIETAFLNAL VYLSPNVECD LTYHNVYSRD PNYLNLFIIV MENRNLHSPE
310 320 330 340 350
YLEMALPLFC KAMSKLPLAA QGKLIRLWSK YNADQIRRMM ETFQQLITYK
360 370 380 390 400
VISNEFNSRN LVNDDDAIVA ASKCLKMVYY ANVVGGEVDT NHNEEDDEEP
410 420 430 440 450
IPESSELTLQ ELLGEERRNK KGPRVDPLET ELGVKTLDCR KPLIPFEEFI
460 470 480 490 500
NEPLNEVLEM DKDYTFFKVE TENKFSFMTC PFILNAVTKN LGLYYDNRIR
510 520 530 540 550
MYSERRITVL YSLVQGQQLN PYLRLKVRRD HIIDDALVRL EMIAMENPAD
560 570 580 590 600
LKKQLYVEFE GEQGVDEGGV SKEFFQLVVE EIFNPDIGMF TYDESTKLFW
610 620 630 640 650
FNPSSFETEG QFTLIGIVLG LAIYNNCILD VHFPMVVYRK LMGKKGTFRD
660 670 680 690 700
LGDSHPVLYQ SLKDLLEYEG NVEDDMMITF QISQTDLFGN PMMYDLKENG
710 720 730 740 750
DKIPITNENR KEFVNLYSDY ILNKSVEKQF KAFRRGFHMV TNESPLKYLF
760 770 780 790 800
RPEEIELLIC GSRNLDFQAL EETTEYDGGY TRDSVLIREF WEIVHSFTDE
810 820 830 840 850
QKRLFLQFTT GTDRAPVGGL GKLKMIIAKN GPDTERLPTS HTCFNVLLLP
860 870
EYSSKEKLKE RLLKAITYAK GFGML
Length:875
Mass (Da):100,688
Last modified:November 25, 2008 - v4
Checksum:iF80F0502B3B3838A
GO
Isoform I (identifier: Q05086-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:852
Mass (Da):97,968
Checksum:i3C061DA8D216055A
GO
Isoform III (identifier: Q05086-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MEKLHQCYWK → MATACKR

Show »
Length:872
Mass (Da):100,102
Checksum:iAB4C9B22356C9556
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti359R → RNLVNEFNSR AA sequence (PubMed:8380895).Curated1
Sequence conflicti423P → L in AAA35542 (PubMed:8380895).Curated1
Sequence conflicti647 – 649TFR → LFV in AAA35542 (PubMed:8380895).Curated3
Sequence conflicti669E → V in AAA35542 (PubMed:8380895).Curated1
Sequence conflicti686D → N in AAA35542 (PubMed:8380895).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00785244C → Y Probable polymorphism. 1 Publication1
Natural variantiVAR_00814262R → H1 PublicationCorresponds to variant dbSNP:rs587784511Ensembl.1
Natural variantiVAR_073196129T → K in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781241Ensembl.1
Natural variantiVAR_073197140C → R Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs587782907Ensembl.1
Natural variantiVAR_073198156V → G Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs587782915Ensembl.1
Natural variantiVAR_007853201A → T2 PublicationsCorresponds to variant dbSNP:rs147145506Ensembl.1
Natural variantiVAR_073199235D → V in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587780581Ensembl.1
Natural variantiVAR_073200260L → H in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587780582Ensembl.1
Natural variantiVAR_073201260L → Q in AS; unknown pathological significance. 1 Publication1
Natural variantiVAR_073202286L → W in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587780583Ensembl.1
Natural variantiVAR_047516290V → G3 PublicationsCorresponds to variant dbSNP:rs1059383Ensembl.1
Natural variantiVAR_073203293N → T Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs587782908Ensembl.1
Natural variantiVAR_073204358S → T Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs141984760Ensembl.1
Natural variantiVAR_008143372S → P1 Publication1
Natural variantiVAR_073205458L → P in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781242Ensembl.1
Natural variantiVAR_073206481P → L in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587780584Ensembl.1
Natural variantiVAR_073207500R → P in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781243Ensembl.1
Natural variantiVAR_073208501M → I Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs587782916Ensembl.1
Natural variantiVAR_073209568G → R in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781233Ensembl.1
Natural variantiVAR_073210589M → K in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781244Ensembl.1
Natural variantiVAR_073211607E → Q in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781235Ensembl.1
Natural variantiVAR_073212611Q → E Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs587782918Ensembl.1
Natural variantiVAR_073213611Q → P Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs587782919Ensembl.1
Natural variantiVAR_073214679T → I in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781236Ensembl.1
Natural variantiVAR_073215696L → R Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs587782920Ensembl.1
Natural variantiVAR_073216713F → C in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781237Ensembl.1
Natural variantiVAR_073217785V → I Common polymorphism; may be associated with AS. 1 PublicationCorresponds to variant dbSNP:rs587782910Ensembl.1
Natural variantiVAR_008144826I → II in AS. 1 Publication1
Natural variantiVAR_073218850P → L in AS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587781239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0067051 – 23Missing in isoform I. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_0067061 – 10MEKLHQCYWK → MATACKR in isoform III. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98021
, X98027, X98022, X98023, X98024, X98025, X98026, X98028, X98029, X98030 Genomic DNA Translation: CAA66653.1
X98031 mRNA Translation: CAA66654.1
X98032 mRNA Translation: CAA66655.1
X98033 mRNA Translation: CAA66656.1
AC100774 Genomic DNA No translation available.
AK292514 mRNA Translation: BAF85203.1
AC124997 Genomic DNA No translation available.
CH471151 Genomic DNA Translation: EAW57645.1
L07557 mRNA Translation: AAA35542.1
AF016708
, AF016703, AF016704, AF016705, AF016706, AF016707 Genomic DNA Translation: AAB69154.1
U84404 mRNA Translation: AAB49301.1
AJ001107 Genomic DNA Translation: CAA04534.1
AJ001108 Genomic DNA Translation: CAA04535.1
AJ001109 Genomic DNA Translation: CAA04536.1
AJ001110 Genomic DNA Translation: CAA04537.1
AJ001111 Genomic DNA Translation: CAA04538.1
AJ001112 Genomic DNA Translation: CAA04539.1
CCDSiCCDS32177.1 [Q05086-2]
CCDS45191.1 [Q05086-3]
CCDS45192.1 [Q05086-1]
RefSeqiNP_000453.2, NM_000462.3 [Q05086-1]
NP_570853.1, NM_130838.1 [Q05086-2]
NP_570854.1, NM_130839.2 [Q05086-3]
XP_005268324.1, XM_005268267.4
XP_005268325.1, XM_005268268.4
XP_005268326.1, XM_005268269.4
XP_005268327.1, XM_005268270.4
XP_005268328.1, XM_005268271.4
XP_006720738.1, XM_006720675.3
XP_006720739.1, XM_006720676.3
XP_011520296.1, XM_011521994.2 [Q05086-1]
XP_011520297.1, XM_011521995.2 [Q05086-1]
XP_016878033.1, XM_017022544.1 [Q05086-1]
XP_016878034.1, XM_017022545.1 [Q05086-1]
XP_016878035.1, XM_017022546.1 [Q05086-1]
XP_016878036.1, XM_017022547.1 [Q05086-3]
XP_016878037.1, XM_017022548.1 [Q05086-3]
XP_016878038.1, XM_017022549.1
XP_016878039.1, XM_017022550.1 [Q05086-3]
XP_016878040.1, XM_017022551.1
XP_016878041.1, XM_017022552.1
XP_016878042.1, XM_017022553.1
XP_016878043.1, XM_017022554.1 [Q05086-2]
XP_016878044.1, XM_017022555.1 [Q05086-2]
UniGeneiHs.598862

Genome annotation databases

EnsembliENST00000232165; ENSP00000232165; ENSG00000114062 [Q05086-2]
ENST00000397954; ENSP00000381045; ENSG00000114062 [Q05086-1]
ENST00000428984; ENSP00000401265; ENSG00000114062 [Q05086-2]
ENST00000438097; ENSP00000411258; ENSG00000114062 [Q05086-2]
ENST00000566215; ENSP00000457771; ENSG00000114062 [Q05086-2]
ENST00000614096; ENSP00000481796; ENSG00000114062 [Q05086-3]
ENST00000630424; ENSP00000486349; ENSG00000114062 [Q05086-2]
ENST00000637886; ENSP00000490258; ENSG00000114062 [Q05086-3]
ENST00000638011; ENSP00000490111; ENSG00000114062 [Q05086-2]
ENST00000638155; ENSP00000490557; ENSG00000114062 [Q05086-2]
GeneIDi7337
KEGGihsa:7337
UCSCiuc001zaq.4 human [Q05086-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUBE3A_HUMAN
AccessioniPrimary (citable) accession number: Q05086
Secondary accession number(s): A8K8Z9
, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: July 18, 2018
This is version 191 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health