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Protein

Inhibin alpha chain

Gene

Inha

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Inhibin deficient mice are viable but are acutely sensitive to development of gonadal sex-cord stromal tumors.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

ReactomeiR-MMU-209822 Glycoprotein hormones

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin alpha chain
Gene namesi
Name:Inha
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96569 Inha

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
PropeptideiPRO_000003368821 – 63By similarityAdd BLAST43
PropeptideiPRO_000003368964 – 233Inhibin alpha N-terminal regionBy similarityAdd BLAST170
ChainiPRO_0000033690234 – 366Inhibin alpha chainAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi263 ↔ 328By similarity
Glycosylationi269N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi292 ↔ 363By similarity
Disulfide bondi296 ↔ 365By similarity
Disulfide bondi327InterchainBy similarity

Post-translational modificationi

Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei63 – 64CleavageBy similarity2
Sitei233 – 234CleavageBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ04997
PaxDbiQ04997
PRIDEiQ04997

PTM databases

iPTMnetiQ04997
PhosphoSitePlusiQ04997

Expressioni

Gene expression databases

BgeeiENSMUSG00000032968
CleanExiMM_INHA
GenevisibleiQ04997 MM

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200761, 1 interactor
STRINGi10090.ENSMUSP00000040310

Structurei

3D structure databases

ProteinModelPortaliQ04997
SMRiQ04997
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00390000005935
HOGENOMiHOG000013165
HOVERGENiHBG052131
InParanoidiQ04997
KOiK05500
OMAiFIFHYCH
OrthoDBiEOG091G0CTF
TreeFamiTF331531

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR017175 Inhibin_asu
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PTHR11848:SF117 PTHR11848:SF117, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037328 Inhibin_alpha_subunit, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSQRSLLLL LLLTLRDVDS CQGPELVREL VLAKVKALFL DALGPPAMDG
60 70 80 90 100
EGGDPGIRRL PRRHAVGGFM HRTSEPEEED VSQAILFPAT GATCEDQPAA
110 120 130 140 150
RGLAQEAEEG LFTYVFRPSQ HIRSHQVTSA QLWFHTGLGR KSTAAANSSA
160 170 180 190 200
PLLDLLVLSS GGPMAVPVSL GQGPPRWAVL HLAASAFPLL THPILVLLLR
210 220 230 240 250
CPLCSCSGRP ETTPFLVAHT RARAPSAGER ARRSTPSVPW PWSPAALRLL
260 270 280 290 300
QRPPEEPAAH AFCHRAALNI SFQELGWDRW IVHPPSFIFH YCHGSCGMPT
310 320 330 340 350
SDLPLPVPGV PPTPVQPLFL VPGAKPCCAA LPGSMRSLRV RTTSDGGYSF
360
KYEMVPNLIT QHCACI
Length:366
Mass (Da):39,550
Last modified:July 27, 2011 - v2
Checksum:i2CFD44AD9D41B66B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165A → R in AAA39314 (PubMed:1632772).Curated1
Sequence conflicti171G → V in CAA49324 (PubMed:8330535).Curated1
Sequence conflicti336R → T in CAA49324 (PubMed:8330535).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69618 mRNA Translation: CAA49324.1
M95525, M95526 Genomic DNA Translation: AAA39314.1
CH466548 Genomic DNA Translation: EDL00422.1
BC056627 mRNA Translation: AAH56627.1
X55957 mRNA Translation: CAA39424.1
CCDSiCCDS15078.1
PIRiJC1106
RefSeqiNP_034694.3, NM_010564.5
UniGeneiMm.1100

Genome annotation databases

EnsembliENSMUST00000037330; ENSMUSP00000040310; ENSMUSG00000032968
GeneIDi16322
KEGGimmu:16322
UCSCiuc007bps.1 mouse

Similar proteinsi

Entry informationi

Entry nameiINHA_MOUSE
AccessioniPrimary (citable) accession number: Q04997
Secondary accession number(s): Q6GTG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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