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Protein

mRNA transport factor GFD1

Gene

GFD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-copy suppressor of mutant alleles of ATP-dependent RNA helicase DBP5, which is involved in mRNA export from the nucleus. It may also play an important role in a late stage of NAB2-mRNA export.3 Publications

Miscellaneous

Present with 2733 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • mRNA export from nucleus Source: SGD

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32931-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA transport factor GFD1
Alternative name(s):
Good for full DBP5 activity protein 1
Gene namesi
Name:GFD1
Ordered Locus Names:YMR255W
ORF Names:YM9920.09
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR255W
SGDiS000004868 GFD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874771 – 188mRNA transport factor GFD1Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04839
PaxDbiQ04839
PRIDEiQ04839

PTM databases

iPTMnetiQ04839

Interactioni

Subunit structurei

Interacts with GLE1, NUP42, NAB2, ZDS1 and probably DBP5. Forms a complex with GLE1 and NAB2.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35433, 59 interactors
DIPiDIP-1254N
IntActiQ04839, 9 interactors
MINTiQ04839
STRINGi4932.YMR255W

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi127 – 149Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LCNX-ray2.00C/D123-151[»]
ProteinModelPortaliQ04839
SMRiQ04839
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04839

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili119 – 164Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 136Lys-richAdd BLAST120
Compositional biasi152 – 155Poly-Gln4

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000066053
InParanoidiQ04839
KOiK18731
OMAiSKWADAP
OrthoDBiEOG092C5WPI

Family and domain databases

InterProiView protein in InterPro
IPR020401 mRNA_transport_factor_GFD1
PfamiView protein in Pfam
PF17331 GFD1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD098974 mRNA_transport_factor_GFD1, 1 hit

Sequencei

Sequence statusi: Complete.

Q04839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLESIWADA PDEEPIKKQK PSHKRSNNNK KNNNSRWSNE SSSNNKKKDS
60 70 80 90 100
VNKVKNNKGN HESKTKNKIK ETLPREKKPP HSQGKISPVS ESLAINPFSQ
110 120 130 140 150
KATEISPPPV SPSKMKTTKT QSKQDTASKM KLLKKKIEEQ REILQKTHHK
160 170 180
NQQQQVLMDF LNDEGSSNWV DDDEEELILQ RLKTSLKI
Length:188
Mass (Da):21,571
Last modified:November 1, 1997 - v1
Checksum:i6C835BD4BD048EB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007064 Genomic DNA Translation: AAC50003.1
Z48639 Genomic DNA Translation: CAA88582.1
BK006946 Genomic DNA Translation: DAA10155.1
PIRiS53077
RefSeqiNP_013982.1, NM_001182762.1

Genome annotation databases

EnsemblFungiiYMR255W; YMR255W; YMR255W
GeneIDi855297
KEGGisce:YMR255W

Similar proteinsi

Entry informationi

Entry nameiGFD1_YEAST
AccessioniPrimary (citable) accession number: Q04839
Secondary accession number(s): D6W081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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