UniProtKB - Q04888 (SOX10_MOUSE)
Transcription factor SOX-10
Sox10
Functioni
Transcription factor that plays a central role in developing and mature glia (PubMed:24204311, PubMed:27532821).
Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:24204311, PubMed:27532821).
Once induced, MYRF cooperates with SOX10 to implement the myelination program (PubMed:24204311).
Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity).
Transcriptional activator of MBP, via binding to the gene promoter (By similarity).
By similarity2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 104 – 172 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor binding Source: MGI
- identical protein binding Source: MGI
- promoter-specific chromatin binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: MGI
GO - Biological processi
- cell differentiation Source: MGI
- cell maturation Source: MGI
- cellular response to progesterone stimulus Source: Ensembl
- cellular response to xenobiotic stimulus Source: Ensembl
- central nervous system myelination Source: UniProtKB
- developmental growth Source: MGI
- digestive tract morphogenesis Source: MGI
- enteric nervous system development Source: UniProtKB
- in utero embryonic development Source: MGI
- lacrimal gland development Source: MGI
- melanocyte differentiation Source: MGI
- morphogenesis of a branching epithelium Source: MGI
- morphogenesis of an epithelium Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of Schwann cell proliferation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- neural crest cell migration Source: UniProtKB
- oligodendrocyte development Source: UniProtKB
- oligodendrocyte differentiation Source: UniProtKB
- peripheral nervous system development Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of gliogenesis Source: UniProtKB
- positive regulation of myelination Source: MGI
- positive regulation of neuroblast proliferation Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription elongation from RNA polymerase II promoter Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SOX-10Alternative name(s): Protein SOX-21 Transcription factor SOX-M |
Gene namesi | Name:Sox10 Synonyms:Sox-10, Sox21 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98358, Sox10 |
VEuPathDBi | HostDB:ENSMUSG00000033006 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 2 Publications
Mitochondrion
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048747 | 1 – 466 | Transcription factor SOX-10Add BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q04888 |
PaxDbi | Q04888 |
PeptideAtlasi | Q04888 |
PRIDEi | Q04888 |
ProteomicsDBi | 257378 |
PTM databases
iPTMneti | Q04888 |
PhosphoSitePlusi | Q04888 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000033006, Expressed in vestibular membrane of cochlear duct and 300 other tissues |
ExpressionAtlasi | Q04888, baseline and differential |
Genevisiblei | Q04888, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- DNA-binding transcription factor binding Source: MGI
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203397, 2 interactors |
STRINGi | 10090.ENSMUSP00000039466 |
Miscellaneous databases
RNActi | Q04888, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 67 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 62 – 102 | Dimerization (DIM)By similarityAdd BLAST | 41 | |
Regioni | 160 – 200 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 213 – 275 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 228 – 310 | Transactivation domain (TAM)By similarityAdd BLAST | 83 | |
Regioni | 344 – 375 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 353 – 466 | Transactivation domain (TAC)By similarityAdd BLAST | 114 | |
Regioni | 433 – 466 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 67 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 160 – 184 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 251 – 266 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 357 – 375 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 436 – 466 | Polar residuesSequence analysisAdd BLAST | 31 |
Domaini
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000158046 |
HOGENOMi | CLU_031800_0_0_1 |
InParanoidi | Q04888 |
OMAi | PPHYADQ |
OrthoDBi | 782373at2759 |
PhylomeDBi | Q04888 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR022151, Sox_N |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12444, Sox_N, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE
60 70 80 90 100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS
110 120 130 140 150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK
160 170 180 190 200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGA
210 220 230 240 250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ
260 270 280 290 300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY
310 320 330 340 350
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV
360 370 380 390 400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF
410 420 430 440 450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH
460
SPTHWEQPVY TTLSRP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8VI24 | A0A2R8VI24_MOUSE | Transcription factor SOX-10 | Sox10 | 205 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | G → V in AAB49282 (PubMed:9027483).Curated | 1 | |
Sequence conflicti | 119 | R → P in CAA79484 (PubMed:8441686).Curated | 1 | |
Sequence conflicti | 357 | K → E in AAB49282 (PubMed:9027483).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 11 | E → V. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF017182 mRNA Translation: AAB99738.1 Different initiation. AF047043 mRNA Translation: AAC24564.1 U66141 mRNA Translation: AAB49282.1 Frameshift. BC018551 mRNA Translation: AAH18551.1 BC023356 mRNA Translation: AAH23356.1 BC025171 mRNA Translation: AAH25171.1 Z18959 mRNA Translation: CAA79484.1 U70441 mRNA Translation: AAC52859.1 |
CCDSi | CCDS49668.1 |
PIRi | S30242 |
RefSeqi | NP_035567.1, NM_011437.1 |
Genome annotation databases
Ensembli | ENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006 ENSMUST00000230532; ENSMUSP00000155574; ENSMUSG00000033006 |
GeneIDi | 20665 |
KEGGi | mmu:20665 |
UCSCi | uc007wsu.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF017182 mRNA Translation: AAB99738.1 Different initiation. AF047043 mRNA Translation: AAC24564.1 U66141 mRNA Translation: AAB49282.1 Frameshift. BC018551 mRNA Translation: AAH18551.1 BC023356 mRNA Translation: AAH23356.1 BC025171 mRNA Translation: AAH25171.1 Z18959 mRNA Translation: CAA79484.1 U70441 mRNA Translation: AAC52859.1 |
CCDSi | CCDS49668.1 |
PIRi | S30242 |
RefSeqi | NP_035567.1, NM_011437.1 |
3D structure databases
AlphaFoldDBi | Q04888 |
SMRi | Q04888 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203397, 2 interactors |
STRINGi | 10090.ENSMUSP00000039466 |
PTM databases
iPTMneti | Q04888 |
PhosphoSitePlusi | Q04888 |
Proteomic databases
MaxQBi | Q04888 |
PaxDbi | Q04888 |
PeptideAtlasi | Q04888 |
PRIDEi | Q04888 |
ProteomicsDBi | 257378 |
Protocols and materials databases
Antibodypediai | 3774, 983 antibodies from 47 providers |
Genome annotation databases
Ensembli | ENSMUST00000040019; ENSMUSP00000039466; ENSMUSG00000033006 ENSMUST00000230532; ENSMUSP00000155574; ENSMUSG00000033006 |
GeneIDi | 20665 |
KEGGi | mmu:20665 |
UCSCi | uc007wsu.2, mouse |
Organism-specific databases
CTDi | 6663 |
MGIi | MGI:98358, Sox10 |
VEuPathDBi | HostDB:ENSMUSG00000033006 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000158046 |
HOGENOMi | CLU_031800_0_0_1 |
InParanoidi | Q04888 |
OMAi | PPHYADQ |
OrthoDBi | 782373at2759 |
PhylomeDBi | Q04888 |
Miscellaneous databases
BioGRID-ORCSi | 20665, 7 hits in 72 CRISPR screens |
ChiTaRSi | Sox10, mouse |
PROi | PR:Q04888 |
RNActi | Q04888, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033006, Expressed in vestibular membrane of cochlear duct and 300 other tissues |
ExpressionAtlasi | Q04888, baseline and differential |
Genevisiblei | Q04888, MM |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR022151, Sox_N |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12444, Sox_N, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SOX10_MOUSE | |
Accessioni | Q04888Primary (citable) accession number: Q04888 Secondary accession number(s): O08518 P70416 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | July 15, 1999 | |
Last modified: | May 25, 2022 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot