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Entry version 187 (13 Nov 2019)
Sequence version 1 (01 Jun 1994)
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Protein

Proto-oncogene c-Rel

Gene

REL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1169091 Activation of NF-kappaB in B cells

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q04864

SIGNOR Signaling Network Open Resource

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SIGNORi
Q04864

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene c-Rel
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9954 REL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
164910 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q04864

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
5966

Open Targets

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OpenTargetsi
ENSG00000162924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34321

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q04864

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
REL

Domain mapping of disease mutations (DMDM)

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DMDMi
548720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051652 – 619Proto-oncogene c-RelAdd BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei267Phosphoserine; by PKASequence analysis1
Modified residuei503Phosphoserine1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q04864

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q04864

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q04864

MaxQB - The MaxQuant DataBase

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MaxQBi
Q04864

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04864

PeptideAtlas

More...
PeptideAtlasi
Q04864

PRoteomics IDEntifications database

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PRIDEi
Q04864

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58288 [Q04864-1]
61167

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04864

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q04864

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162924 Expressed in 204 organ(s), highest expression level in tonsil

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q04864 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q04864 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004404

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NF-kappa-B p65-c-Rel complex.

Component of the NF-kappa-B p50-c-Rel complex.

Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity).

Interacts with NKIRAS1.

Interacts with NFKBIB (By similarity).

Interacts with NFKBIE.

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A8K5H93EBI-307352,EBI-10174421
B2R8Y43EBI-307352,EBI-10175581
Q96BA43EBI-307352,EBI-10282301
Q9NQ943EBI-307352,EBI-2809489
K7EM053EBI-10829018,EBI-16431307
O147343EBI-307352,EBI-1237371
Q9NRZ53EBI-307352,EBI-1754287
P099173EBI-307352,EBI-79934
O953763EBI-307352,EBI-711158
Q8TDY43EBI-307352,EBI-2609717
Q7Z3C63EBI-307352,EBI-727146
Q8N5M13EBI-10829018,EBI-1166928
P542533EBI-307352,EBI-930964
A0A0S2Z5G43EBI-10829018,EBI-16429704
B4DE543EBI-10829018,EBI-16429313
Q8N9N5-25EBI-10829018,EBI-11524452
Q8N9N5-73EBI-10829018,EBI-16429296
Q9NY433EBI-307352,EBI-10316571
A0A0S2Z3283EBI-10829018,EBI-16435728
Q96RK43EBI-10829018,EBI-1805814
P559573EBI-307352,EBI-519672
P55957-23EBI-307352,EBI-10215147
Q96LC93EBI-307352,EBI-3919268
Q9H3H33EBI-307352,EBI-721765
Q9NX043EBI-307352,EBI-8643161
A0A0S2Z6I73EBI-10829018,EBI-16435493
Q96LT73EBI-307352,EBI-2961725
Q9NP863EBI-307352,EBI-10311131
F6RF563EBI-307352,EBI-10177725
P427733EBI-10829018,EBI-711290
A8MT693EBI-307352,EBI-5529694
Q96LK03EBI-307352,EBI-741885
Q9UFW83EBI-307352,EBI-723153
Q131113EBI-307352,EBI-1020839
Q9Y6H13EBI-307352,EBI-2321769
Q96Q773EBI-307352,EBI-10292696
Q9BW663EBI-307352,EBI-739784
P610243EBI-307352,EBI-456371
Q9P218-23EBI-307352,EBI-10318410
P276583EBI-307352,EBI-747133
Q8N6683EBI-307352,EBI-1550112
Q96FN43EBI-307352,EBI-7097057
Q105703EBI-307352,EBI-347859
Q9NSA33EBI-307352,EBI-747082
P493663EBI-307352,EBI-741925
Q9NQL93EBI-307352,EBI-9679045
P040533EBI-307352,EBI-1220259
Q9Y6G93EBI-307352,EBI-2556107
Q5JVL46EBI-307352,EBI-743105
Q9H6Z94EBI-307352,EBI-1175354
Q141523EBI-307352,EBI-366617
O153713EBI-307352,EBI-353818
O605733EBI-307352,EBI-398610
Q135413EBI-307352,EBI-74090
P632413EBI-307352,EBI-373150
Q9GZV43EBI-307352,EBI-748028
O958343EBI-307352,EBI-1054588
O15197-23EBI-307352,EBI-10182490
Q7L7753EBI-307352,EBI-6255981
Q9Y3B23EBI-307352,EBI-371892
Q9NQT43EBI-307352,EBI-371876
Q96B263EBI-307352,EBI-371922
Q141923EBI-307352,EBI-701903
P681063EBI-307352,EBI-6693977
Q8NFF53EBI-307352,EBI-742815
P21333-23EBI-307352,EBI-9641086
Q9BVV23EBI-307352,EBI-744935
P981773EBI-307352,EBI-4481939
Q495W53EBI-307352,EBI-2907712
O952573EBI-307352,EBI-448202
Q8IVS83EBI-307352,EBI-748515
P629933EBI-307352,EBI-401755
O149293EBI-307352,EBI-2339359
Q8WUI4-53EBI-307352,EBI-10276431
O002913EBI-307352,EBI-473886
P063403EBI-307352,EBI-10194851
Q9UBY93EBI-307352,EBI-739361
Q9UBH03EBI-307352,EBI-465156
Q08E863EBI-307352,EBI-10226057
Q5THT13EBI-307352,EBI-10247181
Q9BYQ23EBI-307352,EBI-10185730
Q148473EBI-307352,EBI-742828
Q96BZ83EBI-10829018,EBI-726510
Q8TCE93EBI-307352,EBI-10274069
P258003EBI-307352,EBI-8639312
P257913EBI-307352,EBI-739696
Q9UIQ63EBI-307352,EBI-2805360
Q9Y3333EBI-307352,EBI-347416
Q9UI953EBI-307352,EBI-77889
Q96A723EBI-307352,EBI-746778
P57077-43EBI-307352,EBI-10215880
Q9Y3163EBI-307352,EBI-1104564
Q9BRT33EBI-307352,EBI-6137472
Q9UBU83EBI-307352,EBI-399246
Q7Z7H83EBI-307352,EBI-723524
Q9UJ703EBI-307352,EBI-372578
O436393EBI-307352,EBI-713635
Q9BU61-23EBI-307352,EBI-10298649
A8K3C23EBI-307352,EBI-10174302
Q145113EBI-307352,EBI-2108053
Q969S23EBI-307352,EBI-10281234
Q9Y4Z23EBI-307352,EBI-10328570
Q006532EBI-307352,EBI-307326
P259633EBI-307352,EBI-307386
O002212EBI-307352,EBI-355098
Q9NPG23EBI-307352,EBI-10311409
Q9Y5B83EBI-307352,EBI-744782
Q5SY163EBI-307352,EBI-1055462
Q86WQ03EBI-307352,EBI-10260040
O958483EBI-307352,EBI-536866
Q9NPJ83EBI-307352,EBI-752122
Q9UMX23EBI-307352,EBI-10281601
Q9UJX03EBI-307352,EBI-9057006
Q928823EBI-307352,EBI-1051152
Q96DC93EBI-307352,EBI-746259
Q018043EBI-307352,EBI-1054396
A0A0S2Z5D33EBI-10829018,EBI-16431731
Q9HBI03EBI-307352,EBI-3921217
Q8WXA23EBI-307352,EBI-10277790
Q8WWB53EBI-307352,EBI-10232538
Q151473EBI-307352,EBI-998637
Q494U13EBI-307352,EBI-10241513
P562823EBI-307352,EBI-713847
O956023EBI-307352,EBI-359472
P628753EBI-307352,EBI-359527
Q969H63EBI-307352,EBI-366525
Q9NQV63EBI-307352,EBI-10312448
P546463EBI-10829018,EBI-1383852
O437413EBI-10829018,EBI-1053424
P257863EBI-307352,EBI-359352
P43115-123EBI-307352,EBI-10234038
Q138823EBI-307352,EBI-1383632
Q9Y2K5-23EBI-307352,EBI-10326419
Q5JT253EBI-307352,EBI-10244509
P472243EBI-307352,EBI-713992
Q8WWW03EBI-307352,EBI-367390
Q14498-33EBI-307352,EBI-6654703
Q6P9E23EBI-307352,EBI-10253121
Q04206-22EBI-307352,EBI-289947
Q04206-33EBI-307352,EBI-10223388
Q8IX063EBI-307352,EBI-10262361
Q0D2K33EBI-307352,EBI-10226430
Q63HN8-63EBI-307352,EBI-10248548
A0A0S2Z4G93EBI-10829018,EBI-16428950
Q9UHP63EBI-307352,EBI-748350
Q5T7Y43EBI-10829018,EBI-16435788
P216733EBI-307352,EBI-711613
O005603EBI-307352,EBI-727004
Q9UDX33EBI-307352,EBI-10320311
O949793EBI-307352,EBI-1767898
Q16181-23EBI-307352,EBI-10176094
Q96H723EBI-307352,EBI-10287091
Q96GZ63EBI-307352,EBI-7225508
P480653EBI-307352,EBI-3843589
Q9BV903EBI-307352,EBI-9675976
O757163EBI-307352,EBI-749295
Q5T011-53EBI-307352,EBI-10245139
Q081173EBI-307352,EBI-717810
Q9HCN33EBI-307352,EBI-10310808
Q8NFZ52EBI-307352,EBI-359372
Q63HR23EBI-307352,EBI-949753
Q9UL333EBI-307352,EBI-747601
Q86UV6-23EBI-307352,EBI-10259086
Q9Y5U23EBI-307352,EBI-717229
Q96PN83EBI-307352,EBI-3918381
Q5T7W73EBI-307352,EBI-8994397
Q6DKK23EBI-307352,EBI-948354
A0A0B4J1Y23EBI-307352,EBI-10220701
Q9NX013EBI-307352,EBI-10309345
P570753EBI-307352,EBI-2105393
P610863EBI-307352,EBI-473850
Q9H8323EBI-307352,EBI-720977
Q9BRG13EBI-307352,EBI-741945
A0A0S2Z4P33EBI-10829018,EBI-16435800
Q6UX983EBI-307352,EBI-10254561
Q8TAU33EBI-307352,EBI-740727
Q7Z3983EBI-307352,EBI-10256834
Q8TBZ83EBI-307352,EBI-10273713
Q7Z3I73EBI-307352,EBI-10172590
A0A0S2Z5X43EBI-10829018,EBI-16429014
A0A0S2Z6P03EBI-10829018,EBI-16429989
Q7L2R63EBI-307352,EBI-9676069

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111898, 240 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q04864

Database of interacting proteins

More...
DIPi
DIP-301N

Protein interaction database and analysis system

More...
IntActi
Q04864, 336 interactors

Molecular INTeraction database

More...
MINTi
Q04864

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295025

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q04864

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 297RHDPROSITE-ProRule annotationAdd BLAST290

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi290 – 295Nuclear localization signalSequence analysis6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG8F Eukaryota
ENOG410XT64 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000264257

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q04864

KEGG Orthology (KO)

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KOi
K09254

Identification of Orthologs from Complete Genome Data

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OMAi
KLWQDCA

Database of Orthologous Groups

More...
OrthoDBi
916931at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q04864

TreeFam database of animal gene trees

More...
TreeFami
TF325632

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01177 IPT_NFkappaB, 1 hit
cd07933 RHD-n_c-Rel, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030505 c-Rel
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR042845 RHD-n_c-Rel
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR24169 PTHR24169, 1 hit
PTHR24169:SF4 PTHR24169:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00057 NFKBTNSCPFCT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00429 IPT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q04864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGAYNPYI EIIEQPRQRG MRFRYKCEGR SAGSIPGEHS TDNNRTYPSI
60 70 80 90 100
QIMNYYGKGK VRITLVTKND PYKPHPHDLV GKDCRDGYYE AEFGQERRPL
110 120 130 140 150
FFQNLGIRCV KKKEVKEAII TRIKAGINPF NVPEKQLNDI EDCDLNVVRL
160 170 180 190 200
CFQVFLPDEH GNLTTALPPV VSNPIYDNRA PNTAELRICR VNKNCGSVRG
210 220 230 240 250
GDEIFLLCDK VQKDDIEVRF VLNDWEAKGI FSQADVHRQV AIVFKTPPYC
260 270 280 290 300
KAITEPVTVK MQLRRPSDQE VSESMDFRYL PDEKDTYGNK AKKQKTTLLF
310 320 330 340 350
QKLCQDHVET GFRHVDQDGL ELLTSGDPPT LASQSAGITV NFPERPRPGL
360 370 380 390 400
LGSIGEGRYF KKEPNLFSHD AVVREMPTGV SSQAESYYPS PGPISSGLSH
410 420 430 440 450
HASMAPLPSS SWSSVAHPTP RSGNTNPLSS FSTRTLPSNS QGIPPFLRIP
460 470 480 490 500
VGNDLNASNA CIYNNADDIV GMEASSMPSA DLYGISDPNM LSNCSVNMMT
510 520 530 540 550
TSSDSMGETD NPRLLSMNLE NPSCNSVLDP RDLRQLHQMS SSSMSAGANS
560 570 580 590 600
NTTVFVSQSD AFEGSDFSCA DNSMINESGP SNSTNPNSHG FVQDSQYSGI
610
GSMQNEQLSD SFPYEFFQV
Length:619
Mass (Da):68,520
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03E1033BDF7B1B30
GO
Isoform 2 (identifier: Q04864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-339: Missing.

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):65,225
Checksum:iE312A59CF1D306A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7Q6A0A2R8Y7Q6_HUMAN
Proto-oncogene c-Rel
REL
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055857308 – 339Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X75042 mRNA Translation: CAA52954.1
DQ314888 Genomic DNA Translation: ABC40747.1
AC010733 Genomic DNA No translation available.
BC117191 mRNA Translation: AAI17192.1
BC143885 mRNA Translation: AAI43886.1
M11595 Genomic DNA Translation: AAA52073.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1864.1 [Q04864-1]
CCDS74515.1 [Q04864-2]

Protein sequence database of the Protein Information Resource

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PIRi
A60646

NCBI Reference Sequences

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RefSeqi
NP_001278675.1, NM_001291746.1 [Q04864-2]
NP_002899.1, NM_002908.3 [Q04864-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295025; ENSP00000295025; ENSG00000162924 [Q04864-1]
ENST00000394479; ENSP00000377989; ENSG00000162924 [Q04864-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5966

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5966

UCSC genome browser

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UCSCi
uc002sam.2 human [Q04864-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75042 mRNA Translation: CAA52954.1
DQ314888 Genomic DNA Translation: ABC40747.1
AC010733 Genomic DNA No translation available.
BC117191 mRNA Translation: AAI17192.1
BC143885 mRNA Translation: AAI43886.1
M11595 Genomic DNA Translation: AAA52073.1
CCDSiCCDS1864.1 [Q04864-1]
CCDS74515.1 [Q04864-2]
PIRiA60646
RefSeqiNP_001278675.1, NM_001291746.1 [Q04864-2]
NP_002899.1, NM_002908.3 [Q04864-1]

3D structure databases

SMRiQ04864
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111898, 240 interactors
CORUMiQ04864
DIPiDIP-301N
IntActiQ04864, 336 interactors
MINTiQ04864
STRINGi9606.ENSP00000295025

PTM databases

iPTMnetiQ04864
PhosphoSitePlusiQ04864

Polymorphism and mutation databases

BioMutaiREL
DMDMi548720

Proteomic databases

EPDiQ04864
jPOSTiQ04864
MassIVEiQ04864
MaxQBiQ04864
PaxDbiQ04864
PeptideAtlasiQ04864
PRIDEiQ04864
ProteomicsDBi58288 [Q04864-1]
61167

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5966

Genome annotation databases

EnsembliENST00000295025; ENSP00000295025; ENSG00000162924 [Q04864-1]
ENST00000394479; ENSP00000377989; ENSG00000162924 [Q04864-2]
GeneIDi5966
KEGGihsa:5966
UCSCiuc002sam.2 human [Q04864-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5966
DisGeNETi5966

GeneCards: human genes, protein and diseases

More...
GeneCardsi
REL
HGNCiHGNC:9954 REL
HPAiCAB004404
MIMi164910 gene
neXtProtiNX_Q04864
OpenTargetsiENSG00000162924
PharmGKBiPA34321

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG8F Eukaryota
ENOG410XT64 LUCA
GeneTreeiENSGT00940000158732
HOGENOMiHOG000264257
InParanoidiQ04864
KOiK09254
OMAiKLWQDCA
OrthoDBi916931at2759
PhylomeDBiQ04864
TreeFamiTF325632

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
SignaLinkiQ04864
SIGNORiQ04864

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
REL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
REL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5966
PharosiQ04864

Protein Ontology

More...
PROi
PR:Q04864

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162924 Expressed in 204 organ(s), highest expression level in tonsil
ExpressionAtlasiQ04864 baseline and differential
GenevisibleiQ04864 HS

Family and domain databases

CDDicd01177 IPT_NFkappaB, 1 hit
cd07933 RHD-n_c-Rel, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR030505 c-Rel
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR042845 RHD-n_c-Rel
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PTHR24169:SF4 PTHR24169:SF4, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04864
Secondary accession number(s): Q17RU2, Q2PNZ7, Q6LDY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 13, 2019
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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