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Protein

Interferon alpha/beta receptor 1

Gene

IFNAR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:8318540). Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-BTA-909733 Interferon alpha/beta signaling
R-BTA-912694 Regulation of IFNA signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha/beta receptor 1
Short name:
IFN-R-1
Short name:
IFN-alpha/beta receptor 1
Alternative name(s):
Type I interferon receptor 1
Gene namesi
Name:IFNAR1
Synonyms:IFNAR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:30054 IFNAR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 437ExtracellularSequence analysisAdd BLAST413
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 560CytoplasmicSequence analysisAdd BLAST102

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001100025 – 560Interferon alpha/beta receptor 1Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi76 ↔ 84By similarity
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi199 ↔ 220By similarity
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi283 ↔ 291By similarity
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi404 ↔ 427By similarity
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi464S-palmitoyl cysteineBy similarity1
Modified residuei467Phosphotyrosine; by TYK2By similarity1
Modified residuei482Phosphotyrosine; by TYK2By similarity1
Modified residuei496PhosphoserineBy similarity1
Cross-linki526Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki527Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei536PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated, leading to its internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex; this prevents receptor internalization and degradation. Probable ubiquitination sites have been identified in human, but are poorly conserved across species.By similarity
Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination. Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.By similarity
Palmitoylation at Cys-464 is required for the activation of STAT1 and STAT2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ04790
PRIDEiQ04790

Expressioni

Gene expression databases

BgeeiENSBTAG00000021819 Expressed in 9 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Heterodimer with IFNAR2. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-467. Interacts with TYK2. Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Interacts with SHMT2; this promotes interaction with ABRAXAS2 and the BRISC complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029080

Structurei

3D structure databases

ProteinModelPortaliQ04790
SMRiQ04790
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 226Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini231 – 329Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini333 – 433Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni492 – 501Important for interaction with TYK2By similarity10

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIP Eukaryota
ENOG4111QEU LUCA
GeneTreeiENSGT00530000063449
HOGENOMiHOG000113067
HOVERGENiHBG052126
InParanoidiQ04790
KOiK05130
OMAiWIKLPGC
OrthoDBiEOG091G04H5

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR016669 Interferon_alpha/beta_rcpt-1
PfamiView protein in Pfam
PF09294 Interfer-bind, 2 hits
PF01108 Tissue_fac, 1 hit
PIRSFiPIRSF016567 IFN_alpha/beta_recept-1, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q04790-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLALLGATTL MLVAGRWVLP AASGEANLKP ENVEIHIIDD NFFLKWNSSS
60 70 80 90 100
ESVKNVTFSA DYQILGTDNW KKLSGCQHIT STKCNFSSVE LENVFEKIEL
110 120 130 140 150
RIRAEEGNNT STWYEVEPFV PFLEAQIGPP DVHLEAEDKA IILSISPPGT
160 170 180 190 200
KDSIMWAMDR SSFRYSVVIW KNSSSLEERT ETVYPEDKIY KLSPEITYCL
210 220 230 240 250
KVKAELRLQS RVGCYSPVYC INTTERHKVP SPENIQINAD NQIYVLKWDY
260 270 280 290 300
PYENATFQAQ WLRAFFKKIP GNHSDKWKQI PNCENVTSTH CVFPREVSSR
310 320 330 340 350
GIYYVRVRAS NGNGTSFWSE EKEFNTEMKT IIFPPVISVK SVTDDSLHVS
360 370 380 390 400
VGASEESENM SVNQLYPLIY EVIFWENTSN AERKVLEKRT NFIFPDLKPL
410 420 430 440 450
TVYCVKARAL IENDRRNKGS SFSDTVCEKT KPGNTSKTWL IVGTCTALFS
460 470 480 490 500
IPVVIYVVSV FLRCVKYVFF PSSKPPSSVD EYFSDQPLRN LLLSTSEEQT
510 520 530 540 550
ERCFIIENAS IITEIEETDE IDEVHKKYSS QTSQDSGNYS NEDENSGSKI
560
SEEFPQQDSV
Length:560
Mass (Da):63,819
Last modified:February 1, 1994 - v2
Checksum:i66D76B72861E1D11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti422F → V in AAA02571 (PubMed:8318540).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68443 mRNA Translation: CAA48484.1
L06320 mRNA Translation: AAA02571.1
PIRiS27387
RefSeqiNP_776977.1, NM_174552.2
UniGeneiBt.4557

Genome annotation databases

EnsembliENSBTAT00000029080; ENSBTAP00000029080; ENSBTAG00000021819
GeneIDi282257
KEGGibta:282257

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68443 mRNA Translation: CAA48484.1
L06320 mRNA Translation: AAA02571.1
PIRiS27387
RefSeqiNP_776977.1, NM_174552.2
UniGeneiBt.4557

3D structure databases

ProteinModelPortaliQ04790
SMRiQ04790
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029080

Proteomic databases

PaxDbiQ04790
PRIDEiQ04790

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029080; ENSBTAP00000029080; ENSBTAG00000021819
GeneIDi282257
KEGGibta:282257

Organism-specific databases

CTDi3454
VGNCiVGNC:30054 IFNAR1

Phylogenomic databases

eggNOGiENOG410IKIP Eukaryota
ENOG4111QEU LUCA
GeneTreeiENSGT00530000063449
HOGENOMiHOG000113067
HOVERGENiHBG052126
InParanoidiQ04790
KOiK05130
OMAiWIKLPGC
OrthoDBiEOG091G04H5

Enzyme and pathway databases

ReactomeiR-BTA-909733 Interferon alpha/beta signaling
R-BTA-912694 Regulation of IFNA signaling

Gene expression databases

BgeeiENSBTAG00000021819 Expressed in 9 organ(s), highest expression level in liver

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR016669 Interferon_alpha/beta_rcpt-1
PfamiView protein in Pfam
PF09294 Interfer-bind, 2 hits
PF01108 Tissue_fac, 1 hit
PIRSFiPIRSF016567 IFN_alpha/beta_recept-1, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiINAR1_BOVIN
AccessioniPrimary (citable) accession number: Q04790
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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