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Entry version 143 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Glucosidase 2 subunit beta

Gene

GTB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature glycoproteins. Specifically required for the cleavage of the final glucose.1 Publication

Miscellaneous

Present with 9760 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:G3O-29801-MONOMER
YEAST:G3O-29801-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucosidase 2 subunit beta
Alternative name(s):
Alpha-glucosidase 2 subunit beta
Alpha-glucosidase II subunit beta
Glucosidase II subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTB1
Ordered Locus Names:YDR221W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YDR221W

Saccharomyces Genome Database

More...
SGDi
S000002629 GTB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024557221 – 702Glucosidase 2 subunit betaAdd BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi699N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q04924

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04924

PRoteomics IDEntifications database

More...
PRIDEi
Q04924

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a catalytic subunit alpha (ROT2) and a subunit beta (GTB1).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ROT2P381382EBI-37493,EBI-21021

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32273, 90 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-417 Glucosidase II complex

Database of interacting proteins

More...
DIPi
DIP-4429N

Protein interaction database and analysis system

More...
IntActi
Q04924, 1 interactor

Molecular INTeraction database

More...
MINTi
Q04924

STRING: functional protein association networks

More...
STRINGi
4932.YDR221W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q04924

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili163 – 228Sequence analysisAdd BLAST66
Coiled coili478 – 517Sequence analysisAdd BLAST40

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047770

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001046

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q04924

KEGG Orthology (KO)

More...
KOi
K08288

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCDCCDC

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026874 Glucosidase_2_bsu
IPR039794 Gtb1-like
IPR036607 PRKCSH
IPR028146 PRKCSH_N

The PANTHER Classification System

More...
PANTHERi
PTHR12630 PTHR12630, 1 hit
PTHR12630:SF1 PTHR12630:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12999 PRKCSH-like, 1 hit
PF13015 PRKCSH_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q04924-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSMFSLFLL LIEQSPLVAS LQQSQRHIVG VPWEKQHLYD SNEPDLTKWH
60 70 80 90 100
CLNHEDIVLD ISQINDGVCD CPDGSDEPGS AACVEDIFKS VAEGGGKVNK
110 120 130 140 150
YFYCDNKGFI PRYIRKSEVA DGICDCCDCS DELLSGYELF DAGSNCSQLK
160 170 180 190 200
NEFDIMASKE LSSYREGKEA LEELERKYGT KEEAITRGNC LEEDKEKASA
210 220 230 240 250
EIKVLSNRLS ENRAKLEQLR GEYFNQLSHD PILYQFEQLN STRLGSDILT
260 270 280 290 300
SFTMVSRVSK GYQDIFKILS DLSEAYTPSL NDKVVNDNIK KFRKVRRRAE
310 320 330 340 350
KAKINADSKI DDEQADNLYL YFTEEVPQIF LKRESENTLR YVIGKSNFVQ
360 370 380 390 400
ALVEGKINYT NDILEYIREF RLIMDDISQN YNVNFQDAGV KSAVDSYKNY
410 420 430 440 450
LGEYGELAEL EPAHPSESLL RSLSEVTSFV NENAPKVLPP DAVESEQDTN
460 470 480 490 500
SDHIGTSGDL RNKLKEILSK LNIFSSRKDL VSLEKRFRSC ESQVSLLENE
510 520 530 540 550
LKQKMDYKKL LDETEDEGTN STAGNLTELL ELMGSQSYCL DDILDNYVYT
560 570 580 590 600
ICFQRPMTEG VIYQAEDKVD GKKVLIGRFK TSGFNVDLNM EKYAEHLKAT
610 620 630 640 650
YDEKSDLISN LAAIQDDDGN MQHYVFGNLN ELNNGLVLEY ENGDQCWNGP
660 670 680 690 700
RRSATVFVRC SDKFKIRSVH EATKCNYIFD VVGPLGCNKT FEYEPPKFNL

SE
Length:702
Mass (Da):79,907
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i237D9756939D57DD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z48612 Genomic DNA Translation: CAA88501.1
BK006938 Genomic DNA Translation: DAA12063.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59428

NCBI Reference Sequences

More...
RefSeqi
NP_010507.3, NM_001180529.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YDR221W_mRNA; YDR221W_mRNA; YDR221W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851807

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YDR221W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48612 Genomic DNA Translation: CAA88501.1
BK006938 Genomic DNA Translation: DAA12063.1
PIRiS59428
RefSeqiNP_010507.3, NM_001180529.3

3D structure databases

SMRiQ04924
ModBaseiSearch...

Protein-protein interaction databases

BioGridi32273, 90 interactors
ComplexPortaliCPX-417 Glucosidase II complex
DIPiDIP-4429N
IntActiQ04924, 1 interactor
MINTiQ04924
STRINGi4932.YDR221W

Proteomic databases

MaxQBiQ04924
PaxDbiQ04924
PRIDEiQ04924

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR221W_mRNA; YDR221W_mRNA; YDR221W
GeneIDi851807
KEGGisce:YDR221W

Organism-specific databases

EuPathDBiFungiDB:YDR221W
SGDiS000002629 GTB1

Phylogenomic databases

GeneTreeiENSGT00510000047770
HOGENOMiHOG000001046
InParanoidiQ04924
KOiK08288
OMAiVCDCCDC

Enzyme and pathway databases

BioCyciMetaCyc:G3O-29801-MONOMER
YEAST:G3O-29801-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q04924

Family and domain databases

InterProiView protein in InterPro
IPR026874 Glucosidase_2_bsu
IPR039794 Gtb1-like
IPR036607 PRKCSH
IPR028146 PRKCSH_N
PANTHERiPTHR12630 PTHR12630, 1 hit
PTHR12630:SF1 PTHR12630:SF1, 1 hit
PfamiView protein in Pfam
PF12999 PRKCSH-like, 1 hit
PF13015 PRKCSH_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLU2B_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04924
Secondary accession number(s): D6VSK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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