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UniProtKB - Q04857 (CO6A1_MOUSE)
Protein
Collagen alpha-1(VI) chain
Gene
Col6a1
Organism
Mus musculus (Mouse)
Status
Functioni
Collagen VI acts as a cell-binding protein.
GO - Molecular functioni
- collagen binding Source: MGI
- platelet-derived growth factor binding Source: MGI
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- cellular response to amino acid stimulus Source: MGI
- endodermal cell differentiation Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-MMU-1442490, Collagen degradation R-MMU-1650814, Collagen biosynthesis and modifying enzymes R-MMU-186797, Signaling by PDGF R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures R-MMU-216083, Integrin cell surface interactions R-MMU-3000178, ECM proteoglycans R-MMU-419037, NCAM1 interactions R-MMU-8948216, Collagen chain trimerization |
Names & Taxonomyi
Protein namesi | Recommended name: Collagen alpha-1(VI) chain |
Gene namesi | Name:Col6a1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88459, Col6a1 |
VEuPathDBi | HostDB:ENSMUSG00000001119 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: BHF-UCL
Plasma Membrane
- sarcolemma Source: MGI
Other locations
- collagen trimer Source: UniProtKB-KW
- collagen-containing extracellular matrix Source: UniProtKB
- extracellular matrix Source: MGI
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Add BLAST | 19 | |
ChainiPRO_0000005759 | 20 – 1025 | Collagen alpha-1(VI) chainAdd BLAST | 1006 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 211 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 515 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 536 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 801 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 893 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Keywords - PTMi
Glycoprotein, HydroxylationProteomic databases
EPDi | Q04857 |
jPOSTi | Q04857 |
MaxQBi | Q04857 |
PaxDbi | Q04857 |
PeptideAtlasi | Q04857 |
PRIDEi | Q04857 |
ProteomicsDBi | 283545 |
PTM databases
GlyGeni | Q04857, 5 sites |
iPTMneti | Q04857 |
PhosphoSitePlusi | Q04857 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001119, Expressed in epididymis and 360 other tissues |
Genevisiblei | Q04857, MM |
Interactioni
Subunit structurei
Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).
GO - Molecular functioni
- platelet-derived growth factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198823, 6 interactors |
ComplexPortali | CPX-2965, Collagen type VI trimer |
IntActi | Q04857, 4 interactors |
MINTi | Q04857 |
STRINGi | 10090.ENSMUSP00000001147 |
Miscellaneous databases
RNActi | Q04857, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 234 | VWFA 1PROSITE-ProRule annotationAdd BLAST | 199 | |
Domaini | 614 – 802 | VWFA 2PROSITE-ProRule annotationAdd BLAST | 189 | |
Domaini | 826 – 1018 | VWFA 3PROSITE-ProRule annotationAdd BLAST | 193 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 20 – 255 | N-terminal globular domainAdd BLAST | 236 | |
Regioni | 252 – 588 | DisorderedSequence analysisAdd BLAST | 337 | |
Regioni | 256 – 591 | Triple-helical regionAdd BLAST | 336 | |
Regioni | 592 – 1025 | C-terminal globular domainAdd BLAST | 434 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 261 – 263 | Cell attachment site | 3 | |
Motifi | 441 – 443 | Cell attachment site | 3 | |
Motifi | 477 – 479 | Cell attachment site | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 302 – 330 | Basic and acidic residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the type VI collagen family.Curated
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00940000162889 |
HOGENOMi | CLU_009158_1_0_1 |
InParanoidi | Q04857 |
OMAi | CCSFDCN |
OrthoDBi | 140989at2759 |
PhylomeDBi | Q04857 |
TreeFami | TF331207 |
Family and domain databases
Gene3Di | 3.40.50.410, 3 hits |
InterProi | View protein in InterPro IPR008160, Collagen IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF01391, Collagen, 5 hits PF00092, VWA, 3 hits |
SMARTi | View protein in SMART SM00327, VWA, 3 hits |
SUPFAMi | SSF53300, SSF53300, 3 hits |
PROSITEi | View protein in PROSITE PS50234, VWFA, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q04857-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLAHALLPL LLQACWVATQ DIQGSKAIAF QDCPVDLFFV LDTSESVALR
60 70 80 90 100
LKPYGALVDK VKSFTKRFID NLRDRYYRCD RNLVWNAGAL HYSDEVEIIR
110 120 130 140 150
GLTRMPSGRD ELKASVDAVK YFGKGTYTDC AIKKGLEELL IGGSHLKENK
160 170 180 190 200
YLIVVTDGHP LEGYKEPCGG LEDAVNEAKH LGIKVFSVAI TPDHLEPRLS
210 220 230 240 250
IIATDHTYRR NFTAADWGHS RDAEEVISQT IDTIVDMIKN NVEQVCCSFE
260 270 280 290 300
CQAARGPPGP RGDPGYEGER GKPGLPGEKG EAGDPGRPGD LGPVGYQGMK
310 320 330 340 350
GEKGSRGEKG SRGPKGYKGE KGKRGIDGVD GMKGETGYPG LPGCKGSPGF
360 370 380 390 400
DGIQGPPGPK GDAGAFGMKG EKGEAGADGE AGRPGNSGSP GDEGDPGEPG
410 420 430 440 450
PPGEKGEAGD EGNAGPDGAP GERGGPGERG PRGTPGVRGP RGDPGEAGPQ
460 470 480 490 500
GDQGREGPVG IPGDSGEAGP IGPKGYRGDE GPPGPEGLRG APGPVGPPGD
510 520 530 540 550
PGLMGERGED GPPGNGTEGF PGFPGYPGNR GPPGLNGTKG YPGLKGDEGE
560 570 580 590 600
VGDPGEDNND ISPRGVKGAK GYRGPEGPQG PPGHVGPPGP DECEILDIIM
610 620 630 640 650
KMCSCCECTC GPIDILFVLD SSESIGLQNF EIAKDFIIKV IDRLSKDELV
660 670 680 690 700
KFEPGQSHAG VVQYSHNQMQ EHVDMRSPNV RNAQDFKEAV KKLQWMAGGT
710 720 730 740 750
FTGEALQYTR DRLLPPTQNN RIALVITDGR SDTQRDTTPL SVLCGADIQV
760 770 780 790 800
VSVGIKDVFG FVAGSDQLNV ISCQGLSQGR PGISLVKENY AELLDDGFLK
810 820 830 840 850
NITAQICIDK KCPDYTCPIT FSSPADITIL LDSSASVGSH NFETTKVFAK
860 870 880 890 900
RLAERFLSAG RADPSQDVRV AVVQYSGQGQ QQPGRAALQF LQNYTVLASS
910 920 930 940 950
VDSMDFINDA TDVNDALSYV TRFYREASSG ATKKRVLLFS DGNSQGATAE
960 970 980 990 1000
AIEKAVQEAQ RAGIEIFVVV VGPQVNEPHI RVLVTGKTAE YDVAFGERHL
1010 1020
FRVPNYQALL RGVLYQTVSR KVALG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 674 – 675 | DM → TL in CAA79152 (PubMed:8489506).Curated | 2 | |
Sequence conflicti | 709 | T → A in CAA79152 (PubMed:8489506).Curated | 1 | |
Sequence conflicti | 943 | Missing in CAA79152 (PubMed:8489506).Curated | 1 | |
Sequence conflicti | 960 | Q → R in CAA79152 (PubMed:8489506).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66405 mRNA Translation: CAA47032.1 X66406 Genomic DNA Translation: CAA47033.1 Z18271 mRNA Translation: CAA79152.1 |
CCDSi | CCDS23952.1 |
PIRi | S34839 |
RefSeqi | NP_034063.1, NM_009933.4 |
Genome annotation databases
Ensembli | ENSMUST00000001147; ENSMUSP00000001147; ENSMUSG00000001119 |
GeneIDi | 12833 |
KEGGi | mmu:12833 |
UCSCi | uc007fux.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66405 mRNA Translation: CAA47032.1 X66406 Genomic DNA Translation: CAA47033.1 Z18271 mRNA Translation: CAA79152.1 |
CCDSi | CCDS23952.1 |
PIRi | S34839 |
RefSeqi | NP_034063.1, NM_009933.4 |
3D structure databases
SMRi | Q04857 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198823, 6 interactors |
ComplexPortali | CPX-2965, Collagen type VI trimer |
IntActi | Q04857, 4 interactors |
MINTi | Q04857 |
STRINGi | 10090.ENSMUSP00000001147 |
PTM databases
GlyGeni | Q04857, 5 sites |
iPTMneti | Q04857 |
PhosphoSitePlusi | Q04857 |
Proteomic databases
EPDi | Q04857 |
jPOSTi | Q04857 |
MaxQBi | Q04857 |
PaxDbi | Q04857 |
PeptideAtlasi | Q04857 |
PRIDEi | Q04857 |
ProteomicsDBi | 283545 |
Protocols and materials databases
Antibodypediai | 10507, 377 antibodies from 39 providers |
DNASUi | 12833 |
Genome annotation databases
Ensembli | ENSMUST00000001147; ENSMUSP00000001147; ENSMUSG00000001119 |
GeneIDi | 12833 |
KEGGi | mmu:12833 |
UCSCi | uc007fux.1, mouse |
Organism-specific databases
CTDi | 1291 |
MGIi | MGI:88459, Col6a1 |
VEuPathDBi | HostDB:ENSMUSG00000001119 |
Phylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00940000162889 |
HOGENOMi | CLU_009158_1_0_1 |
InParanoidi | Q04857 |
OMAi | CCSFDCN |
OrthoDBi | 140989at2759 |
PhylomeDBi | Q04857 |
TreeFami | TF331207 |
Enzyme and pathway databases
Reactomei | R-MMU-1442490, Collagen degradation R-MMU-1650814, Collagen biosynthesis and modifying enzymes R-MMU-186797, Signaling by PDGF R-MMU-2022090, Assembly of collagen fibrils and other multimeric structures R-MMU-216083, Integrin cell surface interactions R-MMU-3000178, ECM proteoglycans R-MMU-419037, NCAM1 interactions R-MMU-8948216, Collagen chain trimerization |
Miscellaneous databases
BioGRID-ORCSi | 12833, 0 hits in 64 CRISPR screens |
ChiTaRSi | Col6a1, mouse |
PROi | PR:Q04857 |
RNActi | Q04857, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001119, Expressed in epididymis and 360 other tissues |
Genevisiblei | Q04857, MM |
Family and domain databases
Gene3Di | 3.40.50.410, 3 hits |
InterProi | View protein in InterPro IPR008160, Collagen IPR002035, VWF_A IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF01391, Collagen, 5 hits PF00092, VWA, 3 hits |
SMARTi | View protein in SMART SM00327, VWA, 3 hits |
SUPFAMi | SSF53300, SSF53300, 3 hits |
PROSITEi | View protein in PROSITE PS50234, VWFA, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CO6A1_MOUSE | |
Accessioni | Q04857Primary (citable) accession number: Q04857 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families