Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor SOX-12

Gene

Sox12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 108HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-12
Gene namesi
Name:Sox12
Synonyms:Sox-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98360 Sox12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487551 – 314Transcription factor SOX-12Add BLAST314

Proteomic databases

MaxQBiQ04890
PaxDbiQ04890
PRIDEiQ04890

PTM databases

PhosphoSitePlusiQ04890

Expressioni

Tissue specificityi

Expressed in embryonic molar and incisor teeth.1 Publication

Developmental stagei

Expressed in the embryo at 11.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000051817 Expressed in 209 organ(s), highest expression level in cardiac ventricle
CleanExiMM_SOX12
GenevisibleiQ04890 MM

Structurei

3D structure databases

ProteinModelPortaliQ04890
SMRiQ04890
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 22Poly-Pro8
Compositional biasi128 – 158Gly-richAdd BLAST31
Compositional biasi167 – 180Glu-richAdd BLAST14
Compositional biasi224 – 249Glu-richAdd BLAST26

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG4111TGC LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231874
HOVERGENiHBG094895
InParanoidiQ04890
KOiK09268
OMAiGDWLMSS
OrthoDBiEOG091G0F15
PhylomeDBiQ04890

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017386 SOX-11/4
IPR031267 SOX-12
PANTHERiPTHR10270:SF221 PTHR10270:SF221, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF038098 SOX-12/11/4a, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04890-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQQRGARAK RDGGPPPPGP GPAAEGAREP GWCKTPSGHI KRPMNAFMVW
60 70 80 90 100
SQHERRKIMD QWPDMHNAEI SKRLGRRWQL LQDSEKIPFV REAERLRLKH
110 120 130 140 150
MADYPDYKYR PRKKSKGAPA KARPRPPGGG GGGSRLKPGP QLPGRGGRRA
160 170 180 190 200
SGGPLGGGAA APEDDDEDEE EELLEVRLLE TPGRELWRMV PAGRAARGPA
210 220 230 240 250
ERAQGPSGEG AAASAASPTL SEDEEPEEEE EEAATAEEGE EETVVSGEEP
260 270 280 290 300
LGFLSRMPPG PAGLDCSALD RDPDLLPPSG TSHFEFPDYC TPEVTEMIAG
310
DWRSSSIADL VFTY
Length:314
Mass (Da):34,083
Last modified:March 29, 2005 - v2
Checksum:iCAB9DEF059F2C5A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90V → E in CAA79486 (PubMed:8921394).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928568 Genomic DNA No translation available.
BC067019 mRNA Translation: AAH67019.1
Z18961 mRNA Translation: CAA79486.1
U70442 mRNA Translation: AAC52860.1
CCDSiCCDS38274.1
PIRiS30240
RefSeqiNP_035568.1, NM_011438.2
UniGeneiMm.28424

Genome annotation databases

EnsembliENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817
ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817
GeneIDi20667
KEGGimmu:20667
UCSCiuc008nfi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928568 Genomic DNA No translation available.
BC067019 mRNA Translation: AAH67019.1
Z18961 mRNA Translation: CAA79486.1
U70442 mRNA Translation: AAC52860.1
CCDSiCCDS38274.1
PIRiS30240
RefSeqiNP_035568.1, NM_011438.2
UniGeneiMm.28424

3D structure databases

ProteinModelPortaliQ04890
SMRiQ04890
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ04890

Proteomic databases

MaxQBiQ04890
PaxDbiQ04890
PRIDEiQ04890

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063332; ENSMUSP00000064250; ENSMUSG00000051817
ENSMUST00000182625; ENSMUSP00000138293; ENSMUSG00000051817
GeneIDi20667
KEGGimmu:20667
UCSCiuc008nfi.1 mouse

Organism-specific databases

CTDi6666
MGIiMGI:98360 Sox12

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG4111TGC LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231874
HOVERGENiHBG094895
InParanoidiQ04890
KOiK09268
OMAiGDWLMSS
OrthoDBiEOG091G0F15
PhylomeDBiQ04890

Miscellaneous databases

ChiTaRSiSox12 mouse
PROiPR:Q04890
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051817 Expressed in 209 organ(s), highest expression level in cardiac ventricle
CleanExiMM_SOX12
GenevisibleiQ04890 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017386 SOX-11/4
IPR031267 SOX-12
PANTHERiPTHR10270:SF221 PTHR10270:SF221, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PIRSFiPIRSF038098 SOX-12/11/4a, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX12_MOUSE
AccessioniPrimary (citable) accession number: Q04890
Secondary accession number(s): A2AS82, P70417, Q6NXL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 29, 2005
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again