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Protein

Transcription factor SOX-10

Gene

Sox10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821). Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311). Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi104 – 172HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-10
Alternative name(s):
Protein SOX-21
Transcription factor SOX-M
Gene namesi
Name:Sox10
Synonyms:Sox-10, Sox21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98358 Sox10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Defects in Sox10 are the cause of the mouse mutant dominant megacolon (dom). While dom/+ heterozygous mice display regional deficiencies of neural crest-derived enteric ganglia in the distal colon, dom/dom homozygous animals are embryonic lethal.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487471 – 466Transcription factor SOX-10Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04888
PaxDbiQ04888
PeptideAtlasiQ04888
PRIDEiQ04888

PTM databases

iPTMnetiQ04888
PhosphoSitePlusiQ04888

Expressioni

Gene expression databases

BgeeiENSMUSG00000033006 Expressed in 283 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_SOX10
MM_SOX21
GenevisibleiQ04888 MM

Interactioni

Subunit structurei

Monomer (PubMed:27532821). Interacts with Armcx3 at the mitochondrial outer membrane surface (PubMed:19304657). Interacts with PAX3 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203397, 2 interactors
STRINGi10090.ENSMUSP00000039466

Structurei

3D structure databases

ProteinModelPortaliQ04888
SMRiQ04888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 41Poly-Gly7

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOVERGENiHBG002061
InParanoidiQ04888
KOiK09270
OMAiRPLYTTI
OrthoDBiEOG091G0EKD

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022151 Sox_N
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12444 Sox_N, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q04888-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE
60 70 80 90 100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS
110 120 130 140 150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK
160 170 180 190 200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGA
210 220 230 240 250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ
260 270 280 290 300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY
310 320 330 340 350
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV
360 370 380 390 400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF
410 420 430 440 450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH
460
SPTHWEQPVY TTLSRP
Length:466
Mass (Da):49,949
Last modified:July 15, 1999 - v2
Checksum:i84862547F039E71F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VI24A0A2R8VI24_MOUSE
Transcription factor SOX-10
Sox10
205Annotation score:

Sequence cautioni

The sequence AAB49282 differs from that shown. Reason: Frameshift at positions 16 and 392.Curated
The sequence AAB99738 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41G → V in AAB49282 (PubMed:9027483).Curated1
Sequence conflicti119R → P in CAA79484 (PubMed:8441686).Curated1
Sequence conflicti357K → E in AAB49282 (PubMed:9027483).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11E → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017182 mRNA Translation: AAB99738.1 Different initiation.
AF047043 mRNA Translation: AAC24564.1
U66141 mRNA Translation: AAB49282.1 Frameshift.
BC018551 mRNA Translation: AAH18551.1
BC023356 mRNA Translation: AAH23356.1
BC025171 mRNA Translation: AAH25171.1
Z18959 mRNA Translation: CAA79484.1
U70441 mRNA Translation: AAC52859.1
CCDSiCCDS49668.1
PIRiS30242
RefSeqiNP_035567.1, NM_011437.1
UniGeneiMm.276739

Genome annotation databases

EnsembliENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006
ENSMUST00000230532; ENSMUSP00000155574; ENSMUSG00000033006
GeneIDi20665
KEGGimmu:20665
UCSCiuc007wsu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017182 mRNA Translation: AAB99738.1 Different initiation.
AF047043 mRNA Translation: AAC24564.1
U66141 mRNA Translation: AAB49282.1 Frameshift.
BC018551 mRNA Translation: AAH18551.1
BC023356 mRNA Translation: AAH23356.1
BC025171 mRNA Translation: AAH25171.1
Z18959 mRNA Translation: CAA79484.1
U70441 mRNA Translation: AAC52859.1
CCDSiCCDS49668.1
PIRiS30242
RefSeqiNP_035567.1, NM_011437.1
UniGeneiMm.276739

3D structure databases

ProteinModelPortaliQ04888
SMRiQ04888
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203397, 2 interactors
STRINGi10090.ENSMUSP00000039466

PTM databases

iPTMnetiQ04888
PhosphoSitePlusiQ04888

Proteomic databases

MaxQBiQ04888
PaxDbiQ04888
PeptideAtlasiQ04888
PRIDEiQ04888

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006
ENSMUST00000230532; ENSMUSP00000155574; ENSMUSG00000033006
GeneIDi20665
KEGGimmu:20665
UCSCiuc007wsu.2 mouse

Organism-specific databases

CTDi6663
MGIiMGI:98358 Sox10

Phylogenomic databases

eggNOGiKOG0527 Eukaryota
ENOG410XT0K LUCA
GeneTreeiENSGT00760000118988
HOVERGENiHBG002061
InParanoidiQ04888
KOiK09270
OMAiRPLYTTI
OrthoDBiEOG091G0EKD

Miscellaneous databases

ChiTaRSiSox10 mouse
PROiPR:Q04888
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033006 Expressed in 283 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_SOX10
MM_SOX21
GenevisibleiQ04888 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022151 Sox_N
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12444 Sox_N, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX10_MOUSE
AccessioniPrimary (citable) accession number: Q04888
Secondary accession number(s): O08518
, O09141, O54856, P70416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1999
Last modified: September 12, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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