UniProtKB - Q04890 (SOX12_MOUSE)
Protein
Transcription factor SOX-12
Gene
Sox12
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (PubMed:18505825, PubMed:18403418, PubMed:30190287). Acts as a transcriptional activator (PubMed:18505825, PubMed:18403418, PubMed:30190287). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18505825, PubMed:18403418). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (PubMed:30190287). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (PubMed:30190287). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238).4 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 40 – 108 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- cell fate commitment Source: InterPro
- positive regulation of regulatory T cell differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
- spinal cord development Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SOX-12 |
Gene namesi | Name:Sox12 Synonyms:Sox-12 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98360, Sox12 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: MGI
Other locations
- protein-DNA complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Knockout mice are viable, fertile and morphologically normal (PubMed:18505825, PubMed:20596238). Increased expression of Sox11 in brain and cartilage at 14.5 dpc, with increased expression in liver and kidney at 16.5 dpc (PubMed:18505825). Increased expression of Sox4 in spinal cord and cartilage at 14.5 dpc, with increased expression in liver at 16.5 dpc (PubMed:18505825). Sox12 knockout naive CD4-positive T cells fail to differentiate into pT reg cells in mice with dextran sulfate sodium (DSS)-induced colitis (PubMed:30190287). Sox4, Sox11, and Sox12 triple knockout mice are embryonically lethal and show severe thinning and undulation of the neural tube (PubMed:20596238).3 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048755 | 1 – 314 | Transcription factor SOX-12Add BLAST | 314 |
Proteomic databases
MaxQBi | Q04890 |
PaxDbi | Q04890 |
PRIDEi | Q04890 |
ProteomicsDBi | 258712 |
PTM databases
PhosphoSitePlusi | Q04890 |
Expressioni
Tissue specificityi
Expressed in splenic and thymic regulatory T-cells (at protein level) (PubMed:30190287). Expressed in embryonic molar and incisor teeth (PubMed:8921394).2 Publications
Developmental stagei
Widely expressed in the developing embryo from 9.5 dpc to 12.5 dpc (PubMed:8441686, PubMed:18505825, PubMed:18403418, PubMed:20596238). Expressed throughout the central and peripheral nervous system, as well as the mesenchyme of many developing organs between 12.5 dpc and 14.5 dpc (PubMed:18403418). Strongly expressed in the lens of the eye, developing cerebral cortex, the dorsal cortical plate, thalamus, hippocampus and cerebellar cortex in the brain at 14.5 dpc (PubMed:18505825). Expressed in skin, spinal cord, lung, liver, intestine, kidney, heart, muscle, cartilage from 14.5 dpc to 18.5 dpc (PubMed:18505825). Abundantly expressed in the brain, heart and lung, with low expression in the liver, pancreas, and small intestine at postnatal day 2 (PubMed:18403418).4 Publications
Inductioni
Induced by T-cell receptor signaling in naive CD4-positive T-cells and in splenic and thymic regulatory T-cells (PubMed:30190287). Up-regulated in splenic T reg cells by dextran sulfate sodium (DSS)-induced colitis (PubMed:30190287).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000051817, Expressed in cortical plate and 230 other tissues |
Genevisiblei | Q04890, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000138293 |
Miscellaneous databases
RNActi | Q04890, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 282 – 314 | Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F21 PublicationAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 15 – 22 | Poly-Pro | 8 | |
Compositional biasi | 128 – 158 | Gly-richAdd BLAST | 31 | |
Compositional biasi | 167 – 180 | Glu-richAdd BLAST | 14 | |
Compositional biasi | 224 – 249 | Glu-richAdd BLAST | 26 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000163140 |
HOGENOMi | CLU_043342_0_0_1 |
InParanoidi | Q04890 |
OMAi | GEPAWCK |
OrthoDBi | 1186233at2759 |
PhylomeDBi | Q04890 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR031267, SOX-12 IPR017386, SOX-12/11/4 |
PANTHERi | PTHR10270:SF221, PTHR10270:SF221, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
PIRSFi | PIRSF038098, SOX-12/11/4a, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04890-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQQRGARAK RDGGPPPPGP GPAAEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGG GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
SGGPLGGGAA APEDDDEDEE EELLEVRLLE TPGRELWRMV PAGRAARGPA
210 220 230 240 250
ERAQGPSGEG AAASAASPTL SEDEEPEEEE EEAATAEEGE EETVVSGEEP
260 270 280 290 300
LGFLSRMPPG PAGLDCSALD RDPDLLPPSG TSHFEFPDYC TPEVTEMIAG
310
DWRSSSIADL VFTY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | V → E in CAA79486 (PubMed:8921394).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928568 Genomic DNA No translation available. BC067019 mRNA Translation: AAH67019.1 Z18961 mRNA Translation: CAA79486.1 U70442 mRNA Translation: AAC52860.1 |
CCDSi | CCDS38274.1 |
PIRi | S30240 |
RefSeqi | NP_035568.1, NM_011438.2 |
Genome annotation databases
Ensembli | ENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817 ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817 |
GeneIDi | 20667 |
KEGGi | mmu:20667 |
UCSCi | uc008nfi.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928568 Genomic DNA No translation available. BC067019 mRNA Translation: AAH67019.1 Z18961 mRNA Translation: CAA79486.1 U70442 mRNA Translation: AAC52860.1 |
CCDSi | CCDS38274.1 |
PIRi | S30240 |
RefSeqi | NP_035568.1, NM_011438.2 |
3D structure databases
SMRi | Q04890 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000138293 |
PTM databases
PhosphoSitePlusi | Q04890 |
Proteomic databases
MaxQBi | Q04890 |
PaxDbi | Q04890 |
PRIDEi | Q04890 |
ProteomicsDBi | 258712 |
Protocols and materials databases
Antibodypediai | 6130, 222 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817 ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817 |
GeneIDi | 20667 |
KEGGi | mmu:20667 |
UCSCi | uc008nfi.1, mouse |
Organism-specific databases
CTDi | 6666 |
MGIi | MGI:98360, Sox12 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000163140 |
HOGENOMi | CLU_043342_0_0_1 |
InParanoidi | Q04890 |
OMAi | GEPAWCK |
OrthoDBi | 1186233at2759 |
PhylomeDBi | Q04890 |
Miscellaneous databases
BioGRID-ORCSi | 20667, 7 hits in 52 CRISPR screens |
ChiTaRSi | Sox12, mouse |
PROi | PR:Q04890 |
RNActi | Q04890, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000051817, Expressed in cortical plate and 230 other tissues |
Genevisiblei | Q04890, MM |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR031267, SOX-12 IPR017386, SOX-12/11/4 |
PANTHERi | PTHR10270:SF221, PTHR10270:SF221, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
PIRSFi | PIRSF038098, SOX-12/11/4a, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOX12_MOUSE | |
Accessioni | Q04890Primary (citable) accession number: Q04890 Secondary accession number(s): A2AS82, P70417, Q6NXL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | March 29, 2005 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot