UniProtKB - Q04787 (BSH_DROME)
Protein
Brain-specific homeobox protein
Gene
bsh
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
DNA binding protein that function as transcriptional activator (By similarity). May play a role in the determination and function of cell types in the brain.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 274 – 333 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- brain development Source: UniProtKB
- neuron fate commitment Source: FlyBase
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-8853884, Transcriptional Regulation by VENTX |
Names & Taxonomyi
Protein namesi | Recommended name: Brain-specific homeobox protein |
Gene namesi | Name:bsh ORF Names:CG10604 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000529, bsh |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: GO_Central
- nucleus Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048841 | 1 – 429 | Brain-specific homeobox proteinAdd BLAST | 429 |
Proteomic databases
PaxDbi | Q04787 |
Expressioni
Tissue specificityi
Embryonic brain; accumulates in approximately 30 cells in each brain hemisphere. One of these cells is closely associated with the terminus of the larval visual nerve (Bolwig's nerve).1 Publication
Developmental stagei
Expressed during embryogenesis with very low levels found in the larva and adult.1 Publication
Gene expression databases
Bgeei | FBgn0000529, Expressed in central nervous system and 11 other tissues |
Genevisiblei | Q04787, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 61242, 28 interactors |
DIPi | DIP-17210N |
IntActi | Q04787, 5 interactors |
STRINGi | 7227.FBpp0088920 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 177 – 191 | Pro-richAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the distal-less homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0491, Eukaryota |
GeneTreei | ENSGT00940000165097 |
HOGENOMi | CLU_049799_0_0_1 |
InParanoidi | Q04787 |
OMAi | ANEPVDF |
OrthoDBi | 858478at2759 |
PhylomeDBi | Q04787 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04787-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMLNEASLS PADAHAHANA TTPTHSKAAA MASATTMLTT KTPFSIEHIL
60 70 80 90 100
FQNLNSASNN NNSSDTNGIA ANTNNYAPKS SRNAVKSARS AFAHDNNPHK
110 120 130 140 150
HPSQHSHPPQ SHPPASASAS ATATARSNQA ASGYAGEDYG KSMHSTPRSN
160 170 180 190 200
HHSRHGTSHY NGDQISQQLG SGAAQHPPVP TTQPQPPPPP PLNGGSGASN
210 220 230 240 250
GVLYPNAPYT DHGFLQMTLG YLSPSSGTYK SVDPYFLSQA SLFGGAPFFG
260 270 280 290 300
APGCVPELAL GLGMGVNALR HCRRRKARTV FSDPQLSGLE KRFEGQRYLS
310 320 330 340 350
TPERVELATA LGLSETQVKT WFQNRRMKHK KQLRRRDNAN EPVDFSRSEP
360 370 380 390 400
GKQPGEATSS SGDSKHGKLN PGSVGGTPTQ PTSEQQLQMC LMQQGYSTDD
410 420
YSDLEADSGD EDNSSDVDIV GDAKLYQLT
Sequence cautioni
The sequence AAB59219 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 301 | T → P in AAB59219 (PubMed:8101170).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53843.3 AE014134 Genomic DNA Translation: AAS64721.2 BT022203 mRNA Translation: AAY51597.1 L06475 Genomic DNA Translation: AAB59219.1 Frameshift. |
RefSeqi | NP_477350.2, NM_058002.3 NP_995728.2, NM_206006.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0089320; FBpp0088920; FBgn0000529 FBtr0343855; FBpp0310398; FBgn0000529 |
GeneIDi | 35266 |
KEGGi | dme:Dmel_CG10604 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAF53843.3 AE014134 Genomic DNA Translation: AAS64721.2 BT022203 mRNA Translation: AAY51597.1 L06475 Genomic DNA Translation: AAB59219.1 Frameshift. |
RefSeqi | NP_477350.2, NM_058002.3 NP_995728.2, NM_206006.2 |
3D structure databases
SMRi | Q04787 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 61242, 28 interactors |
DIPi | DIP-17210N |
IntActi | Q04787, 5 interactors |
STRINGi | 7227.FBpp0088920 |
Proteomic databases
PaxDbi | Q04787 |
Genome annotation databases
EnsemblMetazoai | FBtr0089320; FBpp0088920; FBgn0000529 FBtr0343855; FBpp0310398; FBgn0000529 |
GeneIDi | 35266 |
KEGGi | dme:Dmel_CG10604 |
Organism-specific databases
CTDi | 35266 |
FlyBasei | FBgn0000529, bsh |
Phylogenomic databases
eggNOGi | KOG0491, Eukaryota |
GeneTreei | ENSGT00940000165097 |
HOGENOMi | CLU_049799_0_0_1 |
InParanoidi | Q04787 |
OMAi | ANEPVDF |
OrthoDBi | 858478at2759 |
PhylomeDBi | Q04787 |
Enzyme and pathway databases
Reactomei | R-DME-8853884, Transcriptional Regulation by VENTX |
Miscellaneous databases
BioGRID-ORCSi | 35266, 0 hits in 1 CRISPR screen |
GenomeRNAii | 35266 |
PROi | PR:Q04787 |
Gene expression databases
Bgeei | FBgn0000529, Expressed in central nervous system and 11 other tissues |
Genevisiblei | Q04787, DM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BSH_DROME | |
Accessioni | Q04787Primary (citable) accession number: Q04787 Secondary accession number(s): Q4V6V3, Q7KT32, Q9VIS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | June 13, 2006 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families