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Entry version 148 (18 Sep 2019)
Sequence version 2 (01 Sep 2009)
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Protein

Sialomucin core protein 24

Gene

CD164

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialomucin core protein 24
Short name:
MUC-24
Alternative name(s):
Endolyn
Multi-glycosylated core protein 24
Short name:
MGC-24
Short name:
MGC-24v
CD_antigen: CD164
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD164
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:1632 CD164

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603356 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q04900

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 162ExtracellularSequence analysisAdd BLAST139
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 197CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal dominant, 66 (DFNA66)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
8763

MalaCards human disease database

More...
MalaCardsi
CD164
MIMi616969 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000135535

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26191

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q04900

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD164

Domain mapping of disease mutations (DMDM)

More...
DMDMi
257051036

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001929224 – 197Sialomucin core protein 24Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly N- and O-glycosylated; contains sialic acid.1 Publication
The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.

Keywords - PTMi

Glycoprotein, Proteoglycan

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1481

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q04900

MaxQB - The MaxQuant DataBase

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MaxQBi
Q04900

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q04900

PeptideAtlas

More...
PeptideAtlasi
Q04900

PRoteomics IDEntifications database

More...
PRIDEi
Q04900

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58289 [Q04900-1]
58290 [Q04900-2]
58291 [Q04900-3]
58292 [Q04900-4]
58293 [Q04900-5]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1744

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04900

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q04900

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q04900

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.5 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by CXCL12 in prostate cancer cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135535 Expressed in 237 organ(s), highest expression level in colonic mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q04900 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q04900 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA010636

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (isoform 4).

Interacts with CXCR4.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114297, 4 interactors

Database of interacting proteins

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DIPi
DIP-43970N

Protein interaction database and analysis system

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IntActi
Q04900, 12 interactors

Molecular INTeraction database

More...
MINTi
Q04900

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309376

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni191 – 197Required for endosomal and lysosomal localizationBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi105 – 152Thr-richAdd BLAST48

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CD164 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0NP Eukaryota
ENOG410XVJX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063929

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q04900

KEGG Orthology (KO)

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KOi
K06546

Database of Orthologous Groups

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OrthoDBi
1643926at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q04900

TreeFam database of animal gene trees

More...
TreeFami
TF333380

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007947 CD164_MGC24

The PANTHER Classification System

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PANTHERi
PTHR11337 PTHR11337, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05283 MGC-24, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01701 CD164ANTIGEN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q04900-1) [UniParc]FASTAAdd to basket
Also known as: CD164(E1-6)

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL
60 70 80 90 100
PLVTTPAPET CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC
110 120 130 140 150
QVGNTTDFCS VSTATPVPTA NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT
160 170 180 190
PTSQPVRKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL
Length:197
Mass (Da):20,917
Last modified:September 1, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4855E02646F4CB35
GO
Isoform 2 (identifier: Q04900-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-197: GVQAVIFFLYKFCKSKERNYHTL → EIRCHTRNYIPDLKK

Show »
Length:189
Mass (Da):20,011
Checksum:iAC1E49F139D50B10
GO
Isoform 3 (identifier: Q04900-3) [UniParc]FASTAAdd to basket
Also known as: CD164(Delta 4)

The sequence of this isoform differs from the canonical sequence as follows:
     111-123: Missing.

Show »
Length:184
Mass (Da):19,689
Checksum:iFB689B760D2EE1FC
GO
Isoform 4 (identifier: Q04900-4) [UniParc]FASTAAdd to basket
Also known as: CD164(Delta 5)

The sequence of this isoform differs from the canonical sequence as follows:
     124-142: Missing.

Show »
Length:178
Mass (Da):19,017
Checksum:i06FC14ECF6372314
GO
Isoform 5 (identifier: Q04900-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-157: GTTNNTVTPTSQPVR → EIRCHTRNYIPDLKK
     158-197: Missing.

Show »
Length:157
Mass (Da):16,736
Checksum:i9F0212BE11D4F958
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9B4D6R9B4_HUMAN
Sialomucin core protein 24
CD164
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037972111 – 123Missing in isoform 3. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_037973124 – 142Missing in isoform 4. 3 PublicationsAdd BLAST19
Alternative sequenceiVSP_038018143 – 157GTTNN…SQPVR → EIRCHTRNYIPDLKK in isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_038019158 – 197Missing in isoform 5. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_037974175 – 197GVQAV…NYHTL → EIRCHTRNYIPDLKK in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D14043 mRNA Translation: BAA03130.1
AF106518 mRNA Translation: AAC82473.1
AF263279 mRNA Translation: AAF85965.1
AF299341 mRNA Translation: AAG53906.1
AF299342 mRNA Translation: AAG53907.1
AF299343 mRNA Translation: AAG53908.1
AF299340 Genomic DNA Translation: AAG53903.1
AF299340 Genomic DNA Translation: AAG53904.1
AF299340 Genomic DNA Translation: AAG53905.1
AK298684 mRNA Translation: BAG60847.1
AK303525 mRNA Translation: BAG64553.1
AK312357 mRNA Translation: BAG35275.1
AK315908 mRNA Translation: BAH14279.1
AL359711 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48348.1
CH471051 Genomic DNA Translation: EAW48352.1
CH471051 Genomic DNA Translation: EAW48349.1
CH471051 Genomic DNA Translation: EAW48353.1
CH471051 Genomic DNA Translation: EAW48354.1
CH471051 Genomic DNA Translation: EAW48355.1
BC011522 mRNA Translation: AAH11522.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47462.1 [Q04900-5]
CCDS47463.1 [Q04900-2]
CCDS47464.1 [Q04900-3]
CCDS47465.1 [Q04900-4]
CCDS5073.1 [Q04900-1]

Protein sequence database of the Protein Information Resource

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PIRi
JX0235

NCBI Reference Sequences

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RefSeqi
NP_001135873.1, NM_001142401.2 [Q04900-3]
NP_001135874.1, NM_001142402.2 [Q04900-4]
NP_001135875.1, NM_001142403.2 [Q04900-2]
NP_001135876.1, NM_001142404.2 [Q04900-5]
NP_001333429.1, NM_001346500.1
NP_006007.2, NM_006016.5 [Q04900-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000275080; ENSP00000275080; ENSG00000135535 [Q04900-3]
ENST00000310786; ENSP00000309376; ENSG00000135535 [Q04900-1]
ENST00000324953; ENSP00000314177; ENSG00000135535 [Q04900-4]
ENST00000413644; ENSP00000402237; ENSG00000135535 [Q04900-2]
ENST00000512821; ENSP00000427546; ENSG00000135535 [Q04900-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8763

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8763

UCSC genome browser

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UCSCi
uc003ptd.4 human [Q04900-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14043 mRNA Translation: BAA03130.1
AF106518 mRNA Translation: AAC82473.1
AF263279 mRNA Translation: AAF85965.1
AF299341 mRNA Translation: AAG53906.1
AF299342 mRNA Translation: AAG53907.1
AF299343 mRNA Translation: AAG53908.1
AF299340 Genomic DNA Translation: AAG53903.1
AF299340 Genomic DNA Translation: AAG53904.1
AF299340 Genomic DNA Translation: AAG53905.1
AK298684 mRNA Translation: BAG60847.1
AK303525 mRNA Translation: BAG64553.1
AK312357 mRNA Translation: BAG35275.1
AK315908 mRNA Translation: BAH14279.1
AL359711 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48348.1
CH471051 Genomic DNA Translation: EAW48352.1
CH471051 Genomic DNA Translation: EAW48349.1
CH471051 Genomic DNA Translation: EAW48353.1
CH471051 Genomic DNA Translation: EAW48354.1
CH471051 Genomic DNA Translation: EAW48355.1
BC011522 mRNA Translation: AAH11522.1
CCDSiCCDS47462.1 [Q04900-5]
CCDS47463.1 [Q04900-2]
CCDS47464.1 [Q04900-3]
CCDS47465.1 [Q04900-4]
CCDS5073.1 [Q04900-1]
PIRiJX0235
RefSeqiNP_001135873.1, NM_001142401.2 [Q04900-3]
NP_001135874.1, NM_001142402.2 [Q04900-4]
NP_001135875.1, NM_001142403.2 [Q04900-2]
NP_001135876.1, NM_001142404.2 [Q04900-5]
NP_001333429.1, NM_001346500.1
NP_006007.2, NM_006016.5 [Q04900-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi114297, 4 interactors
DIPiDIP-43970N
IntActiQ04900, 12 interactors
MINTiQ04900
STRINGi9606.ENSP00000309376

PTM databases

GlyConnecti1744
iPTMnetiQ04900
PhosphoSitePlusiQ04900
SwissPalmiQ04900

Polymorphism and mutation databases

BioMutaiCD164
DMDMi257051036

Proteomic databases

CPTACiCPTAC-1481
MassIVEiQ04900
MaxQBiQ04900
PaxDbiQ04900
PeptideAtlasiQ04900
PRIDEiQ04900
ProteomicsDBi58289 [Q04900-1]
58290 [Q04900-2]
58291 [Q04900-3]
58292 [Q04900-4]
58293 [Q04900-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8763

Genome annotation databases

EnsembliENST00000275080; ENSP00000275080; ENSG00000135535 [Q04900-3]
ENST00000310786; ENSP00000309376; ENSG00000135535 [Q04900-1]
ENST00000324953; ENSP00000314177; ENSG00000135535 [Q04900-4]
ENST00000413644; ENSP00000402237; ENSG00000135535 [Q04900-2]
ENST00000512821; ENSP00000427546; ENSG00000135535 [Q04900-5]
GeneIDi8763
KEGGihsa:8763
UCSCiuc003ptd.4 human [Q04900-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8763
DisGeNETi8763

GeneCards: human genes, protein and diseases

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GeneCardsi
CD164
HGNCiHGNC:1632 CD164
HPAiHPA010636
MalaCardsiCD164
MIMi603356 gene
616969 phenotype
neXtProtiNX_Q04900
OpenTargetsiENSG00000135535
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA26191

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J0NP Eukaryota
ENOG410XVJX LUCA
GeneTreeiENSGT00530000063929
InParanoidiQ04900
KOiK06546
OrthoDBi1643926at2759
PhylomeDBiQ04900
TreeFamiTF333380

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CD164 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD164

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8763
PharosiQ04900

Protein Ontology

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PROi
PR:Q04900

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000135535 Expressed in 237 organ(s), highest expression level in colonic mucosa
ExpressionAtlasiQ04900 baseline and differential
GenevisibleiQ04900 HS

Family and domain databases

InterProiView protein in InterPro
IPR007947 CD164_MGC24
PANTHERiPTHR11337 PTHR11337, 1 hit
PfamiView protein in Pfam
PF05283 MGC-24, 1 hit
PRINTSiPR01701 CD164ANTIGEN

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC24_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04900
Secondary accession number(s): B4DQ85
, E1P5E7, E1P5E8, E1P5E9, O95413, Q5JSU6, Q9BPV0, Q9NR26
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 1, 2009
Last modified: September 18, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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