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Protein

26S proteasome non-ATPase regulatory subunit 3

Gene

rpn-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 3
Alternative name(s):
26S proteasome regulatory subunit rpn-3
Gene namesi
Name:rpn-3
ORF Names:C30C11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC30C11.2 ; CE00101 ; WBGene00004460 ; rpn-3

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738181 – 50426S proteasome non-ATPase regulatory subunit 3Add BLAST504

Proteomic databases

EPDiQ04908
PaxDbiQ04908
PeptideAtlasiQ04908
PRIDEiQ04908

Expressioni

Gene expression databases

BgeeiWBGene00004460

Interactioni

Subunit structurei

The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
dss-1Q95Y722EBI-312239,EBI-312245

Protein-protein interaction databases

BioGridi41400, 4 interactors
DIPiDIP-25350N
IntActiQ04908, 4 interactors
STRINGi6239.C30C11.2.1

Structurei

3D structure databases

ProteinModelPortaliQ04908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 433PCIPROSITE-ProRule annotationAdd BLAST180

Sequence similaritiesi

Belongs to the proteasome subunit S3 family.Curated

Phylogenomic databases

eggNOGiKOG2581 Eukaryota
ENOG410XS40 LUCA
GeneTreeiENSGT00490000043406
HOGENOMiHOG000193909
InParanoidiQ04908
KOiK03033
OMAiAMRYPPK
OrthoDBiEOG091G05QN
PhylomeDBiQ04908

Family and domain databases

InterProiView protein in InterPro
IPR013586 26S_Psome_reg_C
IPR000717 PCI_dom
IPR035267 PSMD3
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10758:SF2 PTHR10758:SF2, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
PF08375 Rpn3_C, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

Q04908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKTGETVV EKMEVDEAKQ DVPATEPAKD LNAIAVENIK EQLAALDKGE
60 70 80 90 100
EHLITRVLQV LPKTRKQIND NVLYKLVSSH LSSDAQFAEG MLKYLHYTPA
110 120 130 140 150
ADTEVQPMDT SNVKTKSPKK GVKPVFASPE SDCYLRLLVL LHLYAQKKNT
160 170 180 190 200
EALALGENQL TSIYNFDRRT LDGLAAKTLY FLCVIYEREG RLFDHQGFLN
210 220 230 240 250
SRLRTATLRN FSESQAVLIC WLLRCYLINR QYQSAAHLVS KVAFPDNASN
260 270 280 290 300
NDLARYMYYQ GRIKALQLDY NSAAGYFLQA QRKAPQEGAI GFKQAVQKWV
310 320 330 340 350
VVIGLLQGEI PDRSVFRQPI YRKCLAHYLD LSRGVRDGDV ARFNHNLEQF
360 370 380 390 400
KTQFEADDTL TLIVRLRQNV IKTAIKQISL AYSRIYIKDI AKKLYITNET
410 420 430 440 450
ETEYIVAKAI ADGAIDAVIT SDVRDGPRYM QSSETADIYR TSEPQAHFDT
460 470 480 490 500
RIRYCLELHN QAVKALRYPP KKKIAVETIE QAREREQQEL EFAKELADED

DDDF
Length:504
Mass (Da):57,507
Last modified:February 1, 1994 - v1
Checksum:i062E476685FCD0A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080722 Genomic DNA Translation: CCD66158.1
PIRiS44783
RefSeqiNP_498869.1, NM_066468.4
UniGeneiCel.5638

Genome annotation databases

EnsemblMetazoaiC30C11.2.1; C30C11.2.1; WBGene00004460
C30C11.2.2; C30C11.2.2; WBGene00004460
GeneIDi176196
KEGGicel:CELE_C30C11.2
UCSCiC30C11.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSMD3_CAEEL
AccessioniPrimary (citable) accession number: Q04908
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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