UniProtKB - Q04864 (REL_HUMAN)
Proto-oncogene c-Rel
REL
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- inflammatory response Source: GO_Central
- innate immune response Source: GO_Central
- negative regulation of gene expression Source: CACAO
- negative regulation of interferon-beta production Source: CACAO
- negative regulation of neuron death Source: Ensembl
- NIK/NF-kappaB signaling Source: GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cytokine Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q04864 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells |
SignaLinki | Q04864 |
SIGNORi | Q04864 |
Names & Taxonomyi
Protein namesi | Recommended name: Proto-oncogene c-Rel |
Gene namesi | Name:REL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9954, REL |
MIMi | 164910, gene |
neXtProti | NX_Q04864 |
VEuPathDBi | HostDB:ENSG00000162924.13 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: CACAO
Other locations
- chromatin Source: NTNU_SB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 5966 |
OpenTargetsi | ENSG00000162924 |
PharmGKBi | PA34321 |
Miscellaneous databases
Pharosi | Q04864, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4296310 |
Genetic variation databases
BioMutai | REL |
DMDMi | 548720 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000205165 | 2 – 619 | Proto-oncogene c-RelAdd BLAST | 618 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 267 | Phosphoserine; by PKASequence analysis | 1 | |
Modified residuei | 503 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q04864 |
jPOSTi | Q04864 |
MassIVEi | Q04864 |
MaxQBi | Q04864 |
PaxDbi | Q04864 |
PeptideAtlasi | Q04864 |
PRIDEi | Q04864 |
ProteomicsDBi | 58288 [Q04864-1] 61167 |
PTM databases
GlyGeni | Q04864, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q04864 |
PhosphoSitePlusi | Q04864 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162924, Expressed in bone marrow and 222 other tissues |
ExpressionAtlasi | Q04864, baseline and differential |
Genevisiblei | Q04864, HS |
Organism-specific databases
HPAi | ENSG00000162924, Low tissue specificity |
Interactioni
Subunit structurei
Component of the NF-kappa-B p65-c-Rel complex.
Component of the NF-kappa-B p50-c-Rel complex.
Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity).
Interacts with NKIRAS1.
Interacts with NFKBIB (By similarity).
Interacts with NFKBIE.
By similarity6 PublicationsBinary interactionsi
Q04864
Isoform 2 [Q04864-2]
Protein-protein interaction databases
BioGRIDi | 111898, 351 interactors |
ComplexPortali | CPX-5830, NF-kappaB DNA-binding transcription factor complex, p52/c-Rel CPX-5832, NF-kappaB DNA-binding transcription factor complex, p50/c-Rel CPX-5834, NF-kappaB DNA-binding transcription factor complex, p65/c-Rel CPX-5836, NF-kappaB DNA-binding transcription factor complex, c-Rel/c-Rel |
CORUMi | Q04864 |
DIPi | DIP-301N |
IntActi | Q04864, 335 interactors |
MINTi | Q04864 |
STRINGi | 9606.ENSP00000295025 |
Miscellaneous databases
RNActi | Q04864, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 297 | RHDPROSITE-ProRule annotationAdd BLAST | 290 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 290 – 295 | Nuclear localization signalSequence analysis | 6 |
Phylogenomic databases
eggNOGi | ENOG502QQS6, Eukaryota |
GeneTreei | ENSGT00940000158732 |
HOGENOMi | CLU_004343_5_0_1 |
InParanoidi | Q04864 |
OMAi | NCPVNMI |
OrthoDBi | 916931at2759 |
PhylomeDBi | Q04864 |
TreeFami | TF325632 |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit cd07933, RHD-n_c-Rel, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR030505, c-Rel IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR042845, RHD-n_c-Rel IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF4, PTHR24169:SF4, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASGAYNPYI EIIEQPRQRG MRFRYKCEGR SAGSIPGEHS TDNNRTYPSI
60 70 80 90 100
QIMNYYGKGK VRITLVTKND PYKPHPHDLV GKDCRDGYYE AEFGQERRPL
110 120 130 140 150
FFQNLGIRCV KKKEVKEAII TRIKAGINPF NVPEKQLNDI EDCDLNVVRL
160 170 180 190 200
CFQVFLPDEH GNLTTALPPV VSNPIYDNRA PNTAELRICR VNKNCGSVRG
210 220 230 240 250
GDEIFLLCDK VQKDDIEVRF VLNDWEAKGI FSQADVHRQV AIVFKTPPYC
260 270 280 290 300
KAITEPVTVK MQLRRPSDQE VSESMDFRYL PDEKDTYGNK AKKQKTTLLF
310 320 330 340 350
QKLCQDHVET GFRHVDQDGL ELLTSGDPPT LASQSAGITV NFPERPRPGL
360 370 380 390 400
LGSIGEGRYF KKEPNLFSHD AVVREMPTGV SSQAESYYPS PGPISSGLSH
410 420 430 440 450
HASMAPLPSS SWSSVAHPTP RSGNTNPLSS FSTRTLPSNS QGIPPFLRIP
460 470 480 490 500
VGNDLNASNA CIYNNADDIV GMEASSMPSA DLYGISDPNM LSNCSVNMMT
510 520 530 540 550
TSSDSMGETD NPRLLSMNLE NPSCNSVLDP RDLRQLHQMS SSSMSAGANS
560 570 580 590 600
NTTVFVSQSD AFEGSDFSCA DNSMINESGP SNSTNPNSHG FVQDSQYSGI
610
GSMQNEQLSD SFPYEFFQV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y7Q6 | A0A2R8Y7Q6_HUMAN | Proto-oncogene c-Rel | REL | 61 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055857 | 308 – 339 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75042 mRNA Translation: CAA52954.1 DQ314888 Genomic DNA Translation: ABC40747.1 AC010733 Genomic DNA No translation available. BC117191 mRNA Translation: AAI17192.1 BC143885 mRNA Translation: AAI43886.1 M11595 Genomic DNA Translation: AAA52073.1 |
CCDSi | CCDS1864.1 [Q04864-1] CCDS74515.1 [Q04864-2] |
PIRi | A60646 |
RefSeqi | NP_001278675.1, NM_001291746.1 [Q04864-2] NP_002899.1, NM_002908.3 [Q04864-1] |
Genome annotation databases
Ensembli | ENST00000295025; ENSP00000295025; ENSG00000162924 [Q04864-1] ENST00000394479; ENSP00000377989; ENSG00000162924 [Q04864-2] |
GeneIDi | 5966 |
KEGGi | hsa:5966 |
UCSCi | uc002sam.2, human [Q04864-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75042 mRNA Translation: CAA52954.1 DQ314888 Genomic DNA Translation: ABC40747.1 AC010733 Genomic DNA No translation available. BC117191 mRNA Translation: AAI17192.1 BC143885 mRNA Translation: AAI43886.1 M11595 Genomic DNA Translation: AAA52073.1 |
CCDSi | CCDS1864.1 [Q04864-1] CCDS74515.1 [Q04864-2] |
PIRi | A60646 |
RefSeqi | NP_001278675.1, NM_001291746.1 [Q04864-2] NP_002899.1, NM_002908.3 [Q04864-1] |
3D structure databases
SMRi | Q04864 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111898, 351 interactors |
ComplexPortali | CPX-5830, NF-kappaB DNA-binding transcription factor complex, p52/c-Rel CPX-5832, NF-kappaB DNA-binding transcription factor complex, p50/c-Rel CPX-5834, NF-kappaB DNA-binding transcription factor complex, p65/c-Rel CPX-5836, NF-kappaB DNA-binding transcription factor complex, c-Rel/c-Rel |
CORUMi | Q04864 |
DIPi | DIP-301N |
IntActi | Q04864, 335 interactors |
MINTi | Q04864 |
STRINGi | 9606.ENSP00000295025 |
Chemistry databases
ChEMBLi | CHEMBL4296310 |
PTM databases
GlyGeni | Q04864, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q04864 |
PhosphoSitePlusi | Q04864 |
Genetic variation databases
BioMutai | REL |
DMDMi | 548720 |
Proteomic databases
EPDi | Q04864 |
jPOSTi | Q04864 |
MassIVEi | Q04864 |
MaxQBi | Q04864 |
PaxDbi | Q04864 |
PeptideAtlasi | Q04864 |
PRIDEi | Q04864 |
ProteomicsDBi | 58288 [Q04864-1] 61167 |
Protocols and materials databases
Antibodypediai | 3830, 815 antibodies |
DNASUi | 5966 |
Genome annotation databases
Ensembli | ENST00000295025; ENSP00000295025; ENSG00000162924 [Q04864-1] ENST00000394479; ENSP00000377989; ENSG00000162924 [Q04864-2] |
GeneIDi | 5966 |
KEGGi | hsa:5966 |
UCSCi | uc002sam.2, human [Q04864-1] |
Organism-specific databases
CTDi | 5966 |
DisGeNETi | 5966 |
GeneCardsi | REL |
HGNCi | HGNC:9954, REL |
HPAi | ENSG00000162924, Low tissue specificity |
MIMi | 164910, gene |
neXtProti | NX_Q04864 |
OpenTargetsi | ENSG00000162924 |
PharmGKBi | PA34321 |
VEuPathDBi | HostDB:ENSG00000162924.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQS6, Eukaryota |
GeneTreei | ENSGT00940000158732 |
HOGENOMi | CLU_004343_5_0_1 |
InParanoidi | Q04864 |
OMAi | NCPVNMI |
OrthoDBi | 916931at2759 |
PhylomeDBi | Q04864 |
TreeFami | TF325632 |
Enzyme and pathway databases
PathwayCommonsi | Q04864 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells |
SignaLinki | Q04864 |
SIGNORi | Q04864 |
Miscellaneous databases
BioGRID-ORCSi | 5966, 7 hits in 1011 CRISPR screens |
ChiTaRSi | REL, human |
GeneWikii | REL |
GenomeRNAii | 5966 |
Pharosi | Q04864, Tbio |
PROi | PR:Q04864 |
RNActi | Q04864, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162924, Expressed in bone marrow and 222 other tissues |
ExpressionAtlasi | Q04864, baseline and differential |
Genevisiblei | Q04864, HS |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit cd07933, RHD-n_c-Rel, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR030505, c-Rel IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR008967, p53-like_TF_DNA-bd IPR042845, RHD-n_c-Rel IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF4, PTHR24169:SF4, 1 hit |
Pfami | View protein in Pfam PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429, IPT, 1 hit |
SUPFAMi | SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | REL_HUMAN | |
Accessioni | Q04864Primary (citable) accession number: Q04864 Secondary accession number(s): Q17RU2, Q2PNZ7, Q6LDY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | April 7, 2021 | |
This is version 196 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot