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UniProtKB - Q04800 (FRP1_SCHPO)
Protein
Ferric reductase transmembrane component 1
Gene
frp1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity).
Catalyzes the reductive uptake of Fe3+-salts and Fe3+ bound to catecholate or hydroxamate siderophores (By similarity).
Fe3+ is reduced to Fe2+, which then dissociates from the siderophore and can be imported by the high-affinity Fe2+ transport complex in the plasma membrane (By similarity).
Also participates in Cu2+ reduction and Cu+ uptake (By similarity).
By similarityCatalytic activityi
- EC:1.16.1.9By similarity
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 157 | Iron (heme 1 axial ligand)By similarity | 1 | |
Metal bindingi | 171 | Iron (heme 2 axial ligand)By similarity | 1 | |
Metal bindingi | 225 | Iron (heme 1 axial ligand)By similarity | 1 | |
Metal bindingi | 239 | Iron (heme 2 axial ligand)By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 317 – 323 | FADSequence analysis | 7 | |
Nucleotide bindingi | 419 – 427 | NADSequence analysis | 9 |
GO - Molecular functioni
- ferric-chelate reductase (NADPH) activity Source: UniProtKB-EC
- ferric-chelate reductase activity Source: PomBase
- flavin adenine dinucleotide binding Source: PomBase
- iron ion binding Source: PomBase
GO - Biological processi
- cellular response to iron ion starvation Source: PomBase
- copper ion transmembrane transport Source: PomBase
- reductive iron assimilation Source: PomBase
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Ion transport, Iron transport, Transport |
Ligand | FAD, Flavoprotein, Heme, Iron, Metal-binding, NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Ferric reductase transmembrane component 1Curated (EC:1.16.1.9By similarity)Alternative name(s): Ferric-chelate reductase 1Curated |
Gene namesi | Name:frp1 ORF Names:SPBC1683.09c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC1683.09c, frp1 |
VEuPathDBi | FungiDB:SPBC1683.09c |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
Plasma Membrane
- plasma membrane Source: PomBase
Other locations
- integral component of membrane Source: PomBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 73 – 93 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 193 – 213 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 417 – 437 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210152 | 1 – 564 | Ferric reductase transmembrane component 1Add BLAST | 564 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 268 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 360 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 362 | Phosphoserine1 Publication | 1 | |
Modified residuei | 381 | Phosphoserine1 Publication | 1 | |
Modified residuei | 383 | Phosphoserine1 Publication | 1 | |
Glycosylationi | 501 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q04800 |
PaxDbi | Q04800 |
PTM databases
iPTMneti | Q04800 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 276264, 23 interactors |
STRINGi | 4896.SPBC1683.09c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 254 | Ferric oxidoreductaseSequence analysisAdd BLAST | 134 | |
Domaini | 255 – 410 | FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST | 156 |
Sequence similaritiesi
Belongs to the ferric reductase (FRE) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0039, Eukaryota |
HOGENOMi | CLU_035348_0_0_1 |
InParanoidi | Q04800 |
OMAi | YMYATFA |
PhylomeDBi | Q04800 |
Family and domain databases
Gene3Di | 3.40.50.80, 1 hit |
InterProi | View protein in InterPro IPR013112, FAD-bd_8 IPR017927, FAD-bd_FR_type IPR013130, Fe3_Rdtase_TM_dom IPR013121, Fe_red_NAD-bd_6 IPR039261, FNR_nucleotide-bd IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF08022, FAD_binding_8, 1 hit PF01794, Ferric_reduct, 1 hit PF08030, NAD_binding_6, 1 hit |
SUPFAMi | SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04800-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAINSSDKWT VIAICLILGI LLAFILMFWL ERFRVIIKSN AHKHDPSDKR
60 70 80 90 100
QIWLEKYYLF VRQIYTYLVT HKVILTLIAV PVVFAISIPF IGMQTPASSH
110 120 130 140 150
GKQTTQVSTG NWSKNAVAAR LGFLACGLYV TSYFFSIKNN PFALLLISSH
160 170 180 190 200
EKMNYVHRRL SQYAIMIGAI HGFAYIGLAA QGKRALLTAR VTIIGYVILG
210 220 230 240 250
LMVIMIVSSL PFFRRRFYEW FFVLHHMCSI GFLITIWLHH RRCVVYMKVC
260 270 280 290 300
VAVYVFDRGC RMLRSFLNRS KFDVVLVEDD LIYMKGPRPK KSFFGLPWGA
310 320 330 340 350
GNHMYINIPS LSYWQIHPFT IASVPSDDFI ELFVAVRAGF TKRLAKKVSS
360 370 380 390 400
KSLSDVSDIN ISDEKIEKNG DVGIEVMERH SLSQEDLVFE SSAAKVSVLM
410 420 430 440 450
DGPYGPVSNP YKDYSYLFLF AGGVGVSYIL PIILDTIKKQ SRTVHITFVW
460 470 480 490 500
SARSSALLNI VHKSLCEAVR YTEMNINIFC HLTNSYPVEE VSSLNSQSAR
510 520 530 540 550
NYSLQYLNGR PDVNDYFKDF LHATGTQTAA LASCGSDKLL RHLKSCVNTH
560
SPSTVDLYQH YEEI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07749 Genomic DNA Translation: AAA68045.1 CU329671 Genomic DNA Translation: CAB91171.1 |
PIRi | A48141 |
RefSeqi | NP_595065.1, NM_001020971.2 |
Genome annotation databases
EnsemblFungii | SPBC1683.09c.1; SPBC1683.09c.1:pep; SPBC1683.09c |
GeneIDi | 2539711 |
KEGGi | spo:SPBC1683.09c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07749 Genomic DNA Translation: AAA68045.1 CU329671 Genomic DNA Translation: CAB91171.1 |
PIRi | A48141 |
RefSeqi | NP_595065.1, NM_001020971.2 |
3D structure databases
SMRi | Q04800 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 276264, 23 interactors |
STRINGi | 4896.SPBC1683.09c.1 |
PTM databases
iPTMneti | Q04800 |
Proteomic databases
MaxQBi | Q04800 |
PaxDbi | Q04800 |
Genome annotation databases
EnsemblFungii | SPBC1683.09c.1; SPBC1683.09c.1:pep; SPBC1683.09c |
GeneIDi | 2539711 |
KEGGi | spo:SPBC1683.09c |
Organism-specific databases
PomBasei | SPBC1683.09c, frp1 |
VEuPathDBi | FungiDB:SPBC1683.09c |
Phylogenomic databases
eggNOGi | KOG0039, Eukaryota |
HOGENOMi | CLU_035348_0_0_1 |
InParanoidi | Q04800 |
OMAi | YMYATFA |
PhylomeDBi | Q04800 |
Miscellaneous databases
PROi | PR:Q04800 |
Family and domain databases
Gene3Di | 3.40.50.80, 1 hit |
InterProi | View protein in InterPro IPR013112, FAD-bd_8 IPR017927, FAD-bd_FR_type IPR013130, Fe3_Rdtase_TM_dom IPR013121, Fe_red_NAD-bd_6 IPR039261, FNR_nucleotide-bd IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF08022, FAD_binding_8, 1 hit PF01794, Ferric_reduct, 1 hit PF08030, NAD_binding_6, 1 hit |
SUPFAMi | SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FRP1_SCHPO | |
Accessioni | Q04800Primary (citable) accession number: Q04800 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families