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Entry version 190 (22 Apr 2020)
Sequence version 1 (01 Jun 1994)
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Protein

Proto-oncogene c-Rel

Gene

REL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1169091 Activation of NF-kappaB in B cells

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q04864

SIGNOR Signaling Network Open Resource

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SIGNORi
Q04864

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene c-Rel
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:REL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9954 REL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
164910 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q04864

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
5966

Open Targets

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OpenTargetsi
ENSG00000162924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34321

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q04864 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
REL

Domain mapping of disease mutations (DMDM)

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DMDMi
548720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002051652 – 619Proto-oncogene c-RelAdd BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei267Phosphoserine; by PKASequence analysis1
Modified residuei503Phosphoserine1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q04864

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q04864

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q04864

MaxQB - The MaxQuant DataBase

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MaxQBi
Q04864

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q04864

PeptideAtlas

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PeptideAtlasi
Q04864

PRoteomics IDEntifications database

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PRIDEi
Q04864

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58288 [Q04864-1]
61167

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04864

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q04864

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162924 Expressed in tonsil and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q04864 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q04864 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000162924 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NF-kappa-B p65-c-Rel complex.

Component of the NF-kappa-B p50-c-Rel complex.

Component of the NF-kappa-B p52-c-Rel complex. Homodimer; component of the NF-kappa-B c-Rel-c-Rel complex (By similarity).

Interacts with NKIRAS1.

Interacts with NFKBIB (By similarity).

Interacts with NFKBIE.

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q04864
With#Exp.IntAct
A8K5H93EBI-307352,EBI-10174421
B2R8Y43EBI-307352,EBI-10175581
Q96BA43EBI-307352,EBI-10282301
A1CF [Q9NQ94]3EBI-307352,EBI-2809489
ACOT8 [O14734]3EBI-307352,EBI-1237371
AGPAT4 [Q9NRZ5]3EBI-307352,EBI-1754287
ALOX5 [P09917]3EBI-307352,EBI-79934
ARIH2 [O95376]3EBI-307352,EBI-711158
ASAP3 [Q8TDY4]3EBI-307352,EBI-2609717
ATG9A [Q7Z3C6]3EBI-307352,EBI-727146
ATPAF2 [Q8N5M1]3EBI-307352,EBI-1166928
ATXN1 [P54253]3EBI-307352,EBI-930964
BARHL2 [Q9NY43]3EBI-307352,EBI-10316571
BID [P55957]3EBI-307352,EBI-519672
BID - isoform 2 [P55957-2]3EBI-307352,EBI-10215147
BMF [Q96LC9]3EBI-307352,EBI-3919268
C11orf68 [Q9H3H3]3EBI-307352,EBI-721765
C1orf109 [Q9NX04]3EBI-307352,EBI-8643161
C9orf72 [Q96LT7]3EBI-307352,EBI-2961725
CABP5 [Q9NP86]3EBI-307352,EBI-10311131
CCNJL [F6RF56]3EBI-307352,EBI-10177725
CDKN2C [P42773]4EBI-307352,EBI-711290
CENPX [A8MT69]3EBI-307352,EBI-5529694
CEP19 [Q96LK0]3EBI-307352,EBI-741885
CGGBP1 [Q9UFW8]4EBI-307352,EBI-723153
CHAF1A [Q13111]3EBI-307352,EBI-1020839
CHCHD2 [Q9Y6H1]3EBI-307352,EBI-2321769
CIB3 [Q96Q77]3EBI-307352,EBI-10292696
CINP [Q9BW66]3EBI-307352,EBI-739784
CKS1B [P61024]3EBI-307352,EBI-456371
COL20A1 - isoform 2 [Q9P218-2]3EBI-307352,EBI-10318410
COL8A1 [P27658]3EBI-307352,EBI-747133
COMMD1 [Q8N668]3EBI-307352,EBI-1550112
CPNE2 [Q96FN4]3EBI-307352,EBI-7097057
CPSF1 [Q10570]3EBI-307352,EBI-347859
CTNNBIP1 [Q9NSA3]3EBI-307352,EBI-747082
DHPS [P49366]3EBI-307352,EBI-741925
DMRT3 [Q9NQL9]3EBI-307352,EBI-9679045
DNTT [P04053]3EBI-307352,EBI-1220259
DYNC1LI1 [Q9Y6G9]4EBI-307352,EBI-2556107
EFHC1 [Q5JVL4]7EBI-307352,EBI-743105
EGLN3 [Q9H6Z9]4EBI-307352,EBI-1175354
EIF3A [Q14152]3EBI-307352,EBI-366617
EIF3D [O15371]3EBI-307352,EBI-353818
EIF4E2 [O60573]3EBI-307352,EBI-398610
EIF4EBP1 [Q13541]3EBI-307352,EBI-74090
EIF5A [P63241]3EBI-307352,EBI-373150
EIF5A2 [Q9GZV4]3EBI-307352,EBI-748028
EML2 [O95834]3EBI-307352,EBI-1054588
EPHB6 - isoform 2 [O15197-2]3EBI-307352,EBI-10182490
EPM2AIP1 [Q7L775]3EBI-307352,EBI-6255981
EXOSC1 [Q9Y3B2]4EBI-307352,EBI-371892
EXOSC5 [Q9NQT4]3EBI-307352,EBI-371876
EXOSC8 [Q96B26]3EBI-307352,EBI-371922
FHL2 [Q14192]3EBI-307352,EBI-701903
FKBP1B [P68106]3EBI-307352,EBI-6693977
FLAD1 [Q8NFF5]3EBI-307352,EBI-742815
FLNA - isoform 2 [P21333-2]3EBI-307352,EBI-9641086
FNDC11 [Q9BVV2]3EBI-307352,EBI-744935
FOXO4 [P98177]3EBI-307352,EBI-4481939
FUT11 [Q495W5]3EBI-307352,EBI-2907712
GADD45G [O95257]4EBI-307352,EBI-448202
GLYCTK [Q8IVS8]3EBI-307352,EBI-748515
GRB2 [P62993]3EBI-307352,EBI-401755
HAT1 [O14929]3EBI-307352,EBI-2339359
HDAC7 - isoform 5 [Q8WUI4-5]3EBI-307352,EBI-10276431
HIP1 [O00291]3EBI-307352,EBI-473886
HLA-DOA [P06340]3EBI-307352,EBI-10194851
HSPB7 [Q9UBY9]3EBI-307352,EBI-739361
IL36RN [Q9UBH0]3EBI-307352,EBI-465156
KIAA0100 [Q08E86]3EBI-307352,EBI-10226057
KLHL32 [Q5THT1]3EBI-307352,EBI-10247181
KRTAP9-4 [Q9BYQ2]3EBI-307352,EBI-10185730
LASP1 [Q14847]3EBI-307352,EBI-742828
LGALS14 [Q8TCE9]4EBI-307352,EBI-10274069
LMO1 [P25800]3EBI-307352,EBI-8639312
LMO2 [P25791]3EBI-307352,EBI-739696
LNPEP [Q9UIQ6]3EBI-307352,EBI-2805360
LSM2 [Q9Y333]3EBI-307352,EBI-347416
MAD2L2 [Q9UI95]3EBI-307352,EBI-77889
MAGOHB [Q96A72]3EBI-307352,EBI-746778
MAP3K7CL - isoform D [P57077-4]3EBI-307352,EBI-10215880
MEMO1 [Q9Y316]3EBI-307352,EBI-1104564
MIEN1 [Q9BRT3]3EBI-307352,EBI-6137472
MORF4L1 [Q9UBU8]3EBI-307352,EBI-399246
MRPL10 [Q7Z7H8]3EBI-307352,EBI-723524
NAGK [Q9UJ70]3EBI-307352,EBI-372578
NCK2 [O43639]3EBI-307352,EBI-713635
NDUFAF3 - isoform b [Q9BU61-2]3EBI-307352,EBI-10298649
NECAP1 [A8K3C2]3EBI-307352,EBI-10174302
NEDD9 [Q14511]3EBI-307352,EBI-2108053
NEIL2 [Q969S2]3EBI-307352,EBI-10281234
NEUROG3 [Q9Y4Z2]3EBI-307352,EBI-10328570
NFKB2 [Q00653]2EBI-307352,EBI-307326
NFKBIA [P25963]3EBI-307352,EBI-307386
NFKBIE [O00221]2EBI-307352,EBI-355098
NGB [Q9NPG2]3EBI-307352,EBI-10311409
NME7 [Q9Y5B8]3EBI-307352,EBI-744782
NOL9 [Q5SY16]3EBI-307352,EBI-1055462
NR2C2AP [Q86WQ0]3EBI-307352,EBI-10260040
NUDT14 [O95848]3EBI-307352,EBI-536866
NXT2 [Q9NPJ8]3EBI-307352,EBI-752122
OAZ3 [Q9UMX2]3EBI-307352,EBI-10281601
OSGIN1 [Q9UJX0]3EBI-307352,EBI-9057006
OSTF1 [Q92882]3EBI-307352,EBI-1051152
OTUB2 [Q96DC9]3EBI-307352,EBI-746259
OTUD4 [Q01804]3EBI-307352,EBI-1054396
PARVG [Q9HBI0]3EBI-307352,EBI-3921217
PATE1 [Q8WXA2]3EBI-307352,EBI-10277790
PIH1D2 [Q8WWB5]4EBI-307352,EBI-10232538
PLCB4 [Q15147]3EBI-307352,EBI-998637
PLEKHN1 [Q494U1]4EBI-307352,EBI-10241513
POLE2 [P56282]3EBI-307352,EBI-713847
POLR1A [O95602]3EBI-307352,EBI-359472
POLR2L [P62875]3EBI-307352,EBI-359527
POP5 [Q969H6]3EBI-307352,EBI-366525
PRDM10 [Q9NQV6]3EBI-307352,EBI-10312448
PSMA1 [P25786]3EBI-307352,EBI-359352
PTGER3 - isoform 12 [P43115-12]3EBI-307352,EBI-10234038
PTK6 [Q13882]3EBI-307352,EBI-1383632
R3HDM2 - isoform 2 [Q9Y2K5-2]3EBI-307352,EBI-10326419
RAB41 [Q5JT25]3EBI-307352,EBI-10244509
RABIF [P47224]3EBI-307352,EBI-713992
RASSF5 [Q8WWW0]3EBI-307352,EBI-367390
RBM39 - isoform 3 [Q14498-3]3EBI-307352,EBI-6654703
RECK [Q6P9E2]3EBI-307352,EBI-10253121
RELA - isoform 2 [Q04206-2]2EBI-307352,EBI-289947
RELA - isoform 3 [Q04206-3]3EBI-307352,EBI-10223388
REXO1L1P [Q8IX06]3EBI-307352,EBI-10262361
RIPPLY1 [Q0D2K3]3EBI-307352,EBI-10226430
RNF213 - isoform 4 [Q63HN8-6]3EBI-307352,EBI-10248548
RSPH14 [Q9UHP6]3EBI-307352,EBI-748350
SAT1 [P21673]3EBI-307352,EBI-711613
SDCBP [O00560]3EBI-307352,EBI-727004
SEC14L4 [Q9UDX3]3EBI-307352,EBI-10320311
SEC31A [O94979]3EBI-307352,EBI-1767898
SEPTIN7 - isoform 2 [Q16181-2]3EBI-307352,EBI-10176094
SLC39A13 [Q96H72]3EBI-307352,EBI-10287091
SLC41A3 [Q96GZ6]3EBI-307352,EBI-7225508
SLC6A12 [P48065]3EBI-307352,EBI-3843589
SNRNP25 [Q9BV90]3EBI-307352,EBI-9675976
STK16 [O75716]3EBI-307352,EBI-749295
SZT2 - isoform 3 [Q5T011-5]3EBI-307352,EBI-10245139
TLE5 [Q08117]3EBI-307352,EBI-717810
TMEM8A [Q9HCN3]3EBI-307352,EBI-10310808
TNIP2 [Q8NFZ5]2EBI-307352,EBI-359372
TNS2 [Q63HR2]3EBI-307352,EBI-949753
TRAPPC2L [Q9UL33]3EBI-307352,EBI-747601
TRIM74 - isoform 2 [Q86UV6-2]3EBI-307352,EBI-10259086
TSSC4 [Q9Y5U2]3EBI-307352,EBI-717229
TSSK3 [Q96PN8]3EBI-307352,EBI-3918381
TSTD2 [Q5T7W7]3EBI-307352,EBI-8994397
TTC19 [Q6DKK2]3EBI-307352,EBI-948354
TTC21A [A0A0B4J1Y2]3EBI-307352,EBI-10220701
TXNL4B [Q9NX01]3EBI-307352,EBI-10309345
UBASH3A [P57075]3EBI-307352,EBI-2105393
UBE2K [P61086]3EBI-307352,EBI-473850
UBE2Z [Q9H832]3EBI-307352,EBI-720977
VPS25 [Q9BRG1]4EBI-307352,EBI-741945
ZDHHC24 [Q6UX98]3EBI-307352,EBI-10254561
ZNF417 [Q8TAU3]3EBI-307352,EBI-740727
ZNF550 [Q7Z398]3EBI-307352,EBI-10256834
ZNF564 [Q8TBZ8]3EBI-307352,EBI-10273713
ZNF572 [Q7Z3I7]3EBI-307352,EBI-10172590
ZNF765 [Q7L2R6]3EBI-307352,EBI-9676069
Isoform 2 [Q04864-2]
With#Exp.IntAct
ACBD4 [K7EM05]3EBI-10829018,EBI-16431307
ACOT12 [Q8WYK0]3EBI-10829018,EBI-11954993
ACOT8 [O14734]3EBI-10829018,EBI-1237371
AKT2 [P31751]3EBI-10829018,EBI-296058
AQP1 [P29972]3EBI-10829018,EBI-745213
ARFIP2 [P53365]3EBI-10829018,EBI-638194
ARL16 [Q0P5N6]3EBI-10829018,EBI-10186132
ARMC7 [Q9H6L4]3EBI-10829018,EBI-742909
ASAP3 [Q8TDY4]3EBI-10829018,EBI-2609717
ASMTL [O95671]3EBI-10829018,EBI-743231
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-10829018,EBI-12006308
ATP6V0D2 [Q8N8Y2]3EBI-10829018,EBI-3923949
ATP6V1C2 - isoform 2 [Q8NEY4-2]3EBI-10829018,EBI-10270867
ATPAF2 [Q8N5M1]3EBI-10829018,EBI-1166928
ATXN1 [P54253]3EBI-10829018,EBI-930964
BANP [A0A0S2Z5G4]3EBI-10829018,EBI-16429704
BANP [B4DE54]3EBI-10829018,EBI-16429313
BANP - isoform 2 [Q8N9N5-2]6EBI-10829018,EBI-11524452
BANP - isoform 7 [Q8N9N5-7]3EBI-10829018,EBI-16429296
BBS4 [A0A0S2Z328]3EBI-10829018,EBI-16435728
BBS4 [Q96RK4]3EBI-10829018,EBI-1805814
BCL2L15 [Q5TBC7]3EBI-10829018,EBI-10247136
BCL6 [P41182]3EBI-10829018,EBI-765407
C11orf68 - isoform 3 [Q9H3H3-3]3EBI-10829018,EBI-12002214
C14orf119 [Q9NWQ9]3EBI-10829018,EBI-725606
C1orf109 [Q9NX04]3EBI-10829018,EBI-8643161
C1orf50 [Q9BV19]3EBI-10829018,EBI-2874661
C1orf74 [Q96LT6]3EBI-10829018,EBI-12049899
C6orf142 [A0A0S2Z6I7]3EBI-10829018,EBI-16435493
CACNA1S [Q13698]3EBI-10829018,EBI-5329490
CCNC [P24863]3EBI-10829018,EBI-395261
CDK18 [Q07002]3EBI-10829018,EBI-746238
CDKN1A [P38936]3EBI-10829018,EBI-375077
CDKN2C [P42773]3EBI-10829018,EBI-711290
CDKN2D [P55273]3EBI-10829018,EBI-745859
CDR2L [Q86X02]3EBI-10829018,EBI-11063830
CEP19 [Q96LK0]3EBI-10829018,EBI-741885
CFAP206 [Q8IYR0]3EBI-10829018,EBI-749051
CGGBP1 [Q9UFW8]3EBI-10829018,EBI-723153
CHAF1A [Q13111]3EBI-10829018,EBI-1020839
CHIC2 [Q9UKJ5]3EBI-10829018,EBI-741528
CINP [Q9BW66]3EBI-10829018,EBI-739784
CLIP1 [P30622]3EBI-10829018,EBI-2683569
CPNE2 [Q96FN4]3EBI-10829018,EBI-7097057
CPNE7 - isoform 2 [Q9UBL6-2]3EBI-10829018,EBI-12012272
CSNK2A1 [P68400]3EBI-10829018,EBI-347804
CTNNA3 - isoform 2 [Q9UI47-2]3EBI-10829018,EBI-11962928
CYB5R2 - isoform 2 [Q6BCY4-2]3EBI-10829018,EBI-12102608
DDX6 [P26196]3EBI-10829018,EBI-351257
DEF6 [Q9H4E7]3EBI-10829018,EBI-745369
DHPS [P49366]3EBI-10829018,EBI-741925
DMRT3 [Q9NQL9]3EBI-10829018,EBI-9679045
EFHC1 [Q5JVL4]6EBI-10829018,EBI-743105
EHHADH [Q08426]3EBI-10829018,EBI-2339219
EIF4A3 [P38919]3EBI-10829018,EBI-299104
EIF4EBP1 [Q13541]3EBI-10829018,EBI-74090
EIF5A [P63241]3EBI-10829018,EBI-373150
EIF5A2 [Q9GZV4]3EBI-10829018,EBI-748028
EMD [P50402]3EBI-10829018,EBI-489887
EPHB6 - isoform 2 [O15197-2]3EBI-10829018,EBI-10182490
ESRRA [P11474]3EBI-10829018,EBI-372412
ESRRG - isoform 3 [P62508-3]3EBI-10829018,EBI-12001340
EXOSC1 [Q9Y3B2]3EBI-10829018,EBI-371892
EXOSC5 [Q9NQT4]3EBI-10829018,EBI-371876
FAAP20 - isoform 4 [Q6NZ36-4]3EBI-10829018,EBI-12013806
FAM90A1 [Q86YD7]3EBI-10829018,EBI-6658203
FKBP1B - isoform 2 [P68106-2]3EBI-10829018,EBI-11998976
FLAD1 - isoform 2 [Q8NFF5-2]3EBI-10829018,EBI-11526128
FNDC3B - isoform 3 [Q53EP0-3]3EBI-10829018,EBI-10242151
GLYCTK [Q8IVS8]3EBI-10829018,EBI-748515
GPKOW [Q92917]3EBI-10829018,EBI-746309
GRAP [Q13588]3EBI-10829018,EBI-2847510
HAT1 [O14929]3EBI-10829018,EBI-2339359
hCG_1987119 [A0A024R8L2]3EBI-10829018,EBI-14103818
HDAC7 - isoform 6 [Q8WUI4-6]3EBI-10829018,EBI-12094670
HNRNPF [P52597]3EBI-10829018,EBI-352986
HSD17B14 [Q9BPX1]3EBI-10829018,EBI-742664
HSPB7 [Q9UBY9]3EBI-10829018,EBI-739361
IL36RN [Q9UBH0]3EBI-10829018,EBI-465156
KCTD6 [Q8NC69]3EBI-10829018,EBI-2511344
KCTD7 - isoform 2 [Q96MP8-2]3EBI-10829018,EBI-11954971
KLHL42 [Q9P2K6]3EBI-10829018,EBI-739890
L3MBTL2 [Q969R5]3EBI-10829018,EBI-739909
LENG1 [Q96BZ8]4EBI-10829018,EBI-726510
MAD2L2 [Q9UI95]3EBI-10829018,EBI-77889
MAGOHB [Q96A72]3EBI-10829018,EBI-746778
MAPRE3 [Q9UPY8]3EBI-10829018,EBI-726739
MB21D2 [Q8IYB1]3EBI-10829018,EBI-11323212
MBD3 - isoform 2 [O95983-2]3EBI-10829018,EBI-11978579
MENT [Q9BUN1]3EBI-10829018,EBI-12022316
MID2 - isoform 2 [Q9UJV3-2]3EBI-10829018,EBI-10172526
MIEN1 [Q9BRT3]3EBI-10829018,EBI-6137472
MIPOL1 [Q8TD10]3EBI-10829018,EBI-2548751
MMP2 [P08253]3EBI-10829018,EBI-1033518
MORF4L2 [Q15014]3EBI-10829018,EBI-399257
MSRB3 - isoform 2 [Q8IXL7-2]3EBI-10829018,EBI-10699187
MTURN [Q8N3F0]3EBI-10829018,EBI-11980301
NABP1 [Q96AH0]3EBI-10829018,EBI-2889252
NCK2 [O43639]3EBI-10829018,EBI-713635
NEIL2 [Q969S2]3EBI-10829018,EBI-10281234
NGB [Q9NPG2]3EBI-10829018,EBI-10311409
NMRK1 [Q9NWW6]3EBI-10829018,EBI-10315485
NOXA1 - isoform 2 [Q86UR1-2]3EBI-10829018,EBI-12025760
NR2C2AP [Q86WQ0]3EBI-10829018,EBI-10260040
NUDT10 [Q8NFP7]3EBI-10829018,EBI-726826
OAZ3 - isoform 2 [Q9UMX2-2]3EBI-10829018,EBI-12049527
OSGIN1 [Q9UJX0]3EBI-10829018,EBI-9057006
OTUB2 [Q96DC9]3EBI-10829018,EBI-746259
PADI3 [Q9ULW8]3EBI-10829018,EBI-10488185
PAK1IP1 [A0A0S2Z5D3]3EBI-10829018,EBI-16431731
PARVG [Q9HBI0]3EBI-10829018,EBI-3921217
PCYT2 [Q99447]3EBI-10829018,EBI-750317
PELI2 [Q9HAT8]3EBI-10829018,EBI-448407
PICK1 [Q9NRD5]3EBI-10829018,EBI-79165
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-10829018,EBI-12014286
PM20D2 [Q8IYS1]3EBI-10829018,EBI-11339910
POLR2L [P62875]3EBI-10829018,EBI-359527
PRKAA2 [P54646]4EBI-10829018,EBI-1383852
PRKAB2 [O43741]4EBI-10829018,EBI-1053424
PRPF31 [Q8WWY3]3EBI-10829018,EBI-1567797
PSMA4 [P25789]3EBI-10829018,EBI-359310
PSMB8 - isoform 2 [P28062-2]3EBI-10829018,EBI-372312
PSORS1C2 [Q9UIG4]3EBI-10829018,EBI-11974061
QARS [P47897]3EBI-10829018,EBI-347462
RAB29 [O14966]3EBI-10829018,EBI-372165
RAD23A [P54725]3EBI-10829018,EBI-746453
RAD51D [O75771]3EBI-10829018,EBI-1055693
RNF6 [A0A0S2Z4G9]3EBI-10829018,EBI-16428950
RTL8C [A6ZKI3]3EBI-10829018,EBI-10174072
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-10829018,EBI-11984663
S100A1 [Q5T7Y4]3EBI-10829018,EBI-16435788
SAMD11 [Q96NU1]3EBI-10829018,EBI-14067109
SCNM1 [Q9BWG6]3EBI-10829018,EBI-748391
SEC14L4 [Q9UDX3]3EBI-10829018,EBI-10320311
SHC3 [Q92529]3EBI-10829018,EBI-79084
SIX1 [Q15475]3EBI-10829018,EBI-743675
SMG9 [Q9H0W8]3EBI-10829018,EBI-2872322
SNRNP25 [Q9BV90]3EBI-10829018,EBI-9675976
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-10829018,EBI-11995806
SPG21 [Q9NZD8]3EBI-10829018,EBI-742688
SPRY1 [O43609]3EBI-10829018,EBI-3866665
STAMBPL1 [Q96FJ0]3EBI-10829018,EBI-745021
STK16 [O75716]3EBI-10829018,EBI-749295
SULT2B1 [O00204]3EBI-10829018,EBI-749441
SUOX [P51687]3EBI-10829018,EBI-3921347
TBC1D21 [Q8IYX1]3EBI-10829018,EBI-12018146
TBC1D22B [Q9NU19]3EBI-10829018,EBI-8787464
TCL1A [P56279]3EBI-10829018,EBI-749995
TCP11L1 [Q9NUJ3]3EBI-10829018,EBI-2555179
THOC1 [Q96FV9]3EBI-10829018,EBI-1765605
TLX3 [O43711]3EBI-10829018,EBI-3939165
TMEM8A [Q9HCN3]3EBI-10829018,EBI-10310808
TRAPPC2L - isoform 2 [Q9UL33-2]3EBI-10829018,EBI-11119202
TRAPPC6A - isoform 2 [O75865-2]3EBI-10829018,EBI-8451480
TRIM68 [Q6AZZ1]3EBI-10829018,EBI-2130449
TSC22D3 [Q99576]3EBI-10829018,EBI-750174
TSEN15 [Q8WW01]3EBI-10829018,EBI-372432
TSSK3 [Q96PN8]3EBI-10829018,EBI-3918381
TSTD2 [Q5T7W7]3EBI-10829018,EBI-8994397
UBASH3B [Q8TF42]3EBI-10829018,EBI-1380492
UBE2D4 [Q9Y2X8]3EBI-10829018,EBI-745527
UBXN7 [O94888]3EBI-10829018,EBI-1993627
WNK3 [Q9BYP7]3EBI-10829018,EBI-1182602
YARS [A0A0S2Z4P3]3EBI-10829018,EBI-16435800
YJU2 [Q9BW85]3EBI-10829018,EBI-10300345
ZBED8 [Q8IZ13]3EBI-10829018,EBI-7186123
ZBTB16 [Q05516]3EBI-10829018,EBI-711925
ZDHHC24 [Q6UX98]3EBI-10829018,EBI-10254561
ZIC1 [Q15915]3EBI-10829018,EBI-11963196
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-10829018,EBI-740232
ZNF688 [A0A0S2Z5X4]3EBI-10829018,EBI-16429014
ZNF688 [A0A0S2Z6P0]3EBI-10829018,EBI-16429989
ZNF76 [P36508]3EBI-10829018,EBI-7254550

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111898, 240 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q04864

Database of interacting proteins

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DIPi
DIP-301N

Protein interaction database and analysis system

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IntActi
Q04864, 334 interactors

Molecular INTeraction database

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MINTi
Q04864

STRING: functional protein association networks

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STRINGi
9606.ENSP00000295025

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q04864 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q04864

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 297RHDPROSITE-ProRule annotationAdd BLAST290

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi290 – 295Nuclear localization signalSequence analysis6

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG8F Eukaryota
ENOG410XT64 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158732

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_004343_5_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q04864

KEGG Orthology (KO)

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KOi
K09254

Identification of Orthologs from Complete Genome Data

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OMAi
KLWQDCA

Database of Orthologous Groups

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OrthoDBi
916931at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q04864

TreeFam database of animal gene trees

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TreeFami
TF325632

Family and domain databases

Conserved Domains Database

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CDDi
cd01177 IPT_NFkappaB, 1 hit
cd07933 RHD-n_c-Rel, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030505 c-Rel
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR042845 RHD-n_c-Rel
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR24169 PTHR24169, 1 hit
PTHR24169:SF4 PTHR24169:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00057 NFKBTNSCPFCT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00429 IPT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q04864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGAYNPYI EIIEQPRQRG MRFRYKCEGR SAGSIPGEHS TDNNRTYPSI
60 70 80 90 100
QIMNYYGKGK VRITLVTKND PYKPHPHDLV GKDCRDGYYE AEFGQERRPL
110 120 130 140 150
FFQNLGIRCV KKKEVKEAII TRIKAGINPF NVPEKQLNDI EDCDLNVVRL
160 170 180 190 200
CFQVFLPDEH GNLTTALPPV VSNPIYDNRA PNTAELRICR VNKNCGSVRG
210 220 230 240 250
GDEIFLLCDK VQKDDIEVRF VLNDWEAKGI FSQADVHRQV AIVFKTPPYC
260 270 280 290 300
KAITEPVTVK MQLRRPSDQE VSESMDFRYL PDEKDTYGNK AKKQKTTLLF
310 320 330 340 350
QKLCQDHVET GFRHVDQDGL ELLTSGDPPT LASQSAGITV NFPERPRPGL
360 370 380 390 400
LGSIGEGRYF KKEPNLFSHD AVVREMPTGV SSQAESYYPS PGPISSGLSH
410 420 430 440 450
HASMAPLPSS SWSSVAHPTP RSGNTNPLSS FSTRTLPSNS QGIPPFLRIP
460 470 480 490 500
VGNDLNASNA CIYNNADDIV GMEASSMPSA DLYGISDPNM LSNCSVNMMT
510 520 530 540 550
TSSDSMGETD NPRLLSMNLE NPSCNSVLDP RDLRQLHQMS SSSMSAGANS
560 570 580 590 600
NTTVFVSQSD AFEGSDFSCA DNSMINESGP SNSTNPNSHG FVQDSQYSGI
610
GSMQNEQLSD SFPYEFFQV
Length:619
Mass (Da):68,520
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03E1033BDF7B1B30
GO
Isoform 2 (identifier: Q04864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-339: Missing.

Show »
Length:587
Mass (Da):65,225
Checksum:iE312A59CF1D306A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7Q6A0A2R8Y7Q6_HUMAN
Proto-oncogene c-Rel
REL
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055857308 – 339Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X75042 mRNA Translation: CAA52954.1
DQ314888 Genomic DNA Translation: ABC40747.1
AC010733 Genomic DNA No translation available.
BC117191 mRNA Translation: AAI17192.1
BC143885 mRNA Translation: AAI43886.1
M11595 Genomic DNA Translation: AAA52073.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1864.1 [Q04864-1]
CCDS74515.1 [Q04864-2]

Protein sequence database of the Protein Information Resource

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PIRi
A60646

NCBI Reference Sequences

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RefSeqi
NP_001278675.1, NM_001291746.1 [Q04864-2]
NP_002899.1, NM_002908.3 [Q04864-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295025; ENSP00000295025; ENSG00000162924 [Q04864-1]
ENST00000394479; ENSP00000377989; ENSG00000162924 [Q04864-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5966

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5966

UCSC genome browser

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UCSCi
uc002sam.2 human [Q04864-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75042 mRNA Translation: CAA52954.1
DQ314888 Genomic DNA Translation: ABC40747.1
AC010733 Genomic DNA No translation available.
BC117191 mRNA Translation: AAI17192.1
BC143885 mRNA Translation: AAI43886.1
M11595 Genomic DNA Translation: AAA52073.1
CCDSiCCDS1864.1 [Q04864-1]
CCDS74515.1 [Q04864-2]
PIRiA60646
RefSeqiNP_001278675.1, NM_001291746.1 [Q04864-2]
NP_002899.1, NM_002908.3 [Q04864-1]

3D structure databases

SMRiQ04864
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111898, 240 interactors
CORUMiQ04864
DIPiDIP-301N
IntActiQ04864, 334 interactors
MINTiQ04864
STRINGi9606.ENSP00000295025

PTM databases

iPTMnetiQ04864
PhosphoSitePlusiQ04864

Polymorphism and mutation databases

BioMutaiREL
DMDMi548720

Proteomic databases

EPDiQ04864
jPOSTiQ04864
MassIVEiQ04864
MaxQBiQ04864
PaxDbiQ04864
PeptideAtlasiQ04864
PRIDEiQ04864
ProteomicsDBi58288 [Q04864-1]
61167

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3830 791 antibodies

The DNASU plasmid repository

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DNASUi
5966

Genome annotation databases

EnsembliENST00000295025; ENSP00000295025; ENSG00000162924 [Q04864-1]
ENST00000394479; ENSP00000377989; ENSG00000162924 [Q04864-2]
GeneIDi5966
KEGGihsa:5966
UCSCiuc002sam.2 human [Q04864-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5966
DisGeNETi5966

GeneCards: human genes, protein and diseases

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GeneCardsi
REL
HGNCiHGNC:9954 REL
HPAiENSG00000162924 Low tissue specificity
MIMi164910 gene
neXtProtiNX_Q04864
OpenTargetsiENSG00000162924
PharmGKBiPA34321

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IG8F Eukaryota
ENOG410XT64 LUCA
GeneTreeiENSGT00940000158732
HOGENOMiCLU_004343_5_0_1
InParanoidiQ04864
KOiK09254
OMAiKLWQDCA
OrthoDBi916931at2759
PhylomeDBiQ04864
TreeFamiTF325632

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
SignaLinkiQ04864
SIGNORiQ04864

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
REL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
REL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5966
PharosiQ04864 Tbio

Protein Ontology

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PROi
PR:Q04864
RNActiQ04864 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162924 Expressed in tonsil and 203 other tissues
ExpressionAtlasiQ04864 baseline and differential
GenevisibleiQ04864 HS

Family and domain databases

CDDicd01177 IPT_NFkappaB, 1 hit
cd07933 RHD-n_c-Rel, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR030505 c-Rel
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR042845 RHD-n_c-Rel
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PTHR24169:SF4 PTHR24169:SF4, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04864
Secondary accession number(s): Q17RU2, Q2PNZ7, Q6LDY0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 22, 2020
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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