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Entry version 157 (17 Jun 2020)
Sequence version 4 (09 Feb 2010)
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Protein

Transcription factor SOX-13

Gene

Sox13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:9524265, PubMed:9421502). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (PubMed:26525805). Binds to the gene promoter of MBP and acts as a transcriptional repressor (PubMed:26525805). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (PubMed:17218525, PubMed:23562159, PubMed:30413363). Required for the differentiation of Vgamma2-positive gamma-delta T-cells, a subset of IL17A expressing gamma-delta T-cells (PubMed:23562159). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (PubMed:23562159). Promotes brown adipocyte differentiation (PubMed:27923061). Inhibitor of WNT signaling (By similarity).By similarity7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi416 – 484HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor SOX-13
Alternative name(s):
SRY (Sex determining region Y)-box 13
Short name:
mSox13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sox13
Synonyms:Sox-13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98361 Sox13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show severe growth abnormalities (PubMed:17218525). Severe reduction in the number of Rorc and Vgamma2-positive mature thymocytes in fetal and adult mice caused by the loss of Blk expression in Vgamma2-postive immature thymocytes (PubMed:23562159). This results in a severe reduction of Il17a-producing Vgamma2-positive gamma-delta T-cells in the spleen, lymph nodes and dermis (PubMed:17218525, PubMed:23562159). In addition, the number of Vgamma4-positive thymocytes in the fetal thymus is transiently reduced, with levels returning to normal in neonatal and adult mice (PubMed:23562159). Proliferation of CD3, CD4, and CD8-negative (triple negative) thymocytes and gamma-delta thymocytes is increased (PubMed:17218525). Double knockout of Sox13 and Tcf7/Tcf1 shows a reduced number of DN1d cells (PubMed:30413363). No defects in oligodendrocyte precursor cells specification and in their differentiation into myelinating oligodendrocytes (PubMed:26525805). However, in Sox13 and Sox6 double knockout mice, causes a slight increase in the number of prematurely differentiated oligodendrocytes in the spinal tube compared to Sox6 knockout mice (PubMed:26525805). No defects in the integumentary system morphology and in hair development (PubMed:30638933).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000487571 – 613Transcription factor SOX-13Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei327PhosphoserineBy similarity1
Modified residuei374PhosphoserineBy similarity1
Modified residuei377PhosphoserineBy similarity1
Modified residuei378PhosphoserineBy similarity1
Modified residuei604PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q04891

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04891

PRoteomics IDEntifications database

More...
PRIDEi
Q04891

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04891

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q04891

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in beta-cells in pancreatic islets of Langerhans (at protein level) (PubMed:10871192). Expressed in a subset of invariant natural killer (iNK) T-cells (at protein level) (PubMed:30413363). Expressed in oligodendroglial cells in the spinal cord (at protein level) (PubMed:26525805). In the hematopoietic system, expressed in gamma-delta T-cell lineage, specifically in immature Vgamma2-positive gamma-delta thymocytes, with expression decreasing upon maturation (PubMed:17218525, PubMed:23562159, PubMed:30413363). Expressed in DN1d cells, a subset of DN1 (TCR, CD4 and CD8 negative, also known as TN1) thymocyte progenitors, and in DN2 (also known as TN2) thymocyte progenitors (PubMed:17218525, PubMed:30413363). Expressed in the ovary and kidney (PubMed:9524265). Expressed in the peripheral lymphoid organs (PubMed:17218525).6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the visceral mesoderm of the yolk sac from 9.5 dpc to 15.5 dpc (at protein level) (PubMed:16835393, PubMed:30413363). Expressed in the sclerotome of developing somites and the derivative vertebrae and ribs between 9.5 dpc and 12.5 dpc (PubMed:16835393). Expressed in the rostral perichondrial area and mesenchyme of the limb bud in the prospective arm region and hand plate at 10.5 dpc, proximal mesenchyme expression in the forelimb then decreases between 11.5 dpc and 12.5 dpc until expression is consolidated to the arm regions of the developing limb at 12.5 dpc and forelimb digits at 13.5 dpc (PubMed:16835393). Expressed at variable levels in the prospective forebrain to the hindbrain and all neural tube cell layers from 9.5 dpc to postnatal day 6 (P6) (PubMed:16835393, PubMed:26525805). Expressed in immature oligodendrocyte precursor cells and astrocytes at 15.5 dpc, additionally expressed in precursor and differentiating oligodendrocytes in the neural tube from 18.5 dpc to P6 (PubMed:26525805). Highly expressed in embryonic arterial walls at 13.5 dpc (PubMed:9421502). Low levels are found in the inner ear at 13.5 dpc and in some cells in the thymus at 16.5 dpc (PubMed:9421502). Initially expressed in the hair follicles of the whisker pad vibrissae at 14.5 dpc, expression continues in the hair placode and in hair germ and peg during hair follicle morphogenesis to 18 dpc (PubMed:9421502, PubMed:30638933). Expressed in the newborn hair follicle epithelial sheath, this expression weakens at P15, reexpressed in the hair follicle bulge and secondary germ regions at P22, with expression continuing in the root sheath of the hair follicle at P28 (PubMed:30638933). Expressed in trophoblast giant cells of the spongiotrophoblast and labyrinth layers of the placenta at 15.5 dpc (PubMed:16835393). Expressed in DN1d cells, a subset of DN1 precursor thymocytes, from 16 dpc onwards (PubMed:30413363). Expressed in the tracheal epithelium below the vocal cord at 18 dpc (PubMed:9421502). Expression is transiently increased during brown adipocyte differentiation (PubMed:27923061).6 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000070643 Expressed in ear and 199 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q04891 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; homodimerization reduces DNA binding efficiency (By similarity).

Interacts with isoform 2 of TCF7/TCF1 (via N-terminus); inhibits WNT-mediated transcriptional activity (PubMed:17218525).

Interacts with HHEX (via N-terminus); abolishes the SOX13-mediated inhibition of WNT-mediated transcriptional activity via competitive inhibition of the SOX13-TCF7 complex (PubMed:20028982).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000119729

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q04891 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q04891

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 336Required for homodimerizationBy similarityAdd BLAST260

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi177 – 214Gln-richAdd BLAST38
Compositional biasi218 – 332Pro-richAdd BLAST115

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0528 Eukaryota
ENOG410YZNG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158759

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q04891

KEGG Orthology (KO)

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KOi
K09269

Identification of Orthologs from Complete Genome Data

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OMAi
KMSNCGP

Database of Orthologous Groups

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OrthoDBi
465521at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q04891

TreeFam database of animal gene trees

More...
TreeFami
TF320471

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR029547 SOX-13

The PANTHER Classification System

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PANTHERi
PTHR45789:SF4 PTHR45789:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00505 HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q04891-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMQSPVSVQ LAPDSASTMV NCTIKSEEKK EPCHEAPQGA APAVETQPGD
60 70 80 90 100
PALASQDATN AKAPPQDCAS PESSGSPEPK RPAASEAASG SQERLDFNRN
110 120 130 140 150
LQEVVPAIEK LLSSDWKERF LGRSNVEAKD VKGTQESLAE KELQLLVMIH
160 170 180 190 200
QLSALRDQLL TAHSEQKNMA AMLFEKQQQQ MELARQQQEQ IAKQQQQLIQ
210 220 230 240 250
QQHKINLLQQ QIQQVNMPYV MIPAFPPSHQ PLPVTPDSQL ALPIQPIPCK
260 270 280 290 300
PVEYPLQLLH SPPAPVVKRS GVAAHHPLQE PPQPLNLTAK PKVPELPNTS
310 320 330 340 350
SSPSLKMNSC GPRPASHGAP TRDLQSSPPS LPLGFLGEGD AVTKAIQDAR
360 370 380 390 400
QLLHSHSGAL ENSPNTPFRK DLISLDSSPA KERLEESCVH PLEEAMLSCD
410 420 430 440 450
MDGSRHFSES RNSSHIKRPM NAFMVWAKDE RRKILQAFPD MHNSSISKIL
460 470 480 490 500
GSRWKSMTNQ EKQPYYEEQA RLSRQHLEKY PDYKYKPRPK RTCVVEGRRL
510 520 530 540 550
RVGEYKALMR TRRQGARQSY TIPPQAGQAQ VSSDILFPRA AGLPLARPLV
560 570 580 590 600
EHYDPQGLDP NMPVIINTCS LREEGEGTDD RHSVADGEMY RYSEDEDSEG
610
DEKSDEELVV LTD
Length:613
Mass (Da):68,168
Last modified:February 9, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF62C88A052436E91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7I3D3Z7I3_MOUSE
Transcription factor SOX-13
Sox13
504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07130 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA25786 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA04278 differs from that shown. Several frameshifts.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3M → L in BAA25786 (PubMed:9524265).Curated1
Sequence conflicti53L → P in AAH07130 (PubMed:15489334).Curated1
Sequence conflicti59 – 60TN → AT in AAH07130 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC007130 mRNA Translation: AAH07130.1 Different initiation.
AB006329 mRNA Translation: BAA25786.1 Different initiation.
AJ000740 mRNA Translation: CAA04278.1 Sequence problems.
Z18962 mRNA Translation: CAA79487.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS48363.1

Protein sequence database of the Protein Information Resource

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PIRi
JC6550
S30241

NCBI Reference Sequences

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RefSeqi
NP_035569.2, NM_011439.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643
ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643

Database of genes from NCBI RefSeq genomes

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GeneIDi
20668

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20668

UCSC genome browser

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UCSCi
uc007cqk.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007130 mRNA Translation: AAH07130.1 Different initiation.
AB006329 mRNA Translation: BAA25786.1 Different initiation.
AJ000740 mRNA Translation: CAA04278.1 Sequence problems.
Z18962 mRNA Translation: CAA79487.1
CCDSiCCDS48363.1
PIRiJC6550
S30241
RefSeqiNP_035569.2, NM_011439.2

3D structure databases

SMRiQ04891
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119729

PTM databases

iPTMnetiQ04891
PhosphoSitePlusiQ04891

Proteomic databases

MaxQBiQ04891
PaxDbiQ04891
PRIDEiQ04891

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
11334 172 antibodies

Genome annotation databases

EnsembliENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643
ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643
GeneIDi20668
KEGGimmu:20668
UCSCiuc007cqk.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9580
MGIiMGI:98361 Sox13

Phylogenomic databases

eggNOGiKOG0528 Eukaryota
ENOG410YZNG LUCA
GeneTreeiENSGT00940000158759
InParanoidiQ04891
KOiK09269
OMAiKMSNCGP
OrthoDBi465521at2759
PhylomeDBiQ04891
TreeFamiTF320471

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
20668 2 hits in 12 CRISPR screens

Protein Ontology

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PROi
PR:Q04891
RNActiQ04891 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000070643 Expressed in ear and 199 other tissues
GenevisibleiQ04891 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR029547 SOX-13
PANTHERiPTHR45789:SF4 PTHR45789:SF4, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOX13_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04891
Secondary accession number(s): Q922L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 9, 2010
Last modified: June 17, 2020
This is version 157 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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