Activin receptor type-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• [receptor-protein]-L-threonine

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  + ATP

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  = [receptor-protein]-O-phospho-L-threonine

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  + ADP

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  + H⁺

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  EC:2.7.11.30
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  Source: Rhea

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  [receptor-protein]-L-threonine

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  L-threonine residue

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  +

  ATP

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  =

  [receptor-protein]-O-phospho-L-threonine

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  O-phospho-L-threonine residue

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  ADP

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  +

  H⁺

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• [receptor-protein]-L-serine

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  + ATP

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  = [receptor-protein]-O-phospho-L-serine

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  + ADP

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  + H⁺

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  EC:2.7.11.30
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  Source: Rhea

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  [receptor-protein]-L-serine

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  L-serine residue

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  ATP

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  =

  [receptor-protein]-O-phospho-L-serine

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  O-phospho-L-serine residue

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  ADP

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  +

  H⁺

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<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activin binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."
    Attisano L., Carcamo J., Ventura F., Weis F.M., Massague J., Wrana J.L.
    Cell 75:671-680(1993) [PubMed] [Europe PMC] [Abstract]
• activin receptor activity, type I Source: Ensembl
• ATP binding Source: HGNC-UCLInferred from direct assayⁱ
  • "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7."
    Inman G.J., Nicolas F.J., Callahan J.F., Harling J.D., Gaster L.M., Reith A.D., Laping N.J., Hill C.S.
    Mol. Pharmacol. 62:65-74(2002) [PubMed] [Europe PMC] [Abstract]
• cadherin binding Source: ARUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J. Cell. Sci. 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• peptide hormone binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells."
    Chen V.T., Peng C., Leung P.C.
    Reprod. Biol. Endocrinol. 1:29-29(2003) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from direct assayⁱ
  • "BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H.
    J. Biol. Chem. 283:20948-20958(2008) [PubMed] [Europe PMC] [Abstract]
• protein kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • "Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration."
    Romero D., Terzic A., Conley B.A., Craft C.S., Jovanovic B., Bergan R.C., Vary C.P.
    Carcinogenesis 31:359-366(2010) [PubMed] [Europe PMC] [Abstract]
• protein serine/threonine kinase activity Source: HGNC-UCLInferred from direct assayⁱ
  • "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7."
    Inman G.J., Nicolas F.J., Callahan J.F., Harling J.D., Gaster L.M., Reith A.D., Laping N.J., Hill C.S.
    Mol. Pharmacol. 62:65-74(2002) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine kinase binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J. Cell. Sci. 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: HGNC-UCLInferred from direct assayⁱ
  • "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7."
    Inman G.J., Nicolas F.J., Callahan J.F., Harling J.D., Gaster L.M., Reith A.D., Laping N.J., Hill C.S.
    Mol. Pharmacol. 62:65-74(2002) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta binding Source: UniProtKBInferred from direct assayⁱ
  • "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."
    Attisano L., Carcamo J., Ventura F., Weis F.M., Massague J., Wrana J.L.
    Cell 75:671-680(1993) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor activity, type I Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transmembrane receptor protein serine/threonine kinase activity Source: UniProtKBNon-traceable author statementⁱ
  • "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."
    Attisano L., Carcamo J., Ventura F., Weis F.M., Massague J., Wrana J.L.
    Cell 75:671-680(1993) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activin receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• acute inflammatory response Source: Ensembl
• angiogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• atrial septum primum morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• atrioventricular valve morphogenesis Source: BHF-UCL
• BMP signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H.
    J. Biol. Chem. 283:20948-20958(2008) [PubMed] [Europe PMC] [Abstract]
• BMP signaling pathway involved in heart development Source: BHF-UCL
• branching involved in blood vessel morphogenesis Source: Ensembl
• cardiac muscle cell fate commitment Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to BMP stimulus Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin."
    Xia Y., Babitt J.L., Sidis Y., Chung R.T., Lin H.Y.
    Blood 111:5195-5204(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to growth factor stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• determination of left/right symmetry Source: Ensembl
• embryonic heart tube morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• endocardial cushion cell fate commitment Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• endocardial cushion fusion Source: BHF-UCL
• endocardial cushion morphogenesis Source: BHF-UCL
• G1/S transition of mitotic cell cycle Source: HGNC-UCLInferred from mutant phenotypeⁱ
  • "The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells."
    Hashimoto O., Yamato K., Koseki T., Ohguchi M., Ishisaki A., Shoji H., Nakamura T., Hayashi Y., Sugino H., Nishihara T.
    Cell. Signal. 10:743-749(1998) [PubMed] [Europe PMC] [Abstract]
• gastrulation with mouth forming second Source: Ensembl
• germ cell development Source: Ensembl
• heart development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: Ensembl
• mesoderm formation Source: Ensembl
• mitral valve morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of activin receptor signaling pathway Source: HGNC-UCLInferred from mutant phenotypeⁱ
  • "The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells."
    Hashimoto O., Yamato K., Koseki T., Ohguchi M., Ishisaki A., Shoji H., Nakamura T., Hayashi Y., Sugino H., Nishihara T.
    Cell. Signal. 10:743-749(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells."
    Hashimoto O., Yamato K., Koseki T., Ohguchi M., Ishisaki A., Shoji H., Nakamura T., Hayashi Y., Sugino H., Nishihara T.
    Cell. Signal. 10:743-749(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of signal transduction Source: HGNC-UCLInferred from mutant phenotypeⁱ
  • "The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells."
    Hashimoto O., Yamato K., Koseki T., Ohguchi M., Ishisaki A., Shoji H., Nakamura T., Hayashi Y., Sugino H., Nishihara T.
    Cell. Signal. 10:743-749(1998) [PubMed] [Europe PMC] [Abstract]
• neural crest cell migration Source: Ensembl
• pathway-restricted SMAD protein phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • "Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration."
    Romero D., Terzic A., Conley B.A., Craft C.S., Jovanovic B., Bergan R.C., Vary C.P.
    Carcinogenesis 31:359-366(2010) [PubMed] [Europe PMC] [Abstract]
• peptidyl-threonine phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • "Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration."
    Romero D., Terzic A., Conley B.A., Craft C.S., Jovanovic B., Bergan R.C., Vary C.P.
    Carcinogenesis 31:359-366(2010) [PubMed] [Europe PMC] [Abstract]
• pharyngeal system development Source: Ensembl
• positive regulation of bone mineralization Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H.
    J. Biol. Chem. 283:20948-20958(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell migration Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration."
    Romero D., Terzic A., Conley B.A., Craft C.S., Jovanovic B., Bergan R.C., Vary C.P.
    Carcinogenesis 31:359-366(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of determination of dorsal identity Source: BHF-UCLInferred from direct assayⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
• positive regulation of osteoblast differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H.
    J. Biol. Chem. 283:20948-20958(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J. Cell. Sci. 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."
    Attisano L., Carcamo J., Ventura F., Weis F.M., Massague J., Wrana J.L.
    Cell 75:671-680(1993) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Dominant-negative ALK2 allele associates with congenital heart defects."
    Smith K.A., Joziasse I.C., Chocron S., van Dinther M., Guryev V., Verhoeven M.C., Rehmann H., van der Smagt J.J., Doevendans P.A., Cuppen E., Mulder B.J., Ten Dijke P., Bakkers J.
    Circulation 119:3062-3069(2009) [PubMed] [Europe PMC] [Abstract]
• protein phosphorylation Source: HGNC-UCLInferred from direct assayⁱ
  • "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7."
    Inman G.J., Nicolas F.J., Callahan J.F., Harling J.D., Gaster L.M., Reith A.D., Laping N.J., Hill C.S.
    Mol. Pharmacol. 62:65-74(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of ossification Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.8

    "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva."
    Shore E.M., Xu M., Feldman G.J., Fenstermacher D.A., Brown M.A., Kaplan F.S.
    Nat. Genet. 38:525-527(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT FOP HIS-206.
• smooth muscle cell differentiation Source: Ensembl
• transforming growth factor beta receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."
    Attisano L., Carcamo J., Ventura F., Weis F.M., Massague J., Wrana J.L.
    Cell 75:671-680(1993) [PubMed] [Europe PMC] [Abstract]
• ventricular septum morphogenesis Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cadherin binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J. Cell. Sci. 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from direct assayⁱ
  • "BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells."
    Lavery K., Swain P., Falb D., Alaoui-Ismaili M.H.
    J. Biol. Chem. 283:20948-20958(2008) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine kinase binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling."
    Benn A., Bredow C., Casanova I., Vukicevic S., Knaus P.
    J. Cell. Sci. 129:206-218(2016) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: HGNC-UCLInferred from direct assayⁱ
  • "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7."
    Inman G.J., Nicolas F.J., Callahan J.F., Harling J.D., Gaster L.M., Reith A.D., Laping N.J., Hill C.S.
    Mol. Pharmacol. 62:65-74(2002) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta binding Source: UniProtKBInferred from direct assayⁱ
  • "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."
    Attisano L., Carcamo J., Ventura F., Weis F.M., Massague J., Wrana J.L.
    Cell 75:671-680(1993) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG 
        60         70         80         90        100
QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 
       110        120        130        140        150
RNITAQLPTK GKSFPGTQNF HLEVGLIILS VVFAVCLLAC LLGVALRKFK 
       160        170        180        190        200
RRNQERLNPR DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV 
       210        220        230        240        250
QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE 
       260        270        280        290        300
LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 
       310        320        330        340        350
DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC 
       360        370        380        390        400
CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 
       410        420        430        440        450
RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV 
       460        470        480        490        500
DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN 

SLDKLKTDC                                              

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases