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Protein

Macrophage-stimulating protein receptor

Gene

MST1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.3 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Activity regulationi

In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1114ATP1
Active sitei1208Proton acceptor1 Publication1
Binding sitei1212ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1088 – 1096ATP9
Nucleotide bindingi1161 – 1164ATP4

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • enzyme binding Source: UniProtKB
  • macrophage colony-stimulating factor receptor activity Source: ProtInc
  • transmembrane receptor protein tyrosine kinase activity Source: GO_Central
  • transmembrane signaling receptor activity Source: GO_Central
  • Wnt-protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processImmunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-8852405 Signaling by MST1
SignaLinkiQ04912
SIGNORiQ04912

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage-stimulating protein receptor (EC:2.7.10.1)
Short name:
MSP receptor
Alternative name(s):
CDw136
Protein-tyrosine kinase 8
p185-Ron
CD_antigen: CD136
Cleaved into the following 2 chains:
Gene namesi
Name:MST1R
Synonyms:PTK8, RON
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000164078.12
HGNCiHGNC:7381 MST1R
MIMi600168 gene
neXtProtiNX_Q04912

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 957ExtracellularSequence analysisAdd BLAST933
Transmembranei958 – 978HelicalSequence analysisAdd BLAST21
Topological domaini979 – 1400CytoplasmicSequence analysisAdd BLAST422

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Nasopharyngeal carcinoma, 3 (NPCA3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA form of nasopharyngeal carcinoma, a malignant neoplasm that originates in the nasopharyngeal epithelium and includes 4 subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and papillary adenocarcinoma.
See also OMIM:617075
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076928306R → H in NPCA3. 1 PublicationCorresponds to variant dbSNP:rs200046052EnsemblClinVar.1
Natural variantiVAR_076929327A → T in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200757776Ensembl.1
Natural variantiVAR_076930670V → G in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201024956Ensembl.1
Natural variantiVAR_076931973A → T in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs773053723Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4486
MalaCardsiMST1R
MIMi255995 phenotype
617075 phenotype
OpenTargetsiENSG00000164078
PharmGKBiPA31186

Chemistry databases

ChEMBLiCHEMBL2689
GuidetoPHARMACOLOGYi1816

Polymorphism and mutation databases

BioMutaiMST1R
DMDMi294862462

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002445225 – 1400Macrophage-stimulating protein receptorAdd BLAST1376
ChainiPRO_000002445325 – 304Macrophage-stimulating protein receptor alpha chainSequence analysisAdd BLAST280
ChainiPRO_0000024454310 – 1400Macrophage-stimulating protein receptor beta chainSequence analysisAdd BLAST1091

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 104PROSITE-ProRule annotation1 Publication
Disulfide bondi107 ↔ 162PROSITE-ProRule annotation1 Publication
Disulfide bondi135 ↔ 143PROSITE-ProRule annotation1 Publication
Disulfide bondi174 ↔ 177PROSITE-ProRule annotation1 Publication
Disulfide bondi300 ↔ 367PROSITE-ProRule annotation1 Publication
Disulfide bondi385 ↔ 407PROSITE-ProRule annotation1 Publication
Disulfide bondi386 ↔ 422PROSITE-ProRule annotation1 Publication
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi488N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi527 ↔ 545PROSITE-ProRule annotation1 Publication
Disulfide bondi533 ↔ 567PROSITE-ProRule annotation1 Publication
Disulfide bondi536 ↔ 552PROSITE-ProRule annotation1 Publication
Disulfide bondi548 ↔ 558PROSITE-ProRule annotation1 Publication
Glycosylationi654N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi720N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi841N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi897N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1238Phosphotyrosine; by autocatalysis2 Publications1
Modified residuei1239Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1353Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1360Phosphotyrosine; by autocatalysis1 Publication1

Post-translational modificationi

Proteolytic processing yields the two subunits.
Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site.2 Publications
Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ04912
PeptideAtlasiQ04912
PRIDEiQ04912
ProteomicsDBi58294
58295 [Q04912-2]
58296 [Q04912-3]
58297 [Q04912-4]
58298 [Q04912-5]
58299 [Q04912-6]

PTM databases

iPTMnetiQ04912
PhosphoSitePlusiQ04912

Expressioni

Tissue specificityi

Expressed in colon, skin, lung and bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000164078 Expressed in 125 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_MST1R
ExpressionAtlasiQ04912 baseline and differential
GenevisibleiQ04912 HS

Organism-specific databases

HPAiCAB008972
HPA007657
HPA008180

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2. Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1. Interacts with integrin beta1/ITGB1 in a ligand-independent fashion.7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110592, 24 interactors
DIPiDIP-6029N
IntActiQ04912, 15 interactors
MINTiQ04912
STRINGi9606.ENSP00000296474

Chemistry databases

BindingDBiQ04912

Structurei

Secondary structure

11400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ04912
SMRiQ04912
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 522SemaPROSITE-ProRule annotationAdd BLAST492
Domaini569 – 671IPT/TIG 1Add BLAST103
Domaini684 – 767IPT/TIG 2Add BLAST84
Domaini770 – 860IPT/TIG 3Add BLAST91
Domaini1082 – 1345Protein kinasePROSITE-ProRule annotationAdd BLAST264

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi306 – 309Poly-Arg4
Compositional biasi962 – 968Poly-Leu7

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
KOG3610 Eukaryota
ENOG410XRIK LUCA
GeneTreeiENSGT00810000125384
HOGENOMiHOG000220900
HOVERGENiHBG006348
InParanoidiQ04912
KOiK05100
OMAiQHELRGD
OrthoDBiEOG091G0751
PhylomeDBiQ04912
TreeFamiTF317402

Family and domain databases

CDDicd11279 Sema_RON, 1 hit
Gene3Di2.130.10.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016201 PSI
IPR039413 RON_Sema
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016244 Tyr_kinase_HGF/MSP_rcpt
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PIRSFiPIRSF000617 TyrPK_HGF-R, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF56112 SSF56112, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS51004 SEMA, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform RON (identifier: Q04912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS
60 70 80 90 100
AGGLVQAMVT YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG
110 120 130 140 150
CQTCAACGPG PHGPPGDTDT KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP
160 170 180 190 200
QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS PLGTRVTVVE QGQASYFYVA
210 220 230 240 250
SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPK HLVSYSIEYV
260 270 280 290 300
HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC
310 320 330 340 350
RFAPKRRRRG APEGGQPYPV LRVAHSAPVG AQLATELSIA EGQEVLFGVF
360 370 380 390 400
VTGKDGGPGV GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF
410 420 430 440 450
FQSPSFCPNP PGLEALSPNT SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA
460 470 480 490 500
LYVTRLDNVT VAHMGTMDGR ILQVELVRSL NYLLYVSNFS LGDSGQPVQR
510 520 530 540 550
DVSRLGDHLL FASGDQVFQV PIQGPGCRHF LTCGRCLRAW HFMGCGWCGN
560 570 580 590 600
MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG
610 620 630 640 650
LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV
660 670 680 690 700
GPTNVSLTVT NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT
710 720 730 740 750
CLTLEGQSLS VGTSRAVLVN GTECLLARVS EGQLLCATPP GATVASVPLS
760 770 780 790 800
LQVGGAQVPG SWTFQYREDP VVLSISPNCG YINSHITICG QHLTSAWHLV
810 820 830 840 850
LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG NLSARGDGAA
860 870 880 890 900
GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGINVTV
910 920 930 940 950
GGESCQHEFR GDMVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVRPGP
960 970 980 990 1000
DGVPQSTLLG ILLPLLLLVA ALATALVFSY WWRRKQLVLP PNLNDLASLD
1010 1020 1030 1040 1050
QTAGATPLPI LYSGSDYRSG LALPAIDGLD STTCVHGASF SDSEDESCVP
1060 1070 1080 1090 1100
LLRKESIQLR DLDSALLAEV KDVLIPHERV VTHSDRVIGK GHFGVVYHGE
1110 1120 1130 1140 1150
YIDQAQNRIQ CAIKSLSRIT EMQQVEAFLR EGLLMRGLNH PNVLALIGIM
1160 1170 1180 1190 1200
LPPEGLPHVL LPYMCHGDLL QFIRSPQRNP TVKDLISFGL QVARGMEYLA
1210 1220 1230 1240 1250
EQKFVHRDLA ARNCMLDESF TVKVADFGLA RDILDREYYS VQQHRHARLP
1260 1270 1280 1290 1300
VKWMALESLQ TYRFTTKSDV WSFGVLLWEL LTRGAPPYRH IDPFDLTHFL
1310 1320 1330 1340 1350
AQGRRLPQPE YCPDSLYQVM QQCWEADPAV RPTFRVLVGE VEQIVSALLG
1360 1370 1380 1390 1400
DHYVQLPATY MNLGPSTSHE MNVRPEQPQF SPMPGNVRRP RPLSEPPRPT
Length:1,400
Mass (Da):152,241
Last modified:March 28, 2018 - v3
Checksum:i358672D466B8E70D
GO
Isoform Delta-RON (identifier: Q04912-2) [UniParc]FASTAAdd to basket
Also known as: sf-RON

The sequence of this isoform differs from the canonical sequence as follows:
     884-932: Missing.

Note: Lacks part of the extracellular domain, oligomerizes and is constitutively activated. Expressed at higher level in cancer cells.1 Publication
Show »
Length:1,351
Mass (Da):147,247
Checksum:iFD7630F7E9DFA584
GO
Isoform RON-1 (identifier: Q04912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-495: ELVRSLNYLLYVSNFSLGDSG → GPHPHSPLALGPCLHPHFAHI
     496-1400: Missing.

Show »
Length:495
Mass (Da):52,519
Checksum:i3F99D0A454B25721
GO
Isoform RON-2 (identifier: Q04912-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-516: Missing.
     628-647: PVPRKDFVEEFECELEPLGT → YNLVPPLPFPEGGNQAAPSP
     648-1400: Missing.

Show »
Length:541
Mass (Da):57,721
Checksum:i9BC028F4170B1BFC
GO
Isoform RON-3 (identifier: Q04912-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     884-907: YIGLGAVADCVGINVTVGGESCQH → VSVRDRGRDSWGSESRGQPTGWSS
     908-1400: Missing.

Show »
Length:907
Mass (Da):97,315
Checksum:iDDC3A5776146ECCB
GO
Isoform RON-4 (identifier: Q04912-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     628-647: PVPRKDFVEEFECELEPLGT → YNLVPPLPFPEGGNQAAPSP
     648-1400: Missing.

Show »
Length:647
Mass (Da):69,265
Checksum:iBE4234918FE98C33
GO
Isoform RON-5 (identifier: Q04912-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-516: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,294
Mass (Da):140,697
Checksum:i56F7C7253989155A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZQ8A0A087WZQ8_HUMAN
Macrophage-stimulating protein rece...
MST1R
574Annotation score:
J3KQS7J3KQS7_HUMAN
Macrophage-stimulating protein rece...
MST1R
1,032Annotation score:
H7C074H7C074_HUMAN
Macrophage-stimulating protein rece...
MST1R
285Annotation score:
H2E272H2E272_HUMAN
MST1R variant RON30
MST1R
254Annotation score:
H7C3Z8H7C3Z8_HUMAN
Macrophage-stimulating protein rece...
MST1R
270Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209A → G in CAA49634 (PubMed:8386824).Curated1
Sequence conflicti813R → RQ in ACF47620 (PubMed:18593464).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04176875R → S1 PublicationCorresponds to variant dbSNP:rs35887539Ensembl.1
Natural variantiVAR_04176995P → T1 PublicationCorresponds to variant dbSNP:rs55908300Ensembl.1
Natural variantiVAR_041770185R → C1 PublicationCorresponds to variant dbSNP:rs55633379Ensembl.1
Natural variantiVAR_076928306R → H in NPCA3. 1 PublicationCorresponds to variant dbSNP:rs200046052EnsemblClinVar.1
Natural variantiVAR_006350322R → Q2 PublicationsCorresponds to variant dbSNP:rs2230593Ensembl.1
Natural variantiVAR_076929327A → T in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200757776Ensembl.1
Natural variantiVAR_041771356G → D1 PublicationCorresponds to variant dbSNP:rs35924402Ensembl.1
Natural variantiVAR_029238434S → L1 PublicationCorresponds to variant dbSNP:rs2230591Ensembl.1
Natural variantiVAR_029239440N → S. Corresponds to variant dbSNP:rs2230592Ensembl.1
Natural variantiVAR_041772465G → D1 PublicationCorresponds to variant dbSNP:rs34564898Ensembl.1
Natural variantiVAR_041773504R → C1 PublicationCorresponds to variant dbSNP:rs34350470Ensembl.1
Natural variantiVAR_041774523Q → R2 PublicationsCorresponds to variant dbSNP:rs2230590Ensembl.1
Natural variantiVAR_041775613Q → P1 PublicationCorresponds to variant dbSNP:rs35986685EnsemblClinVar.1
Natural variantiVAR_076930670V → G in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201024956Ensembl.1
Natural variantiVAR_041776900V → M1 PublicationCorresponds to variant dbSNP:rs56091918Ensembl.1
Natural variantiVAR_076931973A → T in NPCA3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs773053723Ensembl.1
Natural variantiVAR_0617491195G → S. Corresponds to variant dbSNP:rs7433231Ensembl.1
Natural variantiVAR_0417771304R → G1 Publication1
Natural variantiVAR_0245771335R → G1 PublicationCorresponds to variant dbSNP:rs1062633Ensembl.1
Natural variantiVAR_0417781360Y → C1 PublicationCorresponds to variant dbSNP:rs56330223Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038919411 – 516Missing in isoform RON-2 and isoform RON-5. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_038920475 – 495ELVRS…LGDSG → GPHPHSPLALGPCLHPHFAH I in isoform RON-1. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_038921496 – 1400Missing in isoform RON-1. 1 PublicationAdd BLAST905
Alternative sequenceiVSP_038922628 – 647PVPRK…EPLGT → YNLVPPLPFPEGGNQAAPSP in isoform RON-2 and isoform RON-4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_038923648 – 1400Missing in isoform RON-2 and isoform RON-4. 1 PublicationAdd BLAST753
Alternative sequenceiVSP_005007884 – 932Missing in isoform Delta-RON. CuratedAdd BLAST49
Alternative sequenceiVSP_038924884 – 907YIGLG…ESCQH → VSVRDRGRDSWGSESRGQPT GWSS in isoform RON-3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_038925908 – 1400Missing in isoform RON-3. 1 PublicationAdd BLAST493

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70040 mRNA Translation: CAA49634.1
EU826582 mRNA Translation: ACF47618.1
EU826583 mRNA Translation: ACF47619.1
EU826584 mRNA Translation: ACF47620.1
EU826585 mRNA Translation: ACF47621.1
AC105935 Genomic DNA No translation available.
KC876868 Genomic DNA No translation available.
CCDSiCCDS2807.1 [Q04912-1]
CCDS58833.1 [Q04912-2]
CCDS82777.1 [Q04912-7]
PIRiI38185
RefSeqiNP_001231866.1, NM_001244937.2 [Q04912-2]
NP_002438.2, NM_002447.3 [Q04912-1]
UniGeneiHs.517973

Genome annotation databases

EnsembliENST00000296474; ENSP00000296474; ENSG00000164078 [Q04912-1]
ENST00000344206; ENSP00000341325; ENSG00000164078 [Q04912-2]
ENST00000621387; ENSP00000482642; ENSG00000164078 [Q04912-7]
GeneIDi4486
KEGGihsa:4486
UCSCiuc003cxy.5 human [Q04912-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70040 mRNA Translation: CAA49634.1
EU826582 mRNA Translation: ACF47618.1
EU826583 mRNA Translation: ACF47619.1
EU826584 mRNA Translation: ACF47620.1
EU826585 mRNA Translation: ACF47621.1
AC105935 Genomic DNA No translation available.
KC876868 Genomic DNA No translation available.
CCDSiCCDS2807.1 [Q04912-1]
CCDS58833.1 [Q04912-2]
CCDS82777.1 [Q04912-7]
PIRiI38185
RefSeqiNP_001231866.1, NM_001244937.2 [Q04912-2]
NP_002438.2, NM_002447.3 [Q04912-1]
UniGeneiHs.517973

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PLSX-ray2.24A1060-1357[»]
4FWWX-ray1.85A42-568[»]
4QT8X-ray3.00A/B25-683[»]
ProteinModelPortaliQ04912
SMRiQ04912
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110592, 24 interactors
DIPiDIP-6029N
IntActiQ04912, 15 interactors
MINTiQ04912
STRINGi9606.ENSP00000296474

Chemistry databases

BindingDBiQ04912
ChEMBLiCHEMBL2689
GuidetoPHARMACOLOGYi1816

PTM databases

iPTMnetiQ04912
PhosphoSitePlusiQ04912

Polymorphism and mutation databases

BioMutaiMST1R
DMDMi294862462

Proteomic databases

PaxDbiQ04912
PeptideAtlasiQ04912
PRIDEiQ04912
ProteomicsDBi58294
58295 [Q04912-2]
58296 [Q04912-3]
58297 [Q04912-4]
58298 [Q04912-5]
58299 [Q04912-6]

Protocols and materials databases

DNASUi4486
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296474; ENSP00000296474; ENSG00000164078 [Q04912-1]
ENST00000344206; ENSP00000341325; ENSG00000164078 [Q04912-2]
ENST00000621387; ENSP00000482642; ENSG00000164078 [Q04912-7]
GeneIDi4486
KEGGihsa:4486
UCSCiuc003cxy.5 human [Q04912-1]

Organism-specific databases

CTDi4486
DisGeNETi4486
EuPathDBiHostDB:ENSG00000164078.12
GeneCardsiMST1R
HGNCiHGNC:7381 MST1R
HPAiCAB008972
HPA007657
HPA008180
MalaCardsiMST1R
MIMi255995 phenotype
600168 gene
617075 phenotype
neXtProtiNX_Q04912
OpenTargetsiENSG00000164078
PharmGKBiPA31186
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1095 Eukaryota
KOG3610 Eukaryota
ENOG410XRIK LUCA
GeneTreeiENSGT00810000125384
HOGENOMiHOG000220900
HOVERGENiHBG006348
InParanoidiQ04912
KOiK05100
OMAiQHELRGD
OrthoDBiEOG091G0751
PhylomeDBiQ04912
TreeFamiTF317402

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-8852405 Signaling by MST1
SignaLinkiQ04912
SIGNORiQ04912

Miscellaneous databases

ChiTaRSiMST1R human
GeneWikiiMST1R
GenomeRNAii4486
PROiPR:Q04912
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164078 Expressed in 125 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_MST1R
ExpressionAtlasiQ04912 baseline and differential
GenevisibleiQ04912 HS

Family and domain databases

CDDicd11279 Sema_RON, 1 hit
Gene3Di2.130.10.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016201 PSI
IPR039413 RON_Sema
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016244 Tyr_kinase_HGF/MSP_rcpt
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PIRSFiPIRSF000617 TyrPK_HGF-R, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF56112 SSF56112, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRON_HUMAN
AccessioniPrimary (citable) accession number: Q04912
Secondary accession number(s): A0A087WZG2
, B5A944, B5A945, B5A946, B5A947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 196 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  8. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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