UniProtKB - Q04771 (ACVR1_HUMAN)
Protein
Activin receptor type-1
Gene
ACVR1
Organism
Homo sapiens (Human)
Status
Functioni
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).By similarity
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 235 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 336 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 214 – 222 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- activin binding Source: UniProtKB
- activin receptor activity, type I Source: Ensembl
- ATP binding Source: HGNC-UCL
- cadherin binding Source: ARUK-UCL
- metal ion binding Source: UniProtKB-KW
- peptide hormone binding Source: UniProtKB
- protein homodimerization activity Source: BHF-UCL
- protein kinase activity Source: BHF-UCL
- protein serine/threonine kinase activity Source: HGNC-UCL
- protein tyrosine kinase binding Source: ARUK-UCL
- SMAD binding Source: HGNC-UCL
- transforming growth factor beta binding Source: UniProtKB
- transforming growth factor beta receptor activity, type I Source: GO_Central
- transmembrane receptor protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- activin receptor signaling pathway Source: BHF-UCL
- acute inflammatory response Source: Ensembl
- angiogenesis Source: GO_Central
- atrial septum primum morphogenesis Source: BHF-UCL
- atrioventricular valve morphogenesis Source: BHF-UCL
- BMP signaling pathway Source: BHF-UCL
- BMP signaling pathway involved in heart development Source: BHF-UCL
- branching involved in blood vessel morphogenesis Source: Ensembl
- cardiac muscle cell fate commitment Source: BHF-UCL
- cellular response to BMP stimulus Source: BHF-UCL
- cellular response to growth factor stimulus Source: GO_Central
- determination of left/right symmetry Source: Ensembl
- dorsal/ventral pattern formation Source: GO_Central
- embryonic heart tube morphogenesis Source: BHF-UCL
- endocardial cushion cell fate commitment Source: BHF-UCL
- endocardial cushion fusion Source: BHF-UCL
- endocardial cushion morphogenesis Source: BHF-UCL
- G1/S transition of mitotic cell cycle Source: HGNC-UCL
- gastrulation with mouth forming second Source: Ensembl
- germ cell development Source: Ensembl
- heart development Source: GO_Central
- in utero embryonic development Source: Ensembl
- mesoderm formation Source: Ensembl
- mitral valve morphogenesis Source: BHF-UCL
- negative regulation of activin receptor signaling pathway Source: HGNC-UCL
- negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of signal transduction Source: HGNC-UCL
- neural crest cell migration Source: Ensembl
- pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- peptidyl-threonine phosphorylation Source: BHF-UCL
- pharyngeal system development Source: Ensembl
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of determination of dorsal identity Source: BHF-UCL
- positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- positive regulation of osteoblast differentiation Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- protein phosphorylation Source: HGNC-UCL
- regulation of ossification Source: UniProtKB
- smooth muscle cell differentiation Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: UniProtKB
- ventricular septum morphogenesis Source: BHF-UCL
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | Q04771 |
SignaLinki | Q04771 |
SIGNORi | Q04771 |
Names & Taxonomyi
Protein namesi | Recommended name: Activin receptor type-1 (EC:2.7.11.30)Alternative name(s): Activin receptor type I Short name: ACTR-I Activin receptor-like kinase 2 Short name: ALK-2 Serine/threonine-protein kinase receptor R1 Short name: SKR1 TGF-B superfamily receptor type I Short name: TSR-I |
Gene namesi | Name:ACVR1 Synonyms:ACVRLK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:171, ACVR1 |
MIMi | 102576, gene |
neXtProti | NX_Q04771 |
VEuPathDBi | HostDB:ENSG00000115170.13 |
Subcellular locationi
Other locations
Plasma Membrane
- activin receptor complex Source: UniProtKB
- BMP receptor complex Source: GO_Central
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
- apical part of cell Source: Ensembl
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 123 | ExtracellularSequence analysisAdd BLAST | 103 | |
Transmembranei | 124 – 146 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 147 – 509 | CytoplasmicSequence analysisAdd BLAST | 363 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Fibrodysplasia ossificans progressiva (FOP)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare autosomal dominant connective tissue disorder resulting in skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to a debilitating ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058418 | 197 – 198 | PF → L in FOP; variant phenotype. 1 Publication | 2 | |
Natural variantiVAR_058419 | 202 | R → I in FOP; with some atypical features. 1 PublicationCorresponds to variant dbSNP:rs387906591EnsemblClinVar. | 1 | |
Natural variantiVAR_028444 | 206 | R → H in FOP. 2 PublicationsCorresponds to variant dbSNP:rs121912678EnsemblClinVar. | 1 | |
Natural variantiVAR_058420 | 207 | Q → E in FOP; with some atypical features. 1 Publication | 1 | |
Natural variantiVAR_058421 | 328 | G → E in FOP; variant phenotype. 2 PublicationsCorresponds to variant dbSNP:rs387906589EnsemblClinVar. | 1 | |
Natural variantiVAR_058422 | 328 | G → R in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906588EnsemblClinVar. | 1 | |
Natural variantiVAR_058423 | 328 | G → W in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906588EnsemblClinVar. | 1 | |
Natural variantiVAR_058424 | 356 | G → D in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs121912679EnsemblClinVar. | 1 | |
Natural variantiVAR_058425 | 375 | R → P in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906590EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 90 |
MalaCardsi | ACVR1 |
MIMi | 135100, phenotype |
OpenTargetsi | ENSG00000115170 |
Orphaneti | 337, Fibrodysplasia ossificans progressiva |
PharmGKBi | PA24492 |
Miscellaneous databases
Pharosi | Q04771, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5903 |
DrugBanki | DB00171, ATP DB08597, Dorsomorphin DB12010, Fostamatinib |
DrugCentrali | Q04771 |
GuidetoPHARMACOLOGYi | 1785 |
Genetic variation databases
BioMutai | ACVR1 |
DMDMi | 462447 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
ChainiPRO_0000024394 | 21 – 509 | Activin receptor type-1Add BLAST | 489 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 501 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q04771 |
jPOSTi | Q04771 |
MassIVEi | Q04771 |
MaxQBi | Q04771 |
PaxDbi | Q04771 |
PeptideAtlasi | Q04771 |
PRIDEi | Q04771 |
ProteomicsDBi | 58283 |
PTM databases
GlyGeni | Q04771, 1 site |
iPTMneti | Q04771 |
PhosphoSitePlusi | Q04771 |
Expressioni
Tissue specificityi
Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
Gene expression databases
Bgeei | ENSG00000115170, Expressed in cartilage tissue and 245 other tissues |
ExpressionAtlasi | Q04771, baseline and differential |
Genevisiblei | Q04771, HS |
Organism-specific databases
HPAi | ENSG00000115170, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- cadherin binding Source: ARUK-UCL
- protein homodimerization activity Source: BHF-UCL
- protein tyrosine kinase binding Source: ARUK-UCL
- SMAD binding Source: HGNC-UCL
- transforming growth factor beta binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 106605, 90 interactors |
DIPi | DIP-212N |
IntActi | Q04771, 20 interactors |
MINTi | Q04771 |
STRINGi | 9606.ENSP00000263640 |
Chemistry databases
BindingDBi | Q04771 |
Miscellaneous databases
RNActi | Q04771, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q04771 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q04771 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 178 – 207 | GSPROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 208 – 502 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 295 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000160160 |
HOGENOMi | CLU_000288_8_5_1 |
InParanoidi | Q04771 |
OMAi | CQGQQCF |
OrthoDBi | 1299087at2759 |
PhylomeDBi | Q04771 |
TreeFami | TF314724 |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q04771-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG
60 70 80 90 100
QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN
110 120 130 140 150
RNITAQLPTK GKSFPGTQNF HLEVGLIILS VVFAVCLLAC LLGVALRKFK
160 170 180 190 200
RRNQERLNPR DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV
210 220 230 240 250
QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE
260 270 280 290 300
LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL
310 320 330 340 350
DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC
360 370 380 390 400
CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK
410 420 430 440 450
RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV
460 470 480 490 500
DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN
SLDKLKTDC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JHJ7 | C9JHJ7_HUMAN | Activin receptor type-1 | ACVR1 | 87 | Annotation score: | ||
A0A1B0GXA9 | A0A1B0GXA9_HUMAN | Activin receptor type-1 | ACVR1 | 86 | Annotation score: | ||
C9JW28 | C9JW28_HUMAN | Activin receptor type-1 | ACVR1 | 21 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041392 | 15 | A → G1 PublicationCorresponds to variant dbSNP:rs13406336EnsemblClinVar. | 1 | |
Natural variantiVAR_041393 | 41 | S → F1 PublicationCorresponds to variant dbSNP:rs55957214Ensembl. | 1 | |
Natural variantiVAR_041394 | 47 | H → Q1 PublicationCorresponds to variant dbSNP:rs34056189EnsemblClinVar. | 1 | |
Natural variantiVAR_041395 | 115 | P → S in a melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_058418 | 197 – 198 | PF → L in FOP; variant phenotype. 1 Publication | 2 | |
Natural variantiVAR_058419 | 202 | R → I in FOP; with some atypical features. 1 PublicationCorresponds to variant dbSNP:rs387906591EnsemblClinVar. | 1 | |
Natural variantiVAR_028444 | 206 | R → H in FOP. 2 PublicationsCorresponds to variant dbSNP:rs121912678EnsemblClinVar. | 1 | |
Natural variantiVAR_058420 | 207 | Q → E in FOP; with some atypical features. 1 Publication | 1 | |
Natural variantiVAR_058421 | 328 | G → E in FOP; variant phenotype. 2 PublicationsCorresponds to variant dbSNP:rs387906589EnsemblClinVar. | 1 | |
Natural variantiVAR_058422 | 328 | G → R in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906588EnsemblClinVar. | 1 | |
Natural variantiVAR_058423 | 328 | G → W in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906588EnsemblClinVar. | 1 | |
Natural variantiVAR_058424 | 356 | G → D in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs121912679EnsemblClinVar. | 1 | |
Natural variantiVAR_058425 | 375 | R → P in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906590EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02911 mRNA Translation: AAA36614.1 Z22534 mRNA Translation: CAA80256.1 BC033867 mRNA Translation: AAH33867.1 |
CCDSi | CCDS2206.1 |
PIRi | A45992 |
RefSeqi | NP_001096.1, NM_001105.4 NP_001104537.1, NM_001111067.2 NP_001334592.1, NM_001347663.1 NP_001334593.1, NM_001347664.1 NP_001334594.1, NM_001347665.1 NP_001334595.1, NM_001347666.1 NP_001334596.1, NM_001347667.1 XP_006712888.1, XM_006712825.3 XP_011510410.1, XM_011512108.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L02911 mRNA Translation: AAA36614.1 Z22534 mRNA Translation: CAA80256.1 BC033867 mRNA Translation: AAH33867.1 |
CCDSi | CCDS2206.1 |
PIRi | A45992 |
RefSeqi | NP_001096.1, NM_001105.4 NP_001104537.1, NM_001111067.2 NP_001334592.1, NM_001347663.1 NP_001334593.1, NM_001347664.1 NP_001334594.1, NM_001347665.1 NP_001334595.1, NM_001347666.1 NP_001334596.1, NM_001347667.1 XP_006712888.1, XM_006712825.3 XP_011510410.1, XM_011512108.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3H9R | X-ray | 2.35 | A | 172-499 | [»] | |
3MTF | X-ray | 2.15 | A/B | 201-499 | [»] | |
3OOM | X-ray | 2.00 | A | 201-499 | [»] | |
3Q4U | X-ray | 1.82 | A/B/C/D | 201-499 | [»] | |
4BGG | X-ray | 2.56 | A/B/C/D | 201-499 | [»] | |
4C02 | X-ray | 2.17 | A | 172-499 | [»] | |
4DYM | X-ray | 2.42 | A | 201-499 | [»] | |
5OXG | X-ray | 2.13 | A/B/C/D | 201-499 | [»] | |
5OY6 | X-ray | 2.56 | A/B/C/D | 201-499 | [»] | |
6ACR | X-ray | 2.01 | A/B | 201-499 | [»] | |
6EIX | X-ray | 2.30 | A | 172-509 | [»] | |
6GI6 | X-ray | 1.98 | A | 201-499 | [»] | |
6GIN | X-ray | 2.20 | A/B | 201-499 | [»] | |
6GIP | X-ray | 2.17 | A | 201-499 | [»] | |
6I1S | X-ray | 1.52 | A | 172-499 | [»] | |
6JUX | X-ray | 1.75 | A | 201-499 | [»] | |
6SRH | X-ray | 1.25 | A/B | 201-499 | [»] | |
6SZM | X-ray | 1.42 | A/B | 201-499 | [»] | |
6T6D | X-ray | 2.56 | A/B/C/D | 201-499 | [»] | |
6T8N | X-ray | 1.77 | A/B | 201-499 | [»] | |
6TN8 | X-ray | 1.63 | A | 201-499 | [»] | |
6Z36 | X-ray | 1.37 | A/B | 201-499 | [»] | |
6ZGC | X-ray | 2.67 | A/B/C/D | 201-499 | [»] | |
7A21 | X-ray | 2.14 | A/B | 201-499 | [»] | |
SMRi | Q04771 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106605, 90 interactors |
DIPi | DIP-212N |
IntActi | Q04771, 20 interactors |
MINTi | Q04771 |
STRINGi | 9606.ENSP00000263640 |
Chemistry databases
BindingDBi | Q04771 |
ChEMBLi | CHEMBL5903 |
DrugBanki | DB00171, ATP DB08597, Dorsomorphin DB12010, Fostamatinib |
DrugCentrali | Q04771 |
GuidetoPHARMACOLOGYi | 1785 |
PTM databases
GlyGeni | Q04771, 1 site |
iPTMneti | Q04771 |
PhosphoSitePlusi | Q04771 |
Genetic variation databases
BioMutai | ACVR1 |
DMDMi | 462447 |
Proteomic databases
EPDi | Q04771 |
jPOSTi | Q04771 |
MassIVEi | Q04771 |
MaxQBi | Q04771 |
PaxDbi | Q04771 |
PeptideAtlasi | Q04771 |
PRIDEi | Q04771 |
ProteomicsDBi | 58283 |
Protocols and materials databases
Antibodypediai | 2371, 605 antibodies |
DNASUi | 90 |
Genome annotation databases
Organism-specific databases
CTDi | 90 |
DisGeNETi | 90 |
GeneCardsi | ACVR1 |
HGNCi | HGNC:171, ACVR1 |
HPAi | ENSG00000115170, Low tissue specificity |
MalaCardsi | ACVR1 |
MIMi | 102576, gene 135100, phenotype |
neXtProti | NX_Q04771 |
OpenTargetsi | ENSG00000115170 |
Orphaneti | 337, Fibrodysplasia ossificans progressiva |
PharmGKBi | PA24492 |
VEuPathDBi | HostDB:ENSG00000115170.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000160160 |
HOGENOMi | CLU_000288_8_5_1 |
InParanoidi | Q04771 |
OMAi | CQGQQCF |
OrthoDBi | 1299087at2759 |
PhylomeDBi | Q04771 |
TreeFami | TF314724 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | Q04771 |
SignaLinki | Q04771 |
SIGNORi | Q04771 |
Miscellaneous databases
BioGRID-ORCSi | 90, 6 hits in 910 CRISPR screens |
ChiTaRSi | ACVR1, human |
EvolutionaryTracei | Q04771 |
GeneWikii | ACVR1 |
GenomeRNAii | 90 |
Pharosi | Q04771, Tchem |
PROi | PR:Q04771 |
RNActi | Q04771, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115170, Expressed in cartilage tissue and 245 other tissues |
ExpressionAtlasi | Q04771, baseline and differential |
Genevisiblei | Q04771, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACVR1_HUMAN | |
Accessioni | Q04771Primary (citable) accession number: Q04771 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 208 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human and mouse protein kinases
Human and mouse protein kinases: classification and index