Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor SOX-14

Gene

Sox14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 76HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-14
Gene namesi
Name:Sox14
Synonyms:Sox-14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:98362 Sox14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487601 – 240Transcription factor SOX-14Add BLAST240

Proteomic databases

PaxDbiQ04892
PeptideAtlasiQ04892
PRIDEiQ04892

PTM databases

iPTMnetiQ04892
PhosphoSitePlusiQ04892

Expressioni

Tissue specificityi

Highly expressed in developing brain and spinal cord.1 Publication

Gene expression databases

BgeeiENSMUSG00000053747 Expressed in 31 organ(s), highest expression level in head
CleanExiMM_SOX14
ExpressionAtlasiQ04892 baseline and differential
GenevisibleiQ04892 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203401, 1 interactor
STRINGi10090.ENSMUSP00000091310

Structurei

3D structure databases

ProteinModelPortaliQ04892
SMRiQ04892
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IPZF Eukaryota
ENOG41115Y8 LUCA
GeneTreeiENSGT00760000118988
HOVERGENiHBG105618
InParanoidiQ04892
KOiK09267
OMAiTLGCPSQ
OrthoDBiEOG091G0F15
PhylomeDBiQ04892
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022097 SOX_fam
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q04892-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS
60 70 80 90 100
EAEKRPYIDE AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG
110 120 130 140 150
DTDPLKAAGL PVGASDGLLS APEKARAFLP PASAPYSLLD PAQFSSSAIQ
160 170 180 190 200
KMGEVPHTLA TSALPYASTL GYQNGAFGSL SCPSQHTHTH PSPTNPGYVV
210 220 230 240
PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
Length:240
Mass (Da):26,515
Last modified:August 14, 2001 - v2
Checksum:i158D8AE76571C856
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1I8S4R1I8_MOUSE
Transcription factor SOX-14
Sox14
177Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193437 Genomic DNA Translation: AAF62397.1
AF193435 mRNA Translation: AAF62396.1
AF182357 Genomic DNA Translation: AAF19353.1
Z18963 mRNA Translation: CAA79488.1
CCDSiCCDS57695.1
PIRiS30244
RefSeqiNP_035570.1, NM_011440.1
UniGeneiMm.261595

Genome annotation databases

EnsembliENSMUST00000054819; ENSMUSP00000091310; ENSMUSG00000053747
GeneIDi20669
KEGGimmu:20669
UCSCiuc012gzb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193437 Genomic DNA Translation: AAF62397.1
AF193435 mRNA Translation: AAF62396.1
AF182357 Genomic DNA Translation: AAF19353.1
Z18963 mRNA Translation: CAA79488.1
CCDSiCCDS57695.1
PIRiS30244
RefSeqiNP_035570.1, NM_011440.1
UniGeneiMm.261595

3D structure databases

ProteinModelPortaliQ04892
SMRiQ04892
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203401, 1 interactor
STRINGi10090.ENSMUSP00000091310

PTM databases

iPTMnetiQ04892
PhosphoSitePlusiQ04892

Proteomic databases

PaxDbiQ04892
PeptideAtlasiQ04892
PRIDEiQ04892

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054819; ENSMUSP00000091310; ENSMUSG00000053747
GeneIDi20669
KEGGimmu:20669
UCSCiuc012gzb.1 mouse

Organism-specific databases

CTDi8403
MGIiMGI:98362 Sox14

Phylogenomic databases

eggNOGiENOG410IPZF Eukaryota
ENOG41115Y8 LUCA
GeneTreeiENSGT00760000118988
HOVERGENiHBG105618
InParanoidiQ04892
KOiK09267
OMAiTLGCPSQ
OrthoDBiEOG091G0F15
PhylomeDBiQ04892
TreeFamiTF351735

Miscellaneous databases

PROiPR:Q04892
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053747 Expressed in 31 organ(s), highest expression level in head
CleanExiMM_SOX14
ExpressionAtlasiQ04892 baseline and differential
GenevisibleiQ04892 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022097 SOX_fam
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX14_MOUSE
AccessioniPrimary (citable) accession number: Q04892
Secondary accession number(s): Q9JLC9, Q9JLD0, Q9QXU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 14, 2001
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again