UniProtKB - Q04894 (ADH6_YEAST)
Protein
NADP-dependent alcohol dehydrogenase 6
Gene
ADH6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
NADP-dependent alcohol dehydrogenase with a broad substrate specificity.
Miscellaneous
Present with 21700 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:1.1.1.2
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 46 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 68 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 100 | Zinc 2By similarity | 1 | |
Metal bindingi | 103 | Zinc 2By similarity | 1 | |
Metal bindingi | 106 | Zinc 2By similarity | 1 | |
Metal bindingi | 114 | Zinc 2By similarity | 1 | |
Metal bindingi | 163 | Zinc 1; catalyticBy similarity | 1 | |
Binding sitei | 215 | NADBy similarity | 1 | |
Binding sitei | 348 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 187 – 192 | NADBy similarity | 6 | |
Nucleotide bindingi | 275 – 277 | NADBy similarity | 3 |
GO - Molecular functioni
- alcohol dehydrogenase (NADP+) activity Source: SGD
- hydroxymethylfurfural reductase (NADH) activity Source: SGD
- hydroxymethylfurfural reductase (NADPH) activity Source: SGD
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- alcohol metabolic process Source: SGD
- cellular aldehyde metabolic process Source: SGD
- furaldehyde metabolic process Source: SGD
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NADP, Zinc |
Enzyme and pathway databases
SABIO-RKi | Q04894 |
Names & Taxonomyi
Protein namesi | Recommended name: NADP-dependent alcohol dehydrogenase 6 (EC:1.1.1.2)Alternative name(s): NADP-dependent alcohol dehydrogenase VI ScADHVI |
Gene namesi | Name:ADH6 Ordered Locus Names:YMR318C ORF Names:YM9924.10C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004937, ADH6 |
VEuPathDBi | FungiDB:YMR318C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160734 | 1 – 360 | NADP-dependent alcohol dehydrogenase 6Add BLAST | 360 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 131 | PhosphoserineCombined sources | 1 | |
Modified residuei | 359 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q04894 |
PaxDbi | Q04894 |
PRIDEi | Q04894 |
PTM databases
iPTMneti | Q04894 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35498, 82 interactors |
DIPi | DIP-6308N |
IntActi | Q04894, 4 interactors |
STRINGi | 4932.YMR318C |
Miscellaneous databases
RNActi | Q04894, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q04894 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q04894 |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG0023, Eukaryota |
GeneTreei | ENSGT00940000176642 |
HOGENOMi | CLU_026673_20_2_1 |
InParanoidi | Q04894 |
OMAi | WTEFHKN |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04894-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSYPEKFEGI AIQSHEDWKN PKKTKYDPKP FYDHDIDIKI EACGVCGSDI
60 70 80 90 100
HCAAGHWGNM KMPLVVGHEI VGKVVKLGPK SNSGLKVGQR VGVGAQVFSC
110 120 130 140 150
LECDRCKNDN EPYCTKFVTT YSQPYEDGYV SQGGYANYVR VHEHFVVPIP
160 170 180 190 200
ENIPSHLAAP LLCGGLTVYS PLVRNGCGPG KKVGIVGLGG IGSMGTLISK
210 220 230 240 250
AMGAETYVIS RSSRKREDAM KMGADHYIAT LEEGDWGEKY FDTFDLIVVC
260 270 280 290 300
ASSLTDIDFN IMPKAMKVGG RIVSISIPEQ HEMLSLKPYG LKAVSISYSA
310 320 330 340 350
LGSIKELNQL LKLVSEKDIK IWVETLPVGE AGVHEAFERM EKGDVRYRFT
360
LVGYDKEFSD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z54141 Genomic DNA Translation: CAA90836.1 BK006946 Genomic DNA Translation: DAA10220.1 |
PIRi | S59311 |
RefSeqi | NP_014051.3, NM_001182831.3 |
Genome annotation databases
EnsemblFungii | YMR318C_mRNA; YMR318C; YMR318C |
GeneIDi | 855368 |
KEGGi | sce:YMR318C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z54141 Genomic DNA Translation: CAA90836.1 BK006946 Genomic DNA Translation: DAA10220.1 |
PIRi | S59311 |
RefSeqi | NP_014051.3, NM_001182831.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PIW | X-ray | 3.00 | A/B | 1-360 | [»] | |
1PS0 | X-ray | 3.01 | A | 1-360 | [»] | |
1Q1N | X-ray | 3.15 | A | 1-360 | [»] | |
SMRi | Q04894 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35498, 82 interactors |
DIPi | DIP-6308N |
IntActi | Q04894, 4 interactors |
STRINGi | 4932.YMR318C |
PTM databases
iPTMneti | Q04894 |
Proteomic databases
MaxQBi | Q04894 |
PaxDbi | Q04894 |
PRIDEi | Q04894 |
Genome annotation databases
EnsemblFungii | YMR318C_mRNA; YMR318C; YMR318C |
GeneIDi | 855368 |
KEGGi | sce:YMR318C |
Organism-specific databases
SGDi | S000004937, ADH6 |
VEuPathDBi | FungiDB:YMR318C |
Phylogenomic databases
eggNOGi | KOG0023, Eukaryota |
GeneTreei | ENSGT00940000176642 |
HOGENOMi | CLU_026673_20_2_1 |
InParanoidi | Q04894 |
OMAi | WTEFHKN |
Enzyme and pathway databases
SABIO-RKi | Q04894 |
Miscellaneous databases
EvolutionaryTracei | Q04894 |
PROi | PR:Q04894 |
RNActi | Q04894, protein |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADH6_YEAST | |
Accessioni | Q04894Primary (citable) accession number: Q04894 Secondary accession number(s): D6W0E6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families