Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 205 (16 Oct 2019)
Sequence version 3 (28 Mar 2018)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Macrophage-stimulating protein receptor

Gene

MST1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1114ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1208Proton acceptor1 Publication1
Binding sitei1212ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1088 – 1096ATP9
Nucleotide bindingi1161 – 1164ATP4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processImmunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8852405 Signaling by MST1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q04912

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q04912

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Macrophage-stimulating protein receptor (EC:2.7.10.1)
Short name:
MSP receptor
Alternative name(s):
CDw136
Protein-tyrosine kinase 8
p185-Ron
CD_antigen: CD136
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MST1R
Synonyms:PTK8, RON
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7381 MST1R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600168 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q04912

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 957ExtracellularSequence analysisAdd BLAST933
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei958 – 978HelicalSequence analysisAdd BLAST21
Topological domaini979 – 1400CytoplasmicSequence analysisAdd BLAST422

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nasopharyngeal carcinoma, 3 (NPCA3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of nasopharyngeal carcinoma, a malignant neoplasm that originates in the nasopharyngeal epithelium and includes 4 subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and papillary adenocarcinoma.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076928306R → H in NPCA3. 1 PublicationCorresponds to variant dbSNP:rs200046052EnsemblClinVar.1
Natural variantiVAR_076929327A → T in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200757776Ensembl.1
Natural variantiVAR_076930670V → G in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201024956Ensembl.1
Natural variantiVAR_076931973A → T in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs773053723Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4486

MalaCards human disease database

More...
MalaCardsi
MST1R
MIMi617075 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000164078

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31186

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q04912

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2689

Drug and drug target database

More...
DrugBanki
DB12010 Fostamatinib

DrugCentral

More...
DrugCentrali
Q04912

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1816

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MST1R

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862462

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002445225 – 1400Macrophage-stimulating protein receptorAdd BLAST1376
ChainiPRO_000002445325 – 304Macrophage-stimulating protein receptor alpha chainSequence analysisAdd BLAST280
ChainiPRO_0000024454310 – 1400Macrophage-stimulating protein receptor beta chainSequence analysisAdd BLAST1091

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi101 ↔ 104PROSITE-ProRule annotation1 Publication
Disulfide bondi107 ↔ 162PROSITE-ProRule annotation1 Publication
Disulfide bondi135 ↔ 143PROSITE-ProRule annotation1 Publication
Disulfide bondi174 ↔ 177PROSITE-ProRule annotation1 Publication
Disulfide bondi300 ↔ 367PROSITE-ProRule annotation1 Publication
Disulfide bondi385 ↔ 407PROSITE-ProRule annotation1 Publication
Disulfide bondi386 ↔ 422PROSITE-ProRule annotation1 Publication
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi488N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi527 ↔ 545PROSITE-ProRule annotation1 Publication
Disulfide bondi533 ↔ 567PROSITE-ProRule annotation1 Publication
Disulfide bondi536 ↔ 552PROSITE-ProRule annotation1 Publication
Disulfide bondi548 ↔ 558PROSITE-ProRule annotation1 Publication
Glycosylationi654N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi720N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi841N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi897N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1238Phosphotyrosine; by autocatalysis2 Publications1
Modified residuei1239Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1353Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1360Phosphotyrosine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic processing yields the two subunits.
Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site.2 Publications
Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q04912

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q04912

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04912

PeptideAtlas

More...
PeptideAtlasi
Q04912

PRoteomics IDEntifications database

More...
PRIDEi
Q04912

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58294 [Q04912-1]
58295 [Q04912-2]
58296 [Q04912-3]
58297 [Q04912-4]
58298 [Q04912-5]
58299 [Q04912-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04912

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q04912

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in colon, skin, lung and bone marrow.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164078 Expressed in 125 organ(s), highest expression level in mucosa of transverse colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q04912 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q04912 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008972
HPA007657
HPA008180

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2.

Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1.

Interacts with integrin beta1/ITGB1 in a ligand-independent fashion.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110592, 34 interactors

Database of interacting proteins

More...
DIPi
DIP-6029N

Protein interaction database and analysis system

More...
IntActi
Q04912, 15 interactors

Molecular INTeraction database

More...
MINTi
Q04912

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296474

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q04912

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 522SemaPROSITE-ProRule annotationAdd BLAST492
Domaini569 – 671IPT/TIG 1Add BLAST103
Domaini684 – 767IPT/TIG 2Add BLAST84
Domaini770 – 860IPT/TIG 3Add BLAST91
Domaini1082 – 1345Protein kinasePROSITE-ProRule annotationAdd BLAST264

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi306 – 309Poly-Arg4
Compositional biasi962 – 968Poly-Leu7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1095 Eukaryota
KOG3610 Eukaryota
ENOG410XRIK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157842

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220900

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q04912

KEGG Orthology (KO)

More...
KOi
K05100

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNSFYQE

Database of Orthologous Groups

More...
OrthoDBi
408584at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q04912

TreeFam database of animal gene trees

More...
TreeFami
TF317402

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11279 Sema_RON, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016201 PSI
IPR039413 RON_Sema
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016244 Tyr_kinase_HGF/MSP_rcpt
IPR015943 WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000617 TyrPK_HGF-R, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF56112 SSF56112, 1 hit
SSF81296 SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform RON (identifier: Q04912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS
60 70 80 90 100
AGGLVQAMVT YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG
110 120 130 140 150
CQTCAACGPG PHGPPGDTDT KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP
160 170 180 190 200
QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS PLGTRVTVVE QGQASYFYVA
210 220 230 240 250
SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPK HLVSYSIEYV
260 270 280 290 300
HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC
310 320 330 340 350
RFAPKRRRRG APEGGQPYPV LRVAHSAPVG AQLATELSIA EGQEVLFGVF
360 370 380 390 400
VTGKDGGPGV GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF
410 420 430 440 450
FQSPSFCPNP PGLEALSPNT SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA
460 470 480 490 500
LYVTRLDNVT VAHMGTMDGR ILQVELVRSL NYLLYVSNFS LGDSGQPVQR
510 520 530 540 550
DVSRLGDHLL FASGDQVFQV PIQGPGCRHF LTCGRCLRAW HFMGCGWCGN
560 570 580 590 600
MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG
610 620 630 640 650
LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV
660 670 680 690 700
GPTNVSLTVT NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT
710 720 730 740 750
CLTLEGQSLS VGTSRAVLVN GTECLLARVS EGQLLCATPP GATVASVPLS
760 770 780 790 800
LQVGGAQVPG SWTFQYREDP VVLSISPNCG YINSHITICG QHLTSAWHLV
810 820 830 840 850
LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG NLSARGDGAA
860 870 880 890 900
GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGINVTV
910 920 930 940 950
GGESCQHEFR GDMVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVRPGP
960 970 980 990 1000
DGVPQSTLLG ILLPLLLLVA ALATALVFSY WWRRKQLVLP PNLNDLASLD
1010 1020 1030 1040 1050
QTAGATPLPI LYSGSDYRSG LALPAIDGLD STTCVHGASF SDSEDESCVP
1060 1070 1080 1090 1100
LLRKESIQLR DLDSALLAEV KDVLIPHERV VTHSDRVIGK GHFGVVYHGE
1110 1120 1130 1140 1150
YIDQAQNRIQ CAIKSLSRIT EMQQVEAFLR EGLLMRGLNH PNVLALIGIM
1160 1170 1180 1190 1200
LPPEGLPHVL LPYMCHGDLL QFIRSPQRNP TVKDLISFGL QVARGMEYLA
1210 1220 1230 1240 1250
EQKFVHRDLA ARNCMLDESF TVKVADFGLA RDILDREYYS VQQHRHARLP
1260 1270 1280 1290 1300
VKWMALESLQ TYRFTTKSDV WSFGVLLWEL LTRGAPPYRH IDPFDLTHFL
1310 1320 1330 1340 1350
AQGRRLPQPE YCPDSLYQVM QQCWEADPAV RPTFRVLVGE VEQIVSALLG
1360 1370 1380 1390 1400
DHYVQLPATY MNLGPSTSHE MNVRPEQPQF SPMPGNVRRP RPLSEPPRPT
Length:1,400
Mass (Da):152,241
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i358672D466B8E70D
GO
Isoform Delta-RON (identifier: Q04912-2) [UniParc]FASTAAdd to basket
Also known as: sf-RON

The sequence of this isoform differs from the canonical sequence as follows:
     884-932: Missing.

Note: Lacks part of the extracellular domain, oligomerizes and is constitutively activated. Expressed at higher level in cancer cells.1 Publication
Show »
Length:1,351
Mass (Da):147,247
Checksum:iFD7630F7E9DFA584
GO
Isoform RON-1 (identifier: Q04912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-495: ELVRSLNYLLYVSNFSLGDSG → GPHPHSPLALGPCLHPHFAHI
     496-1400: Missing.

Show »
Length:495
Mass (Da):52,519
Checksum:i3F99D0A454B25721
GO
Isoform RON-2 (identifier: Q04912-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-516: Missing.
     628-647: PVPRKDFVEEFECELEPLGT → YNLVPPLPFPEGGNQAAPSP
     648-1400: Missing.

Show »
Length:541
Mass (Da):57,721
Checksum:i9BC028F4170B1BFC
GO
Isoform RON-3 (identifier: Q04912-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-907: YIGLGAVADCVGINVTVGGESCQH → VSVRDRGRDSWGSESRGQPTGWSS
     908-1400: Missing.

Show »
Length:907
Mass (Da):97,315
Checksum:iDDC3A5776146ECCB
GO
Isoform RON-4 (identifier: Q04912-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     628-647: PVPRKDFVEEFECELEPLGT → YNLVPPLPFPEGGNQAAPSP
     648-1400: Missing.

Show »
Length:647
Mass (Da):69,265
Checksum:iBE4234918FE98C33
GO
Isoform RON-5 (identifier: Q04912-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-516: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,294
Mass (Da):140,697
Checksum:i56F7C7253989155A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZQ8A0A087WZQ8_HUMAN
Macrophage-stimulating protein rece...
MST1R
574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQS7J3KQS7_HUMAN
Macrophage-stimulating protein rece...
MST1R
1,032Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C074H7C074_HUMAN
Macrophage-stimulating protein rece...
MST1R
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H2E272H2E272_HUMAN
MST1R variant RON30
MST1R
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3Z8H7C3Z8_HUMAN
Macrophage-stimulating protein rece...
MST1R
270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti209A → G in CAA49634 (PubMed:8386824).Curated1
Sequence conflicti813R → RQ in ACF47620 (PubMed:18593464).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04176875R → S1 PublicationCorresponds to variant dbSNP:rs35887539Ensembl.1
Natural variantiVAR_04176995P → T1 PublicationCorresponds to variant dbSNP:rs55908300Ensembl.1
Natural variantiVAR_041770185R → C1 PublicationCorresponds to variant dbSNP:rs55633379Ensembl.1
Natural variantiVAR_076928306R → H in NPCA3. 1 PublicationCorresponds to variant dbSNP:rs200046052EnsemblClinVar.1
Natural variantiVAR_006350322R → Q2 PublicationsCorresponds to variant dbSNP:rs2230593Ensembl.1
Natural variantiVAR_076929327A → T in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200757776Ensembl.1
Natural variantiVAR_041771356G → D1 PublicationCorresponds to variant dbSNP:rs35924402Ensembl.1
Natural variantiVAR_029238434S → L1 PublicationCorresponds to variant dbSNP:rs2230591Ensembl.1
Natural variantiVAR_029239440N → S. Corresponds to variant dbSNP:rs2230592Ensembl.1
Natural variantiVAR_041772465G → D1 PublicationCorresponds to variant dbSNP:rs34564898Ensembl.1
Natural variantiVAR_041773504R → C1 PublicationCorresponds to variant dbSNP:rs34350470Ensembl.1
Natural variantiVAR_041774523Q → R2 PublicationsCorresponds to variant dbSNP:rs2230590Ensembl.1
Natural variantiVAR_041775613Q → P1 PublicationCorresponds to variant dbSNP:rs35986685EnsemblClinVar.1
Natural variantiVAR_076930670V → G in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201024956Ensembl.1
Natural variantiVAR_041776900V → M1 PublicationCorresponds to variant dbSNP:rs56091918Ensembl.1
Natural variantiVAR_076931973A → T in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs773053723Ensembl.1
Natural variantiVAR_0617491195G → S. Corresponds to variant dbSNP:rs7433231Ensembl.1
Natural variantiVAR_0417771304R → G1 PublicationCorresponds to variant dbSNP:rs528985327Ensembl.1
Natural variantiVAR_0245771335R → G1 PublicationCorresponds to variant dbSNP:rs1062633Ensembl.1
Natural variantiVAR_0417781360Y → C1 PublicationCorresponds to variant dbSNP:rs56330223Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038919411 – 516Missing in isoform RON-2 and isoform RON-5. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_038920475 – 495ELVRS…LGDSG → GPHPHSPLALGPCLHPHFAH I in isoform RON-1. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_038921496 – 1400Missing in isoform RON-1. 1 PublicationAdd BLAST905
Alternative sequenceiVSP_038922628 – 647PVPRK…EPLGT → YNLVPPLPFPEGGNQAAPSP in isoform RON-2 and isoform RON-4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_038923648 – 1400Missing in isoform RON-2 and isoform RON-4. 1 PublicationAdd BLAST753
Alternative sequenceiVSP_005007884 – 932Missing in isoform Delta-RON. CuratedAdd BLAST49
Alternative sequenceiVSP_038924884 – 907YIGLG…ESCQH → VSVRDRGRDSWGSESRGQPT GWSS in isoform RON-3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_038925908 – 1400Missing in isoform RON-3. 1 PublicationAdd BLAST493

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X70040 mRNA Translation: CAA49634.1
EU826582 mRNA Translation: ACF47618.1
EU826583 mRNA Translation: ACF47619.1
EU826584 mRNA Translation: ACF47620.1
EU826585 mRNA Translation: ACF47621.1
AC105935 Genomic DNA No translation available.
KC876868 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2807.1 [Q04912-1]
CCDS58833.1 [Q04912-2]
CCDS82777.1 [Q04912-7]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38185

NCBI Reference Sequences

More...
RefSeqi
NP_001231866.1, NM_001244937.2 [Q04912-2]
NP_002438.2, NM_002447.3 [Q04912-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296474; ENSP00000296474; ENSG00000164078 [Q04912-1]
ENST00000344206; ENSP00000341325; ENSG00000164078 [Q04912-2]
ENST00000621387; ENSP00000482642; ENSG00000164078 [Q04912-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4486

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4486

UCSC genome browser

More...
UCSCi
uc003cxy.5 human [Q04912-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70040 mRNA Translation: CAA49634.1
EU826582 mRNA Translation: ACF47618.1
EU826583 mRNA Translation: ACF47619.1
EU826584 mRNA Translation: ACF47620.1
EU826585 mRNA Translation: ACF47621.1
AC105935 Genomic DNA No translation available.
KC876868 Genomic DNA No translation available.
CCDSiCCDS2807.1 [Q04912-1]
CCDS58833.1 [Q04912-2]
CCDS82777.1 [Q04912-7]
PIRiI38185
RefSeqiNP_001231866.1, NM_001244937.2 [Q04912-2]
NP_002438.2, NM_002447.3 [Q04912-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PLSX-ray2.24A1060-1357[»]
4FWWX-ray1.85A42-568[»]
4QT8X-ray3.00A/B25-683[»]
SMRiQ04912
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110592, 34 interactors
DIPiDIP-6029N
IntActiQ04912, 15 interactors
MINTiQ04912
STRINGi9606.ENSP00000296474

Chemistry databases

ChEMBLiCHEMBL2689
DrugBankiDB12010 Fostamatinib
DrugCentraliQ04912
GuidetoPHARMACOLOGYi1816

PTM databases

iPTMnetiQ04912
PhosphoSitePlusiQ04912

Polymorphism and mutation databases

BioMutaiMST1R
DMDMi294862462

Proteomic databases

jPOSTiQ04912
MassIVEiQ04912
PaxDbiQ04912
PeptideAtlasiQ04912
PRIDEiQ04912
ProteomicsDBi58294 [Q04912-1]
58295 [Q04912-2]
58296 [Q04912-3]
58297 [Q04912-4]
58298 [Q04912-5]
58299 [Q04912-6]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q04912

The DNASU plasmid repository

More...
DNASUi
4486

Genome annotation databases

EnsembliENST00000296474; ENSP00000296474; ENSG00000164078 [Q04912-1]
ENST00000344206; ENSP00000341325; ENSG00000164078 [Q04912-2]
ENST00000621387; ENSP00000482642; ENSG00000164078 [Q04912-7]
GeneIDi4486
KEGGihsa:4486
UCSCiuc003cxy.5 human [Q04912-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4486
DisGeNETi4486

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MST1R
HGNCiHGNC:7381 MST1R
HPAiCAB008972
HPA007657
HPA008180
MalaCardsiMST1R
MIMi600168 gene
617075 phenotype
neXtProtiNX_Q04912
OpenTargetsiENSG00000164078
PharmGKBiPA31186

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
KOG3610 Eukaryota
ENOG410XRIK LUCA
GeneTreeiENSGT00940000157842
HOGENOMiHOG000220900
InParanoidiQ04912
KOiK05100
OMAiNNSFYQE
OrthoDBi408584at2759
PhylomeDBiQ04912
TreeFamiTF317402

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-8852405 Signaling by MST1
SignaLinkiQ04912
SIGNORiQ04912

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MST1R human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MST1R

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4486
PharosiQ04912

Protein Ontology

More...
PROi
PR:Q04912

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164078 Expressed in 125 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ04912 baseline and differential
GenevisibleiQ04912 HS

Family and domain databases

CDDicd11279 Sema_RON, 1 hit
Gene3Di2.130.10.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016201 PSI
IPR039413 RON_Sema
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016244 Tyr_kinase_HGF/MSP_rcpt
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PIRSFiPIRSF000617 TyrPK_HGF-R, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF56112 SSF56112, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRON_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04912
Secondary accession number(s): A0A087WZG2
, B5A944, B5A945, B5A946, B5A947
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: March 28, 2018
Last modified: October 16, 2019
This is version 205 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  8. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again