UniProtKB - Q04917 (1433F_HUMAN)
14-3-3 protein eta
YWHAH
Functioni
GO - Molecular functioni
- actin binding Source: Ensembl
- enzyme binding Source: BHF-UCL
- glucocorticoid receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
- insulin-like growth factor receptor binding Source: UniProtKB
- ion channel binding Source: BHF-UCL
- protein domain specific binding Source: UniProtKB
- protein heterodimerization activity Source: BHF-UCL
- sodium channel regulator activity Source: BHF-UCL
GO - Biological processi
- glucocorticoid catabolic process Source: UniProtKB
- glucocorticoid receptor signaling pathway Source: UniProtKB
- intracellular protein transport Source: UniProtKB
- membrane depolarization during action potential Source: BHF-UCL
- membrane organization Source: Reactome
- negative regulation of dendrite morphogenesis Source: UniProtKB
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of neuron differentiation Source: UniProtKB
- regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
- regulation of sodium ion transport Source: BHF-UCL
- regulation of synaptic plasticity Source: UniProtKB
- substantia nigra development Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q04917 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
SignaLinki | Q04917 |
SIGNORi | Q04917 |
Names & Taxonomyi
Protein namesi | Recommended name: 14-3-3 protein etaAlternative name(s): Protein AS1 |
Gene namesi | Name:YWHAH Synonyms:YWHA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000128245.14 |
HGNCi | HGNC:12853, YWHAH |
MIMi | 113508, gene |
neXtProti | NX_Q04917 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrion Source: GOC
Plasma Membrane
- plasma membrane Source: BHF-UCL
Other locations
- cytoplasm Source: UniProtKB
- intercalated disc Source: BHF-UCL
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7533 |
OpenTargetsi | ENSG00000128245 |
PharmGKBi | PA37442 |
Miscellaneous databases
Pharosi | Q04917, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3708585 |
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Polymorphism and mutation databases
BioMutai | YWHAH |
DMDMi | 1345593 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000058623 | 2 – 246 | 14-3-3 protein etaAdd BLAST | 245 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylglycine1 Publication | 1 | |
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 59 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q04917 |
jPOSTi | Q04917 |
MassIVEi | Q04917 |
MaxQBi | Q04917 |
PaxDbi | Q04917 |
PeptideAtlasi | Q04917 |
PRIDEi | Q04917 |
ProteomicsDBi | 58300 |
TopDownProteomicsi | Q04917 |
PTM databases
iPTMneti | Q04917 |
MetOSitei | Q04917 |
PhosphoSitePlusi | Q04917 |
SwissPalmi | Q04917 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000128245, Expressed in cerebral cortex and 240 other tissues |
ExpressionAtlasi | Q04917, baseline and differential |
Genevisiblei | Q04917, HS |
Organism-specific databases
HPAi | ENSG00000128245, Tissue enriched (brain) |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA.
Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.
Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B.
Interacts with GAB2.
Interacts with KCNK18 in a phosphorylation-dependent manner.
Interacts with SAMSN1 (By similarity).
Interacts with the 'Ser-241' phosphorylated form of PDPK1.
Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).
Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).
Interacts with SLITRK1 (PubMed:19640509).
By similarity9 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 57 | Interaction with phosphoserine on interacting protein | 1 | |
Sitei | 132 | Interaction with phosphoserine on interacting protein | 1 |
Binary interactionsi
Hide detailsQ04917
GO - Molecular functioni
- actin binding Source: Ensembl
- enzyme binding Source: BHF-UCL
- glucocorticoid receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
- insulin-like growth factor receptor binding Source: UniProtKB
- ion channel binding Source: BHF-UCL
- protein domain specific binding Source: UniProtKB
- protein heterodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 113365, 259 interactors |
CORUMi | Q04917 |
DIPi | DIP-27566N |
ELMi | Q04917 |
IntActi | Q04917, 487 interactors |
MINTi | Q04917 |
STRINGi | 9606.ENSP00000248975 |
Chemistry databases
BindingDBi | Q04917 |
Miscellaneous databases
RNActi | Q04917, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q04917 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q04917 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01010000222256 |
HOGENOMi | CLU_058290_0_0_1 |
InParanoidi | Q04917 |
OMAi | ELPECHP |
OrthoDBi | 1176818at2759 |
PhylomeDBi | Q04917 |
TreeFami | TF102003 |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK
60 70 80 90 100
NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV
110 120 130 140 150
LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS
160 170 180 190 200
EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA
210 220 230 240
FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2IDB2 | A2IDB2_HUMAN | 14-3-3 protein eta | YWHAH | 162 | Annotation score: | ||
A2IDB1 | A2IDB1_HUMAN | 14-3-3 protein eta | YWHAH | 72 | Annotation score: | ||
F8WEB6 | F8WEB6_HUMAN | 14-3-3 protein eta | YWHAH | 39 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 | N → T in CAA40620 (PubMed:8515476).Curated | 1 | |
Sequence conflicti | 157 | A → G in AAA35483 (PubMed:8218406).Curated | 1 | |
Sequence conflicti | 237 | Q → L in AAA35483 (PubMed:8218406).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20422 mRNA Translation: AAA35483.1 X80536 Genomic DNA Translation: CAA56676.1 X78138 mRNA Translation: CAA55017.1 X57345 mRNA Translation: CAA40620.1 D78577 Genomic DNA Translation: BAA11418.1 S80794 mRNA Translation: AAB36036.1 CR456612 mRNA Translation: CAG30498.1 Z82248 Genomic DNA No translation available. BC003047 mRNA Translation: AAH03047.1 |
CCDSi | CCDS13901.1 |
PIRi | S34756 S38509 S38532 |
RefSeqi | NP_003396.1, NM_003405.3 |
Genome annotation databases
Ensembli | ENST00000248975; ENSP00000248975; ENSG00000128245 |
GeneIDi | 7533 |
KEGGi | hsa:7533 |
UCSCi | uc003alz.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20422 mRNA Translation: AAA35483.1 X80536 Genomic DNA Translation: CAA56676.1 X78138 mRNA Translation: CAA55017.1 X57345 mRNA Translation: CAA40620.1 D78577 Genomic DNA Translation: BAA11418.1 S80794 mRNA Translation: AAB36036.1 CR456612 mRNA Translation: CAG30498.1 Z82248 Genomic DNA No translation available. BC003047 mRNA Translation: AAH03047.1 |
CCDSi | CCDS13901.1 |
PIRi | S34756 S38509 S38532 |
RefSeqi | NP_003396.1, NM_003405.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2C63 | X-ray | 2.15 | A/B/C/D | 2-246 | [»] | |
2C74 | X-ray | 2.70 | A/B | 2-246 | [»] | |
SMRi | Q04917 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113365, 259 interactors |
CORUMi | Q04917 |
DIPi | DIP-27566N |
ELMi | Q04917 |
IntActi | Q04917, 487 interactors |
MINTi | Q04917 |
STRINGi | 9606.ENSP00000248975 |
Chemistry databases
BindingDBi | Q04917 |
ChEMBLi | CHEMBL3708585 |
DrugBanki | DB12695, Phenethyl Isothiocyanate |
PTM databases
iPTMneti | Q04917 |
MetOSitei | Q04917 |
PhosphoSitePlusi | Q04917 |
SwissPalmi | Q04917 |
Polymorphism and mutation databases
BioMutai | YWHAH |
DMDMi | 1345593 |
Proteomic databases
EPDi | Q04917 |
jPOSTi | Q04917 |
MassIVEi | Q04917 |
MaxQBi | Q04917 |
PaxDbi | Q04917 |
PeptideAtlasi | Q04917 |
PRIDEi | Q04917 |
ProteomicsDBi | 58300 |
TopDownProteomicsi | Q04917 |
Protocols and materials databases
Antibodypediai | 11204, 298 antibodies |
DNASUi | 7533 |
Genome annotation databases
Ensembli | ENST00000248975; ENSP00000248975; ENSG00000128245 |
GeneIDi | 7533 |
KEGGi | hsa:7533 |
UCSCi | uc003alz.4, human |
Organism-specific databases
CTDi | 7533 |
DisGeNETi | 7533 |
EuPathDBi | HostDB:ENSG00000128245.14 |
GeneCardsi | YWHAH |
HGNCi | HGNC:12853, YWHAH |
HPAi | ENSG00000128245, Tissue enriched (brain) |
MIMi | 113508, gene |
neXtProti | NX_Q04917 |
OpenTargetsi | ENSG00000128245 |
PharmGKBi | PA37442 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01010000222256 |
HOGENOMi | CLU_058290_0_0_1 |
InParanoidi | Q04917 |
OMAi | ELPECHP |
OrthoDBi | 1176818at2759 |
PhylomeDBi | Q04917 |
TreeFami | TF102003 |
Enzyme and pathway databases
PathwayCommonsi | Q04917 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
SignaLinki | Q04917 |
SIGNORi | Q04917 |
Miscellaneous databases
BioGRID-ORCSi | 7533, 3 hits in 843 CRISPR screens |
ChiTaRSi | YWHAH, human |
EvolutionaryTracei | Q04917 |
GeneWikii | YWHAH |
GenomeRNAii | 7533 |
Pharosi | Q04917, Tchem |
PROi | PR:Q04917 |
RNActi | Q04917, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128245, Expressed in cerebral cortex and 240 other tissues |
ExpressionAtlasi | Q04917, baseline and differential |
Genevisiblei | Q04917, HS |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1433F_HUMAN | |
Accessioni | Q04917Primary (citable) accession number: Q04917 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 221 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM