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Protein

Sialomucin core protein 24

Gene

CD164

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).By similarity3 Publications

GO - Biological processi

Keywordsi

Biological processCell adhesion, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Sialomucin core protein 24
Short name:
MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name:
MGC-24
Short name:
MGC-24v
CD_antigen: CD164
Gene namesi
Name:CD164
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135535.14
HGNCiHGNC:1632 CD164
MIMi603356 gene
neXtProtiNX_Q04900

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 162ExtracellularSequence analysisAdd BLAST139
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 197CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 66 (DFNA66)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:616969

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNETi8763
MalaCardsiCD164
MIMi616969 phenotype
OpenTargetsiENSG00000135535
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA26191

Polymorphism and mutation databases

BioMutaiCD164
DMDMi257051036

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001929224 – 197Sialomucin core protein 24Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Highly N- and O-glycosylated; contains sialic acid.1 Publication
The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ04900
PaxDbiQ04900
PeptideAtlasiQ04900
PRIDEiQ04900
ProteomicsDBi58289
58290 [Q04900-2]
58291 [Q04900-3]
58292 [Q04900-4]
58293 [Q04900-5]

PTM databases

GlyConnecti1744
iPTMnetiQ04900
PhosphoSitePlusiQ04900

Expressioni

Tissue specificityi

Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.5 Publications

Inductioni

Up-regulated by CXCL12 in prostate cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000135535 Expressed in 237 organ(s), highest expression level in colonic mucosa
CleanExiHS_CD164
ExpressionAtlasiQ04900 baseline and differential
GenevisibleiQ04900 HS

Organism-specific databases

HPAiHPA010636

Interactioni

Subunit structurei

Homodimer (isoform 4). Interacts with CXCR4.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114297, 4 interactors
DIPiDIP-43970N
IntActiQ04900, 12 interactors
MINTiQ04900
STRINGi9606.ENSP00000309376

Structurei

3D structure databases

ProteinModelPortaliQ04900
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 197Required for endosomal and lysosomal localizationBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 152Thr-richAdd BLAST48

Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0NP Eukaryota
ENOG410XVJX LUCA
GeneTreeiENSGT00530000063929
HOVERGENiHBG052534
InParanoidiQ04900
KOiK06546
OrthoDBiEOG091G141K
PhylomeDBiQ04900
TreeFamiTF333380

Family and domain databases

InterProiView protein in InterPro
IPR007947 CD164_MGC24
PANTHERiPTHR11337 PTHR11337, 1 hit
PfamiView protein in Pfam
PF05283 MGC-24, 1 hit
PRINTSiPR01701 CD164ANTIGEN

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q04900-1) [UniParc]FASTAAdd to basket
Also known as: CD164(E1-6)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL
60 70 80 90 100
PLVTTPAPET CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC
110 120 130 140 150
QVGNTTDFCS VSTATPVPTA NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT
160 170 180 190
PTSQPVRKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL
Length:197
Mass (Da):20,917
Last modified:September 1, 2009 - v2
Checksum:i4855E02646F4CB35
GO
Isoform 2 (identifier: Q04900-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-197: GVQAVIFFLYKFCKSKERNYHTL → EIRCHTRNYIPDLKK

Show »
Length:189
Mass (Da):20,011
Checksum:iAC1E49F139D50B10
GO
Isoform 3 (identifier: Q04900-3) [UniParc]FASTAAdd to basket
Also known as: CD164(Delta 4)

The sequence of this isoform differs from the canonical sequence as follows:
     111-123: Missing.

Show »
Length:184
Mass (Da):19,689
Checksum:iFB689B760D2EE1FC
GO
Isoform 4 (identifier: Q04900-4) [UniParc]FASTAAdd to basket
Also known as: CD164(Delta 5)

The sequence of this isoform differs from the canonical sequence as follows:
     124-142: Missing.

Show »
Length:178
Mass (Da):19,017
Checksum:i06FC14ECF6372314
GO
Isoform 5 (identifier: Q04900-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-157: GTTNNTVTPTSQPVR → EIRCHTRNYIPDLKK
     158-197: Missing.

Show »
Length:157
Mass (Da):16,736
Checksum:i9F0212BE11D4F958
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9B4D6R9B4_HUMAN
Sialomucin core protein 24
CD164
163Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037972111 – 123Missing in isoform 3. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_037973124 – 142Missing in isoform 4. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_038018143 – 157GTTNN…SQPVR → EIRCHTRNYIPDLKK in isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_038019158 – 197Missing in isoform 5. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_037974175 – 197GVQAV…NYHTL → EIRCHTRNYIPDLKK in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14043 mRNA Translation: BAA03130.1
AF106518 mRNA Translation: AAC82473.1
AF263279 mRNA Translation: AAF85965.1
AF299341 mRNA Translation: AAG53906.1
AF299342 mRNA Translation: AAG53907.1
AF299343 mRNA Translation: AAG53908.1
AF299340 Genomic DNA Translation: AAG53903.1
AF299340 Genomic DNA Translation: AAG53904.1
AF299340 Genomic DNA Translation: AAG53905.1
AK298684 mRNA Translation: BAG60847.1
AK303525 mRNA Translation: BAG64553.1
AK312357 mRNA Translation: BAG35275.1
AK315908 mRNA Translation: BAH14279.1
AL359711 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48348.1
CH471051 Genomic DNA Translation: EAW48352.1
CH471051 Genomic DNA Translation: EAW48349.1
CH471051 Genomic DNA Translation: EAW48353.1
CH471051 Genomic DNA Translation: EAW48354.1
CH471051 Genomic DNA Translation: EAW48355.1
BC011522 mRNA Translation: AAH11522.1
CCDSiCCDS47462.1 [Q04900-5]
CCDS47463.1 [Q04900-2]
CCDS47464.1 [Q04900-3]
CCDS47465.1 [Q04900-4]
CCDS5073.1 [Q04900-1]
PIRiJX0235
RefSeqiNP_001135873.1, NM_001142401.2 [Q04900-3]
NP_001135874.1, NM_001142402.2 [Q04900-4]
NP_001135875.1, NM_001142403.2 [Q04900-2]
NP_001135876.1, NM_001142404.2 [Q04900-5]
NP_001333429.1, NM_001346500.1
NP_006007.2, NM_006016.5 [Q04900-1]
UniGeneiHs.520313

Genome annotation databases

EnsembliENST00000275080; ENSP00000275080; ENSG00000135535 [Q04900-3]
ENST00000310786; ENSP00000309376; ENSG00000135535 [Q04900-1]
ENST00000324953; ENSP00000314177; ENSG00000135535 [Q04900-4]
ENST00000413644; ENSP00000402237; ENSG00000135535 [Q04900-2]
ENST00000512821; ENSP00000427546; ENSG00000135535 [Q04900-5]
GeneIDi8763
KEGGihsa:8763
UCSCiuc003ptd.4 human [Q04900-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14043 mRNA Translation: BAA03130.1
AF106518 mRNA Translation: AAC82473.1
AF263279 mRNA Translation: AAF85965.1
AF299341 mRNA Translation: AAG53906.1
AF299342 mRNA Translation: AAG53907.1
AF299343 mRNA Translation: AAG53908.1
AF299340 Genomic DNA Translation: AAG53903.1
AF299340 Genomic DNA Translation: AAG53904.1
AF299340 Genomic DNA Translation: AAG53905.1
AK298684 mRNA Translation: BAG60847.1
AK303525 mRNA Translation: BAG64553.1
AK312357 mRNA Translation: BAG35275.1
AK315908 mRNA Translation: BAH14279.1
AL359711 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48348.1
CH471051 Genomic DNA Translation: EAW48352.1
CH471051 Genomic DNA Translation: EAW48349.1
CH471051 Genomic DNA Translation: EAW48353.1
CH471051 Genomic DNA Translation: EAW48354.1
CH471051 Genomic DNA Translation: EAW48355.1
BC011522 mRNA Translation: AAH11522.1
CCDSiCCDS47462.1 [Q04900-5]
CCDS47463.1 [Q04900-2]
CCDS47464.1 [Q04900-3]
CCDS47465.1 [Q04900-4]
CCDS5073.1 [Q04900-1]
PIRiJX0235
RefSeqiNP_001135873.1, NM_001142401.2 [Q04900-3]
NP_001135874.1, NM_001142402.2 [Q04900-4]
NP_001135875.1, NM_001142403.2 [Q04900-2]
NP_001135876.1, NM_001142404.2 [Q04900-5]
NP_001333429.1, NM_001346500.1
NP_006007.2, NM_006016.5 [Q04900-1]
UniGeneiHs.520313

3D structure databases

ProteinModelPortaliQ04900
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114297, 4 interactors
DIPiDIP-43970N
IntActiQ04900, 12 interactors
MINTiQ04900
STRINGi9606.ENSP00000309376

PTM databases

GlyConnecti1744
iPTMnetiQ04900
PhosphoSitePlusiQ04900

Polymorphism and mutation databases

BioMutaiCD164
DMDMi257051036

Proteomic databases

MaxQBiQ04900
PaxDbiQ04900
PeptideAtlasiQ04900
PRIDEiQ04900
ProteomicsDBi58289
58290 [Q04900-2]
58291 [Q04900-3]
58292 [Q04900-4]
58293 [Q04900-5]

Protocols and materials databases

DNASUi8763
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275080; ENSP00000275080; ENSG00000135535 [Q04900-3]
ENST00000310786; ENSP00000309376; ENSG00000135535 [Q04900-1]
ENST00000324953; ENSP00000314177; ENSG00000135535 [Q04900-4]
ENST00000413644; ENSP00000402237; ENSG00000135535 [Q04900-2]
ENST00000512821; ENSP00000427546; ENSG00000135535 [Q04900-5]
GeneIDi8763
KEGGihsa:8763
UCSCiuc003ptd.4 human [Q04900-1]

Organism-specific databases

CTDi8763
DisGeNETi8763
EuPathDBiHostDB:ENSG00000135535.14
GeneCardsiCD164
HGNCiHGNC:1632 CD164
HPAiHPA010636
MalaCardsiCD164
MIMi603356 gene
616969 phenotype
neXtProtiNX_Q04900
OpenTargetsiENSG00000135535
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA26191
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0NP Eukaryota
ENOG410XVJX LUCA
GeneTreeiENSGT00530000063929
HOVERGENiHBG052534
InParanoidiQ04900
KOiK06546
OrthoDBiEOG091G141K
PhylomeDBiQ04900
TreeFamiTF333380

Miscellaneous databases

ChiTaRSiCD164 human
GeneWikiiCD164
GenomeRNAii8763
PROiPR:Q04900
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135535 Expressed in 237 organ(s), highest expression level in colonic mucosa
CleanExiHS_CD164
ExpressionAtlasiQ04900 baseline and differential
GenevisibleiQ04900 HS

Family and domain databases

InterProiView protein in InterPro
IPR007947 CD164_MGC24
PANTHERiPTHR11337 PTHR11337, 1 hit
PfamiView protein in Pfam
PF05283 MGC-24, 1 hit
PRINTSiPR01701 CD164ANTIGEN
ProtoNetiSearch...

Entry informationi

Entry nameiMUC24_HUMAN
AccessioniPrimary (citable) accession number: Q04900
Secondary accession number(s): B4DQ85
, E1P5E7, E1P5E8, E1P5E9, O95413, Q5JSU6, Q9BPV0, Q9NR26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 1, 2009
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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