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Protein

Proto-oncogene c-Rel

Gene

REL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1169091 Activation of NF-kappaB in B cells

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q04864

SIGNOR Signaling Network Open Resource

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SIGNORi
Q04864

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene c-Rel
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000162924.13

Human Gene Nomenclature Database

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HGNCi
HGNC:9954 REL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
164910 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q04864

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
5966

Open Targets

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OpenTargetsi
ENSG00000162924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34321

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
REL

Domain mapping of disease mutations (DMDM)

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DMDMi
548720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051652 – 619Proto-oncogene c-RelAdd BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei267Phosphoserine; by PKASequence analysis1
Modified residuei503Phosphoserine1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q04864

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q04864

MaxQB - The MaxQuant DataBase

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MaxQBi
Q04864

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q04864

PeptideAtlas

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PeptideAtlasi
Q04864

PRoteomics IDEntifications database

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PRIDEi
Q04864

ProteomicsDB human proteome resource

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ProteomicsDBi
58288

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q04864

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q04864

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162924 Expressed in 204 organ(s), highest expression level in tonsil

CleanEx database of gene expression profiles

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CleanExi
HS_REL

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q04864 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB004404

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p50-c-Rel complex. Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity). Interacts with NKIRAS1. Interacts with NFKBIB (By similarity). Interacts with NFKBIE.By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A8K5H93EBI-307352,EBI-10174421
B2R8Y43EBI-307352,EBI-10175581
Q96BA43EBI-307352,EBI-10282301
A1CFQ9NQ943EBI-307352,EBI-2809489
ACBD4K7EM053EBI-10829018,EBI-16431307
ACOT8O147343EBI-307352,EBI-1237371
AESQ081173EBI-307352,EBI-717810
AGPAT4Q9NRZ53EBI-307352,EBI-1754287
ALOX5P099173EBI-307352,EBI-79934
ARIH2O953763EBI-307352,EBI-711158
ASAP3Q8TDY43EBI-307352,EBI-2609717
ATG9AQ7Z3C63EBI-307352,EBI-727146
ATPAF2Q8N5M13EBI-10829018,EBI-1166928
ATXN1P542533EBI-307352,EBI-930964
BANPA0A0S2Z5G43EBI-10829018,EBI-16429704
BANPB4DE543EBI-10829018,EBI-16429313
BANPQ8N9N5-25EBI-10829018,EBI-11524452
BANPQ8N9N5-73EBI-10829018,EBI-16429296
BARHL2Q9NY433EBI-307352,EBI-10316571
BBS4A0A0S2Z3283EBI-10829018,EBI-16435728
BBS4Q96RK43EBI-10829018,EBI-1805814
BIDP559573EBI-307352,EBI-519672
BIDP55957-23EBI-307352,EBI-10215147
BMFQ96LC93EBI-307352,EBI-3919268
C11orf68Q9H3H33EBI-307352,EBI-721765
C1orf109Q9NX043EBI-307352,EBI-8643161
C6orf142A0A0S2Z6I73EBI-10829018,EBI-16435493
C9orf72Q96LT73EBI-307352,EBI-2961725
CABP5Q9NP863EBI-307352,EBI-10311131
CCNJLF6RF563EBI-307352,EBI-10177725
CDKN2CP427733EBI-307352,EBI-711290
CENPXA8MT693EBI-307352,EBI-5529694
CEP19Q96LK03EBI-307352,EBI-741885
CGGBP1Q9UFW83EBI-307352,EBI-723153
CHAF1AQ131113EBI-307352,EBI-1020839
CHCHD2Q9Y6H13EBI-307352,EBI-2321769
CIB3Q96Q773EBI-307352,EBI-10292696
CINPQ9BW663EBI-307352,EBI-739784
CKS1BP610243EBI-307352,EBI-456371
COL20A1Q9P218-23EBI-307352,EBI-10318410
COL8A1P276583EBI-307352,EBI-747133
COMMD1Q8N6683EBI-307352,EBI-1550112
CPNE2Q96FN43EBI-307352,EBI-7097057
CPSF1Q105703EBI-307352,EBI-347859
CTNNBIP1Q9NSA33EBI-307352,EBI-747082
DHPSP493663EBI-307352,EBI-741925
DMRT3Q9NQL93EBI-307352,EBI-9679045
DNTTP040533EBI-307352,EBI-1220259
DYNC1LI1Q9Y6G93EBI-307352,EBI-2556107
EFHC1Q5JVL46EBI-307352,EBI-743105
EGLN3Q9H6Z94EBI-307352,EBI-1175354
EIF3AQ24JU43EBI-307352,EBI-10239221
EIF3DO153713EBI-307352,EBI-353818
EIF4E2O605733EBI-307352,EBI-398610
EIF4EBP1Q135413EBI-307352,EBI-74090
EIF5AP632413EBI-307352,EBI-373150
EIF5A2Q9GZV43EBI-307352,EBI-748028
EML2O958343EBI-307352,EBI-1054588
EPHB6O15197-23EBI-307352,EBI-10182490
EPM2AIP1Q7L7753EBI-307352,EBI-6255981
EXOSC1Q9Y3B23EBI-307352,EBI-371892
EXOSC5Q9NQT43EBI-307352,EBI-371876
EXOSC8Q96B263EBI-307352,EBI-371922
FHL2Q141923EBI-307352,EBI-701903
FKBP1BP681063EBI-307352,EBI-6693977
FLAD1Q8NFF53EBI-307352,EBI-742815
FLNAP21333-23EBI-307352,EBI-9641086
FNDC11Q9BVV23EBI-307352,EBI-744935
FOXO4P981773EBI-307352,EBI-4481939
FUT11Q495W53EBI-307352,EBI-2907712
GADD45GO952573EBI-307352,EBI-448202
GLYCTKQ8IVS83EBI-307352,EBI-748515
GRB2P629933EBI-307352,EBI-401755
HAT1O149293EBI-307352,EBI-2339359
HDAC7Q8WUI4-53EBI-307352,EBI-10276431
HIP1O002913EBI-307352,EBI-473886
HLA-DOAP063403EBI-307352,EBI-10194851
HSPB7Q9UBY93EBI-307352,EBI-739361
IL36RNQ9UBH03EBI-307352,EBI-465156
KIAA0100Q08E863EBI-307352,EBI-10226057
KLHL32Q5THT13EBI-307352,EBI-10247181
KRTAP9-4Q9BYQ23EBI-307352,EBI-10185730
LASP1Q148473EBI-307352,EBI-742828
LGALS14Q8TCE93EBI-307352,EBI-10274069
LMO1P258003EBI-307352,EBI-8639312
LMO2P257913EBI-307352,EBI-739696
LNPEPQ9UIQ63EBI-307352,EBI-2805360
LSM2Q9Y3333EBI-307352,EBI-347416
MAD2L2Q9UI953EBI-307352,EBI-77889
MAGOHBQ96A723EBI-307352,EBI-746778
MAP3K7CLP57077-43EBI-307352,EBI-10215880
MEMO1Q9Y3163EBI-307352,EBI-1104564
MIEN1Q9BRT33EBI-307352,EBI-6137472
MORF4L1Q9UBU83EBI-307352,EBI-399246
MRPL10Q7Z7H83EBI-307352,EBI-723524
NAGKQ9UJ703EBI-307352,EBI-372578
NCK2O436393EBI-307352,EBI-713635
NDUFAF3Q9BU61-23EBI-307352,EBI-10298649
NECAP1A8K3C23EBI-307352,EBI-10174302
NEDD9Q145113EBI-307352,EBI-2108053
NEIL2Q969S23EBI-307352,EBI-10281234
NEUROG3Q9Y4Z23EBI-307352,EBI-10328570
NFKBIAP259632EBI-307352,EBI-307386
NGBQ9NPG23EBI-307352,EBI-10311409
NME7Q9Y5B83EBI-307352,EBI-744782
NOL9Q5SY163EBI-307352,EBI-1055462
NR2C2APQ86WQ03EBI-307352,EBI-10260040
NUDT14O958483EBI-307352,EBI-536866
NXT2Q9NPJ83EBI-307352,EBI-752122
OAZ3Q9UMX23EBI-307352,EBI-10281601
OSGIN1Q9UJX03EBI-307352,EBI-9057006
OSTF1Q928823EBI-307352,EBI-1051152
OTUB2Q96DC93EBI-307352,EBI-746259
OTUD4Q018043EBI-307352,EBI-1054396
PAK1IP1A0A0S2Z5D33EBI-10829018,EBI-16431731
PARVGQ9HBI03EBI-307352,EBI-3921217
PATE1Q8WXA23EBI-307352,EBI-10277790
PIH1D2Q8WWB53EBI-307352,EBI-10232538
PLCB4Q151473EBI-307352,EBI-998637
PLEKHN1Q494U13EBI-307352,EBI-10241513
POLE2P562823EBI-307352,EBI-713847
POLR1AO956023EBI-307352,EBI-359472
POLR2LP628753EBI-307352,EBI-359527
POP5Q969H63EBI-307352,EBI-366525
PRDM10Q9NQV63EBI-307352,EBI-10312448
PSMA1P257863EBI-307352,EBI-359352
PTGER3P43115-123EBI-307352,EBI-10234038
PTK6Q138823EBI-307352,EBI-1383632
R3HDM2Q9Y2K5-23EBI-307352,EBI-10326419
RAB41Q5JT253EBI-307352,EBI-10244509
RABIFP472243EBI-307352,EBI-713992
RASSF5Q8WWW03EBI-307352,EBI-367390
RBM39Q14498-33EBI-307352,EBI-6654703
RECKQ6P9E23EBI-307352,EBI-10253121
RELAQ04206-33EBI-307352,EBI-10223388
REXO1L1PQ8IX063EBI-307352,EBI-10262361
RIPPLY1Q0D2K33EBI-307352,EBI-10226430
RNF213Q63HN8-63EBI-307352,EBI-10248548
RNF6A0A0S2Z4G93EBI-10829018,EBI-16428950
RSPH14Q9UHP63EBI-307352,EBI-748350
S100A1Q5T7Y43EBI-10829018,EBI-16435788
SAT1P216733EBI-307352,EBI-711613
SDCBPO005603EBI-307352,EBI-727004
SEC14L4Q9UDX33EBI-307352,EBI-10320311
SEC31AO949793EBI-307352,EBI-1767898
SEPT7Q16181-23EBI-307352,EBI-10176094
SLC39A13Q96H723EBI-307352,EBI-10287091
SLC41A3Q96GZ63EBI-307352,EBI-7225508
SLC6A12P480653EBI-307352,EBI-3843589
SNRNP25Q9BV903EBI-307352,EBI-9675976
STK16O757163EBI-307352,EBI-749295
SZT2Q5T011-53EBI-307352,EBI-10245139
TMEM8AQ9HCN33EBI-307352,EBI-10310808
TNS2Q63HR23EBI-307352,EBI-949753
TRAPPC2LQ9UL333EBI-307352,EBI-747601
TRIM74Q86UV6-23EBI-307352,EBI-10259086
TSSC4Q9Y5U23EBI-307352,EBI-717229
TSSK3Q96PN83EBI-307352,EBI-3918381
TSTD2Q5T7W73EBI-307352,EBI-8994397
TTC19Q6DKK23EBI-307352,EBI-948354
TTC21AA0A0B4J1Y23EBI-307352,EBI-10220701
TXNL4BQ9NX013EBI-307352,EBI-10309345
UBASH3AP570753EBI-307352,EBI-2105393
UBE2KP610863EBI-307352,EBI-473850
UBE2ZQ9H8323EBI-307352,EBI-720977
VPS25Q9BRG13EBI-307352,EBI-741945
YARSA0A0S2Z4P33EBI-10829018,EBI-16435800
ZDHHC24Q6UX983EBI-307352,EBI-10254561
ZNF417Q8TAU33EBI-307352,EBI-740727
ZNF550Q7Z3983EBI-307352,EBI-10256834
ZNF564Q8TBZ83EBI-307352,EBI-10273713
ZNF572Q7Z3I73EBI-307352,EBI-10172590
ZNF688A0A0S2Z5X43EBI-10829018,EBI-16429014
ZNF688A0A0S2Z6P03EBI-10829018,EBI-16429989
ZNF765Q7L2R63EBI-307352,EBI-9676069

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111898, 213 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q04864

Database of interacting proteins

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DIPi
DIP-301N

Protein interaction database and analysis system

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IntActi
Q04864, 307 interactors

Molecular INTeraction database

More...
MINTi
Q04864

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295025

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q04864

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q04864

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 297RHDPROSITE-ProRule annotationAdd BLAST290

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi290 – 295Nuclear localization signalSequence analysis6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG8F Eukaryota
ENOG410XT64 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000264257

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG017916

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q04864

KEGG Orthology (KO)

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KOi
K09254

Identification of Orthologs from Complete Genome Data

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OMAi
LLFQKLW

Database of Orthologous Groups

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OrthoDBi
916931at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q04864

TreeFam database of animal gene trees

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TreeFami
TF325632

Family and domain databases

Conserved Domains Database

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CDDi
cd01177 IPT_NFkappaB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030505 c-Rel
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR24169 PTHR24169, 1 hit
PTHR24169:SF4 PTHR24169:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00057 NFKBTNSCPFCT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00429 IPT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q04864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGAYNPYI EIIEQPRQRG MRFRYKCEGR SAGSIPGEHS TDNNRTYPSI
60 70 80 90 100
QIMNYYGKGK VRITLVTKND PYKPHPHDLV GKDCRDGYYE AEFGQERRPL
110 120 130 140 150
FFQNLGIRCV KKKEVKEAII TRIKAGINPF NVPEKQLNDI EDCDLNVVRL
160 170 180 190 200
CFQVFLPDEH GNLTTALPPV VSNPIYDNRA PNTAELRICR VNKNCGSVRG
210 220 230 240 250
GDEIFLLCDK VQKDDIEVRF VLNDWEAKGI FSQADVHRQV AIVFKTPPYC
260 270 280 290 300
KAITEPVTVK MQLRRPSDQE VSESMDFRYL PDEKDTYGNK AKKQKTTLLF
310 320 330 340 350
QKLCQDHVET GFRHVDQDGL ELLTSGDPPT LASQSAGITV NFPERPRPGL
360 370 380 390 400
LGSIGEGRYF KKEPNLFSHD AVVREMPTGV SSQAESYYPS PGPISSGLSH
410 420 430 440 450
HASMAPLPSS SWSSVAHPTP RSGNTNPLSS FSTRTLPSNS QGIPPFLRIP
460 470 480 490 500
VGNDLNASNA CIYNNADDIV GMEASSMPSA DLYGISDPNM LSNCSVNMMT
510 520 530 540 550
TSSDSMGETD NPRLLSMNLE NPSCNSVLDP RDLRQLHQMS SSSMSAGANS
560 570 580 590 600
NTTVFVSQSD AFEGSDFSCA DNSMINESGP SNSTNPNSHG FVQDSQYSGI
610
GSMQNEQLSD SFPYEFFQV
Length:619
Mass (Da):68,520
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03E1033BDF7B1B30
GO
Isoform 2 (identifier: Q04864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-339: Missing.

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):65,225
Checksum:iE312A59CF1D306A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7Q6A0A2R8Y7Q6_HUMAN
Proto-oncogene c-Rel
REL
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055857308 – 339Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X75042 mRNA Translation: CAA52954.1
DQ314888 Genomic DNA Translation: ABC40747.1
AC010733 Genomic DNA No translation available.
BC117191 mRNA Translation: AAI17192.1
BC143885 mRNA Translation: AAI43886.1
M11595 Genomic DNA Translation: AAA52073.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1864.1 [Q04864-1]
CCDS74515.1 [Q04864-2]

Protein sequence database of the Protein Information Resource

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PIRi
A60646

NCBI Reference Sequences

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RefSeqi
NP_001278675.1, NM_001291746.1 [Q04864-2]
NP_002899.1, NM_002908.3 [Q04864-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.631886
Hs.633256

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295025; ENSP00000295025; ENSG00000162924 [Q04864-1]
ENST00000394479; ENSP00000377989; ENSG00000162924 [Q04864-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5966

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5966

UCSC genome browser

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UCSCi
uc002sam.2 human [Q04864-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75042 mRNA Translation: CAA52954.1
DQ314888 Genomic DNA Translation: ABC40747.1
AC010733 Genomic DNA No translation available.
BC117191 mRNA Translation: AAI17192.1
BC143885 mRNA Translation: AAI43886.1
M11595 Genomic DNA Translation: AAA52073.1
CCDSiCCDS1864.1 [Q04864-1]
CCDS74515.1 [Q04864-2]
PIRiA60646
RefSeqiNP_001278675.1, NM_001291746.1 [Q04864-2]
NP_002899.1, NM_002908.3 [Q04864-1]
UniGeneiHs.631886
Hs.633256

3D structure databases

ProteinModelPortaliQ04864
SMRiQ04864
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111898, 213 interactors
CORUMiQ04864
DIPiDIP-301N
IntActiQ04864, 307 interactors
MINTiQ04864
STRINGi9606.ENSP00000295025

PTM databases

iPTMnetiQ04864
PhosphoSitePlusiQ04864

Polymorphism and mutation databases

BioMutaiREL
DMDMi548720

Proteomic databases

EPDiQ04864
jPOSTiQ04864
MaxQBiQ04864
PaxDbiQ04864
PeptideAtlasiQ04864
PRIDEiQ04864
ProteomicsDBi58288

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5966
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295025; ENSP00000295025; ENSG00000162924 [Q04864-1]
ENST00000394479; ENSP00000377989; ENSG00000162924 [Q04864-2]
GeneIDi5966
KEGGihsa:5966
UCSCiuc002sam.2 human [Q04864-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5966
DisGeNETi5966
EuPathDBiHostDB:ENSG00000162924.13

GeneCards: human genes, protein and diseases

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GeneCardsi
REL
HGNCiHGNC:9954 REL
HPAiCAB004404
MIMi164910 gene
neXtProtiNX_Q04864
OpenTargetsiENSG00000162924
PharmGKBiPA34321

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG8F Eukaryota
ENOG410XT64 LUCA
GeneTreeiENSGT00940000158732
HOGENOMiHOG000264257
HOVERGENiHBG017916
InParanoidiQ04864
KOiK09254
OMAiLLFQKLW
OrthoDBi916931at2759
PhylomeDBiQ04864
TreeFamiTF325632

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
SignaLinkiQ04864
SIGNORiQ04864

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
REL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5966

Protein Ontology

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PROi
PR:Q04864

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162924 Expressed in 204 organ(s), highest expression level in tonsil
CleanExiHS_REL
GenevisibleiQ04864 HS

Family and domain databases

CDDicd01177 IPT_NFkappaB, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR030505 c-Rel
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PTHR24169:SF4 PTHR24169:SF4, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04864
Secondary accession number(s): Q17RU2, Q2PNZ7, Q6LDY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 16, 2019
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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