YWHAH

Functionⁱ

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.1 Publication

GO - Molecular functionⁱ

actin binding Source: Ensembl
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- "Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation."
  Palmer D., Jimmo S.L., Raymond D.R., Wilson L.S., Carter R.L., Maurice D.H.
  J. Biol. Chem. 282:9411-9419(2007) [PubMed] [Europe PMC] [Abstract]
glucocorticoid receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- "Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein."
  Wakui H., Wright A.P., Gustafsson J., Zilliacus J.
  J. Biol. Chem. 272:8153-8156(1997) [PubMed] [Europe PMC] [Abstract]
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- Ref.24
  "Structural basis for protein-protein interactions in the 14-3-3 protein family."
  Yang X., Lee W.H., Sobott F., Papagrigoriou E., Robinson C.V., Grossmann J.G., Sundstroem M., Doyle D.A., Elkins J.M.
  Proc. Natl. Acad. Sci. U.S.A. 103:17237-17242(2006) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS), IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH PHOSPHOSERINE MOTIFS, SUBUNIT.
- "A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes."
  Gloeckner C.J., Boldt K., Schumacher A., Roepman R., Ueffing M.
  Proteomics 7:4228-4234(2007) [PubMed] [Europe PMC] [Abstract]
insulin-like growth factor receptor binding Source: UniProtKB
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- "14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity."
  Kagan A., Melman Y.F., Krumerman A., McDonald T.V.
  EMBO J. 21:1889-1898(2002) [PubMed] [Europe PMC] [Abstract]
- "14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5."
  Allouis M., Le Bouffant F., Wilders R., Peroz D., Schott J.J., Noireaud J., Le Marec H., Merot J., Escande D., Baro I.
  Circ. Res. 98:1538-1546(2006) [PubMed] [Europe PMC] [Abstract]
protein domain specific binding Source: UniProtKB
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- "14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity."
  Kagan A., Melman Y.F., Krumerman A., McDonald T.V.
  EMBO J. 21:1889-1898(2002) [PubMed] [Europe PMC] [Abstract]
sodium channel regulator activity
Source: BHF-UCL
Inferred from direct assayⁱ
- "14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5."
  Allouis M., Le Bouffant F., Wilders R., Peroz D., Schott J.J., Noireaud J., Le Marec H., Merot J., Escande D., Baro I.
  Circ. Res. 98:1538-1546(2006) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111447 Activation of BAD and translocation to mitochondria R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
SignaLinkⁱ	Q04917
SIGNORⁱ	Q04917

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 14-3-3 protein eta Alternative name(s): Protein AS1
Gene namesⁱ	Name:YWHAH Synonyms:YWHA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12853 YWHAH
MIMⁱ	113508 gene
neXtProtⁱ	NX_Q04917

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7533
Open Targets More...OpenTargetsⁱ	ENSG00000128245
PharmGKBⁱ	PA37442

Chemistry databases

ChEMBLⁱ	CHEMBL3708585

ChEMBLⁱ

CHEMBL3708585

Polymorphism and mutation databases

BioMutaⁱ	YWHAH
DMDMⁱ	1345593

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed2 Publications
ChainⁱPRO_0000058623	2 – 246	14-3-3 protein etaAdd BLAST		245

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycine1 Publication	1
Modified residueⁱ	25	PhosphoserineCombined sources	1
Modified residueⁱ	59	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q04917
jPOSTⁱ	Q04917
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04917
PaxDbⁱ	Q04917
PeptideAtlas More...PeptideAtlasⁱ	Q04917
PRIDEⁱ	Q04917
ProteomicsDBⁱ	58300
TopDownProteomicsⁱ	Q04917

PTM databases

iPTMnetⁱ	Q04917
PhosphoSitePlusⁱ	Q04917
SwissPalmⁱ	Q04917

Expressionⁱ

Tissue specificityⁱ

Expressed mainly in the brain and present in other tissues albeit at lower levels.

Gene expression databases

Bgeeⁱ	ENSG00000128245 Expressed in 227 organ(s), highest expression level in cerebral cortex
ExpressionAtlasⁱ	Q04917 baseline and differential
Genevisibleⁱ	Q04917 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025918

HPAⁱ

CAB025918

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity).

Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA.

Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.

Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B.

Interacts with GAB2.

Interacts with KCNK18 in a phosphorylation-dependent manner.

Interacts with SAMSN1 (By similarity).

Interacts with the 'Ser-241' phosphorylated form of PDPK1.

Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).

Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).

Interacts with SLITRK1 (PubMed:19640509).

By similarity9 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	57	Interaction with phosphoserine on interacting protein		1
Siteⁱ	132	Interaction with phosphoserine on interacting protein		1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		5	EBI-306940,EBI-306940
AKT1S1	Q96B36	3	EBI-306940,EBI-720593
CAMKK1	Q8N5S9	5	EBI-306940,EBI-6424030
CDC25B	P30305	4	EBI-306940,EBI-1051746
CDK14	O94921	3	EBI-306940,EBI-1043945
CSNK1A1	P67828	8	EBI-306940,EBI-7540603	From Oryctolagus cuniculus.
GREM1	O60565	5	EBI-306940,EBI-944395
HDAC4	P56524	4	EBI-306940,EBI-308629
KANK1	Q14678-2	3	EBI-306940,EBI-6173812
LRRK2	Q5S007	3	EBI-306940,EBI-5323863
MARK2	Q7KZI7	8	EBI-306940,EBI-516560
MARK3	P27448	4	EBI-306940,EBI-707595
MARK4	Q96L34	6	EBI-306940,EBI-302319
PARD3	Q8TEW0	6	EBI-306940,EBI-81968
PARD6A	Q9NPB6	2	EBI-306940,EBI-81876
PARD6B	Q9BYG5	3	EBI-306940,EBI-295391
PARD6G	Q9BYG4	2	EBI-306940,EBI-295417
PRKCI	P41743	3	EBI-306940,EBI-286199
RAF1	P04049	6	EBI-306940,EBI-365996
Rnd3	P61588	2	EBI-306940,EBI-6930266	From Mus musculus.
SNCA	P37840-1	9	EBI-306940,EBI-9684465

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113365, 238 interactors
CORUMⁱ	Q04917
Database of interacting proteins More...DIPⁱ	DIP-27566N
ELMⁱ	Q04917
IntActⁱ	Q04917, 222 interactors
Molecular INTeraction database More...MINTⁱ	Q04917
STRINGⁱ	9606.ENSP00000248975

Chemistry databases

BindingDBⁱ

Q04917

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 16	Combined sources	13
Helixⁱ	20 – 31	Combined sources	12
Helixⁱ	39 – 73	Combined sources	35
Helixⁱ	76 – 106	Combined sources	31
Turnⁱ	107 – 111	Combined sources	5
Helixⁱ	117 – 137	Combined sources	21
Helixⁱ	140 – 164	Combined sources	25
Helixⁱ	170 – 185	Combined sources	16
Helixⁱ	190 – 206	Combined sources	17
Helixⁱ	207 – 210	Combined sources	4
Turnⁱ	213 – 215	Combined sources	3
Helixⁱ	216 – 234	Combined sources	19

Show more details

3D structure databases

SMRⁱ	Q04917
ModBaseⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q04917

EvolutionaryTraceⁱ

Q04917

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0841 Eukaryota COG5040 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00960000186635
HOGENOMⁱ	HOG000240379
InParanoidⁱ	Q04917
KEGG Orthology (KO) More...KOⁱ	K16198
OMAⁱ	QFESKVF
Database of Orthologous Groups More...OrthoDBⁱ	1176818at2759
PhylomeDBⁱ	Q04917
TreeFamⁱ	TF102003

Family and domain databases

Gene3Dⁱ	1.20.190.20, 1 hit
InterProⁱ	View protein in InterPro IPR000308 14-3-3 IPR023409 14-3-3_CS IPR036815 14-3-3_dom_sf IPR023410 14-3-3_domain
PANTHERⁱ	PTHR18860 PTHR18860, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00244 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868 14-3-3, 1 hit
PRINTSⁱ	PR00305 1433ZETA
SMARTⁱ	View protein in SMART SM00101 14_3_3, 1 hit
SUPFAMⁱ	SSF48445 SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796 1433_1, 1 hit PS00797 1433_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q04917-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK 
        60         70         80         90        100
NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV 
       110        120        130        140        150
LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS 
       160        170        180        190        200
EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA 
       210        220        230        240 
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN

Length:246

Mass (Da):28,219

Last modified:January 23, 2007 - v4

Checksum:ⁱD70FBC100C45D6E5

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A2IDB2	A2IDB2_HUMAN	14-3-3 protein eta 14-3-3 protein eta	YWHAH	162	Annotation score:
A2IDB1	A2IDB1_HUMAN	14-3-3 protein eta 14-3-3 protein eta	YWHAH	72	Annotation score:
F8WEB6	F8WEB6_HUMAN	14-3-3 protein eta 14-3-3 protein eta	YWHAH	39	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	144	N → T in CAA40620 (PubMed:8515476).Curated	1
Sequence conflictⁱ	157	A → G in AAA35483 (PubMed:8218406).Curated	1
Sequence conflictⁱ	237	Q → L in AAA35483 (PubMed:8218406).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L20422 mRNA Translation: AAA35483.1 X80536 Genomic DNA Translation: CAA56676.1 X78138 mRNA Translation: CAA55017.1 X57345 mRNA Translation: CAA40620.1 D78577 Genomic DNA Translation: BAA11418.1 S80794 mRNA Translation: AAB36036.1 CR456612 mRNA Translation: CAG30498.1 Z82248 Genomic DNA No translation available. BC003047 mRNA Translation: AAH03047.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13901.1
PIRⁱ	S34756 S38509 S38532
NCBI Reference Sequences More...RefSeqⁱ	NP_003396.1, NM_003405.3

Genome annotation databases

Ensemblⁱ	ENST00000248975; ENSP00000248975; ENSG00000128245
GeneIDⁱ	7533
KEGGⁱ	hsa:7533
UCSC genome browser More...UCSCⁱ	uc003alz.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q04917	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, isoform CRA_b		HUMAN		246	UniRef100_Q04917
14-3-3 protein eta		MACMU		246
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (Predicted)		PAPAN		246
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta		PANTR		246
14-3-3 protein eta		CALJA		246
+9

Protein	Similar proteins		Species	Score	Length	Source
Q04917	14-3-3 protein eta	)	MOUSE		246	UniRef90_Q04917
14-3-3 protein eta		BOVIN		246
14-3-3 protein eta		RAT		246
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, isoform CRA_b		HUMAN		246
14-3-3 protein eta		MACMU		246
+86

Protein	Similar proteins		Species	Score	Length	Source
Q04917	14-3-3 protein eta	)	MOUSE		246	UniRef50_Q04917
14-3-3 protein eta		BOVIN		246
14-3-3 protein eta		RAT		246
14-3-3 protein zeta/delta		SHEEP		245
14-3-3-like protein 1		CAEEL		248
+288

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L20422 mRNA Translation: AAA35483.1 X80536 Genomic DNA Translation: CAA56676.1 X78138 mRNA Translation: CAA55017.1 X57345 mRNA Translation: CAA40620.1 D78577 Genomic DNA Translation: BAA11418.1 S80794 mRNA Translation: AAB36036.1 CR456612 mRNA Translation: CAG30498.1 Z82248 Genomic DNA No translation available. BC003047 mRNA Translation: AAH03047.1
CCDSⁱ	CCDS13901.1
PIRⁱ	S34756 S38509 S38532
RefSeqⁱ	NP_003396.1, NM_003405.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2C63	X-ray	2.15	A/B/C/D	2-246	[»]
	2C74	X-ray	2.70	A/B	2-246	[»]
SMRⁱ	Q04917
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113365, 238 interactors
CORUMⁱ	Q04917
DIPⁱ	DIP-27566N
ELMⁱ	Q04917
IntActⁱ	Q04917, 222 interactors
MINTⁱ	Q04917
STRINGⁱ	9606.ENSP00000248975

Chemistry databases

BindingDBⁱ	Q04917
ChEMBLⁱ	CHEMBL3708585

PTM databases

iPTMnetⁱ	Q04917
PhosphoSitePlusⁱ	Q04917
SwissPalmⁱ	Q04917

Polymorphism and mutation databases

BioMutaⁱ	YWHAH
DMDMⁱ	1345593

Proteomic databases

EPDⁱ	Q04917
jPOSTⁱ	Q04917
MaxQBⁱ	Q04917
PaxDbⁱ	Q04917
PeptideAtlasⁱ	Q04917
PRIDEⁱ	Q04917
ProteomicsDBⁱ	58300
TopDownProteomicsⁱ	Q04917

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7533
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000248975; ENSP00000248975; ENSG00000128245
GeneIDⁱ	7533
KEGGⁱ	hsa:7533
UCSCⁱ	uc003alz.4 human

Organism-specific databases

CTDⁱ	7533
DisGeNETⁱ	7533
GeneCardsⁱ	YWHAH
HGNCⁱ	HGNC:12853 YWHAH
HPAⁱ	CAB025918
MIMⁱ	113508 gene
neXtProtⁱ	NX_Q04917
OpenTargetsⁱ	ENSG00000128245
PharmGKBⁱ	PA37442
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0841 Eukaryota COG5040 LUCA
GeneTreeⁱ	ENSGT00960000186635
HOGENOMⁱ	HOG000240379
InParanoidⁱ	Q04917
KOⁱ	K16198
OMAⁱ	QFESKVF
OrthoDBⁱ	1176818at2759
PhylomeDBⁱ	Q04917
TreeFamⁱ	TF102003

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111447 Activation of BAD and translocation to mitochondria R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
SignaLinkⁱ	Q04917
SIGNORⁱ	Q04917

Miscellaneous databases

ChiTaRSⁱ	YWHAH human
EvolutionaryTraceⁱ	Q04917
GeneWikiⁱ	YWHAH
GenomeRNAiⁱ	7533
Protein Ontology More...PROⁱ	PR:Q04917
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128245 Expressed in 227 organ(s), highest expression level in cerebral cortex
ExpressionAtlasⁱ	Q04917 baseline and differential
Genevisibleⁱ	Q04917 HS

Family and domain databases

Gene3Dⁱ	1.20.190.20, 1 hit
InterProⁱ	View protein in InterPro IPR000308 14-3-3 IPR023409 14-3-3_CS IPR036815 14-3-3_dom_sf IPR023410 14-3-3_domain
PANTHERⁱ	PTHR18860 PTHR18860, 1 hit
Pfamⁱ	View protein in Pfam PF00244 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868 14-3-3, 1 hit
PRINTSⁱ	PR00305 1433ZETA
SMARTⁱ	View protein in SMART SM00101 14_3_3, 1 hit
SUPFAMⁱ	SSF48445 SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796 1433_1, 1 hit PS00797 1433_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1433F_HUMAN
Accessionⁱ	Q04917Primary (citable) accession number: Q04917
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	January 23, 2007
	Last modified:	July 31, 2019
	This is version 211 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q04917 (1433F_HUMAN)

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14-3-3 protein eta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Mitochondrion

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ