UniProtKB - Q04887 (SOX9_MOUSE)
Protein
Transcription factor SOX-9
Gene
Sox9
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:10319868, PubMed:11371614, PubMed:12414734, PubMed:15132997, PubMed:18415932, PubMed:20940257, PubMed:28263186). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes COL2A1, COL4A2, COL9A1, COL11A2 and ACAN, SOX5 and SOX6 (PubMed:9119111, PubMed:10805756, PubMed:12414734, PubMed:15694126, PubMed:17525254, PubMed:26146088, PubMed:26150426, PubMed:26910618, PubMed:28263186). Also binds to some promoter regions (PubMed:20940257). Plays a central role in successive steps of chondrocyte differentiation (PubMed:11371614, PubMed:12414734, PubMed:22421045). Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (PubMed:11371614, PubMed:12414734). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (PubMed:11371614, PubMed:12414734, PubMed:15529345). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes by lowering beta-catenin (CTNNB1) signaling and RUNX2 expression (PubMed:22421045, PubMed:31121357). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells and transactivating COL10A1 along with MEF2C (PubMed:21367821, PubMed:22421045). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO (FOXO1 and FOXO3) transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). Mechanistically, helps, but is not required, to remove epigenetic signatures of transcriptional repression and deposit active promoter and enhancer marks at chondrocyte-specific genes (PubMed:30021842). Acts in cooperation with the Hedgehog pathway-dependent GLI (GLI1 and GLI3) transcription factors (PubMed:29659575). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells: involved in the lung epithelium during branching morphogenesis, by balancing proliferation and differentiation and regulating the extracellular matrix (PubMed:24191021). Controls epithelial branching during kidney development (PubMed:21212101).23 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 105 – 173 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- bHLH transcription factor binding Source: MGI
- chromatin binding Source: UniProtKB
- cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- pre-mRNA intronic binding Source: MGI
- protein kinase A catalytic subunit binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: MGI
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- anterior head development Source: MGI
- aortic valve morphogenesis Source: MGI
- astrocyte fate commitment Source: MGI
- branching involved in ureteric bud morphogenesis Source: UniProtKB
- bronchus cartilage development Source: MGI
- cAMP-mediated signaling Source: UniProtKB
- cartilage condensation Source: MGI
- cartilage development Source: UniProtKB
- cell-cell adhesion Source: MGI
- cell differentiation Source: MGI
- cell fate commitment Source: MGI
- cell fate specification Source: MGI
- cellular response to BMP stimulus Source: UniProtKB
- cellular response to epidermal growth factor stimulus Source: UniProtKB
- cellular response to heparin Source: UniProtKB
- cellular response to interleukin-1 Source: Ensembl
- cellular response to mechanical stimulus Source: UniProtKB
- cellular response to retinoic acid Source: MGI
- cellular response to transforming growth factor beta stimulus Source: UniProtKB
- central nervous system development Source: UniProtKB
- chondrocyte development Source: MGI
- chondrocyte differentiation Source: UniProtKB
- chondrocyte differentiation involved in endochondral bone morphogenesis Source: UniProtKB
- chondrocyte hypertrophy Source: UniProtKB
- chromatin remodeling Source: UniProtKB
- cochlea morphogenesis Source: MGI
- cytoskeleton organization Source: MGI
- endocardial cushion morphogenesis Source: MGI
- endochondral bone morphogenesis Source: MGI
- endocrine pancreas development Source: MGI
- epidermal growth factor receptor signaling pathway Source: UniProtKB
- epithelial cell proliferation involved in prostatic bud elongation Source: MGI
- epithelial to mesenchymal transition Source: MGI
- epithelial tube branching involved in lung morphogenesis Source: MGI
- ERK1 and ERK2 cascade Source: UniProtKB
- extracellular matrix organization Source: MGI
- growth plate cartilage chondrocyte growth Source: UniProtKB
- hair follicle development Source: MGI
- Harderian gland development Source: MGI
- heart development Source: MGI
- heart valve development Source: UniProtKB
- heart valve formation Source: MGI
- heart valve morphogenesis Source: MGI
- homeostasis of number of cells within a tissue Source: MGI
- intestinal epithelial structure maintenance Source: MGI
- intrahepatic bile duct development Source: MGI
- lacrimal gland development Source: MGI
- limb bud formation Source: UniProtKB
- lung epithelial cell differentiation Source: MGI
- lung smooth muscle development Source: MGI
- male germ-line sex determination Source: MGI
- male gonad development Source: MGI
- male sex determination Source: MGI
- mammary gland development Source: UniProtKB
- metanephric nephron tubule formation Source: MGI
- metanephric tubule development Source: UniProtKB
- morphogenesis of a branching epithelium Source: MGI
- morphogenesis of an epithelium Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of beta-catenin-TCF complex assembly Source: UniProtKB
- negative regulation of biomineral tissue development Source: UniProtKB
- negative regulation of bone mineralization Source: MGI
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- negative regulation of cell population proliferation Source: MGI
- negative regulation of chondrocyte differentiation Source: MGI
- negative regulation of epithelial cell differentiation Source: MGI
- negative regulation of epithelial cell proliferation Source: MGI
- negative regulation of fatty acid oxidation Source: UniProtKB
- negative regulation of gene expression Source: MGI
- negative regulation of immune system process Source: UniProtKB
- negative regulation of mesenchymal cell apoptotic process Source: MGI
- negative regulation of myoblast differentiation Source: MGI
- negative regulation of ossification Source: UniProtKB
- negative regulation of osteoblast differentiation Source: UniProtKB
- negative regulation of photoreceptor cell differentiation Source: MGI
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- neural crest cell development Source: MGI
- neural crest cell fate specification Source: UniProtKB
- Notch signaling pathway Source: MGI
- notochord development Source: UniProtKB
- nucleosome assembly Source: UniProtKB
- oligodendrocyte differentiation Source: MGI
- ossification Source: UniProtKB
- otic vesicle development Source: UniProtKB
- otic vesicle formation Source: MGI
- positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
- positive regulation of cartilage development Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cell proliferation involved in heart morphogenesis Source: MGI
- positive regulation of chondrocyte differentiation Source: UniProtKB
- positive regulation of chondrocyte proliferation Source: MGI
- positive regulation of epithelial cell differentiation Source: MGI
- positive regulation of epithelial cell migration Source: MGI
- positive regulation of epithelial cell proliferation Source: UniProtKB
- positive regulation of extracellular matrix assembly Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of kidney development Source: UniProtKB
- positive regulation of male gonad development Source: UniProtKB
- positive regulation of mesenchymal cell proliferation Source: MGI
- positive regulation of mesenchymal stem cell differentiation Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of protein catabolic process Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- prostate gland development Source: UniProtKB
- prostate gland morphogenesis Source: MGI
- protein-containing complex assembly Source: UniProtKB
- protein kinase B signaling Source: UniProtKB
- protein localization to nucleus Source: MGI
- regulation of branching involved in lung morphogenesis Source: MGI
- regulation of cell adhesion Source: MGI
- regulation of cell cycle process Source: UniProtKB
- regulation of cell differentiation Source: MGI
- regulation of cell population proliferation Source: MGI
- regulation of cell proliferation involved in tissue homeostasis Source: MGI
- regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
- regulation of gene expression Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- renal vesicle induction Source: UniProtKB
- response to fatty acid Source: UniProtKB
- retina development in camera-type eye Source: MGI
- retinal rod cell differentiation Source: MGI
- Sertoli cell development Source: MGI
- Sertoli cell differentiation Source: MGI
- signal transduction Source: UniProtKB
- skeletal system development Source: UniProtKB
- somatic stem cell population maintenance Source: MGI
- spermatogenesis Source: MGI
- tissue homeostasis Source: UniProtKB
- trachea cartilage development Source: MGI
- ureter development Source: MGI
- ureter morphogenesis Source: MGI
- ureter smooth muscle cell differentiation Source: MGI
- ureter urothelium development Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-3769402, Deactivation of the beta-catenin transactivating complex R-MMU-8878166, Transcriptional regulation by RUNX2 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor SOX-9CuratedShort name: mSox91 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98371, Sox9 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation5 Publications
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- protein-containing complex Source: UniProtKB
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Perinatal lethality, with cleft palate, as well as hypoplasia and bending of many skeletal structures derived from cartilage precursors (PubMed:11371614). Heterozygous mice die shortly after birth and display skeletal malformations caused by impaired precartilaginous condensations (PubMed:11371614). In embryonic day (E)12.5 heterozygotes embryos, skeletal elements are smaller (PubMed:11371614, PubMed:11857796). In E14.5 heterozygous embryos, bending of radius, ulna and tibia cartilages is already prominent (PubMed:11371614). Premature mineralization is observed in many bones, including vertebrae and some craniofacial bones in E18.5 heterozygous embryos (PubMed:11371614). Conditional deletion in undifferentiated mesenchymal cells of limb buds before mesenchymal condensations results in a complete absence of both cartilage and bone, while markers for the different axes of limb development show a normal pattern of expression (PubMed:12414734). Conditional deletion in undifferentiated mesenchymal cells of limb buds after chondrogenic mesenchymal condensations causes a severe generalized chondrodysplasia, in which most prechondrocytes are arrested as condensed mesenchymal cells and do not undergo overt differentiation into chondrocytes (PubMed:12414734). Conditional deletion in differentiated growth plate chondrocytes results in severe dwarfism caused by shortened columnar zones in growth plates, leading to an absence of chondrocyte enlargement (PubMed:22421045). Conditional deletion in epithelial cells leads to severe branching defects in the lung (PubMed:24191021).5 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 64 | S → A: Abolished phosphorylation by PKA, leading to deacreased ability to activate transcription of target genes; does not affect subcellular localization; when associated with A-211. 2 Publications | 1 | |
Mutagenesisi | 211 | S → A: Abolished phosphorylation by PKA, leading to deacreased ability to activate transcription of target genes; does not affect subcellular localization; when associated with A-64. 2 Publications | 1 | |
Mutagenesisi | 396 | K → A: Increased stability. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048741 | 1 – 507 | Transcription factor SOX-9Add BLAST | 507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 64 | Phosphoserine; by PKA1 Publication | 1 | |
Modified residuei | 211 | Phosphoserine; by PKA1 Publication | 1 | |
Cross-linki | 396 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication |
Post-translational modificationi
Acetylated; acetylation impairs nuclear localization and ability to transactivate expression of target genes (PubMed:26910618). Deacetylated by SIRT1 (PubMed:26910618).1 Publication
Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling (PubMed:10805756, PubMed:11120880). Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation (PubMed:29644115). Phosphorylated on tyrosine residues; tyrosine dephosphorylation by PTPN11/SHP2 blocks SOX9 phosphorylation by PKA and subsequent SUMOylation (PubMed:29644115).3 Publications
Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation (PubMed:29644115). Sumoylation is induced by BMP signaling pathway (PubMed:29644115).1 Publication
Ubiquitinated; ubiquitination leads to proteasomal degradation and is negatively regulated by DDRGK1.1 Publication
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q04887 |
PaxDbi | Q04887 |
PeptideAtlasi | Q04887 |
PRIDEi | Q04887 |
PTM databases
iPTMneti | Q04887 |
PhosphoSitePlusi | Q04887 |
Expressioni
Tissue specificityi
Expressed in progenitor cells in various organs, including chondroprogenitors, osteoprogenitors and preadipocytes, but is not expressed in most differentiated cell types such as osteoblasts and adipocytes, with the exception of chondrocytes (PubMed:16203988). Highly expressed in developing chondrogenic tissues (PubMed:9119111). Also expressed in some non-chondrogenic tissues such as notochord, otic vesicle and neural tube (PubMed:9119111).2 Publications
Developmental stagei
Predominantly expressed in mesenchymal condensations throughout the embryo before and during the deposition of cartilage (PubMed:7704017). Expressed in multipotent skeletogenic cells (PubMed:9119111). Continues to be expressed during chondrocyte lineage progression, except in terminally differentiating growth plate chondrocytes (PubMed:9119111). Also expressed in some non-chondrogenic tissues such as notochord, otic vesicle and neural tube (PubMed:9119111). In the developing lung, expressed at the distal tips of the branching epithelium as branching occurs and is down-regulated starting at embryonic day (E)16.5, at the onset of terminal differentiation of type 1 and type 2 alveolar cells (PubMed:24191021).3 Publications
Inductioni
Upon lipid starvation conditions, expression is activated by FOXO (FOXO1 and FOXO3).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000000567, Expressed in humerus cartilage element and 473 other tissues |
Genevisiblei | Q04887, MM |
Interactioni
Subunit structurei
Homodimer; homodimerization is required for activity (PubMed:26146088).
Interacts (via C-terminus) with ZNF219; forming a complex that binds to the COL2A1 promoter and activates COL2A1 expression (PubMed:20940257).
Interacts with DDRGK1 (By similarity).
Interacts with EP300/p300 (By similarity).
Interacts with beta-catenin (CTNNB1); inhibiting CTNNB1 activity by competing with the binding sites of TCF/LEF within CTNNB1 (PubMed:15132997).
By similarity3 PublicationsGO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- bHLH transcription factor binding Source: MGI
- protein kinase A catalytic subunit binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203413, 6 interactors |
IntActi | Q04887, 1 interactor |
STRINGi | 10090.ENSMUSP00000000579 |
Miscellaneous databases
RNActi | Q04887, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q04887 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 63 – 103 | Dimerization (DIM)By similarityAdd BLAST | 41 | |
Regioni | 63 – 103 | PQABy similarityAdd BLAST | 41 | |
Regioni | 224 – 307 | Transactivation domain (TAM)By similarityAdd BLAST | 84 | |
Regioni | 392 – 507 | Transactivation domain (TAC)By similarityAdd BLAST | 116 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 275 – 284 | 9aaTAD 1By similarity | 10 | |
Motifi | 290 – 298 | 9aaTAD 2By similarity | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 339 – 415 | Gln/Pro-richAdd BLAST | 77 | |
Compositional biasi | 342 – 346 | Poly-Pro | 5 |
Domaini
The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.By similarity
The PQA region (for proline, glutamine and alanine-rich) helps stabilizing SOX9 and facilitates transactivation. It lacks intrinsic transactivation capability.By similarity
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000158269 |
HOGENOMi | CLU_031800_0_0_1 |
InParanoidi | Q04887 |
OMAi | DYTDHQS |
OrthoDBi | 782373at2759 |
TreeFami | TF351735 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR029548, SOX-9 IPR022151, Sox_N |
PANTHERi | PTHR45803:SF1, PTHR45803:SF1, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12444, Sox_N, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04887-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLLDPFMKM TDEQEKGLSG APSPTMSEDS AGSPCPSGSG SDTENTRPQE
60 70 80 90 100
NTFPKGEPDL KKESEEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK
110 120 130 140 150
NKPHVKRPMN AFMVWAQAAR RKLADQYPHL HNAELSKTLG KLWRLLNESE
160 170 180 190 200
KRPFVEEAER LRVQHKKDHP DYKYQPRRRK SVKNGQAEAE EATEQTHISP
210 220 230 240 250
NAIFKALQAD SPHSSSGMSE VHSPGEHSGQ SQGPPTPPTT PKTDVQAGKV
260 270 280 290 300
DLKREGRPLA EGGRQPPIDF RDVDIGELSS DVISNIETFD VNEFDQYLPP
310 320 330 340 350
NGHPGVPATH GQVTYTGSYG ISSTAPTPAT AGHVWMSKQQ APPPPPQQPP
360 370 380 390 400
QAPQAPQAPP QQQAPPQQPQ APQQQQAHTL TTLSSEPGQS QRTHIKTEQL
410 420 430 440 450
SPSHYSEQQQ HSPQQISYSP FNLPHYSPSY PPITRSQYDY ADHQNSGSYY
460 470 480 490 500
SHAAGQGSGL YSTFTYMNPA QRPMYTPIAD TSGVPSIPQT HSPQHWEQPV
YTQLTRP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | K → R in BAC34018 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF421878 mRNA Translation: AAL16093.1 AK030187 mRNA Translation: BAC26830.1 AK049986 mRNA Translation: BAC34018.1 BC004064 mRNA Translation: AAH04064.1 BC023796 mRNA Translation: AAH23796.1 BC023808 mRNA Translation: AAH23808.1 BC023953 mRNA Translation: AAH23953.1 BC024958 mRNA Translation: AAH24958.1 BC034264 mRNA Translation: AAH34264.1 Z18958 mRNA Translation: CAA79483.1 |
CCDSi | CCDS25595.1 |
PIRi | S30243 S52469 |
RefSeqi | NP_035578.3, NM_011448.4 |
Genome annotation databases
Ensembli | ENSMUST00000000579; ENSMUSP00000000579; ENSMUSG00000000567 |
GeneIDi | 20682 |
KEGGi | mmu:20682 |
UCSCi | uc007med.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF421878 mRNA Translation: AAL16093.1 AK030187 mRNA Translation: BAC26830.1 AK049986 mRNA Translation: BAC34018.1 BC004064 mRNA Translation: AAH04064.1 BC023796 mRNA Translation: AAH23796.1 BC023808 mRNA Translation: AAH23808.1 BC023953 mRNA Translation: AAH23953.1 BC024958 mRNA Translation: AAH24958.1 BC034264 mRNA Translation: AAH34264.1 Z18958 mRNA Translation: CAA79483.1 |
CCDSi | CCDS25595.1 |
PIRi | S30243 S52469 |
RefSeqi | NP_035578.3, NM_011448.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4S2Q | X-ray | 2.70 | D | 103-178 | [»] | |
SMRi | Q04887 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 203413, 6 interactors |
IntActi | Q04887, 1 interactor |
STRINGi | 10090.ENSMUSP00000000579 |
PTM databases
iPTMneti | Q04887 |
PhosphoSitePlusi | Q04887 |
Proteomic databases
MaxQBi | Q04887 |
PaxDbi | Q04887 |
PeptideAtlasi | Q04887 |
PRIDEi | Q04887 |
Protocols and materials databases
Antibodypediai | 915, 874 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000000579; ENSMUSP00000000579; ENSMUSG00000000567 |
GeneIDi | 20682 |
KEGGi | mmu:20682 |
UCSCi | uc007med.2, mouse |
Organism-specific databases
CTDi | 6662 |
MGIi | MGI:98371, Sox9 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000158269 |
HOGENOMi | CLU_031800_0_0_1 |
InParanoidi | Q04887 |
OMAi | DYTDHQS |
OrthoDBi | 782373at2759 |
TreeFami | TF351735 |
Enzyme and pathway databases
Reactomei | R-MMU-3769402, Deactivation of the beta-catenin transactivating complex R-MMU-8878166, Transcriptional regulation by RUNX2 |
Miscellaneous databases
BioGRID-ORCSi | 20682, 2 hits in 17 CRISPR screens |
ChiTaRSi | Sox9, mouse |
PROi | PR:Q04887 |
RNActi | Q04887, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000567, Expressed in humerus cartilage element and 473 other tissues |
Genevisiblei | Q04887, MM |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR029548, SOX-9 IPR022151, Sox_N |
PANTHERi | PTHR45803:SF1, PTHR45803:SF1, 1 hit |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12444, Sox_N, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SOX9_MOUSE | |
Accessioni | Q04887Primary (citable) accession number: Q04887 Secondary accession number(s): Q8C7L2, Q91ZK2, Q99KQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | May 10, 2004 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references