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UniProtKB - Q04837 (SSBP_HUMAN)

Entry version 200 (17 Jun 2020)
Sequence version 1 (01 Oct 1993)
Previous versions | rss
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Protein

Single-stranded DNA-binding protein, mitochondrial

Gene

SSBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork (PubMed:21953457, PubMed:12975372, PubMed:26446790, PubMed:15167897). Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:26446790, PubMed:21953457). In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372). May also function in mtDNA repair (PubMed:23290262).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Single-stranded DNA-binding protein, mitochondrial
Short name:
Mt-SSB
Short name:
MtSSB
Alternative name(s):
PWP1-interacting protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSBP1
Synonyms:SSBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000106028.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:11317 SSBP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600439 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q04837

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49 – 51EGK → AAA in mtSSBloop12; decreased unwinding of double-stranded DNA by the helicase TWNK and increased binding to single-stranded DNA, in vitro. 1 Publication3
Mutagenesisi67 – 75Missing in mtSSBloop23; reduced ability to open template DNA and decreased POLG polymerase activity, in vitro. Also displays decreased unwinding of double-stranded DNA by the helicase TWNK and increased binding to single-stranded DNA. 1 Publication9
Mutagenesisi99 – 100YQ → AA in mtSSBalpha1; decreased POLG polymerase activity, in vitro. No effect on unwinding of double-stranded DNA by the helicase TWNK. 1 Publication2
Mutagenesisi116 – 118YGE → AAA in mtSSB45-1; decreased POLG polymerase activity and increased unwinding of double-stranded DNA by the helicase TWNK, in vitro. 1 Publication3
Mutagenesisi122 – 124KNN → AAA in mtSSB45-2; decreased unwinding of double-stranded DNA by the helicase TWNK, in vitro. 1 Publication3

Organism-specific databases

DisGeNET

More...DisGeNETi		6742

MalaCards human disease database

More...MalaCardsi		SSBP1

Open Targets

More...OpenTargetsi		ENSG00000106028

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36141

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q04837 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SSBP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 16MitochondrionCombined sources1 PublicationAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003326317 – 148Single-stranded DNA-binding protein, mitochondrialAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei67PhosphoserineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei113N6-acetyllysineCombined sources1
Modified residuei122N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q04837

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q04837

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q04837

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q04837

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q04837

PeptideAtlas

More...PeptideAtlasi		Q04837

PRoteomics IDEntifications database

More...PRIDEi		Q04837

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58286

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q04837

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		Q04837

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q04837

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q04837

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q04837

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106028 Expressed in material anatomical entity and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q04837 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q04837 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106028 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (PubMed:23290262).

Interacts with MPG/AAG, through inhibition of its glycosylase activity it potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA (PubMed:23290262).

Interacts with POLDIP2 (PubMed:16428295).

Interacts with PRIMPOL (PubMed:25550423).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112620, 186 interactors

Protein interaction database and analysis system

More...IntActi		Q04837, 129 interactors

Molecular INTeraction database

More...MINTi		Q04837

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000419665

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q04837 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q04837

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q04837

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 141SSBAdd BLAST112

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1653 Eukaryota
COG0629 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002796

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q04837

KEGG Orthology (KO)

More...KOi		K03111

Identification of Orthologs from Complete Genome Data

More...OMAi		SLATHTN

Database of Orthologous Groups

More...OrthoDBi		1304218at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q04837

TreeFam database of animal gene trees

More...TreeFami		TF314629

Family and domain databases

Conserved Domains Database

More...CDDi		cd04496 SSB_OBF, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00984 SSB, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000424 Primosome_PriB/ssb
IPR011344 ssDNA-bd

The PANTHER Classification System

More...PANTHERi		PTHR10302 PTHR10302, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00436 SSB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249 SSF50249, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00621 ssb, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50935 SSB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q04837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRRPVLQVL RQFVRHESET TTSLVLERSL NRVHLLGRVG QDPVLRQVEG 
        60         70         80         90        100
KNPVTIFSLA TNEMWRSGDS EVYQLGDVSQ KTTWHRISVF RPGLRDVAYQ 
       110        120        130        140 
YVKKGSRIYL EGKIDYGEYM DKNNVRRQAT TIIADNIIFL SDQTKEKE
Length:148
Mass (Da):17,260
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98EE9E396D5636C2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUY5E7EUY5_HUMAN
Single-stranded DNA-binding protein...
SSBP1
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0U8C9K0U8_HUMAN
Single-stranded DNA-binding protein...
SSBP1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLD8A0A0G2JLD8_HUMAN
Single-stranded DNA-binding protein...
SSBP1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8J0C9J8J0_HUMAN
Single-stranded DNA-binding protein...
SSBP1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M94556 mRNA Translation: AAA36332.1
AF277319 mRNA Translation: AAK69112.1
BC000895 mRNA Translation: AAH00895.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5866.1

Protein sequence database of the Protein Information Resource

More...PIRi		JN0568

NCBI Reference Sequences

More...RefSeqi		NP_001243439.1, NM_001256510.1
NP_001243440.1, NM_001256511.1
NP_001243441.1, NM_001256512.1
NP_001243442.1, NM_001256513.1
NP_003134.1, NM_003143.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265304; ENSP00000265304; ENSG00000106028
ENST00000465582; ENSP00000420485; ENSG00000106028
ENST00000481508; ENSP00000419665; ENSG00000106028
ENST00000484178; ENSP00000419388; ENSG00000106028
ENST00000498107; ENSP00000419541; ENSG00000106028
ENST00000570667; ENSP00000460028; ENSG00000262771
ENST00000571430; ENSP00000459367; ENSG00000262771
ENST00000574199; ENSP00000461884; ENSG00000262771
ENST00000575059; ENSP00000458815; ENSG00000262771
ENST00000576834; ENSP00000459208; ENSG00000262771
ENST00000612337; ENSP00000480488; ENSG00000106028

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6742

UCSC genome browser

More...UCSCi		uc003vwo.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94556 mRNA Translation: AAA36332.1
AF277319 mRNA Translation: AAK69112.1
BC000895 mRNA Translation: AAH00895.1
CCDSiCCDS5866.1
PIRiJN0568
RefSeqiNP_001243439.1, NM_001256510.1
NP_001243440.1, NM_001256511.1
NP_001243441.1, NM_001256512.1
NP_001243442.1, NM_001256513.1
NP_003134.1, NM_003143.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S3OX-ray2.47A/B17-148[»]
2DUDX-ray2.70A/B16-148[»]
3ULLX-ray2.40A/B17-148[»]
SMRiQ04837
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112620, 186 interactors
IntActiQ04837, 129 interactors
MINTiQ04837
STRINGi9606.ENSP00000419665

PTM databases

iPTMnetiQ04837
MetOSiteiQ04837
PhosphoSitePlusiQ04837

Polymorphism and mutation databases

BioMutaiSSBP1

2D gel databases

UCD-2DPAGEiQ04837

Proteomic databases

EPDiQ04837
jPOSTiQ04837
MassIVEiQ04837
MaxQBiQ04837
PaxDbiQ04837
PeptideAtlasiQ04837
PRIDEiQ04837
ProteomicsDBi58286
TopDownProteomicsiQ04837

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1260 162 antibodies

The DNASU plasmid repository

More...DNASUi		6742

Genome annotation databases

EnsembliENST00000265304; ENSP00000265304; ENSG00000106028
ENST00000465582; ENSP00000420485; ENSG00000106028
ENST00000481508; ENSP00000419665; ENSG00000106028
ENST00000484178; ENSP00000419388; ENSG00000106028
ENST00000498107; ENSP00000419541; ENSG00000106028
ENST00000570667; ENSP00000460028; ENSG00000262771
ENST00000571430; ENSP00000459367; ENSG00000262771
ENST00000574199; ENSP00000461884; ENSG00000262771
ENST00000575059; ENSP00000458815; ENSG00000262771
ENST00000576834; ENSP00000459208; ENSG00000262771
ENST00000612337; ENSP00000480488; ENSG00000106028
GeneIDi6742
KEGGihsa:6742
UCSCiuc003vwo.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6742
DisGeNETi6742
EuPathDBiHostDB:ENSG00000106028.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		SSBP1
HGNCiHGNC:11317 SSBP1
HPAiENSG00000106028 Low tissue specificity
MalaCardsiSSBP1
MIMi600439 gene
neXtProtiNX_Q04837
OpenTargetsiENSG00000106028
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA36141

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1653 Eukaryota
COG0629 LUCA
GeneTreeiENSGT00390000002796
InParanoidiQ04837
KOiK03111
OMAiSLATHTN
OrthoDBi1304218at2759
PhylomeDBiQ04837
TreeFamiTF314629

Enzyme and pathway databases

ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6742 232 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SSBP1 human
EvolutionaryTraceiQ04837

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SSBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6742
PharosiQ04837 Tbio

Protein Ontology

More...PROi		PR:Q04837
RNActiQ04837 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106028 Expressed in material anatomical entity and 235 other tissues
ExpressionAtlasiQ04837 baseline and differential
GenevisibleiQ04837 HS

Family and domain databases

CDDicd04496 SSB_OBF, 1 hit
HAMAPiMF_00984 SSB, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000424 Primosome_PriB/ssb
IPR011344 ssDNA-bd
PANTHERiPTHR10302 PTHR10302, 1 hit
PfamiView protein in Pfam
PF00436 SSB, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00621 ssb, 1 hit
PROSITEiView protein in PROSITE
PS50935 SSB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSBP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04837
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 17, 2020
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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