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UniProtKB - Q04839 (GFD1_YEAST)
Protein
mRNA transport factor GFD1
Gene
GFD1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
High-copy suppressor of mutant alleles of ATP-dependent RNA helicase DBP5, which is involved in mRNA export from the nucleus. It may also play an important role in a late stage of NAB2-mRNA export.
3 PublicationsMiscellaneous
Present with 2733 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- protein-containing complex binding Source: SGD
GO - Biological processi
- mRNA export from nucleus Source: SGD
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: mRNA transport factor GFD1Alternative name(s): Good for full DBP5 activity protein 1 |
Gene namesi | Name:GFD1 Ordered Locus Names:YMR255W ORF Names:YM9920.09 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004868, GFD1 |
VEuPathDBi | FungiDB:YMR255W |
Subcellular locationi
Nucleus
- nuclear pore complex 1 Publication
- Nucleus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
- nuclear pore Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
Cytoplasm, Membrane, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087477 | 1 – 188 | mRNA transport factor GFD1Add BLAST | 188 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 106 | PhosphoserineCombined sources | 1 | |
Modified residuei | 111 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q04839 |
PaxDbi | Q04839 |
PRIDEi | Q04839 |
PTM databases
iPTMneti | Q04839 |
Interactioni
Subunit structurei
Interacts with GLE1, NUP42, NAB2, ZDS1 and probably DBP5.
Forms a complex with GLE1 and NAB2.
4 PublicationsBinary interactionsi
Q04839
With | #Exp. | IntAct |
---|---|---|
DBP5 [P20449] | 2 | EBI-27549,EBI-5617 |
NAB2 [P32505] | 7 | EBI-27549,EBI-11770 |
ZDS1 [P50111] | 3 | EBI-27549,EBI-29626 |
Protein-protein interaction databases
BioGRIDi | 35433, 61 interactors |
DIPi | DIP-1254N |
IntActi | Q04839, 9 interactors |
MINTi | Q04839 |
STRINGi | 4932.YMR255W |
Miscellaneous databases
RNActi | Q04839, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q04839 |
SMRi | Q04839 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q04839 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 128 | DisorderedSequence analysisAdd BLAST | 128 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 119 – 164 | Sequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 42 – 82 | Basic and acidic residuesSequence analysisAdd BLAST | 41 | |
Compositional biasi | 85 – 127 | Polar residuesSequence analysisAdd BLAST | 43 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502SDHJ, Eukaryota |
HOGENOMi | CLU_1442138_0_0_1 |
InParanoidi | Q04839 |
OMAi | ESKWADA |
Family and domain databases
IDEALi | IID50178 |
InterProi | View protein in InterPro IPR020401, mRNA_transport_factor_GFD1 |
Pfami | View protein in Pfam PF17331, GFD1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04839-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLESIWADA PDEEPIKKQK PSHKRSNNNK KNNNSRWSNE SSSNNKKKDS
60 70 80 90 100
VNKVKNNKGN HESKTKNKIK ETLPREKKPP HSQGKISPVS ESLAINPFSQ
110 120 130 140 150
KATEISPPPV SPSKMKTTKT QSKQDTASKM KLLKKKIEEQ REILQKTHHK
160 170 180
NQQQQVLMDF LNDEGSSNWV DDDEEELILQ RLKTSLKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007064 Genomic DNA Translation: AAC50003.1 Z48639 Genomic DNA Translation: CAA88582.1 BK006946 Genomic DNA Translation: DAA10155.1 |
PIRi | S53077 |
RefSeqi | NP_013982.1, NM_001182762.1 |
Genome annotation databases
EnsemblFungii | YMR255W_mRNA; YMR255W; YMR255W |
GeneIDi | 855297 |
KEGGi | sce:YMR255W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF007064 Genomic DNA Translation: AAC50003.1 Z48639 Genomic DNA Translation: CAA88582.1 BK006946 Genomic DNA Translation: DAA10155.1 |
PIRi | S53077 |
RefSeqi | NP_013982.1, NM_001182762.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3LCN | X-ray | 2.00 | C/D | 123-151 | [»] | |
AlphaFoldDBi | Q04839 | |||||
SMRi | Q04839 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35433, 61 interactors |
DIPi | DIP-1254N |
IntActi | Q04839, 9 interactors |
MINTi | Q04839 |
STRINGi | 4932.YMR255W |
PTM databases
iPTMneti | Q04839 |
Proteomic databases
MaxQBi | Q04839 |
PaxDbi | Q04839 |
PRIDEi | Q04839 |
Genome annotation databases
EnsemblFungii | YMR255W_mRNA; YMR255W; YMR255W |
GeneIDi | 855297 |
KEGGi | sce:YMR255W |
Organism-specific databases
SGDi | S000004868, GFD1 |
VEuPathDBi | FungiDB:YMR255W |
Phylogenomic databases
eggNOGi | ENOG502SDHJ, Eukaryota |
HOGENOMi | CLU_1442138_0_0_1 |
InParanoidi | Q04839 |
OMAi | ESKWADA |
Miscellaneous databases
EvolutionaryTracei | Q04839 |
PROi | PR:Q04839 |
RNActi | Q04839, protein |
Family and domain databases
IDEALi | IID50178 |
InterProi | View protein in InterPro IPR020401, mRNA_transport_factor_GFD1 |
Pfami | View protein in Pfam PF17331, GFD1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GFD1_YEAST | |
Accessioni | Q04839Primary (citable) accession number: Q04839 Secondary accession number(s): D6W081 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references