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Protein

Cyclin-dependent kinase 18

Gene

Cdk18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei150ATPPROSITE-ProRule annotation1
Active sitei242Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi127 – 135ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 18 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene namesi
Name:Cdk18
Synonyms:Pctaire3, Pctk3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97518 Cdk18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864911 – 451Cyclin-dependent kinase 18Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei51PhosphoserineBy similarity1
Modified residuei66PhosphoserineCombined sources1
Modified residuei75PhosphoserineBy similarity1
Modified residuei109PhosphoserineCombined sources1
Modified residuei417PhosphoserineBy similarity1
Modified residuei420PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ04899
PeptideAtlasiQ04899
PRIDEiQ04899

PTM databases

iPTMnetiQ04899
PhosphoSitePlusiQ04899

Expressioni

Tissue specificityi

In brain, kidney, intestine and at a much lower level, in fetal tissues.

Gene expression databases

BgeeiENSMUSG00000026437 Expressed in 179 organ(s), highest expression level in colon
CleanExiMM_PCTK3
ExpressionAtlasiQ04899 baseline and differential
GenevisibleiQ04899 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027697

Structurei

3D structure databases

ProteinModelPortaliQ04899
SMRiQ04899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 402Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00900000140869
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ04899
KOiK15596
OMAiQYLDNCG
OrthoDBiEOG091G0CH0
PhylomeDBiQ04899
TreeFamiTF106508

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q04899-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKMKNFKRR LSLSVPRPET IEESLAEFTE QFNQLHTQTN EDGTDEPEQL
60 70 80 90 100
SPGMQYQQRQ NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP
110 120 130 140 150
LTRMSRRASL SDIGFGKLET YVKLDKLGEG TYATVFKGRS KLTENLVALK
160 170 180 190 200
EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDLIHTDR SLTLVFEYLD
210 220 230 240 250
SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHHRKILH RDLKPQNLLI
260 270 280 290 300
NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID
310 320 330 340 350
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE
360 370 380 390 400
FRAYNFPRYL PQPLLSHAPR LDTEGINLLS SLLLYESKSR MSAEAALNHP
410 420 430 440 450
YFQSLGDRVH QLHDTASIFS LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI

F
Length:451
Mass (Da):51,848
Last modified:October 1, 1993 - v1
Checksum:i3FC500519714F7E0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQ42A0A087WQ42_MOUSE
Cyclin-dependent kinase 18
Cdk18
68Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69026 mRNA Translation: CAA48788.1
AK004998 mRNA Translation: BAB23732.1
CCDSiCCDS15281.1
PIRiS30436
RefSeqiNP_032821.1, NM_008795.2
UniGeneiMm.28130

Genome annotation databases

EnsembliENSMUST00000027697; ENSMUSP00000027697; ENSMUSG00000026437
ENSMUST00000112362; ENSMUSP00000107981; ENSMUSG00000026437
GeneIDi18557
KEGGimmu:18557
UCSCiuc007coh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69026 mRNA Translation: CAA48788.1
AK004998 mRNA Translation: BAB23732.1
CCDSiCCDS15281.1
PIRiS30436
RefSeqiNP_032821.1, NM_008795.2
UniGeneiMm.28130

3D structure databases

ProteinModelPortaliQ04899
SMRiQ04899
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027697

PTM databases

iPTMnetiQ04899
PhosphoSitePlusiQ04899

Proteomic databases

PaxDbiQ04899
PeptideAtlasiQ04899
PRIDEiQ04899

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027697; ENSMUSP00000027697; ENSMUSG00000026437
ENSMUST00000112362; ENSMUSP00000107981; ENSMUSG00000026437
GeneIDi18557
KEGGimmu:18557
UCSCiuc007coh.2 mouse

Organism-specific databases

CTDi5129
MGIiMGI:97518 Cdk18

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00900000140869
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ04899
KOiK15596
OMAiQYLDNCG
OrthoDBiEOG091G0CH0
PhylomeDBiQ04899
TreeFamiTF106508

Enzyme and pathway databases

BRENDAi2.7.11.22 3474

Miscellaneous databases

PROiPR:Q04899
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026437 Expressed in 179 organ(s), highest expression level in colon
CleanExiMM_PCTK3
ExpressionAtlasiQ04899 baseline and differential
GenevisibleiQ04899 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDK18_MOUSE
AccessioniPrimary (citable) accession number: Q04899
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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