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Entry version 208 (02 Jun 2021)
Sequence version 1 (01 Oct 1993)
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Protein

Aldo-keto reductase family 1 member C1

Gene

AKR1C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247).

Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942).

Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348).

May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247).

Displays affinity for bile acids (PubMed:8486699).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by hexestrol with an IC50 of 9.5 µM, 1,10-phenanthroline with an IC50 of 55 µM, 1,7-phenanthroline with an IC50 of 72 µM, flufenamic acid with an IC50 of 6.0 µM, indomethacin with an IC50 of 140 µM, ibuprofen with an IC50 of 950 µM, lithocholic acid with an IC50 of 25 µM, ursodeoxycholic acid with an IC50 of 340 µM and chenodeoxycholic acid with an IC50 of 570 µM (PubMed:8573067). The oxidation reaction is inhibited by low micromolar concentrations of NADPH (PubMed:14672942).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.29 min-1 for the reduction of progesterone (PubMed:10998348). kcat is 1.1 min-1 for the reduction of 3beta-hydroxy-5beta-pregnane-20-one (PubMed:10998348). kcat is 1.2 min-1 for the oxidation of (20S)-hydroxypregn-4-en-3-one (PubMed:10998348). kcat is 0.66 min-1 for the reduction of 17beta-hydroxy-5alpha-androstan-3-one (PubMed:10998348). kcat is 0.026 min-1 for the oxidation of 17beta-hydroxy-5alpha-androstan-3-one (PubMed:10998348). kcat is 0.47 min-1 for the reduction of 5alpha-androstan-3,17-dione (PubMed:10998348). kcat is 0.06 min-1 for the oxidation of 3alpha-hydroxy-5alpha-androstan-17-one/androsterone (PubMed:10998348). kcat is 0.18 min-1 for the reduction of 3alpha-hydroxy-5alpha-androstan-17-one/androsterone (PubMed:10998348). kcat is 0.044 min-1 for the oxidation of testosterone (PubMed:10998348). kcat is 3.23 min-1 for the oxidation of 20alpha-hydroxy-5beta-pregnan-3-one (PubMed:10998348). kcat is 0.74 min-1 for the reduction of 17beta-hydroxy-5alpha-androstan-3-one (PubMed:19218247). kcat is 0.75 min-1 for the reduction of 5alpha-dihydrotestosterone sulfate (PubMed:19218247).2 Publications
  1. KM=5 µM for (s)-tetralol1 Publication
  2. KM=38 µM for (s)-indan-1-ol1 Publication
  3. KM=580 µM for benzene dihydrodiol ((1R,2R)-1,2-dihydrobenzene-1,2-diol)1 Publication
  4. KM=3 µM for 5-beta-pregnane-3-alpha,20-alpha-diol1 Publication
  5. KM=3 µM for 5-beta-pregnan-20-alpha-ol-3-one1 Publication
  6. KM=12 µM for 4-pregnen-20-alpha-ol-3-one1 Publication
  7. KM=133 µM for 9-alpha,11-beta-prostaglandin F21 Publication
  8. KM=2 µM for 5-beta-pregnan-3-alpha-ol-20-one1 Publication
  9. KM=1 µM for 5-beta-androstane-3,17-dione1 Publication
  10. KM=12 µM for prostaglandin D21 Publication
  11. KM=2.65 µM for progesterone (in the reduction assay)1 Publication
  12. KM=16.2 µM for 3beta-hydroxy-5beta-pregnane-20-one (in the reduction assay)1 Publication
  13. KM=14.7 µM for (20S)-hydroxypregn-4-en-3-one (in the oxidation assay)1 Publication
  14. KM=80.6 µM for 17beta-hydroxy-5alpha-androstan-3-one (in the reduction assay)1 Publication
  15. KM=4.2 µM for 17beta-hydroxy-5alpha-androstan-3-one (in the reduction assay)1 Publication
  16. KM=31.7 µM for 17beta-hydroxy-5alpha-androstan-3-one (in the oxidation assay)1 Publication
  17. KM=6.77 µM for 5alpha-androstan-3,17-dione (in the reduction assay)1 Publication
  18. KM=41.7 µM for 3alpha-hydroxy-5alpha-androstan-17-one/androsterone (in the oxidation assay)1 Publication
  19. KM=21.0 µM for 3alpha-hydroxy-5alpha-androstan-17-one/androsterone (in the reduction assay)1 Publication
  20. KM=39.8 µM for testosterone (in the oxidation assay)1 Publication
  21. KM=19.4 µM for 20alpha-hydroxy-5beta-pregnan-3-one (in the oxidation assay)1 Publication
  22. KM=5.2 µM for 5alpha-dihydrotestosterone sulfate (in the reduction assay)1 Publication
  1. Vmax=7.85 nmol/min/mg enzyme for the reduction of progesterone1 Publication
  2. Vmax=29.7 nmol/min/mg enzyme for the reduction of 3beta-hydroxy-5beta-pregnane-20-one1 Publication
  3. Vmax=31.9 nmol/min/mg enzyme for the oxidation of (20S)-hydroxypregn-4-en-3-one1 Publication
  4. Vmax=18.0 nmol/min/mg enzyme for the reduction of 17beta-hydroxy-5alpha-androstan-3-one1 Publication
  5. Vmax=0.72 nmol/min/mg enzyme for the oxidation of 17beta-hydroxy-5alpha-androstan-3-one1 Publication
  6. Vmax=12.8 nmol/min/mg enzyme for the reduction of 5alpha-androstan-3,17-dione1 Publication
  7. Vmax=1.59 nmol/min/mg enzyme for the oxidation of 3alpha-hydroxy-5alpha-androstan-17-one/androsterone1 Publication
  8. Vmax=4.79 nmol/min/mg enzyme for the reduction of 3alpha-hydroxy-5alpha-androstan-17-one/androsterone1 Publication
  9. Vmax=1.2 nmol/min/mg enzyme for the oxidation of testosterone1 Publication
  10. Vmax=87.5 nmol/min/mg enzyme for the oxidation of 20alpha-hydroxy-5beta-pregnan-3-one1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Steroid metabolism

This protein is involved in Steroid metabolism.1 Publication
View all proteins of this organism that are known to be involved in Steroid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei24Substrate1
Binding sitei50NADP2 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei54Important for substrate specificityBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei55Proton donorBy similarity1
Sitei84Lowers pKa of active site TyrBy similarity1
Binding sitei117SubstrateBy similarity1
Binding sitei190NADP2 Publications1
Binding sitei222Substrate1
Sitei222May be involved in the mediating step between the transformation of progesterone and the release of the cofactor1
Binding sitei227Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 24NADP2 Publications5
Nucleotide bindingi166 – 167NADP2 Publications2
Nucleotide bindingi216 – 222NADP2 Publications7
Nucleotide bindingi270 – 280NADP2 PublicationsAdd BLAST11

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS10741-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.1.1.149, 2681
1.1.1.270, 2681
1.1.1.357, 2681
1.1.1.50, 2681
1.3.1.20, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q04828

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775, Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-975634, Retinoid metabolism and transport

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
Q04828

SIGNOR Signaling Network Open Resource

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SIGNORi
Q04828

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000802

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldo-keto reductase family 1 member C1Curated (EC:1.1.1.-6 Publications, EC:1.1.1.1121 Publication, EC:1.1.1.2091 Publication, EC:1.1.1.2102 Publications, EC:1.1.1.3572 Publications, EC:1.1.1.511 Publication, EC:1.1.1.531 Publication, EC:1.1.1.621 Publication, EC:1.3.1.202 Publications)
Alternative name(s):
20-alpha-hydroxysteroid dehydrogenase1 Publication (EC:1.1.1.1491 Publication)
Short name:
20-alpha-HSD1 Publication
Chlordecone reductase homolog HAKRC
Dihydrodiol dehydrogenase 11 Publication
Short name:
DD11 Publication
High-affinity hepatic bile acid-binding protein
Short name:
HBAB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKR1C1
Synonyms:DDH, DDH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:384, AKR1C1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600449, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q04828

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000187134.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi127E → D: 30-fold decrease in k(cat)/K(m) value for progesterone reduction; no effect on the K(m) value. 1 Publication1
Mutagenesisi222H → I: Marked decrease in k(cat)/K(m) value for progesterone; 24-fold decrease for progesterone reduction; 18-fold decrease for 20alpha-OHProg oxidation. 95-fold decrease in K(m) value for NADPH. 1 Publication1
Mutagenesisi222H → S: Marked decrease in k(cat)/K(m) value for progesterone; 10-fold decrease for progesterone reduction; 3-fold decrease for 20alpha-OHProg oxidation. 10-fold decrease in K(m) value for NADPH. 1 Publication1
Mutagenesisi304R → L: 70-fold decrease in progesterone reduction. No effect on DHT reduction. 1 Publication1
Mutagenesisi305Y → F: No effect on progesterone reduction. 1 Publication1
Mutagenesisi307T → V: No effect on progesterone reduction. 1 Publication1
Mutagenesisi309D → V: No effect on progesterone reduction. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
1645

MalaCards human disease database

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MalaCardsi
AKR1C1

Open Targets

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OpenTargetsi
ENSG00000187134

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24677

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q04828, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5905

Drug and drug target database

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DrugBanki
DB04674, 2-HYDROXY-3,5-DIIODOBENZOIC ACID
DB00945, Acetylsalicylic acid
DB07768, Epitestosterone
DB01039, Fenofibrate
DB07931, Hexestrol
DB06077, Lumateperone
DB00959, Methylprednisolone
DB00461, Nabumetone
DB00157, NADH
DB03467, Naringenin
DB03461, Nicotinamide adenine dinucleotide phosphate
DB00776, Oxcarbazepine
DB12612, Ozanimod
DB00936, Salicylic acid

DrugCentral

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DrugCentrali
Q04828

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AKR1C1

Domain mapping of disease mutations (DMDM)

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DMDMi
416877

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001246331 – 323Aldo-keto reductase family 1 member C1Add BLAST323

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q04828

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q04828

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q04828

MaxQB - The MaxQuant DataBase

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MaxQBi
Q04828

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q04828

PeptideAtlas

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PeptideAtlasi
Q04828

PRoteomics IDEntifications database

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PRIDEi
Q04828

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58285

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q04828

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q04828

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q04828

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187134, Expressed in islet of Langerhans and 124 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q04828, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q04828, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000187134, Tissue enhanced (liver, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
108012, 14 interactors

Protein interaction database and analysis system

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IntActi
Q04828, 8 interactors

Molecular INTeraction database

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MINTi
Q04828

STRING: functional protein association networks

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STRINGi
9606.ENSP00000370254

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q04828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q04828, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1323
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q04828

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q04828

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1577, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000163208

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q04828

Identification of Orthologs from Complete Genome Data

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OMAi
ATFNALC

Database of Orthologous Groups

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OrthoDBi
1016440at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q04828

TreeFam database of animal gene trees

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TreeFami
TF106492

Family and domain databases

Conserved Domains Database

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CDDi
cd19108, AKR_AKR1C1-35, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020471, AKR
IPR044482, AKR1C
IPR018170, Aldo/ket_reductase_CS
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00248, Aldo_ket_red, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000097, AKR, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00069, ALDKETRDTASE

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51430, SSF51430, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00798, ALDOKETO_REDUCTASE_1, 1 hit
PS00062, ALDOKETO_REDUCTASE_2, 1 hit
PS00063, ALDOKETO_REDUCTASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q04828-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID
60 70 80 90 100
SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE
110 120 130 140 150
RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA
160 170 180 190 200
VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR
210 220 230 240 250
KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR
260 270 280 290 300
TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN
310 320
RNVRYLTLDI FAGPPNYPFS DEY
Length:323
Mass (Da):36,788
Last modified:October 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CB215478FBD29D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y804H0Y804_HUMAN
Aldo-keto reductase family 1 member...
AKR1C1
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NHU4A6NHU4_HUMAN
Aldo-keto reductase family 1 member...
AKR1C1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3S → A no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti95V → D no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti95V → D in AAD14012 (PubMed:8274401).Curated1
Sequence conflicti158G → E no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti158G → E in AAD14012 (PubMed:8274401).Curated1
Sequence conflicti171 – 172RQ → ST no nucleotide entry (PubMed:7626489).Curated2
Sequence conflicti171 – 172RQ → ST in AAD14012 (PubMed:8274401).Curated2
Sequence conflicti183 – 184KY → QV no nucleotide entry (PubMed:7626489).Curated2
Sequence conflicti183 – 184KY → QV in AAD14012 (PubMed:8274401).Curated2
Sequence conflicti222H → L no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti222H → L in AAD14012 (PubMed:8274401).Curated1
Sequence conflicti319F → I no nucleotide entry (PubMed:7626489).Curated1
Sequence conflicti319F → I in AAD14012 (PubMed:8274401).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048214170R → H. Corresponds to variant dbSNP:rs139588200Ensembl.1
Natural variantiVAR_048215172Q → L. Corresponds to variant dbSNP:rs760575583Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86609 mRNA Translation: AAB02880.1
U05861 U05860 Genomic DNA Translation: AAA18115.1
U05684 mRNA Translation: AAA16227.1
AB031083 mRNA Translation: BAA92883.1
AB032150 Genomic DNA Translation: BAA92886.1
BT007197 mRNA Translation: AAP35861.1
AC091817 Genomic DNA No translation available.
AL713867 Genomic DNA No translation available.
BC015490 mRNA Translation: AAH15490.1
BC020216 mRNA Translation: AAH20216.1
BC040210 mRNA Translation: AAH40210.1
S68290 mRNA Translation: AAD14012.1
D26124 mRNA Translation: BAA05121.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7061.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A53436
I73675
S59619
S61515

NCBI Reference Sequences

More...
RefSeqi
NP_001344.2, NM_001353.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380872; ENSP00000370254; ENSG00000187134

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1645

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1645

UCSC genome browser

More...
UCSCi
uc001ihq.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86609 mRNA Translation: AAB02880.1
U05861 U05860 Genomic DNA Translation: AAA18115.1
U05684 mRNA Translation: AAA16227.1
AB031083 mRNA Translation: BAA92883.1
AB032150 Genomic DNA Translation: BAA92886.1
BT007197 mRNA Translation: AAP35861.1
AC091817 Genomic DNA No translation available.
AL713867 Genomic DNA No translation available.
BC015490 mRNA Translation: AAH15490.1
BC020216 mRNA Translation: AAH20216.1
BC040210 mRNA Translation: AAH40210.1
S68290 mRNA Translation: AAD14012.1
D26124 mRNA Translation: BAA05121.1
CCDSiCCDS7061.1
PIRiA53436
I73675
S59619
S61515
RefSeqiNP_001344.2, NM_001353.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MRQX-ray1.59A2-323[»]
3C3UX-ray1.80A1-323[»]
3GUGX-ray1.90A1-323[»]
3NTYX-ray1.87A1-323[»]
4YVPX-ray2.60A/B1-323[»]
6A7AX-ray2.37A1-323[»]
6IJXX-ray2.20A1-323[»]
SMRiQ04828
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108012, 14 interactors
IntActiQ04828, 8 interactors
MINTiQ04828
STRINGi9606.ENSP00000370254

Chemistry databases

BindingDBiQ04828
ChEMBLiCHEMBL5905
DrugBankiDB04674, 2-HYDROXY-3,5-DIIODOBENZOIC ACID
DB00945, Acetylsalicylic acid
DB07768, Epitestosterone
DB01039, Fenofibrate
DB07931, Hexestrol
DB06077, Lumateperone
DB00959, Methylprednisolone
DB00461, Nabumetone
DB00157, NADH
DB03467, Naringenin
DB03461, Nicotinamide adenine dinucleotide phosphate
DB00776, Oxcarbazepine
DB12612, Ozanimod
DB00936, Salicylic acid
DrugCentraliQ04828
SwissLipidsiSLP:000000802

PTM databases

iPTMnetiQ04828
PhosphoSitePlusiQ04828
SwissPalmiQ04828

Genetic variation databases

BioMutaiAKR1C1
DMDMi416877

Proteomic databases

EPDiQ04828
jPOSTiQ04828
MassIVEiQ04828
MaxQBiQ04828
PaxDbiQ04828
PeptideAtlasiQ04828
PRIDEiQ04828
ProteomicsDBi58285

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23969, 320 antibodies

The CPTC Antibody Portal

More...
CPTCi
Q04828, 2 antibodies

The DNASU plasmid repository

More...
DNASUi
1645

Genome annotation databases

EnsembliENST00000380872; ENSP00000370254; ENSG00000187134
GeneIDi1645
KEGGihsa:1645
UCSCiuc001ihq.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1645
DisGeNETi1645

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AKR1C1
HGNCiHGNC:384, AKR1C1
HPAiENSG00000187134, Tissue enhanced (liver, tongue)
MalaCardsiAKR1C1
MIMi600449, gene
neXtProtiNX_Q04828
OpenTargetsiENSG00000187134
PharmGKBiPA24677
VEuPathDBiHostDB:ENSG00000187134.12

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1577, Eukaryota
GeneTreeiENSGT00940000163208
InParanoidiQ04828
OMAiATFNALC
OrthoDBi1016440at2759
PhylomeDBiQ04828
TreeFamiTF106492

Enzyme and pathway databases

BioCyciMetaCyc:HS10741-MONOMER
BRENDAi1.1.1.149, 2681
1.1.1.270, 2681
1.1.1.357, 2681
1.1.1.50, 2681
1.3.1.20, 2681
PathwayCommonsiQ04828
ReactomeiR-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775, Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-975634, Retinoid metabolism and transport
SABIO-RKiQ04828
SIGNORiQ04828

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1645, 8 hits in 925 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AKR1C1, human
EvolutionaryTraceiQ04828

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AKR1C1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1645
PharosiQ04828, Tchem

Protein Ontology

More...
PROi
PR:Q04828
RNActiQ04828, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187134, Expressed in islet of Langerhans and 124 other tissues
ExpressionAtlasiQ04828, baseline and differential
GenevisibleiQ04828, HS

Family and domain databases

CDDicd19108, AKR_AKR1C1-35, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR020471, AKR
IPR044482, AKR1C
IPR018170, Aldo/ket_reductase_CS
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248, Aldo_ket_red, 1 hit
PIRSFiPIRSF000097, AKR, 1 hit
PRINTSiPR00069, ALDKETRDTASE
SUPFAMiSSF51430, SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798, ALDOKETO_REDUCTASE_1, 1 hit
PS00062, ALDOKETO_REDUCTASE_2, 1 hit
PS00063, ALDOKETO_REDUCTASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1C1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04828
Secondary accession number(s): P52896
, Q5SR15, Q7M4N2, Q9UCX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 2, 2021
This is version 208 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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