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Entry version 85 (02 Jun 2021)
Sequence version 1 (01 Oct 1994)
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Protein

Integumentary mucin C.1

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be involved in defense against microbial infections. Protects the epithelia from external environment.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integumentary mucin C.1
Alternative name(s):
FIM-C.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000162379‹1 – 662Integumentary mucin C.1Add BLAST›662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi162 ↔ 188PROSITE-ProRule annotation
Disulfide bondi172 ↔ 187PROSITE-ProRule annotation
Disulfide bondi182 ↔ 199PROSITE-ProRule annotation
Disulfide bondi307 ↔ 333PROSITE-ProRule annotation
Disulfide bondi317 ↔ 332PROSITE-ProRule annotation
Disulfide bondi327 ↔ 344PROSITE-ProRule annotation
Disulfide bondi354 ↔ 380PROSITE-ProRule annotation
Disulfide bondi364 ↔ 379PROSITE-ProRule annotation
Disulfide bondi374 ↔ 391PROSITE-ProRule annotation
Disulfide bondi526 ↔ 552PROSITE-ProRule annotation
Disulfide bondi536 ↔ 551PROSITE-ProRule annotation
Disulfide bondi546 ↔ 563PROSITE-ProRule annotation
Disulfide bondi573 ↔ 599PROSITE-ProRule annotation
Disulfide bondi583 ↔ 598PROSITE-ProRule annotation
Disulfide bondi593 ↔ 610PROSITE-ProRule annotation
Disulfide bondi621 ↔ 647PROSITE-ProRule annotation
Disulfide bondi631 ↔ 646PROSITE-ProRule annotation
Disulfide bondi641 ↔ 658PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Extensively O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skin.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q05049

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati81 – 881-18
Repeati89 – 961-28
Repeati97 – 1041-38
Repeati105 – 1121-48
Repeati113 – 1201-58
Repeati121 – 1281-68
Repeati129 – 1361-78
Repeati137 – 1441-88
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini160 – 203P-type 1PROSITE-ProRule annotationAdd BLAST44
Repeati218 – 2242-17
Repeati225 – 2392-2Add BLAST15
Repeati240 – 2492-310
Repeati250 – 2592-410
Repeati260 – 2752-5Add BLAST16
Repeati276 – 2872-6Add BLAST12
Repeati288 – 2942-77
Repeati295 – 3012-87
Domaini305 – 348P-type 2PROSITE-ProRule annotationAdd BLAST44
Domaini352 – 395P-type 3PROSITE-ProRule annotationAdd BLAST44
Repeati402 – 4113-110
Repeati412 – 4193-28
Repeati420 – 4313-3Add BLAST12
Repeati432 – 4433-4Add BLAST12
Repeati444 – 4533-510
Repeati454 – 4603-67
Repeati461 – 4723-7Add BLAST12
Repeati473 – 4793-87
Repeati480 – 4913-9Add BLAST12
Repeati492 – 4983-107
Repeati499 – 5153-11Add BLAST17
Repeati516 – 5223-127
Domaini524 – 567P-type 4PROSITE-ProRule annotationAdd BLAST44
Domaini571 – 614P-type 5PROSITE-ProRule annotationAdd BLAST44
Domaini619 – 662P-type 6PROSITE-ProRule annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 109DisorderedSequence analysisAdd BLAST83
Regioni81 – 1448 X 8 AA approximate tandem repeats, Ala/Thr-richAdd BLAST64
Regioni122 – 170DisorderedSequence analysisAdd BLAST49
Regioni218 – 3018 X approximate tandem repeats, Thr-richAdd BLAST84
Regioni231 – 297DisorderedSequence analysisAdd BLAST67
Regioni402 – 52212 X approximate tandem repeats, Thr-richAdd BLAST121
Regioni404 – 516DisorderedSequence analysisAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 99Polar residuesSequence analysisAdd BLAST36
Compositional biasi122 – 151Polar residuesSequence analysisAdd BLAST30
Compositional biasi152 – 170Basic and acidic residuesSequence analysisAdd BLAST19

Keywords - Domaini

Repeat

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKWCFYS

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00111, Trefoil, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017994, P_trefoil_chordata
IPR017957, P_trefoil_CS
IPR000519, P_trefoil_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13826, PTHR13826, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00088, Trefoil, 6 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00680, PTREFOIL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00018, PD, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00025, P_TREFOIL_1, 6 hits
PS51448, P_TREFOIL_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q05049-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
APTTAAAVAA TGKDTTAAAE GSAAAEKTAA AGEVSAPPTA AVAATGEDAT
60 70 80 90 100
TAAATAAAET TAAAGEAPTT TTAPATTAAG KAPTTAAATA PTTAAAGAPT
110 120 130 140 150
TATGKAPATA AAPVPTTAAS KAPTTAAAAT HSTAAAAAPT TAASAAKSKE
160 170 180 190 200
RSTSSSSEEE HCHVKPSKRE MCGSKGITKK QCKKKNCCFD PKGHGGIHCF
210 220 230 240 250
HRKPKGHSHE EHTTTTTKAP TTIQIATTTT TPTTTTTTTK ATPTTTTTTK
260 270 280 290 300
ATPTTTTTTK ATTTTTTPTT TTTTTKATTT PTTTTTTTPT TTTTKATTTT
310 320 330 340 350
TTTSGECKME PSKREDCGYS GITESQCRTK GCCFDSSIPQ TKWCFYTLSQ
360 370 380 390 400
VADCKVEPSQ RVDCGFRGIT ADQCRQKNCC FDSSISGTKW CFYSTSQVAA
410 420 430 440 450
TKTTTTPTTT TTPTTTTTTK ATTTTPTTTT TTPTTTTTTT TTTKATTTTP
460 470 480 490 500
TTTTPTTTTT KATTTTPTTT TTTPTTTTTK ATTTTPTTTT TTPTTTTTKA
510 520 530 540 550
TTTTPTTTTT TTTTTKATTT TTSGECKMEP SKRADCGYPG ITESQCRSKG
560 570 580 590 600
CCFDSSIPQT KWCFYSLPQV ADCKVAPSSR VDCGFGGITA DQCRQRNCCF
610 620 630 640 650
DSSISGTKWC FYSTSQGNAM CSGPPTKRRD CGYPGISSSV CINRGCCWDN
660
SVMNVPWCFY RT
Length:662
Mass (Da):67,775
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF085277F1ED2FD40
GO
Isoform 2 (identifier: Q05049-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-350: Missing.

Show »
Length:617
Mass (Da):62,630
Checksum:i5BFCBD50A1BB270D
GO
Isoform 3 (identifier: Q05049-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-498: Missing.

Show »
Length:583
Mass (Da):59,831
Checksum:i6B9C5460621E1819
GO
Isoform 4 (identifier: Q05049-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-259: Missing.
     276-294: Missing.

Show »
Length:633
Mass (Da):64,861
Checksum:i14148E71DC0F4858
GO
Isoform 5 (identifier: Q05049-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-259: Missing.
     278-278: Missing.
     306-350: Missing.

Show »
Length:596
Mass (Da):60,521
Checksum:i180A7E896F67DBA9
GO
Isoform 6 (identifier: Q05049-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-259: Missing.
     276-294: Missing.

Show »
Length:623
Mass (Da):63,857
Checksum:i57CD8C3805BAD5F0
GO
Isoform 7 (identifier: Q05049-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-259: Missing.

Show »
Length:652
Mass (Da):66,771
Checksum:iD4E7DDF98061ED00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti276K → E. 1
Natural varianti354C → R. 1
Natural varianti415T → A. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004646240 – 259Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_004647250 – 259Missing in isoform 4 and isoform 7. 1 Publication10
Alternative sequenceiVSP_004648276 – 294Missing in isoform 4 and isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_004649278Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_004650306 – 350Missing in isoform 2 and isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_004651420 – 498Missing in isoform 3. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L02115 mRNA Translation: AAA74725.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45155

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02115 mRNA Translation: AAA74725.1
PIRiA45155

3D structure databases

SMRiQ05049
ModBaseiSearch...

Phylogenomic databases

OMAiTKWCFYS

Family and domain databases

CDDicd00111, Trefoil, 5 hits
InterProiView protein in InterPro
IPR017994, P_trefoil_chordata
IPR017957, P_trefoil_CS
IPR000519, P_trefoil_dom
PANTHERiPTHR13826, PTHR13826, 5 hits
PfamiView protein in Pfam
PF00088, Trefoil, 6 hits
PRINTSiPR00680, PTREFOIL
SMARTiView protein in SMART
SM00018, PD, 6 hits
PROSITEiView protein in PROSITE
PS00025, P_TREFOIL_1, 6 hits
PS51448, P_TREFOIL_2, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q05049
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 2, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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