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Entry version 145 (10 Feb 2021)
Sequence version 1 (01 Oct 1993)
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Protein

Allantoin permease

Gene

DAL4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transport of allantoin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • allantoin:proton symporter activity Source: SGD
  • nucleobase transmembrane transporter activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPurine metabolism, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.39.3.1, the nucleobase:cation symporter-1 (ncs1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Allantoin permease
Alternative name(s):
Allantoin transport protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAL4
Ordered Locus Names:YIR028W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IX

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001467, DAL4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YIR028W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 144CytoplasmicSequence analysisAdd BLAST144
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 174ExtracellularSequence analysis9
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 198CytoplasmicSequence analysis3
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 243ExtracellularSequence analysisAdd BLAST24
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 269CytoplasmicSequence analysis5
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 311ExtracellularSequence analysisAdd BLAST21
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 351CytoplasmicSequence analysisAdd BLAST19
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 401ExtracellularSequence analysisAdd BLAST29
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 443CytoplasmicSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 466ExtracellularSequence analysis2
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 522CytoplasmicSequence analysisAdd BLAST35
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 560ExtracellularSequence analysisAdd BLAST17
Transmembranei561 – 581HelicalSequence analysisAdd BLAST21
Topological domaini582 – 635CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001979191 – 635Allantoin permeaseAdd BLAST635

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04895

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35019, 30 interactors

Database of interacting proteins

More...
DIPi
DIP-7194N

Protein interaction database and analysis system

More...
IntActi
Q04895, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YIR028W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q04895, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2466, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176299

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021555_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q04895

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVPFPVM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012681, NCS1
IPR001248, Pur-cyt_permease
IPR038271, Pur-cyt_permease_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02133, Transp_cyt_pur, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00800, ncs1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q04895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANDALSAIF SNPSRKGVQP STSIVSYTNN EDDIIDVENG KFNKNKNINT
60 70 80 90 100
NVYVDNSSIE ESEVVPLPET KSIWSKIYYD FIVLDKTTLN VSLKESFLYN
110 120 130 140 150
RDLKPVEEER RCWSWFNYLY FWLADCFNIN TWQIAGTGLQ LGLNWWQCWL
160 170 180 190 200
TVWIGYTFAG IFVVLNSRFG SAYHLSFPIT VRASFGIFFS MWPIINRVVM
210 220 230 240 250
AIVWYAVQAW LGATPVALML KSIFGKNLED RIPNHFGSPN STTFEFMCFF
260 270 280 290 300
IFWVVSIPFV LVAPHKIRHL FTVKAALIPF AAFGFLIWAL KKSHGKIELG
310 320 330 340 350
TLNDYSPHGS EFSWIFVRSL MACVANFAAL IINAPDFGRF AKNPQASLWP
360 370 380 390 400
QLVAIPLFFA ITCLIGIIVT AAGYHLYGVN YWSPLDVLGQ FLETTYTRGT
410 420 430 440 450
RAGVFLISFV FALAQLGTNI SANSLACGAD MTALFPRYIN IRRGSLFCVA
460 470 480 490 500
MALCICPWNL MASSSKFTSA LGAYAIFLSS IAGVICADYF VVRRGYVKLT
510 520 530 540 550
HLFLAQKGSF YMFGNKFGAN WRAFVAYICG IAPNLPGFIG DVGAPKITVS
560 570 580 590 600
EGAMRLYYLG YPVGFFISAV IYLILCYFFP VPGTPVTNFL TEKGWFQRWA
610 620 630
YVEDFEQDWK NELRRDDLCD DTVSIYDGTE EKIVY
Length:635
Mass (Da):71,756
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4728BBC786DC6698
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z15121 Genomic DNA Translation: CAA78826.1
Z38061 Genomic DNA Translation: CAA86188.1
BK006942 Genomic DNA Translation: DAA08575.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S30018

NCBI Reference Sequences

More...
RefSeqi
NP_012294.3, NM_001179550.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YIR028W_mRNA; YIR028W; YIR028W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854846

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YIR028W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15121 Genomic DNA Translation: CAA78826.1
Z38061 Genomic DNA Translation: CAA86188.1
BK006942 Genomic DNA Translation: DAA08575.1
PIRiS30018
RefSeqiNP_012294.3, NM_001179550.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35019, 30 interactors
DIPiDIP-7194N
IntActiQ04895, 1 interactor
STRINGi4932.YIR028W

Protein family/group databases

TCDBi2.A.39.3.1, the nucleobase:cation symporter-1 (ncs1) family

Proteomic databases

PaxDbiQ04895

Genome annotation databases

EnsemblFungiiYIR028W_mRNA; YIR028W; YIR028W
GeneIDi854846
KEGGisce:YIR028W

Organism-specific databases

SGDiS000001467, DAL4
VEuPathDBiFungiDB:YIR028W

Phylogenomic databases

eggNOGiKOG2466, Eukaryota
GeneTreeiENSGT00940000176299
HOGENOMiCLU_021555_2_2_1
InParanoidiQ04895
OMAiGVPFPVM

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q04895
RNActiQ04895, protein

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681, NCS1
IPR001248, Pur-cyt_permease
IPR038271, Pur-cyt_permease_sf
PfamiView protein in Pfam
PF02133, Transp_cyt_pur, 1 hit
TIGRFAMsiTIGR00800, ncs1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAL4_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04895
Secondary accession number(s): D6VVV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: February 10, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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