bsh

Functionⁱ

DNA binding protein that function as transcriptional activator (By similarity). May play a role in the determination and function of cell types in the brain.By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	274 – 333	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 8101170
sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8101170
neuron fate commitment
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 23454478
regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 8101170

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Brain-specific homeobox protein
Gene namesⁱ	Name:bsh ORF Names:CG10604
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome 2L

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0000529 bsh

FlyBaseⁱ

FBgn0000529 bsh

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048841	1 – 429	Brain-specific homeobox proteinAdd BLAST		429

Proteomic databases

PaxDbⁱ	Q04787
PRIDEⁱ	Q04787

Expressionⁱ

Tissue specificityⁱ

Embryonic brain; accumulates in approximately 30 cells in each brain hemisphere. One of these cells is closely associated with the terminus of the larval visual nerve (Bolwig's nerve).1 Publication

Developmental stageⁱ

Expressed during embryogenesis with very low levels found in the larva and adult.1 Publication

Gene expression databases

Bgeeⁱ	FBgn0000529 Expressed in 6 organ(s), highest expression level in central brain primordium (Drosophila)
Genevisibleⁱ	Q04787 DM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	61242, 27 interactors
Database of interacting proteins More...DIPⁱ	DIP-17210N
IntActⁱ	Q04787, 4 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q04787
SMRⁱ	Q04787
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	177 – 191	Pro-richAdd BLAST		15

Sequence similaritiesⁱ

Belongs to the distal-less homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0491 Eukaryota ENOG4111UAT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143996
InParanoidⁱ	Q04787
OMAⁱ	ANEPVDF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QT3
PhylomeDBⁱ	Q04787

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q04787-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAMLNEASLS PADAHAHANA TTPTHSKAAA MASATTMLTT KTPFSIEHIL 
        60         70         80         90        100
FQNLNSASNN NNSSDTNGIA ANTNNYAPKS SRNAVKSARS AFAHDNNPHK 
       110        120        130        140        150
HPSQHSHPPQ SHPPASASAS ATATARSNQA ASGYAGEDYG KSMHSTPRSN 
       160        170        180        190        200
HHSRHGTSHY NGDQISQQLG SGAAQHPPVP TTQPQPPPPP PLNGGSGASN 
       210        220        230        240        250
GVLYPNAPYT DHGFLQMTLG YLSPSSGTYK SVDPYFLSQA SLFGGAPFFG 
       260        270        280        290        300
APGCVPELAL GLGMGVNALR HCRRRKARTV FSDPQLSGLE KRFEGQRYLS 
       310        320        330        340        350
TPERVELATA LGLSETQVKT WFQNRRMKHK KQLRRRDNAN EPVDFSRSEP 
       360        370        380        390        400
GKQPGEATSS SGDSKHGKLN PGSVGGTPTQ PTSEQQLQMC LMQQGYSTDD 
       410        420 
YSDLEADSGD EDNSSDVDIV GDAKLYQLT

Length:429

Mass (Da):45,714

Last modified:June 13, 2006 - v5

Checksum:ⁱ32CF539EE0DEE572

GO

Sequence cautionⁱ

The sequence AAB59219 differs from that shown. Reason: Frameshift at positions 119, 138, 333 and 341.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	301	T → P in AAB59219 (PubMed:8101170).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE014134 Genomic DNA Translation: AAF53843.3 AE014134 Genomic DNA Translation: AAS64721.2 BT022203 mRNA Translation: AAY51597.1 L06475 Genomic DNA Translation: AAB59219.1 Frameshift.
NCBI Reference Sequences More...RefSeqⁱ	NP_477350.2, NM_058002.3 NP_995728.2, NM_206006.2
UniGeneⁱ	Dm.25407

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0089320; FBpp0088920; FBgn0000529 FBtr0343855; FBpp0310398; FBgn0000529
GeneIDⁱ	35266
KEGGⁱ	dme:Dmel_CG10604

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q04787	GD21734		DROSI		429	UniRef90_Q04787
Uncharacterized protein		DROER		429
GM16987		DROSE		429
Uncharacterized protein		DROYA		428

Protein	Similar proteins		Species	Score	Length	Source
Q04787	Uncharacterized protein		DROER		429	UniRef50_Q04787
GM16987		DROSE		429
GD21734		DROSI		429
Uncharacterized protein		DROYA		428
Bsh		DROBS		434
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE014134 Genomic DNA Translation: AAF53843.3 AE014134 Genomic DNA Translation: AAS64721.2 BT022203 mRNA Translation: AAY51597.1 L06475 Genomic DNA Translation: AAB59219.1 Frameshift.
RefSeqⁱ	NP_477350.2, NM_058002.3 NP_995728.2, NM_206006.2
UniGeneⁱ	Dm.25407

3D structure databases

ProteinModelPortalⁱ	Q04787
SMRⁱ	Q04787
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	61242, 27 interactors
DIPⁱ	DIP-17210N
IntActⁱ	Q04787, 4 interactors

Proteomic databases

PaxDbⁱ	Q04787
PRIDEⁱ	Q04787

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0089320; FBpp0088920; FBgn0000529 FBtr0343855; FBpp0310398; FBgn0000529
GeneIDⁱ	35266
KEGGⁱ	dme:Dmel_CG10604

Organism-specific databases

CTDⁱ	35266
FlyBaseⁱ	FBgn0000529 bsh

Phylogenomic databases

eggNOGⁱ	KOG0491 Eukaryota ENOG4111UAT LUCA
GeneTreeⁱ	ENSGT00910000143996
InParanoidⁱ	Q04787
OMAⁱ	ANEPVDF
OrthoDBⁱ	EOG091G0QT3
PhylomeDBⁱ	Q04787

Miscellaneous databases

GenomeRNAiⁱ	35266
Protein Ontology More...PROⁱ	PR:Q04787

Gene expression databases

Bgeeⁱ	FBgn0000529 Expressed in 6 organ(s), highest expression level in central brain primordium (Drosophila)
Genevisibleⁱ	Q04787 DM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BSH_DROME
Accessionⁱ	Q04787Primary (citable) accession number: Q04787 Secondary accession number(s): Q4V6V3, Q7KT32, Q9VIS2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	June 13, 2006
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

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UniProtKB - Q04787 (BSH_DROME)

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Brain-specific homeobox protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ