Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 197 (18 Sep 2019)
Sequence version 1 (01 Oct 1993)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Aldo-keto reductase family 1 member C1

Gene

AKR1C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by hexestrol with an IC50 of 9.5 µM, 1,10-phenanthroline with an IC50 of 55 µM, 1,7-phenanthroline with an IC50 of 72 µM, flufenamic acid with an IC50 of 6.0 µM, indomethacin with an IC50 of 140 µM, ibuprofen with an IC50 of 950 µM, lithocholic acid with an IC50 of 25 µM, ursodeoxycholic acid with an IC50 of 340 µM and chenodeoxycholic acid with an IC50 of 570 µM.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5 µM for (s)-tetralol2 Publications
  2. KM=38 µM for (s)-indan-1-ol2 Publications
  3. KM=580 µM for benzene dihydrodiol2 Publications
  4. KM=3 µM for 5-beta-pregnane-3-alpha,20-alpha-diol2 Publications
  5. KM=3 µM for 5-beta-pregnan-20-alpha-ol-3-one2 Publications
  6. KM=12 µM for 4-pregnen-20-alpha-ol-3-one2 Publications
  7. KM=133 µM for 9-alpha,11-beta-prostaglandin F22 Publications
  8. KM=2 µM for 5-beta-pregnan-3-alpha-ol-20-one2 Publications
  9. KM=1 µM for 5-beta-androstane-3,17-dione2 Publications
  10. KM=12 µM for prostaglandin D22 Publications
  11. KM=0.6 µM for 20-alpha-hydroxyprogesterone (with NADH)2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei24Substrate1
    Binding sitei50NADP2 Publications1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei54Important for substrate specificityBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei55Proton donorBy similarity1
    Sitei84Lowers pKa of active site TyrBy similarity1
    Binding sitei117SubstrateBy similarity1
    Binding sitei190NADP2 Publications1
    Binding sitei222Substrate1
    Sitei222May be involved in the mediating step between the transformation of progesterone and the release of the cofactor1
    Binding sitei227Substrate1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi20 – 24NADP2 Publications5
    Nucleotide bindingi166 – 167NADP2 Publications2
    Nucleotide bindingi216 – 222NADP2 Publications7
    Nucleotide bindingi270 – 280NADP2 PublicationsAdd BLAST11

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS10741-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.1.1.149 2681
    1.1.1.270 2681
    1.1.1.50 2681
    1.3.1.20 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
    R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
    R-HSA-975634 Retinoid metabolism and transport

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q04828

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q04828

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000802

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aldo-keto reductase family 1 member C1 (EC:1.1.1.-)
    Alternative name(s):
    20-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.1492 Publications)
    Short name:
    20-alpha-HSD
    Chlordecone reductase homolog HAKRC
    Dihydrodiol dehydrogenase 1/2
    Short name:
    DD1/DD2
    High-affinity hepatic bile acid-binding protein
    Short name:
    HBAB
    Indanol dehydrogenase (EC:1.1.1.1121 Publication)
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.202 Publications)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:AKR1C1
    Synonyms:DDH, DDH1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:384 AKR1C1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600449 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q04828

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi127E → D: 30-fold decrease in k(cat)/K(m) value for progesterone reduction; no effect on the K(m) value. 1 Publication1
    Mutagenesisi222H → I: Marked decrease in k(cat)/K(m) value for progesterone; 24-fold decrease for progesterone reduction; 18-fold decrease for 20alpha-OHProg oxidation. 95-fold decrease in K(m) value for NADPH. 1 Publication1
    Mutagenesisi222H → S: Marked decrease in k(cat)/K(m) value for progesterone; 10-fold decrease for progesterone reduction; 3-fold decrease for 20alpha-OHProg oxidation. 10-fold decrease in K(m) value for NADPH. 1 Publication1
    Mutagenesisi304R → L: 70-fold decrease in progesterone reduction. No effect on DHT reduction. 1 Publication1
    Mutagenesisi305Y → F: No effect on progesterone reduction. 1 Publication1
    Mutagenesisi307T → V: No effect on progesterone reduction. 1 Publication1
    Mutagenesisi309D → V: No effect on progesterone reduction. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1645

    MalaCards human disease database

    More...
    MalaCardsi
    AKR1C1

    Open Targets

    More...
    OpenTargetsi
    ENSG00000187134

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA24677

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5905

    Drug and drug target database

    More...
    DrugBanki
    DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACID
    DB00945 Acetylsalicylic acid
    DB07768 Epitestosterone
    DB07931 Hexestrol
    DB00461 Nabumetone
    DB00157 NADH
    DB03467 Naringenin
    DB00936 Salicylic acid

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    AKR1C1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    416877

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001246331 – 323Aldo-keto reductase family 1 member C1Add BLAST323

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q04828

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q04828

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q04828

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q04828

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q04828

    PeptideAtlas

    More...
    PeptideAtlasi
    Q04828

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q04828

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    58285

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q04828

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q04828

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q04828

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000187134 Expressed in 102 organ(s), highest expression level in right lobe of liver

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q04828 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q04828 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB047303
    HPA068265

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    PTPN3P260455EBI-2116455,EBI-1047946

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    108012, 9 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q04828, 7 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q04828

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000370254

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q04828

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1323
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q04828

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q04828

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1577 Eukaryota
    COG0656 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000163208

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000250272

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q04828

    KEGG Orthology (KO)

    More...
    KOi
    K00212

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NPKEDHY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1016440at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q04828

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106492

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06660 Aldo_ket_red, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.100, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR018170 Aldo/ket_reductase_CS
    IPR020471 Aldo/keto_reductase
    IPR023210 NADP_OxRdtase_dom
    IPR036812 NADP_OxRdtase_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11732 PTHR11732, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00248 Aldo_ket_red, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000097 AKR, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00069 ALDKETRDTASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51430 SSF51430, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00798 ALDOKETO_REDUCTASE_1, 1 hit
    PS00062 ALDOKETO_REDUCTASE_2, 1 hit
    PS00063 ALDOKETO_REDUCTASE_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q04828-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID
    60 70 80 90 100
    SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE
    110 120 130 140 150
    RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA
    160 170 180 190 200
    VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR
    210 220 230 240 250
    KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR
    260 270 280 290 300
    TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN
    310 320
    RNVRYLTLDI FAGPPNYPFS DEY
    Length:323
    Mass (Da):36,788
    Last modified:October 1, 1993 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CB215478FBD29D5
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0Y804H0Y804_HUMAN
    Aldo-keto reductase family 1 member...
    AKR1C1
    248Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A6NHU4A6NHU4_HUMAN
    Aldo-keto reductase family 1 member...
    AKR1C1
    205Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3S → A no nucleotide entry (PubMed:7626489).Curated1
    Sequence conflicti95V → D no nucleotide entry (PubMed:7626489).Curated1
    Sequence conflicti95V → D in AAD14012 (PubMed:8274401).Curated1
    Sequence conflicti158G → E no nucleotide entry (PubMed:7626489).Curated1
    Sequence conflicti158G → E in AAD14012 (PubMed:8274401).Curated1
    Sequence conflicti171 – 172RQ → ST no nucleotide entry (PubMed:7626489).Curated2
    Sequence conflicti171 – 172RQ → ST in AAD14012 (PubMed:8274401).Curated2
    Sequence conflicti183 – 184KY → QV no nucleotide entry (PubMed:7626489).Curated2
    Sequence conflicti183 – 184KY → QV in AAD14012 (PubMed:8274401).Curated2
    Sequence conflicti222H → L no nucleotide entry (PubMed:7626489).Curated1
    Sequence conflicti222H → L in AAD14012 (PubMed:8274401).Curated1
    Sequence conflicti319F → I no nucleotide entry (PubMed:7626489).Curated1
    Sequence conflicti319F → I in AAD14012 (PubMed:8274401).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048214170R → H. Corresponds to variant dbSNP:rs139588200Ensembl.1
    Natural variantiVAR_048215172Q → L. Corresponds to variant dbSNP:rs11474Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M86609 mRNA Translation: AAB02880.1
    U05861
    , U05853, U05854, U05855, U05857, U05858, U05859, U05860 Genomic DNA Translation: AAA18115.1
    U05684 mRNA Translation: AAA16227.1
    AB031083 mRNA Translation: BAA92883.1
    AB032150 Genomic DNA Translation: BAA92886.1
    BT007197 mRNA Translation: AAP35861.1
    AC091817 Genomic DNA No translation available.
    AL713867 Genomic DNA No translation available.
    BC015490 mRNA Translation: AAH15490.1
    BC020216 mRNA Translation: AAH20216.1
    BC040210 mRNA Translation: AAH40210.1
    S68290 mRNA Translation: AAD14012.1
    D26124 mRNA Translation: BAA05121.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS7061.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A53436
    I73675
    S59619
    S61515

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001344.2, NM_001353.5

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000380872; ENSP00000370254; ENSG00000187134

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1645

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:1645

    UCSC genome browser

    More...
    UCSCi
    uc001ihq.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M86609 mRNA Translation: AAB02880.1
    U05861
    , U05853, U05854, U05855, U05857, U05858, U05859, U05860 Genomic DNA Translation: AAA18115.1
    U05684 mRNA Translation: AAA16227.1
    AB031083 mRNA Translation: BAA92883.1
    AB032150 Genomic DNA Translation: BAA92886.1
    BT007197 mRNA Translation: AAP35861.1
    AC091817 Genomic DNA No translation available.
    AL713867 Genomic DNA No translation available.
    BC015490 mRNA Translation: AAH15490.1
    BC020216 mRNA Translation: AAH20216.1
    BC040210 mRNA Translation: AAH40210.1
    S68290 mRNA Translation: AAD14012.1
    D26124 mRNA Translation: BAA05121.1
    CCDSiCCDS7061.1
    PIRiA53436
    I73675
    S59619
    S61515
    RefSeqiNP_001344.2, NM_001353.5

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1MRQX-ray1.59A2-323[»]
    3C3UX-ray1.80A1-323[»]
    3GUGX-ray1.90A1-323[»]
    3NTYX-ray1.87A1-323[»]
    4YVPX-ray2.60A/B1-323[»]
    6A7AX-ray2.37A1-323[»]
    SMRiQ04828
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi108012, 9 interactors
    IntActiQ04828, 7 interactors
    MINTiQ04828
    STRINGi9606.ENSP00000370254

    Chemistry databases

    BindingDBiQ04828
    ChEMBLiCHEMBL5905
    DrugBankiDB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACID
    DB00945 Acetylsalicylic acid
    DB07768 Epitestosterone
    DB07931 Hexestrol
    DB00461 Nabumetone
    DB00157 NADH
    DB03467 Naringenin
    DB00936 Salicylic acid

    DrugCentral

    More...
    DrugCentrali
    Q04828
    SwissLipidsiSLP:000000802

    PTM databases

    iPTMnetiQ04828
    PhosphoSitePlusiQ04828
    SwissPalmiQ04828

    Polymorphism and mutation databases

    BioMutaiAKR1C1
    DMDMi416877

    Proteomic databases

    EPDiQ04828
    jPOSTiQ04828
    MassIVEiQ04828
    MaxQBiQ04828
    PaxDbiQ04828
    PeptideAtlasiQ04828
    PRIDEiQ04828
    ProteomicsDBi58285

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    1645
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000380872; ENSP00000370254; ENSG00000187134
    GeneIDi1645
    KEGGihsa:1645
    UCSCiuc001ihq.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1645
    DisGeNETi1645

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    AKR1C1
    HGNCiHGNC:384 AKR1C1
    HPAiCAB047303
    HPA068265
    MalaCardsiAKR1C1
    MIMi600449 gene
    neXtProtiNX_Q04828
    OpenTargetsiENSG00000187134
    PharmGKBiPA24677

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1577 Eukaryota
    COG0656 LUCA
    GeneTreeiENSGT00940000163208
    HOGENOMiHOG000250272
    InParanoidiQ04828
    KOiK00212
    OMAiNPKEDHY
    OrthoDBi1016440at2759
    PhylomeDBiQ04828
    TreeFamiTF106492

    Enzyme and pathway databases

    BioCyciMetaCyc:HS10741-MONOMER
    BRENDAi1.1.1.149 2681
    1.1.1.270 2681
    1.1.1.50 2681
    1.3.1.20 2681
    ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol
    R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
    R-HSA-975634 Retinoid metabolism and transport
    SABIO-RKiQ04828
    SIGNORiQ04828

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    AKR1C1 human
    EvolutionaryTraceiQ04828

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    AKR1C1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    1645

    Pharos

    More...
    Pharosi
    Q04828

    Protein Ontology

    More...
    PROi
    PR:Q04828

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000187134 Expressed in 102 organ(s), highest expression level in right lobe of liver
    ExpressionAtlasiQ04828 baseline and differential
    GenevisibleiQ04828 HS

    Family and domain databases

    CDDicd06660 Aldo_ket_red, 1 hit
    Gene3Di3.20.20.100, 1 hit
    InterProiView protein in InterPro
    IPR018170 Aldo/ket_reductase_CS
    IPR020471 Aldo/keto_reductase
    IPR023210 NADP_OxRdtase_dom
    IPR036812 NADP_OxRdtase_dom_sf
    PANTHERiPTHR11732 PTHR11732, 1 hit
    PfamiView protein in Pfam
    PF00248 Aldo_ket_red, 1 hit
    PIRSFiPIRSF000097 AKR, 1 hit
    PRINTSiPR00069 ALDKETRDTASE
    SUPFAMiSSF51430 SSF51430, 1 hit
    PROSITEiView protein in PROSITE
    PS00798 ALDOKETO_REDUCTASE_1, 1 hit
    PS00062 ALDOKETO_REDUCTASE_2, 1 hit
    PS00063 ALDOKETO_REDUCTASE_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1C1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04828
    Secondary accession number(s): P52896
    , Q5SR15, Q7M4N2, Q9UCX2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: September 18, 2019
    This is version 197 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again