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Entry version 170 (07 Apr 2021)
Sequence version 2 (31 Aug 2004)
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Protein

Cell division control protein 42 homolog

Gene

cdc-42

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3 (PubMed:11412996, PubMed:11412997).

Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291).

During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2 (PubMed:19797046, PubMed:19023419).

May play a role in controlling canal length and in maintaining Golgi and ER stability during excretory canal elongation, probably downstream of ccm-3, which may regulate its activity and expression levels (PubMed:25743393).

May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448).

Involved in toca-1 and toca-2-mediated protein trafficking controlling the recycling of endocytic cargo protein mig-14 to the Golgi apparatus (PubMed:25775511).

Plays a role in male tail tip morphogenesis (PubMed:21408209).

Together with kpc-1 and chin-1, plays a role in guiding axons from neurons, including AIY interneurons, into the nerve ring (PubMed:28846083).

10 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-114604, GPVI-mediated activation cascade
R-CEL-182971, EGFR downregulation
R-CEL-194840, Rho GTPase cycle
R-CEL-2029482, Regulation of actin dynamics for phagocytic cup formation
R-CEL-389359, CD28 dependent Vav1 pathway
R-CEL-3928662, EPHB-mediated forward signaling
R-CEL-418885, DCC mediated attractive signaling
R-CEL-5626467, RHO GTPases activate IQGAPs
R-CEL-5627083, RHO GTPases regulate CFTR trafficking
R-CEL-5627123, RHO GTPases activate PAKs
R-CEL-5663220, RHO GTPases Activate Formins
R-CEL-5687128, MAPK6/MAPK4 signaling
R-CEL-8964616, G beta:gamma signalling through CDC42
R-CEL-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division control protein 42 homolog
Alternative name(s):
CDC42Ce
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdc-42Imported
ORF Names:R07G3.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
R07G3.1 ; CE02020 ; WBGene00000390 ; cdc-42

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). RNAi-mediated knockdown in distal tip cells (DTC) causes additional turns during their migration (PubMed:19023419). RNAi-mediated knockdown in addition, causes a truncation of excretory canals associated with the formation of cysts and a reduced distribution of Golgi and ER components along the excretory canal length (PubMed:25743393). RNAi-mediated knockdown results in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space, and accumulation of endocytic cargo protein mig-14 in late endosomes and expansion of recycling endosomes that express toca-1 and toca-2 (PubMed:19798448, PubMed:25775511). RNAi-mediated knockdown enhances the axon guidance defects in glia and sublateral neurons of the kpc-1 gk mutant, in which non-commissural interneurons AIY fail to extend dorsally and enter the nerve ring (PubMed:28846083).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi12G → V in a cwn-1 mutant background results in ALM polarity defects. 1 Publication1
Mutagenesisi61Q → L: May lock enzyme in its GTP-bound active state. Defect in distal tip cell (DTC) migration. Partially rescues the axon guidance defects of AIY interneurons in kpc-1 (gk8) and chin-1 (ns399) double mutants. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001989591 – 188Cell division control protein 42 homologAdd BLAST188
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000281289189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei188Cysteine methyl esterBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q05062

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05062

PeptideAtlas

More...
PeptideAtlasi
Q05062

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the intestine and seam cells.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highest levels at the embryonic stage, decreasing progressively during development, except for an increase at the L3 stage (PubMed:8514766). Expressed in hypodermal cells during elongation throughout the second phase of embryogenesis (PubMed:8824291).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000390, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The GTP-bound, but not the GDP-bound, form binds to the p21-activated kinase (pak-1) (PubMed:8824291). Interaction with par-6 required for activation of the par-3/par-6/pkc-3 complex (PubMed:11412997).

Interacts with toca-1 and toca-2 (PubMed:25775511). May interact with unc-89 (via DH and PH domains); the interaction does not stimulate GTPase activity in vitro (PubMed:18801371).

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
39567, 36 interactors

Database of interacting proteins

More...
DIPi
DIP-24428N

Protein interaction database and analysis system

More...
IntActi
Q05062, 4 interactors

STRING: functional protein association networks

More...
STRINGi
6239.R07G3.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05062

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi32 – 40Effector regionBy similarity9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0393, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041217_21_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05062

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKPKKRC

Database of Orthologous Groups

More...
OrthoDBi
1091615at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q05062

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01874, Cdc42, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037874, Cdc42
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
IPR003578, Small_GTPase_Rho

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00071, Ras, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51420, RHO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q05062-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP
60 70 80 90 100
YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVAPASF ENVREKWVPE
110 120 130 140 150
ISHHCSKTPF LLVGTQVDLR DDPGMLEKLA KNKQKPVSTD VGEKLAKELK
160 170 180 190
AVKYVECSAL TQKGLKNVFD EAILAALDPP QQEKKKKCNI L
Length:191
Mass (Da):21,165
Last modified:August 31, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38B7C025CC0FCB70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 4MQTI → M in AAA51433 (PubMed:8514766).Curated4
Sequence conflicti44V → A in AAC05600 (PubMed:8722777).Curated1
Sequence conflicti140D → Y in AAC05600 (PubMed:8722777).Curated1
Sequence conflicti162 – 164QKG → EKE in AAC05600 (PubMed:8722777).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L10078 mRNA Translation: AAA51433.1
S82771 Genomic DNA Translation: AAC05600.1
BX284602 Genomic DNA Translation: CCD70511.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S68301

NCBI Reference Sequences

More...
RefSeqi
NP_495598.1, NM_063197.7

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
R07G3.1.1; R07G3.1.1; WBGene00000390

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174233

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_R07G3.1

UCSC genome browser

More...
UCSCi
R07G3.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10078 mRNA Translation: AAA51433.1
S82771 Genomic DNA Translation: AAC05600.1
BX284602 Genomic DNA Translation: CCD70511.1
PIRiS68301
RefSeqiNP_495598.1, NM_063197.7

3D structure databases

SMRiQ05062
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi39567, 36 interactors
DIPiDIP-24428N
IntActiQ05062, 4 interactors
STRINGi6239.R07G3.1

Proteomic databases

EPDiQ05062
PaxDbiQ05062
PeptideAtlasiQ05062

Genome annotation databases

EnsemblMetazoaiR07G3.1.1; R07G3.1.1; WBGene00000390
GeneIDi174233
KEGGicel:CELE_R07G3.1
UCSCiR07G3.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174233
WormBaseiR07G3.1 ; CE02020 ; WBGene00000390 ; cdc-42

Phylogenomic databases

eggNOGiKOG0393, Eukaryota
GeneTreeiENSGT00940000153675
HOGENOMiCLU_041217_21_3_1
InParanoidiQ05062
OMAiIKPKKRC
OrthoDBi1091615at2759
PhylomeDBiQ05062

Enzyme and pathway databases

ReactomeiR-CEL-114604, GPVI-mediated activation cascade
R-CEL-182971, EGFR downregulation
R-CEL-194840, Rho GTPase cycle
R-CEL-2029482, Regulation of actin dynamics for phagocytic cup formation
R-CEL-389359, CD28 dependent Vav1 pathway
R-CEL-3928662, EPHB-mediated forward signaling
R-CEL-418885, DCC mediated attractive signaling
R-CEL-5626467, RHO GTPases activate IQGAPs
R-CEL-5627083, RHO GTPases regulate CFTR trafficking
R-CEL-5627123, RHO GTPases activate PAKs
R-CEL-5663220, RHO GTPases Activate Formins
R-CEL-5687128, MAPK6/MAPK4 signaling
R-CEL-8964616, G beta:gamma signalling through CDC42
R-CEL-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q05062

Gene expression databases

BgeeiWBGene00000390, Expressed in pharyngeal muscle cell (C elegans) and 5 other tissues

Family and domain databases

CDDicd01874, Cdc42, 1 hit
InterProiView protein in InterPro
IPR037874, Cdc42
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
IPR003578, Small_GTPase_Rho
PfamiView protein in Pfam
PF00071, Ras, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420, RHO, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDC42_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05062
Secondary accession number(s): P91792
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 31, 2004
Last modified: April 7, 2021
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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