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UniProtKB - Q04917 (1433F_HUMAN)

Entry version 220 (07 Oct 2020)
Sequence version 4 (23 Jan 2007)
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Protein

14-3-3 protein eta

Gene

YWHAH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q04917

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q04917

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q04917

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
14-3-3 protein eta
Alternative name(s):
Protein AS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YWHAH
Synonyms:YWHA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000128245.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:12853, YWHAH

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		113508, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q04917

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7533

Open Targets

More...OpenTargetsi		ENSG00000128245

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37442

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q04917, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3708585

Drug and drug target database

More...DrugBanki		DB12695, Phenethyl Isothiocyanate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YWHAH

Domain mapping of disease mutations (DMDM)

More...DMDMi		1345593

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000586232 – 24614-3-3 protein etaAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycine1 Publication1
Modified residuei25PhosphoserineCombined sources1
Modified residuei59PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q04917

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q04917

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q04917

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q04917

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q04917

PeptideAtlas

More...PeptideAtlasi		Q04917

PRoteomics IDEntifications database

More...PRIDEi		Q04917

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58300

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q04917

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q04917

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q04917

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q04917

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q04917

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in the brain and present in other tissues albeit at lower levels.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128245, Expressed in cerebral cortex and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q04917, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q04917, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000128245, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA.

Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.

Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B.

Interacts with GAB2.

Interacts with KCNK18 in a phosphorylation-dependent manner.

Interacts with SAMSN1 (By similarity).

Interacts with the 'Ser-241' phosphorylated form of PDPK1.

Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).

Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).

Interacts with SLITRK1 (PubMed:19640509).

By similarity9 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei57Interaction with phosphoserine on interacting protein1
Sitei132Interaction with phosphoserine on interacting protein1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113365, 259 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q04917

Database of interacting proteins

More...DIPi		DIP-27566N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q04917

Protein interaction database and analysis system

More...IntActi		Q04917, 487 interactors

Molecular INTeraction database

More...MINTi		Q04917

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000248975

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q04917

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q04917, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q04917

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q04917

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0841, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214540

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_058290_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q04917

KEGG Orthology (KO)

More...KOi		K16198

Identification of Orthologs from Complete Genome Data

More...OMAi		ELPECHP

Database of Orthologous Groups

More...OrthoDBi		1176818at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q04917

TreeFam database of animal gene trees

More...TreeFami		TF102003

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.190.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain

The PANTHER Classification System

More...PANTHERi		PTHR18860, PTHR18860, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00244, 14-3-3, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000868, 14-3-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00305, 1433ZETA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00101, 14_3_3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48445, SSF48445, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q04917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK 
        60         70         80         90        100
NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV 
       110        120        130        140        150
LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS 
       160        170        180        190        200
EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA 
       210        220        230        240 
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN
Length:246
Mass (Da):28,219
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD70FBC100C45D6E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2IDB2A2IDB2_HUMAN
14-3-3 protein eta
YWHAH
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2IDB1A2IDB1_HUMAN
14-3-3 protein eta
YWHAH
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEB6F8WEB6_HUMAN
14-3-3 protein eta
YWHAH
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144N → T in CAA40620 (PubMed:8515476).Curated1
Sequence conflicti157A → G in AAA35483 (PubMed:8218406).Curated1
Sequence conflicti237Q → L in AAA35483 (PubMed:8218406).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L20422 mRNA Translation: AAA35483.1
X80536 Genomic DNA Translation: CAA56676.1
X78138 mRNA Translation: CAA55017.1
X57345 mRNA Translation: CAA40620.1
D78577 Genomic DNA Translation: BAA11418.1
S80794 mRNA Translation: AAB36036.1
CR456612 mRNA Translation: CAG30498.1
Z82248 Genomic DNA No translation available.
BC003047 mRNA Translation: AAH03047.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13901.1

Protein sequence database of the Protein Information Resource

More...PIRi		S34756
S38509
S38532

NCBI Reference Sequences

More...RefSeqi		NP_003396.1, NM_003405.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000248975; ENSP00000248975; ENSG00000128245

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7533

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7533

UCSC genome browser

More...UCSCi		uc003alz.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20422 mRNA Translation: AAA35483.1
X80536 Genomic DNA Translation: CAA56676.1
X78138 mRNA Translation: CAA55017.1
X57345 mRNA Translation: CAA40620.1
D78577 Genomic DNA Translation: BAA11418.1
S80794 mRNA Translation: AAB36036.1
CR456612 mRNA Translation: CAG30498.1
Z82248 Genomic DNA No translation available.
BC003047 mRNA Translation: AAH03047.1
CCDSiCCDS13901.1
PIRiS34756
S38509
S38532
RefSeqiNP_003396.1, NM_003405.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C63X-ray2.15A/B/C/D2-246[»]
2C74X-ray2.70A/B2-246[»]
SMRiQ04917
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113365, 259 interactors
CORUMiQ04917
DIPiDIP-27566N
ELMiQ04917
IntActiQ04917, 487 interactors
MINTiQ04917
STRINGi9606.ENSP00000248975

Chemistry databases

BindingDBiQ04917
ChEMBLiCHEMBL3708585
DrugBankiDB12695, Phenethyl Isothiocyanate

PTM databases

iPTMnetiQ04917
MetOSiteiQ04917
PhosphoSitePlusiQ04917
SwissPalmiQ04917

Polymorphism and mutation databases

BioMutaiYWHAH
DMDMi1345593

Proteomic databases

EPDiQ04917
jPOSTiQ04917
MassIVEiQ04917
MaxQBiQ04917
PaxDbiQ04917
PeptideAtlasiQ04917
PRIDEiQ04917
ProteomicsDBi58300
TopDownProteomicsiQ04917

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11204, 298 antibodies

The DNASU plasmid repository

More...DNASUi		7533

Genome annotation databases

EnsembliENST00000248975; ENSP00000248975; ENSG00000128245
GeneIDi7533
KEGGihsa:7533
UCSCiuc003alz.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7533
DisGeNETi7533
EuPathDBiHostDB:ENSG00000128245.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		YWHAH
HGNCiHGNC:12853, YWHAH
HPAiENSG00000128245, Tissue enriched (brain)
MIMi113508, gene
neXtProtiNX_Q04917
OpenTargetsiENSG00000128245
PharmGKBiPA37442

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0841, Eukaryota
GeneTreeiENSGT01000000214540
HOGENOMiCLU_058290_0_0_1
InParanoidiQ04917
KOiK16198
OMAiELPECHP
OrthoDBi1176818at2759
PhylomeDBiQ04917
TreeFamiTF102003

Enzyme and pathway databases

PathwayCommonsiQ04917
ReactomeiR-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
SignaLinkiQ04917
SIGNORiQ04917

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7533, 3 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YWHAH, human
EvolutionaryTraceiQ04917

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		YWHAH

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7533
PharosiQ04917, Tchem

Protein Ontology

More...PROi		PR:Q04917
RNActiQ04917, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000128245, Expressed in cerebral cortex and 240 other tissues
ExpressionAtlasiQ04917, baseline and differential
GenevisibleiQ04917, HS

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain
PANTHERiPTHR18860, PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244, 14-3-3, 1 hit
PIRSFiPIRSF000868, 14-3-3, 1 hit
PRINTSiPR00305, 1433ZETA
SMARTiView protein in SMART
SM00101, 14_3_3, 1 hit
SUPFAMiSSF48445, SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1433F_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04917
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 220 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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