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Entry version 144 (07 Apr 2021)
Sequence version 1 (01 Nov 1997)
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Protein

Eisosome protein 1

Gene

EIS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal formation of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on plasma membrane and mark the site of endocytosis.1 Publication

Miscellaneous

Present with 5570 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.148.1.1, the plasma membrane organizing center, eisosome (eisosome) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eisosome protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIS1
Ordered Locus Names:YMR031C
ORF Names:YM9973.04C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004633, EIS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YMR031C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002032732 – 843Eisosome protein 1Add BLAST842

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei401PhosphoserineCombined sources1
Modified residuei584PhosphoserineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei720PhosphothreonineCombined sources1
Modified residuei763PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei816PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1
Modified residuei829PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q05050

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q05050

PRoteomics IDEntifications database

More...
PRIDEi
Q05050

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q05050

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35203, 122 interactors

Database of interacting proteins

More...
DIPi
DIP-7982N

Protein interaction database and analysis system

More...
IntActi
Q05050, 9 interactors

Molecular INTeraction database

More...
MINTi
Q05050

STRING: functional protein association networks

More...
STRINGi
4932.YMR031C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q05050, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05050

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EIS1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S8WV, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176658

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013228_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q05050

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHTFSGF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024527, Eisosome1

The PANTHER Classification System

More...
PANTHERi
PTHR28298, PTHR28298, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12757, Eisosome1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q05050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLISAVEDR DIHNIGKTSG GGSRTSSITS SKKSLKHGSK SLRKPKVYQT
60 70 80 90 100
TGEPLSREAL YKAKLKYGVY QSPAQSYSIG VSDAHAASDK AANLAHDNQT
110 120 130 140 150
TVEAYKRMFI DPNATKAASK MGPKVVRNNS ITSATSKTSK ESQTKRKSKE
160 170 180 190 200
SPGAAASKAY SMTMETTSLS SQTNSRSYSI TSASSVLSGA SGSFNSTVNP
210 220 230 240 250
KPKTLNLEKV LVGAEKKAES RIKERWEPEK TNFQYGVKTD EHGNLNQFSF
260 270 280 290 300
SNEMMNNIMA KVDAPKAQDL QKVKKVSAEK EAKSMKFALG AANAVKDMHP
310 320 330 340 350
GEDIDKSIAL KAQKRETYLS QLTSQQVLTL ARANVDRQLD IIEKSDMHRK
360 370 380 390 400
LFTNMEYNKA AVAVAQSNHQ KKTEFHNKIN MGGGLFLSPE DITKIASGLI
410 420 430 440 450
SPVLGEVSER AEAQRAMDEE IAERTEAYNK SSNEWETMER SIISNDAKVL
460 470 480 490 500
TTTANRHQTE KKTSQEKIKA SFDALVARMD TKVAERETLL EDTKSKEIEF
510 520 530 540 550
KKQMQQELKD EKARLDQDLE EWGKKCEQDI TEARKEQEEL LKPYHDDLAN
560 570 580 590 600
AEAEHKTLVE ERDEINAEIS RLQDAIVDHK RKISGYGNDL DAQKNRNIRE
610 620 630 640 650
DDKLLELGQT KESLESHLND DVIILANKAK EQAELSTKEA RLKQLEVDSL
660 670 680 690 700
INERKSELNA TEIELKKEKL NLLEAMKDVA SARGDDKIDE EKVKKLIGMT
710 720 730 740 750
SEEYLTQNKS VEKNVEDLPT QLEKIEEGDE LKKEEIVGAE TKNSGGDGVP
760 770 780 790 800
VSTAAKEATE TSSAVQTKEP EEKISIGNKS SGKEDANDCK SAEHSKEISV
810 820 830 840
SQKAGNNKSL GVSPDSLEHT FSGFSQGSSI EDDQDAISNQ EKK
Length:843
Mass (Da):93,345
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0068D65A229B941D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49213 Genomic DNA Translation: CAA89146.1
BK006946 Genomic DNA Translation: DAA09929.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S53947

NCBI Reference Sequences

More...
RefSeqi
NP_013744.1, NM_001182527.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR031C_mRNA; YMR031C; YMR031C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR031C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49213 Genomic DNA Translation: CAA89146.1
BK006946 Genomic DNA Translation: DAA09929.1
PIRiS53947
RefSeqiNP_013744.1, NM_001182527.1

3D structure databases

SMRiQ05050
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35203, 122 interactors
DIPiDIP-7982N
IntActiQ05050, 9 interactors
MINTiQ05050
STRINGi4932.YMR031C

Protein family/group databases

TCDBi8.A.148.1.1, the plasma membrane organizing center, eisosome (eisosome) family

PTM databases

iPTMnetiQ05050

Proteomic databases

MaxQBiQ05050
PaxDbiQ05050
PRIDEiQ05050

Genome annotation databases

EnsemblFungiiYMR031C_mRNA; YMR031C; YMR031C
GeneIDi855047
KEGGisce:YMR031C

Organism-specific databases

SGDiS000004633, EIS1
VEuPathDBiFungiDB:YMR031C

Phylogenomic databases

eggNOGiENOG502S8WV, Eukaryota
GeneTreeiENSGT00940000176658
HOGENOMiCLU_013228_0_0_1
InParanoidiQ05050
OMAiEHTFSGF

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q05050
RNActiQ05050, protein

Family and domain databases

InterProiView protein in InterPro
IPR024527, Eisosome1
PANTHERiPTHR28298, PTHR28298, 1 hit
PfamiView protein in Pfam
PF12757, Eisosome1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEIS1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05050
Secondary accession number(s): D6VZK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 7, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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