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Protein

Cytokinesis protein 2

Gene

HOF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Throughout most of the cell cycle it forms a double ring that coincides with the septins. After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Mediates cytoskeletal rearrangements required for cytokinesis. In conjunction with the medial actin ring exhibits contraction-like action.2 Publications

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cytoskeletal protein binding Source: SGD
  • identical protein binding Source: IntAct

GO - Biological processi

  • division septum assembly Source: SGD
  • mitotic cytokinesis Source: SGD
  • negative regulation of formin-nucleated actin cable assembly Source: SGD

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32737-MONOMER

Protein family/group databases

MoonDBiQ05080 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokinesis protein 2
Alternative name(s):
Homolog of CDC15 protein 1
Gene namesi
Name:HOF1
Synonyms:CYK2
Ordered Locus Names:YMR032W
ORF Names:YM9973.05
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR032W
SGDiS000004635 HOF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797501 – 669Cytokinesis protein 2Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei337PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ05080
PaxDbiQ05080
PRIDEiQ05080

PTM databases

iPTMnetiQ05080

Interactioni

Subunit structurei

Interacts with INN1.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytoskeletal protein binding Source: SGD
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi35204, 432 interactors
ComplexPortaliCPX-1140 HICS complex
DIPiDIP-2729N
IntActiQ05080, 70 interactors
MINTiQ05080
STRINGi4932.YMR032W

Structurei

Secondary structure

1669
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 8Combined sources4
Helixi15 – 29Combined sources15
Helixi31 – 65Combined sources35
Helixi70 – 99Combined sources30
Helixi102 – 156Combined sources55
Helixi158 – 160Combined sources3
Helixi164 – 253Combined sources90
Helixi258 – 269Combined sources12

3D structure databases

ProteinModelPortaliQ05080
SMRiQ05080
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 261F-BARPROSITE-ProRule annotationAdd BLAST261
Domaini599 – 667SH3PROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili134 – 200Sequence analysisAdd BLAST67

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

HOGENOMiHOG000112128
InParanoidiQ05080
OMAiNNIATLC
OrthoDBiEOG092C3EOZ

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q05080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSYEACFW DPNDNGVNIL LGHISQGIRS CDSMILFFKQ RSELEKDYAR
60 70 80 90 100
RLGAITGKLD KDIGTNMDYG KLNETFNVVL SVEKARAQSH SKQSEILFRQ
110 120 130 140 150
IYTDTKAFAA NLQARYTTLS GKIERLRMDK FNKKKGCEVL QKKLQDAQIR
160 170 180 190 200
FRDLQLNENN MIGAKRVEHN KRELLKWESN SQEYKVQLDV LKQEYKASQK
210 220 230 240 250
FWIHEWAQLS CELQEMENAR ISFLQSKLQQ FATSSMETYI LEQTKMDMLT
260 270 280 290 300
NHLNSFTAAD EISTFSKENG TGRLKHKTSK GDMNSSANWA QMSSISTTSK
310 320 330 340 350
KTESYMDNIR KLSSQLKETE NKRKLASIDK YEKPLPSPEV TMATQFRNST
360 370 380 390 400
PVIRNETKVV ANPTLSLRSS PVQLQSNVDD SVLRQKPDKP RPIVGEEQLK
410 420 430 440 450
PDEDSKNPDE KGLMVHKRNQ SLSSPSESSS SNPTDFSHIK KRQSMESMTT
460 470 480 490 500
SVSSMANSID DSQRFAKSWN SSNRKRKSMS HLQVPSSASS RSDDGGRTPN
510 520 530 540 550
SAHNLNEDDY NTRRDTSTST ILFKPPVAVR GTSRGHTHRQ SMIMQDSSNP
560 570 580 590 600
IEDALYEMER IQSSSKPGTK TGNIMDERGV VRDRGITVTL PIVTSEGFPV
610 620 630 640 650
IEYAKAMYPL IGNEAPGLAN FHKGDYLLIT EIVNKDWYKG EVYDNDRIDR
660
NHRIGLIPYN FIQLLHQGL
Length:669
Mass (Da):76,207
Last modified:November 1, 1997 - v1
Checksum:iAE4A76C2F4043021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49213 Genomic DNA Translation: CAA89147.1
BK006946 Genomic DNA Translation: DAA09930.1
PIRiS53948
RefSeqiNP_013746.1, NM_001182529.1

Genome annotation databases

EnsemblFungiiYMR032W; YMR032W; YMR032W
GeneIDi855048
KEGGisce:YMR032W

Similar proteinsi

Entry informationi

Entry nameiCYK2_YEAST
AccessioniPrimary (citable) accession number: Q05080
Secondary accession number(s): D6VZK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 18, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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