Col6a1

Functionⁱ

Collagen VI acts as a cell-binding protein.

GO - Molecular functionⁱ

extracellular matrix structural constituent conferring tensile strength
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 22159717
- 28071719
platelet-derived growth factor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion Source: UniProtKB-KW
cellular response to amino acid stimulus
Source: MGI
Inferred from direct assayⁱ
- 20548288
endodermal cell differentiation Source: Ensembl
growth plate cartilage chondrocyte morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterotrimerization
Source: MGI
Inferred from sequence orthologyⁱ
- 18400749

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1442490 Collagen degradation R-MMU-1650814 Collagen biosynthesis and modifying enzymes R-MMU-186797 Signaling by PDGF R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures R-MMU-216083 Integrin cell surface interactions R-MMU-3000178 ECM proteoglycans R-MMU-419037 NCAM1 interactions R-MMU-8948216 Collagen chain trimerization

Reactomeⁱ

R-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Collagen alpha-1(VI) chain
Gene namesⁱ	Name:Col6a1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:88459 Col6a1

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Add BLAST		19
ChainⁱPRO_0000005759	20 – 1025	Collagen alpha-1(VI) chainAdd BLAST		1006

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	211	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	515	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	536	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	801	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	893	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMⁱ

Glycoprotein, Hydroxylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04857
PaxDbⁱ	Q04857
PeptideAtlas More...PeptideAtlasⁱ	Q04857
PRIDEⁱ	Q04857

PTM databases

iPTMnetⁱ	Q04857
PhosphoSitePlusⁱ	Q04857

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000001119 Expressed in 341 organ(s), highest expression level in epididymis
CleanExⁱ	MM_COL6A1
Genevisibleⁱ	Q04857 MM

Interactionⁱ

Subunit structureⁱ

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).

GO - Molecular functionⁱ

platelet-derived growth factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198823, 1 interactor
ComplexPortalⁱ	CPX-2965 Collagen type VI trimer
IntActⁱ	Q04857, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q04857
STRINGⁱ	10090.ENSMUSP00000001147

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q04857
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	36 – 234	VWFA 1PROSITE-ProRule annotationAdd BLAST	199
Domainⁱ	614 – 802	VWFA 2PROSITE-ProRule annotationAdd BLAST	189
Domainⁱ	826 – 1018	VWFA 3PROSITE-ProRule annotationAdd BLAST	193

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	20 – 255	N-terminal globular domainAdd BLAST	236
Regionⁱ	256 – 591	Triple-helical regionAdd BLAST	336
Regionⁱ	592 – 1025	C-terminal globular domainAdd BLAST	434

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	261 – 263	Cell attachment site	3
Motifⁱ	441 – 443	Cell attachment site	3
Motifⁱ	477 – 479	Cell attachment site	3

Sequence similaritiesⁱ

Belongs to the type VI collagen family.Curated

Keywords - Domainⁱ

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG3544 Eukaryota ENOG410ZQTS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00820000126981
HOGENOMⁱ	HOG000111863
HOVERGENⁱ	HBG095954
InParanoidⁱ	Q04857
KEGG Orthology (KO) More...KOⁱ	K06238
OMAⁱ	GDPGEDN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01WB
PhylomeDBⁱ	Q04857
TreeFamⁱ	TF331207

Family and domain databases

Gene3Dⁱ	3.40.50.410, 3 hits
InterProⁱ	View protein in InterPro IPR008160 Collagen IPR002035 VWF_A IPR036465 vWFA_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01391 Collagen, 5 hits PF00092 VWA, 3 hits
SMARTⁱ	View protein in SMART SM00327 VWA, 3 hits
SUPFAMⁱ	SSF53300 SSF53300, 3 hits
PROSITEⁱ	View protein in PROSITE PS50234 VWFA, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q04857-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLAHALLPL LLQACWVATQ DIQGSKAIAF QDCPVDLFFV LDTSESVALR 
        60         70         80         90        100
LKPYGALVDK VKSFTKRFID NLRDRYYRCD RNLVWNAGAL HYSDEVEIIR 
       110        120        130        140        150
GLTRMPSGRD ELKASVDAVK YFGKGTYTDC AIKKGLEELL IGGSHLKENK 
       160        170        180        190        200
YLIVVTDGHP LEGYKEPCGG LEDAVNEAKH LGIKVFSVAI TPDHLEPRLS 
       210        220        230        240        250
IIATDHTYRR NFTAADWGHS RDAEEVISQT IDTIVDMIKN NVEQVCCSFE 
       260        270        280        290        300
CQAARGPPGP RGDPGYEGER GKPGLPGEKG EAGDPGRPGD LGPVGYQGMK 
       310        320        330        340        350
GEKGSRGEKG SRGPKGYKGE KGKRGIDGVD GMKGETGYPG LPGCKGSPGF 
       360        370        380        390        400
DGIQGPPGPK GDAGAFGMKG EKGEAGADGE AGRPGNSGSP GDEGDPGEPG 
       410        420        430        440        450
PPGEKGEAGD EGNAGPDGAP GERGGPGERG PRGTPGVRGP RGDPGEAGPQ 
       460        470        480        490        500
GDQGREGPVG IPGDSGEAGP IGPKGYRGDE GPPGPEGLRG APGPVGPPGD 
       510        520        530        540        550
PGLMGERGED GPPGNGTEGF PGFPGYPGNR GPPGLNGTKG YPGLKGDEGE 
       560        570        580        590        600
VGDPGEDNND ISPRGVKGAK GYRGPEGPQG PPGHVGPPGP DECEILDIIM 
       610        620        630        640        650
KMCSCCECTC GPIDILFVLD SSESIGLQNF EIAKDFIIKV IDRLSKDELV 
       660        670        680        690        700
KFEPGQSHAG VVQYSHNQMQ EHVDMRSPNV RNAQDFKEAV KKLQWMAGGT 
       710        720        730        740        750
FTGEALQYTR DRLLPPTQNN RIALVITDGR SDTQRDTTPL SVLCGADIQV 
       760        770        780        790        800
VSVGIKDVFG FVAGSDQLNV ISCQGLSQGR PGISLVKENY AELLDDGFLK 
       810        820        830        840        850
NITAQICIDK KCPDYTCPIT FSSPADITIL LDSSASVGSH NFETTKVFAK 
       860        870        880        890        900
RLAERFLSAG RADPSQDVRV AVVQYSGQGQ QQPGRAALQF LQNYTVLASS 
       910        920        930        940        950
VDSMDFINDA TDVNDALSYV TRFYREASSG ATKKRVLLFS DGNSQGATAE 
       960        970        980        990       1000
AIEKAVQEAQ RAGIEIFVVV VGPQVNEPHI RVLVTGKTAE YDVAFGERHL 
      1010       1020 
FRVPNYQALL RGVLYQTVSR KVALG

Length:1,025

Mass (Da):108,489

Last modified:June 1, 1994 - v1

Checksum:ⁱ2A05DFED8771BBF7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	674 – 675	DM → TL in CAA79152 (PubMed:8489506).Curated	2
Sequence conflictⁱ	709	T → A in CAA79152 (PubMed:8489506).Curated	1
Sequence conflictⁱ	943	Missing in CAA79152 (PubMed:8489506).Curated	1
Sequence conflictⁱ	960	Q → R in CAA79152 (PubMed:8489506).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X66405 mRNA Translation: CAA47032.1 X66406 Genomic DNA Translation: CAA47033.1 Z18271 mRNA Translation: CAA79152.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23952.1
PIRⁱ	S34839
NCBI Reference Sequences More...RefSeqⁱ	NP_034063.1, NM_009933.4
UniGeneⁱ	Mm.2509

Genome annotation databases

Ensemblⁱ	ENSMUST00000001147; ENSMUSP00000001147; ENSMUSG00000001119
GeneIDⁱ	12833
KEGGⁱ	mmu:12833
UCSC genome browser More...UCSCⁱ	uc007fux.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q04857	Col6a1 protein (Fragment)		MOUSE		406	UniRef100_Q04857
Procollagen type VI alpha 1 (Fragment)		MOUSE		165

Protein	Similar proteins		Species	Score	Length	Source
Q04857	Col6a1 protein (Fragment)		MOUSE		406	UniRef90_Q04857
Collagen type VI alpha 1 chain		OTOGA		1032
Uncharacterized protein		PROCO		1031
Collagen alpha-1(VI) chain		CALJA		1028
Uncharacterized protein		Cebus capucinus imitator		1028
+32

Protein	Similar proteins		Species	Score	Length	Source
Q04857	Col6a1 protein (Fragment)		MOUSE		406	UniRef50_Q04857
Collagen type VI alpha 1 chain		OTOGA		1032
Uncharacterized protein		PROCO		1031
Uncharacterized protein		Cebus capucinus imitator		1028
Collagen alpha-1(VI) chain		CALJA		1028
+45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X66405 mRNA Translation: CAA47032.1 X66406 Genomic DNA Translation: CAA47033.1 Z18271 mRNA Translation: CAA79152.1
CCDSⁱ	CCDS23952.1
PIRⁱ	S34839
RefSeqⁱ	NP_034063.1, NM_009933.4
UniGeneⁱ	Mm.2509

3D structure databases

ProteinModelPortalⁱ	Q04857
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198823, 1 interactor
ComplexPortalⁱ	CPX-2965 Collagen type VI trimer
IntActⁱ	Q04857, 4 interactors
MINTⁱ	Q04857
STRINGⁱ	10090.ENSMUSP00000001147

PTM databases

iPTMnetⁱ	Q04857
PhosphoSitePlusⁱ	Q04857

Proteomic databases

MaxQBⁱ	Q04857
PaxDbⁱ	Q04857
PeptideAtlasⁱ	Q04857
PRIDEⁱ	Q04857

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000001147; ENSMUSP00000001147; ENSMUSG00000001119
GeneIDⁱ	12833
KEGGⁱ	mmu:12833
UCSCⁱ	uc007fux.1 mouse

Organism-specific databases

CTDⁱ	1291
MGIⁱ	MGI:88459 Col6a1

Phylogenomic databases

eggNOGⁱ	KOG3544 Eukaryota ENOG410ZQTS LUCA
GeneTreeⁱ	ENSGT00820000126981
HOGENOMⁱ	HOG000111863
HOVERGENⁱ	HBG095954
InParanoidⁱ	Q04857
KOⁱ	K06238
OMAⁱ	GDPGEDN
OrthoDBⁱ	EOG091G01WB
PhylomeDBⁱ	Q04857
TreeFamⁱ	TF331207

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1442490 Collagen degradation R-MMU-1650814 Collagen biosynthesis and modifying enzymes R-MMU-186797 Signaling by PDGF R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures R-MMU-216083 Integrin cell surface interactions R-MMU-3000178 ECM proteoglycans R-MMU-419037 NCAM1 interactions R-MMU-8948216 Collagen chain trimerization

Reactomeⁱ

R-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q04857
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001119 Expressed in 341 organ(s), highest expression level in epididymis
CleanExⁱ	MM_COL6A1
Genevisibleⁱ	Q04857 MM

Family and domain databases

Gene3Dⁱ	3.40.50.410, 3 hits
InterProⁱ	View protein in InterPro IPR008160 Collagen IPR002035 VWF_A IPR036465 vWFA_dom_sf
Pfamⁱ	View protein in Pfam PF01391 Collagen, 5 hits PF00092 VWA, 3 hits
SMARTⁱ	View protein in SMART SM00327 VWA, 3 hits
SUPFAMⁱ	SSF53300 SSF53300, 3 hits
PROSITEⁱ	View protein in PROSITE PS50234 VWFA, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CO6A1_MOUSE
Accessionⁱ	Q04857Primary (citable) accession number: Q04857
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q04857 (CO6A1_MOUSE)

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Collagen alpha-1(VI) chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ