UniProtKB - Q04998 (INHBA_MOUSE)
Protein
Inhibin beta A chain
Gene
Inhba
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
GO - Molecular functioni
- cytokine activity Source: UniProtKB
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: UniProtKB-KW
- identical protein binding Source: MGI
- inhibin binding Source: MGI
- peptide hormone binding Source: MGI
- protein-containing complex binding Source: MGI
- signaling receptor binding Source: MGI
- type II activin receptor binding Source: MGI
GO - Biological processi
- activin receptor signaling pathway Source: BHF-UCL
- cell cycle arrest Source: UniProtKB
- cellular response to cholesterol Source: MGI
- cellular response to follicle-stimulating hormone stimulus Source: MGI
- endodermal cell differentiation Source: MGI
- extrinsic apoptotic signaling pathway Source: MGI
- eyelid development in camera-type eye Source: UniProtKB
- G1/S transition of mitotic cell cycle Source: UniProtKB
- GABAergic neuron differentiation Source: MGI
- hair follicle development Source: UniProtKB
- hematopoietic progenitor cell differentiation Source: MGI
- hemoglobin biosynthetic process Source: UniProtKB
- male gonad development Source: UniProtKB
- mesodermal cell differentiation Source: MGI
- mesoderm formation Source: MGI
- negative regulation of cell cycle Source: UniProtKB
- negative regulation of cell growth Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of hair follicle development Source: MGI
- odontogenesis Source: UniProtKB
- ovarian follicle development Source: UniProtKB
- positive regulation of cellular protein metabolic process Source: MGI
- positive regulation of erythrocyte differentiation Source: UniProtKB
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
- positive regulation of gene expression Source: MGI
- positive regulation of ovulation Source: UniProtKB
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- progesterone secretion Source: UniProtKB
- regulation of follicle-stimulating hormone secretion Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- response to drug Source: UniProtKB
- roof of mouth development Source: UniProtKB
- SMAD protein signal transduction Source: GO_Central
- striatal medium spiny neuron differentiation Source: MGI
Keywordsi
Molecular function | Growth factor, Hormone |
Enzyme and pathway databases
Reactomei | R-MMU-1502540, Signaling by Activin R-MMU-209822, Glycoprotein hormones R-MMU-2473224, Antagonism of Activin by Follistatin |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibin beta A chainAlternative name(s): Activin beta-A chain |
Gene namesi | Name:Inhba |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96570, Inhba |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- activin A complex Source: UniProtKB
- extracellular region Source: UniProtKB
- extracellular space Source: BHF-UCL
- inhibin A complex Source: UniProtKB
Other locations
- perinuclear region of cytoplasm Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
PropeptideiPRO_0000033710 | 21 – 308 | 1 PublicationAdd BLAST | 288 | |
ChainiPRO_0000033711 | 309 – 424 | Inhibin beta A chainAdd BLAST | 116 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 165 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 312 ↔ 320 | By similarity | ||
Disulfide bondi | 319 ↔ 389 | By similarity | ||
Disulfide bondi | 348 ↔ 421 | By similarity | ||
Disulfide bondi | 352 ↔ 423 | By similarity | ||
Disulfide bondi | 388 | InterchainBy similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q04998 |
PeptideAtlasi | Q04998 |
PRIDEi | Q04998 |
PTM databases
GlyGeni | Q04998, 1 site |
PhosphoSitePlusi | Q04998 |
Expressioni
Tissue specificityi
Uterus, ovary and liver.
Gene expression databases
Bgeei | ENSMUSG00000041324, Expressed in decidua and 238 other tissues |
Genevisiblei | Q04998, MM |
Interactioni
Subunit structurei
Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.
Interacts with FST and FSTL3 (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: UniProtKB
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: UniProtKB-KW
- identical protein binding Source: MGI
- inhibin binding Source: MGI
- signaling receptor binding Source: MGI
- type II activin receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200762, 5 interactors |
STRINGi | 10090.ENSMUSP00000047894 |
Chemistry databases
BindingDBi | Q04998 |
Miscellaneous databases
RNActi | Q04998, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157116 |
HOGENOMi | CLU_020515_5_1_1 |
InParanoidi | Q04998 |
OMAi | CDQCQET |
OrthoDBi | 1385831at2759 |
PhylomeDBi | Q04998 |
TreeFami | TF351791 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000491, Inhibin_betaA IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PRINTSi | PR00670, INHIBINBA |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q04998-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLLWLRGFL LASCWIIVRS SPTPGSEGHG SAPDCPSCAL ATLPKDGPNS
60 70 80 90 100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY
110 120 130 140 150
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV
160 170 180 190 200
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGD EAEEMGLKGE
210 220 230 240 250
RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV RIACEQCQES
260 270 280 290 300
GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED
310 320 330 340 350
HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG
360 370 380 390 400
ECPSHIAGTS GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML
410 420
YYDDGQNIIK KDIQNMIVEE CGCS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69619 mRNA Translation: CAA49325.1 BC053527 mRNA Translation: AAH53527.1 |
CCDSi | CCDS26251.1 |
PIRi | A60087, S31440 |
RefSeqi | NP_032406.1, NM_008380.2 XP_006516621.1, XM_006516558.2 XP_006516622.1, XM_006516559.2 XP_011242587.1, XM_011244285.2 XP_011242588.1, XM_011244286.1 |
Genome annotation databases
Ensembli | ENSMUST00000042603; ENSMUSP00000047894; ENSMUSG00000041324 ENSMUST00000164993; ENSMUSP00000132085; ENSMUSG00000041324 |
GeneIDi | 16323 |
KEGGi | mmu:16323 |
UCSCi | uc007pnw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69619 mRNA Translation: CAA49325.1 BC053527 mRNA Translation: AAH53527.1 |
CCDSi | CCDS26251.1 |
PIRi | A60087, S31440 |
RefSeqi | NP_032406.1, NM_008380.2 XP_006516621.1, XM_006516558.2 XP_006516622.1, XM_006516559.2 XP_011242587.1, XM_011244285.2 XP_011242588.1, XM_011244286.1 |
3D structure databases
SMRi | Q04998 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200762, 5 interactors |
STRINGi | 10090.ENSMUSP00000047894 |
Chemistry databases
BindingDBi | Q04998 |
ChEMBLi | CHEMBL3588734 |
PTM databases
GlyGeni | Q04998, 1 site |
PhosphoSitePlusi | Q04998 |
Proteomic databases
PaxDbi | Q04998 |
PeptideAtlasi | Q04998 |
PRIDEi | Q04998 |
Protocols and materials databases
Antibodypediai | 13122, 540 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042603; ENSMUSP00000047894; ENSMUSG00000041324 ENSMUST00000164993; ENSMUSP00000132085; ENSMUSG00000041324 |
GeneIDi | 16323 |
KEGGi | mmu:16323 |
UCSCi | uc007pnw.1, mouse |
Organism-specific databases
CTDi | 3624 |
MGIi | MGI:96570, Inhba |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157116 |
HOGENOMi | CLU_020515_5_1_1 |
InParanoidi | Q04998 |
OMAi | CDQCQET |
OrthoDBi | 1385831at2759 |
PhylomeDBi | Q04998 |
TreeFami | TF351791 |
Enzyme and pathway databases
Reactomei | R-MMU-1502540, Signaling by Activin R-MMU-209822, Glycoprotein hormones R-MMU-2473224, Antagonism of Activin by Follistatin |
Miscellaneous databases
BioGRID-ORCSi | 16323, 2 hits in 18 CRISPR screens |
PROi | PR:Q04998 |
RNActi | Q04998, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041324, Expressed in decidua and 238 other tissues |
Genevisiblei | Q04998, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000491, Inhibin_betaA IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PRINTSi | PR00670, INHIBINBA |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INHBA_MOUSE | |
Accessioni | Q04998Primary (citable) accession number: Q04998 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families