Transcription factor SOX-10

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15729346
• DNA binding Source: UniProtKBInferred from direct assayⁱ
  • 24204311
  • 27532821
• DNA-binding transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • 24204311
  • 27532821
• identical protein binding Source: MGI
• promoter-specific chromatin binding Source: MGI
• RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • 21610032
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • 21610032
• RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • 21610032
• transcriptional activator activity, RNA polymerase II transcription factor binding Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 23575864
• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGIInferred from direct assayⁱ
  • 15729346
• transcription factor binding Source: MGIInferred from direct assayⁱ
  • 19179536
• transcription regulatory region DNA binding Source: MGIInferred from direct assayⁱ
  • 17084361

GO - Biological processⁱ

• cell differentiation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 11799060
• cell maturation Source: MGIInferred from mutant phenotypeⁱ
  • 15102707
• central nervous system myelination Source: UniProtKBInferred from mutant phenotypeⁱ
  • 24204311
  • 27532821
• developmental growth Source: MGIInferred from mutant phenotypeⁱ
  • 16790476
• digestive tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 15843399
  • 6512238
• enteric nervous system development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 15572147
• in utero embryonic development Source: MGIInferred from genetic interactionⁱ
  • 16790476
• lacrimal gland development Source: MGIInferred from mutant phenotypeⁱ
  • 24924191
• melanocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 16790476
• morphogenesis of a branching epithelium Source: MGIInferred from mutant phenotypeⁱ
  • 24924191
• negative regulation of apoptotic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • 15572147
• negative regulation of canonical Wnt signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • 17875931
• negative regulation of Schwann cell proliferation Source: MGI
• negative regulation of transcription, DNA-templated Source: MGI
• neural crest cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • 15572147
• oligodendrocyte development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 24204311
  • 27532821
• oligodendrocyte differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 24204311
  • 27532821
• peripheral nervous system development Source: MGIInferred from genetic interactionⁱ
  • 16790476
• positive regulation of gene expression Source: MGI
• positive regulation of gliogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 15572147
• positive regulation of myelination Source: MGI
• positive regulation of neuroblast proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 16857183
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 21610032
  • 24204311
  • 27532821
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 19304657
• regulation of transcription, DNA-templated Source: MGI
• transcription elongation from RNA polymerase II promoter Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI
• transcription factor binding Source: MGIInferred from direct assayⁱ
  • 19179536

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE 
        60         70         80         90        100
LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS 
       110        120        130        140        150
KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK 
       160        170        180        190        200
RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGA 
       210        220        230        240        250
AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ 
       260        270        280        290        300
SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY 
       310        320        330        340        350
LPPNGHPGHV GSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV 
       360        370        380        390        400
DAKAQVKTET TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF 
       410        420        430        440        450
DYSDHQPSGP YYGHAGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH 
       460 
SPTHWEQPVY TTLSRP                                      

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot