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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13NAD; via amide nitrogenUniRule annotation1
Binding sitei34NADUniRule annotation1
Binding sitei39NADUniRule annotation1
Binding sitei64NADUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei100NADUniRule annotation1
Binding sitei142NADUniRule annotation1
Active sitei174Proton acceptorUniRule annotation1
Binding sitei224SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 79NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciLDEL321956:LBUL_RS00465-MONOMER
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
Ordered Locus Names:LBUL_0100
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Taxonomic identifieri321956 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000604391 – 307L-lactate dehydrogenaseAdd BLAST307

Proteomic databases

PRIDEiQ04CN9

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ04CN9
SMRiQ04CN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 122Substrate bindingUniRule annotation4
Regioni147 – 150Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213793
KOiK00016
OMAiVDELVIC

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q04CN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKVLLVGD GAVGSNFAND LLQTTQVDEL VICDLNKDRA AGDCLDLEDM
60 70 80 90 100
TYFTGQTKLR AGDYSDAADA DVVVITAGVP RKPGESRLDL IKKNEAILRS
110 120 130 140 150
IVDPVVASGF SGIFVVSANP VDILTTLTQK LSGFPKKRVI GTGTSLDSAR
160 170 180 190 200
LRVELAKRLQ VPIESVNAWV LGEHGDSSFE NFSSAVVNGK PLLDYPGMTE
210 220 230 240 250
AALDEIEAHV REKGSEIIVK KGATYYGVAM MLAKIVTAIL ENNDLALPLS
260 270 280 290 300
APLHGEYGIK DEIYLGTLAI INGQGISHVL ELPLNDSELA KMRASAATIK

ATLDSLG
Length:307
Mass (Da):32,725
Last modified:November 14, 2006 - v1
Checksum:i250F00A0D0BDDAA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000412 Genomic DNA Translation: ABJ57783.1
RefSeqiWP_011677908.1, NC_008529.1

Genome annotation databases

EnsemblBacteriaiABJ57783; ABJ57783; LBUL_0100
KEGGilbu:LBUL_0100

Similar proteinsi

Entry informationi

Entry nameiLDH_LACDB
AccessioniPrimary (citable) accession number: Q04CN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: June 20, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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