UniProtKB - Q04KS4 (CPFC_STRP2)
Protein
Coproporphyrin III ferrochelatase
Gene
cpfC
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Functioni
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.UniRule annotation
Catalytic activityi
: protoheme biosynthesis Pathwayi
This protein is involved in the pathway protoheme biosynthesis, which is part of Porphyrin-containing compound metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 29 | SubstrateUniRule annotation | 1 | |
Binding sitei | 118 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 169 | IronUniRule annotation | 1 | |
Metal bindingi | 250 | IronUniRule annotation | 1 |
GO - Molecular functioni
- ferrochelatase activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- heme biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Lyase |
Biological process | Heme biosynthesis, Porphyrin biosynthesis |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | SPNE373153:G1G6V-982-MONOMER |
UniPathwayi | UPA00252 |
Names & Taxonomyi
Protein namesi | Recommended name: Coproporphyrin III ferrochelataseUniRule annotation (EC:4.99.1.9UniRule annotation) |
Gene namesi | Name:cpfCUniRule annotation Ordered Locus Names:SPD_0895 |
Organismi | Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) |
Taxonomic identifieri | 373153 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000019374 | 1 – 364 | Coproporphyrin III ferrochelataseAdd BLAST | 364 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ferrochelatase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0276, Bacteria |
HOGENOMi | CLU_018884_2_1_9 |
OMAi | LGDPYHC |
OrthoDBi | 780534at2 |
Family and domain databases
CDDi | cd00419, Ferrochelatase_C, 1 hit |
HAMAPi | MF_00323, Ferrochelatase, 1 hit |
InterProi | View protein in InterPro IPR001015, Ferrochelatase IPR019772, Ferrochelatase_AS IPR033644, Ferrochelatase_C |
PANTHERi | PTHR11108, PTHR11108, 1 hit |
Pfami | View protein in Pfam PF00762, Ferrochelatase, 1 hit |
TIGRFAMsi | TIGR00109, hemH, 1 hit |
PROSITEi | View protein in PROSITE PS00534, FERROCHELATASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04KS4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKAILMMTF GSPEEITFEG VADFFTNIRR GVRPQDHEIQ TLYDNYVRIG
60 70 80 90 100
GTPLQKITRQ EVTLVEARLG NEYSVYFANK FSSPFIPDVI GQMEADGIEQ
110 120 130 140 150
CICLILEPHY SFYSVMGYEK FLESKQIQFL VIKDWYQEEA LLNYWADEIA
160 170 180 190 200
KILKEEVKQD SFKVIFSAHS VPIFALDFGD PYIDQIFENS KLVAEKLGLS
210 220 230 240 250
SEQYTNTWQS ESDIGIPWIK PDVLEYLREQ TEHPDHYIFV PISFISEHIE
260 270 280 290 300
VLFDNDVECY DLCQEFGVNY HRPPMPNTDS RLIDALVNTV RVNENQEFKE
310 320 330 340 350
FLPEEETFDE LVPSDETKNI LAESEDLQMP EFVKKLIEKK GRENVKMPYL
360
IKKMLEKAGK LPKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000410 Genomic DNA Translation: ABJ55329.1 |
RefSeqi | WP_000709260.1, NC_008533.2 |
Genome annotation databases
EnsemblBacteriai | ABJ55329; ABJ55329; SPD_0895 |
KEGGi | spd:SPD_0895 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000410 Genomic DNA Translation: ABJ55329.1 |
RefSeqi | WP_000709260.1, NC_008533.2 |
3D structure databases
SMRi | Q04KS4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 373153.SPD_0895 |
Genome annotation databases
EnsemblBacteriai | ABJ55329; ABJ55329; SPD_0895 |
KEGGi | spd:SPD_0895 |
Phylogenomic databases
eggNOGi | COG0276, Bacteria |
HOGENOMi | CLU_018884_2_1_9 |
OMAi | LGDPYHC |
OrthoDBi | 780534at2 |
Enzyme and pathway databases
UniPathwayi | UPA00252 |
BioCyci | SPNE373153:G1G6V-982-MONOMER |
Family and domain databases
CDDi | cd00419, Ferrochelatase_C, 1 hit |
HAMAPi | MF_00323, Ferrochelatase, 1 hit |
InterProi | View protein in InterPro IPR001015, Ferrochelatase IPR019772, Ferrochelatase_AS IPR033644, Ferrochelatase_C |
PANTHERi | PTHR11108, PTHR11108, 1 hit |
Pfami | View protein in Pfam PF00762, Ferrochelatase, 1 hit |
TIGRFAMsi | TIGR00109, hemH, 1 hit |
PROSITEi | View protein in PROSITE PS00534, FERROCHELATASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CPFC_STRP2 | |
Accessioni | Q04KS4Primary (citable) accession number: Q04KS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | November 14, 2006 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families