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Protein

Transcription factor SOX-13

Gene

Sox13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi416 – 484HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-13
Alternative name(s):
SRY (Sex determining region Y)-box 13
Short name:
mSox13
Gene namesi
Name:Sox13
Synonyms:Sox-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98361 Sox13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487571 – 613Transcription factor SOX-13Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei327PhosphoserineBy similarity1
Modified residuei374PhosphoserineBy similarity1
Modified residuei377PhosphoserineBy similarity1
Modified residuei378PhosphoserineBy similarity1
Modified residuei604PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04891
PaxDbiQ04891
PRIDEiQ04891

PTM databases

iPTMnetiQ04891
PhosphoSitePlusiQ04891

Expressioni

Tissue specificityi

In the embryo, high levels of expression are found in the arterial walls at 13.5 dpc. Low levels are found in the inner ear at 13.5 dpc and in some cells in the thymus at 16.5 dpc. Expressed in the tracheal epithelium below the vocal cord and in the hair follicles at 18 dpc. In adults, expressed in the ovary and kidney.2 Publications

Gene expression databases

BgeeiENSMUSG00000070643 Expressed in 200 organ(s), highest expression level in ear
CleanExiMM_SOX13
ExpressionAtlasiQ04891 baseline and differential
GenevisibleiQ04891 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092130

Structurei

3D structure databases

ProteinModelPortaliQ04891
SMRiQ04891
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi177 – 214Gln-richAdd BLAST38
Compositional biasi218 – 332Pro-richAdd BLAST115

Phylogenomic databases

eggNOGiKOG0528 Eukaryota
ENOG410YZNG LUCA
GeneTreeiENSGT00760000119274
HOGENOMiHOG000056455
HOVERGENiHBG003915
InParanoidiQ04891
KOiK09269
OMAiCDVDGSR
OrthoDBiEOG091G04EH
PhylomeDBiQ04891
TreeFamiTF320471

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR029547 SOX-13
PANTHERiPTHR10270:SF233 PTHR10270:SF233, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q04891-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMQSPVSVQ LAPDSASTMV NCTIKSEEKK EPCHEAPQGA APAVETQPGD
60 70 80 90 100
PALASQDATN AKAPPQDCAS PESSGSPEPK RPAASEAASG SQERLDFNRN
110 120 130 140 150
LQEVVPAIEK LLSSDWKERF LGRSNVEAKD VKGTQESLAE KELQLLVMIH
160 170 180 190 200
QLSALRDQLL TAHSEQKNMA AMLFEKQQQQ MELARQQQEQ IAKQQQQLIQ
210 220 230 240 250
QQHKINLLQQ QIQQVNMPYV MIPAFPPSHQ PLPVTPDSQL ALPIQPIPCK
260 270 280 290 300
PVEYPLQLLH SPPAPVVKRS GVAAHHPLQE PPQPLNLTAK PKVPELPNTS
310 320 330 340 350
SSPSLKMNSC GPRPASHGAP TRDLQSSPPS LPLGFLGEGD AVTKAIQDAR
360 370 380 390 400
QLLHSHSGAL ENSPNTPFRK DLISLDSSPA KERLEESCVH PLEEAMLSCD
410 420 430 440 450
MDGSRHFSES RNSSHIKRPM NAFMVWAKDE RRKILQAFPD MHNSSISKIL
460 470 480 490 500
GSRWKSMTNQ EKQPYYEEQA RLSRQHLEKY PDYKYKPRPK RTCVVEGRRL
510 520 530 540 550
RVGEYKALMR TRRQGARQSY TIPPQAGQAQ VSSDILFPRA AGLPLARPLV
560 570 580 590 600
EHYDPQGLDP NMPVIINTCS LREEGEGTDD RHSVADGEMY RYSEDEDSEG
610
DEKSDEELVV LTD
Length:613
Mass (Da):68,168
Last modified:February 9, 2010 - v4
Checksum:iF62C88A052436E91
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7I3D3Z7I3_MOUSE
SRY-box containing gene 13, isoform...
Sox13 mCG_6930
504Annotation score:

Sequence cautioni

The sequence AAH07130 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA25786 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA04278 differs from that shown. Several frameshifts.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3M → L in BAA25786 (PubMed:9524265).Curated1
Sequence conflicti53L → P in AAH07130 (PubMed:15489334).Curated1
Sequence conflicti59 – 60TN → AT in AAH07130 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007130 mRNA Translation: AAH07130.1 Different initiation.
AB006329 mRNA Translation: BAA25786.1 Different initiation.
AJ000740 mRNA Translation: CAA04278.1 Sequence problems.
Z18962 mRNA Translation: CAA79487.1
CCDSiCCDS48363.1
PIRiJC6550
S30241
RefSeqiNP_035569.2, NM_011439.2
UniGeneiMm.8575

Genome annotation databases

EnsembliENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643
ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643
GeneIDi20668
KEGGimmu:20668
UCSCiuc007cqk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007130 mRNA Translation: AAH07130.1 Different initiation.
AB006329 mRNA Translation: BAA25786.1 Different initiation.
AJ000740 mRNA Translation: CAA04278.1 Sequence problems.
Z18962 mRNA Translation: CAA79487.1
CCDSiCCDS48363.1
PIRiJC6550
S30241
RefSeqiNP_035569.2, NM_011439.2
UniGeneiMm.8575

3D structure databases

ProteinModelPortaliQ04891
SMRiQ04891
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092130

PTM databases

iPTMnetiQ04891
PhosphoSitePlusiQ04891

Proteomic databases

MaxQBiQ04891
PaxDbiQ04891
PRIDEiQ04891

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643
ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643
GeneIDi20668
KEGGimmu:20668
UCSCiuc007cqk.1 mouse

Organism-specific databases

CTDi9580
MGIiMGI:98361 Sox13

Phylogenomic databases

eggNOGiKOG0528 Eukaryota
ENOG410YZNG LUCA
GeneTreeiENSGT00760000119274
HOGENOMiHOG000056455
HOVERGENiHBG003915
InParanoidiQ04891
KOiK09269
OMAiCDVDGSR
OrthoDBiEOG091G04EH
PhylomeDBiQ04891
TreeFamiTF320471

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

PROiPR:Q04891
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070643 Expressed in 200 organ(s), highest expression level in ear
CleanExiMM_SOX13
ExpressionAtlasiQ04891 baseline and differential
GenevisibleiQ04891 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR029547 SOX-13
PANTHERiPTHR10270:SF233 PTHR10270:SF233, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX13_MOUSE
AccessioniPrimary (citable) accession number: Q04891
Secondary accession number(s): Q922L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 146 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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