Transcription factor SOX-10

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Pax3 functions at a nodal point in melanocyte stem cell differentiation."
    Lang D., Lu M.M., Huang L., Engleka K.A., Zhang M., Chu E.Y., Lipner S., Skoultchi A., Millar S.E., Epstein J.A.
    Nature 433:884-887(2005) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes."
    Hornig J., Froeb F., Vogl M.R., Hermans-Borgmeyer I., Tamm E.R., Wegner M.
    PLoS Genet. 9:E1003907-E1003907(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.10

    "The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes."
    Muth K.N., Piefke S., Weider M., Sock E., Hermans-Borgmeyer I., Wegner M., Kuespert M.
    Glia 64:2120-2132(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT.
• DNA-binding transcription activator activity Source: UniProtKB
• DNA-binding transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes."
    Hornig J., Froeb F., Vogl M.R., Hermans-Borgmeyer I., Tamm E.R., Wegner M.
    PLoS Genet. 9:E1003907-E1003907(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.10

    "The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes."
    Muth K.N., Piefke S., Weider M., Sock E., Hermans-Borgmeyer I., Wegner M., Kuespert M.
    Glia 64:2120-2132(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKBInferred from direct assayⁱ
  • "The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10."
    Agarwal P., Verzi M.P., Nguyen T., Hu J., Ehlers M.L., McCulley D.J., Xu S.M., Dodou E., Anderson J.P., Wei M.L., Black B.L.
    Development 138:2555-2565(2011) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: MGI
• promoter-specific chromatin binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • "The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10."
    Agarwal P., Verzi M.P., Nguyen T., Hu J., Ehlers M.L., McCulley D.J., Xu S.M., Dodou E., Anderson J.P., Wei M.L., Black B.L.
    Development 138:2555-2565(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• transcription factor binding Source: MGIInferred from direct assayⁱ
  • "Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation."
    Kao S.C., Wu H., Xie J., Chang C.P., Ranish J.A., Graef I.A., Crabtree G.R.
    Science 323:651-654(2009) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function."
    Stolt C.C., Schlierf A., Lommes P., Hillgartner S., Werner T., Kosian T., Sock E., Kessaris N., Richardson W.D., Lefebvre V., Wegner M.
    Dev Cell 11:697-709(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell differentiation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10."
    Stolt C.C., Rehberg S., Ader M., Lommes P., Riethmacher D., Schachner M., Bartsch U., Wegner M.
    Genes Dev 16:165-170(2002) [PubMed] [Europe PMC] [Abstract]
• cell maturation Source: MGIInferred from mutant phenotypeⁱ
  • "Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy."
    Stolt C.C., Lommes P., Friedrich R.P., Wegner M.
    Development 131:2349-2358(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to drug Source: Ensembl
• cellular response to progesterone stimulus Source: Ensembl
• central nervous system myelination Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes."
    Hornig J., Froeb F., Vogl M.R., Hermans-Borgmeyer I., Tamm E.R., Wegner M.
    PLoS Genet. 9:E1003907-E1003907(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.10

    "The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes."
    Muth K.N., Piefke S., Weider M., Sock E., Hermans-Borgmeyer I., Wegner M., Kuespert M.
    Glia 64:2120-2132(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT.
• developmental growth Source: MGIInferred from mutant phenotypeⁱ
  • "Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence."
    Kellerer S., Schreiner S., Stolt C.C., Scholz S., Bosl M.R., Wegner M.
    Development 133:2875-2886(2006) [PubMed] [Europe PMC] [Abstract]
• digestive tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease."
    Owens S.E., Broman K.W., Wiltshire T., Elmore J.B., Bradley K.M., Smith J.R., Southard-Smith E.M.
    Hum Mol Genet 14:1549-1558(2005) [PubMed] [Europe PMC] [Abstract]
  • "Association of megacolon with a new dominant spotting gene (Dom) in the mouse."
    Lane P.W., Liu H.M.
    J Hered 75:435-439(1984) [PubMed] [Europe PMC] [Abstract]
• enteric nervous system development Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect."
    Maka M., Stolt C.C., Wegner M.
    Dev Biol 277:155-169(2005) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence."
    Kellerer S., Schreiner S., Stolt C.C., Scholz S., Bosl M.R., Wegner M.
    Development 133:2875-2886(2006) [PubMed] [Europe PMC] [Abstract]
• lacrimal gland development Source: MGIInferred from mutant phenotypeⁱ
  • "FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands."
    Chen Z., Huang J., Liu Y., Dattilo L.K., Huh S.H., Ornitz D., Beebe D.C.
    Development 141:2691-2701(2014) [PubMed] [Europe PMC] [Abstract]
• melanocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence."
    Kellerer S., Schreiner S., Stolt C.C., Scholz S., Bosl M.R., Wegner M.
    Development 133:2875-2886(2006) [PubMed] [Europe PMC] [Abstract]
• morphogenesis of a branching epithelium Source: MGIInferred from mutant phenotypeⁱ
  • "FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands."
    Chen Z., Huang J., Liu Y., Dattilo L.K., Huh S.H., Ornitz D., Beebe D.C.
    Development 141:2691-2701(2014) [PubMed] [Europe PMC] [Abstract]
• morphogenesis of an epithelium Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect."
    Maka M., Stolt C.C., Wegner M.
    Dev Biol 277:155-169(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells."
    Sinner D., Kordich J.J., Spence J.R., Opoka R., Rankin S., Lin S.C., Jonatan D., Zorn A.M., Wells J.M.
    Mol Cell Biol 27:7802-7815(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of Schwann cell proliferation Source: MGI
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neural crest cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect."
    Maka M., Stolt C.C., Wegner M.
    Dev Biol 277:155-169(2005) [PubMed] [Europe PMC] [Abstract]
• oligodendrocyte development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes."
    Hornig J., Froeb F., Vogl M.R., Hermans-Borgmeyer I., Tamm E.R., Wegner M.
    PLoS Genet. 9:E1003907-E1003907(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.10

    "The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes."
    Muth K.N., Piefke S., Weider M., Sock E., Hermans-Borgmeyer I., Wegner M., Kuespert M.
    Glia 64:2120-2132(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT.
• oligodendrocyte differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes."
    Hornig J., Froeb F., Vogl M.R., Hermans-Borgmeyer I., Tamm E.R., Wegner M.
    PLoS Genet. 9:E1003907-E1003907(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.10

    "The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes."
    Muth K.N., Piefke S., Weider M., Sock E., Hermans-Borgmeyer I., Wegner M., Kuespert M.
    Glia 64:2120-2132(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT.
• peripheral nervous system development Source: MGIInferred from genetic interactionⁱ
  • "Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence."
    Kellerer S., Schreiner S., Stolt C.C., Scholz S., Bosl M.R., Wegner M.
    Development 133:2875-2886(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: MGI
• positive regulation of gliogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect."
    Maka M., Stolt C.C., Wegner M.
    Dev Biol 277:155-169(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myelination Source: MGI
• positive regulation of neuroblast proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation."
    Jiao Z., Zhang Z.G., Hornyak T.J., Hozeska A., Zhang R.L., Wang Y., Wang L., Roberts C., Strickland F.M., Chopp M.
    Dev Biol 296:396-408(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10."
    Agarwal P., Verzi M.P., Nguyen T., Hu J., Ehlers M.L., McCulley D.J., Xu S.M., Dodou E., Anderson J.P., Wei M.L., Black B.L.
    Development 138:2555-2565(2011) [PubMed] [Europe PMC] [Abstract]
  • Ref.9

    "The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes."
    Hornig J., Froeb F., Vogl M.R., Hermans-Borgmeyer I., Tamm E.R., Wegner M.
    PLoS Genet. 9:E1003907-E1003907(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.10

    "The dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in myelinating oligodendrocytes."
    Muth K.N., Piefke S., Weider M., Sock E., Hermans-Borgmeyer I., Wegner M., Kuespert M.
    Glia 64:2120-2132(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT.
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • Ref.8

    "The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10."
    Mou Z., Tapper A.R., Gardner P.D.
    J. Biol. Chem. 284:13629-13640(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ARMCX3.
• regulation of transcription, DNA-templated Source: MGI
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription elongation from RNA polymerase II promoter Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI
• transcription factor binding Source: MGIInferred from direct assayⁱ
  • "Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation."
    Kao S.C., Wu H., Xie J., Chang C.P., Ranish J.A., Graef I.A., Crabtree G.R.
    Science 323:651-654(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE 
        60         70         80         90        100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS 
       110        120        130        140        150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK 
       160        170        180        190        200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGA 
       210        220        230        240        250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ 
       260        270        280        290        300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY 
       310        320        330        340        350
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV 
       360        370        380        390        400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF 
       410        420        430        440        450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH 
       460 
SPTHWEQPVY TTLSRP                                      

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot