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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayi
UPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:SPD_0307
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001452 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei51 – 71HelicalUniRule annotationAdd BLAST21
Transmembranei79 – 99HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei169 – 189HelicalUniRule annotationAdd BLAST21
Transmembranei195 – 215HelicalUniRule annotationAdd BLAST21
Transmembranei221 – 243HelicalUniRule annotationAdd BLAST23
Transmembranei247 – 269HelicalUniRule annotationAdd BLAST23
Transmembranei306 – 326HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000030721 – 326Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST326

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_0307

Structurei

3D structure databases

SMRiQ04MC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275124
KOiK01000
OMAiLMSPLHH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04MC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFISISAGIV TFLLTLVGIP AFIQFYRKAQ ITGQQMHEDV KQHQAKAGTP
60 70 80 90 100
TMGGLVFLIT SVLVAFFFAL FSSQFSNNVG MILFILVLYG LVGFLDDFLK
110 120 130 140 150
VFRKINEGLN PKQKLALQLL GGVIFYLFYE RGGDILSVFG YPVHLGFFYI
160 170 180 190 200
FFALFWLVGF SNAVNLTDGV DGLASISVVI SLFAYGVIAY VQGQMDILLV
210 220 230 240 250
ILAMIGGLLG FFIFNHKPAK VFMGDVGSLA LGGMLAAISM ALHQEWTLLI
260 270 280 290 300
IGIVYVFETT SVMMQVSYFK LTGGKRIFRM TPVHHHFELG GLSGKGNPWS
310 320
EWKVDFFFWG VGLLASLLTL AILYLM
Length:326
Mass (Da):36,063
Last modified:November 14, 2006 - v1
Checksum:i2B9E4F9393589401
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA Translation: ABJ54244.1
RefSeqiWP_000470833.1, NC_008533.1

Genome annotation databases

EnsemblBacteriaiABJ54244; ABJ54244; SPD_0307
KEGGispd:SPD_0307

Similar proteinsi

Entry informationi

Entry nameiMRAY_STRP2
AccessioniPrimary (citable) accession number: Q04MC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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