ACVR1

Functionⁱ

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).By similarity

Catalytic activityⁱ

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactorⁱ

Mg²⁺By similarity, Mn²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	235	ATPPROSITE-ProRule annotation		1
Active siteⁱ	336	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	214 – 222	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

activin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8242742
activin receptor activity, type I Source: Ensembl
ATP binding
Source: HGNC
Inferred from direct assayⁱ
- 12065756
metal ion binding Source: UniProtKB-KW
peptide hormone binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12702211
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18436533
protein kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736306
protein serine/threonine kinase activity
Source: HGNC
Inferred from direct assayⁱ
- 12065756
SMAD binding
Source: HGNC
Inferred from direct assayⁱ
- 12065756
transforming growth factor beta binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8242742
transforming growth factor beta receptor activity, type I Source: Ensembl
transmembrane receptor protein serine/threonine kinase activity
Source: UniProtKB
Non-traceable author statementⁱ
- 8242742

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activin receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 19506109
acute inflammatory response Source: Ensembl
atrial septum primum morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19506109
atrioventricular valve morphogenesis Source: BHF-UCL
BMP signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 18436533
BMP signaling pathway involved in heart development Source: BHF-UCL
branching involved in blood vessel morphogenesis Source: Ensembl
cardiac muscle cell fate commitment
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19506109
cellular response to BMP stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18326817
determination of left/right symmetry Source: Ensembl
embryonic heart tube morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19506109
endocardial cushion cell fate commitment
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19506109
endocardial cushion fusion Source: BHF-UCL
endocardial cushion morphogenesis Source: BHF-UCL
G1/S transition of mitotic cell cycle
Source: HGNC
Inferred from mutant phenotypeⁱ
- 9884026
gastrulation with mouth forming second Source: Ensembl
germ cell development Source: Ensembl
in utero embryonic development Source: Ensembl
mesoderm formation Source: Ensembl
mitral valve morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19506109
negative regulation of activin receptor signaling pathway
Source: HGNC
Inferred from mutant phenotypeⁱ
- 9884026
negative regulation of extrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 9884026
negative regulation of signal transduction
Source: HGNC
Inferred from mutant phenotypeⁱ
- 9884026
neural crest cell migration Source: Ensembl
pathway-restricted SMAD protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736306
peptidyl-threonine phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736306
pharyngeal system development Source: Ensembl
positive regulation of bone mineralization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18436533
positive regulation of cell migration
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 19736306
positive regulation of determination of dorsal identity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19506109
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
positive regulation of osteoblast differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18436533
positive regulation of pathway-restricted SMAD protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19506109
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 8242742
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 19506109
protein phosphorylation
Source: HGNC
Inferred from direct assayⁱ
- 12065756
regulation of ossification
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16642017
smooth muscle cell differentiation Source: Ensembl
transforming growth factor beta receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 8242742
ventricular septum morphogenesis Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
SignaLinkⁱ	Q04771
SIGNORⁱ	Q04771

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Activin receptor type-1 (EC:2.7.11.30) Alternative name(s): Activin receptor type I Short name: ACTR-I Activin receptor-like kinase 2 Short name: ALK-2 Serine/threonine-protein kinase receptor R1 Short name: SKR1 TGF-B superfamily receptor type I Short name: TSR-I
Gene namesⁱ	Name:ACVR1 Synonyms:ACVRLK2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115170.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:171 ACVR1
MIMⁱ	102576 gene
neXtProtⁱ	NX_Q04771

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 123	ExtracellularSequence analysisAdd BLAST	103
Transmembraneⁱ	124 – 146	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	147 – 509	CytoplasmicSequence analysisAdd BLAST	363

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Fibrodysplasia ossificans progressiva (FOP)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare autosomal dominant connective tissue disorder resulting in skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to a debilitating ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_058418	197 – 198	PF → L in FOP; variant phenotype. 1 Publication	2
Natural variantⁱVAR_058419	202	R → I in FOP; with some atypical features. 1 PublicationCorresponds to variant dbSNP:rs387906591EnsemblClinVar.	1
Natural variantⁱVAR_028444	206	R → H in FOP. 2 PublicationsCorresponds to variant dbSNP:rs121912678EnsemblClinVar.	1
Natural variantⁱVAR_058420	207	Q → E in FOP; with some atypical features. 1 Publication	1
Natural variantⁱVAR_058421	328	G → E in FOP; variant phenotype. 2 PublicationsCorresponds to variant dbSNP:rs387906589EnsemblClinVar.	1
Natural variantⁱVAR_058422	328	G → R in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906588EnsemblClinVar.	1
Natural variantⁱVAR_058423	328	G → W in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906588EnsemblClinVar.	1
Natural variantⁱVAR_058424	356	G → D in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs121912679EnsemblClinVar.	1
Natural variantⁱVAR_058425	375	R → P in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906590EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	90
MalaCards human disease database More...MalaCardsⁱ	ACVR1
MIMⁱ	135100 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000115170
Orphanetⁱ	337 Fibrodysplasia ossificans progressiva
PharmGKBⁱ	PA24492

Chemistry databases

ChEMBLⁱ	CHEMBL5903
Drug and drug target database More...DrugBankⁱ	DB00171 Adenosine triphosphate
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1785

Polymorphism and mutation databases

BioMutaⁱ	ACVR1
DMDMⁱ	462447

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	By similarityAdd BLAST		20
ChainⁱPRO_0000024394	21 – 509	Activin receptor type-1Add BLAST		489

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	102	N-linked (GlcNAc...) asparagineSequence analysis		1
Modified residueⁱ	501	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q04771
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04771
PaxDbⁱ	Q04771
PeptideAtlas More...PeptideAtlasⁱ	Q04771
PRIDEⁱ	Q04771
ProteomicsDBⁱ	58283

PTM databases

iPTMnetⁱ	Q04771
PhosphoSitePlusⁱ	Q04771

Expressionⁱ

Tissue specificityⁱ

Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.

Gene expression databases

Bgeeⁱ	ENSG00000115170 Expressed in 234 organ(s), highest expression level in cartilage tissue
CleanExⁱ	HS_ACVR1
ExpressionAtlasⁱ	Q04771 baseline and differential
Genevisibleⁱ	Q04771 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007505 HPA046514

HPAⁱ

HPA007505
HPA046514

Interactionⁱ

Subunit structureⁱ

Interacts with FKBP1A. Interacts with FCHO1.2 Publications

GO - Molecular functionⁱ

protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18436533
SMAD binding
Source: HGNC
Inferred from direct assayⁱ
- 12065756
transforming growth factor beta binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8242742

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106605, 72 interactors
Database of interacting proteins More...DIPⁱ	DIP-212N
IntActⁱ	Q04771, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q04771
STRINGⁱ	9606.ENSP00000263640

Chemistry databases

BindingDBⁱ

Q04771

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	180 – 184	Combined sources	5
Beta strandⁱ	192 – 196	Combined sources	5
Helixⁱ	205 – 207	Combined sources	3
Beta strandⁱ	209 – 216	Combined sources	8
Beta strandⁱ	218 – 227	Combined sources	10
Beta strandⁱ	230 – 237	Combined sources	8
Helixⁱ	239 – 241	Combined sources	3
Helixⁱ	242 – 254	Combined sources	13
Beta strandⁱ	265 – 273	Combined sources	9
Beta strandⁱ	276 – 283	Combined sources	8
Helixⁱ	291 – 295	Combined sources	5
Helixⁱ	302 – 320	Combined sources	19
Beta strandⁱ	325 – 327	Combined sources	3
Beta strandⁱ	331 – 333	Combined sources	3
Helixⁱ	339 – 341	Combined sources	3
Beta strandⁱ	342 – 344	Combined sources	3
Beta strandⁱ	350 – 352	Combined sources	3
Beta strandⁱ	359 – 362	Combined sources	4
Turnⁱ	363 – 366	Combined sources	4
Beta strandⁱ	367 – 369	Combined sources	3
Helixⁱ	379 – 381	Combined sources	3
Helixⁱ	384 – 387	Combined sources	4
Helixⁱ	396 – 415	Combined sources	20
Turnⁱ	430 – 434	Combined sources	5
Helixⁱ	441 – 448	Combined sources	8
Helixⁱ	459 – 463	Combined sources	5
Helixⁱ	465 – 477	Combined sources	13
Helixⁱ	482 – 484	Combined sources	3
Helixⁱ	488 – 498	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q04771
SMRⁱ	Q04771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q04771

EvolutionaryTraceⁱ

Q04771

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	178 – 207	GSPROSITE-ProRule annotationAdd BLAST		30
Domainⁱ	208 – 502	Protein kinasePROSITE-ProRule annotationAdd BLAST		295

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2052 Eukaryota ENOG410XQT0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000230587
HOVERGENⁱ	HBG054502
InParanoidⁱ	Q04771
KEGG Orthology (KO) More...KOⁱ	K04675
OMAⁱ	GHLCNMN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BIU
PhylomeDBⁱ	Q04771
TreeFamⁱ	TF314724

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR003605 GS_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF00069 Pkinase, 1 hit PF08515 TGF_beta_GS, 1 hit
PRINTSⁱ	PR00653 ACTIVIN2R
SMARTⁱ	View protein in SMART SM00467 GS, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51256 GS, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q04771-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG 
        60         70         80         90        100
QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 
       110        120        130        140        150
RNITAQLPTK GKSFPGTQNF HLEVGLIILS VVFAVCLLAC LLGVALRKFK 
       160        170        180        190        200
RRNQERLNPR DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV 
       210        220        230        240        250
QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR DEKSWFRETE 
       260        270        280        290        300
LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 
       310        320        330        340        350
DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC 
       360        370        380        390        400
CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 
       410        420        430        440        450
RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV 
       460        470        480        490        500
DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN 

SLDKLKTDC

Length:509

Mass (Da):57,153

Last modified:February 1, 1994 - v1

Checksum:ⁱE2B0F051D19DD052

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JHJ7	C9JHJ7_HUMAN	Activin receptor type-1 Activin receptor type-1	ACVR1	87	Annotation score:
F5GY91	F5GY91_HUMAN	Activin receptor type-1 Activin receptor type-1	ACVR1	72	Annotation score:
C9J1R3	C9J1R3_HUMAN	Activin receptor type-1 Activin receptor type-1	ACVR1	71	Annotation score:
A0A1B0GXA9	A0A1B0GXA9_HUMAN	Activin receptor type-1 Activin receptor type-1	ACVR1	86	Annotation score:
C9JW28	C9JW28_HUMAN	Activin receptor type-1 Activin receptor type-1	ACVR1	21	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041392	15	A → G1 PublicationCorresponds to variant dbSNP:rs13406336EnsemblClinVar.	1
Natural variantⁱVAR_041393	41	S → F1 PublicationCorresponds to variant dbSNP:rs55957214Ensembl.	1
Natural variantⁱVAR_041394	47	H → Q1 PublicationCorresponds to variant dbSNP:rs34056189EnsemblClinVar.	1
Natural variantⁱVAR_041395	115	P → S in a melanoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_058418	197 – 198	PF → L in FOP; variant phenotype. 1 Publication	2
Natural variantⁱVAR_058419	202	R → I in FOP; with some atypical features. 1 PublicationCorresponds to variant dbSNP:rs387906591EnsemblClinVar.	1
Natural variantⁱVAR_028444	206	R → H in FOP. 2 PublicationsCorresponds to variant dbSNP:rs121912678EnsemblClinVar.	1
Natural variantⁱVAR_058420	207	Q → E in FOP; with some atypical features. 1 Publication	1
Natural variantⁱVAR_058421	328	G → E in FOP; variant phenotype. 2 PublicationsCorresponds to variant dbSNP:rs387906589EnsemblClinVar.	1
Natural variantⁱVAR_058422	328	G → R in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906588EnsemblClinVar.	1
Natural variantⁱVAR_058423	328	G → W in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906588EnsemblClinVar.	1
Natural variantⁱVAR_058424	356	G → D in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs121912679EnsemblClinVar.	1
Natural variantⁱVAR_058425	375	R → P in FOP; variant phenotype. 1 PublicationCorresponds to variant dbSNP:rs387906590EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L02911 mRNA Translation: AAA36614.1 Z22534 mRNA Translation: CAA80256.1 BC033867 mRNA Translation: AAH33867.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2206.1
PIRⁱ	A45992
NCBI Reference Sequences More...RefSeqⁱ	NP_001096.1, NM_001105.4 NP_001104537.1, NM_001111067.2 NP_001334592.1, NM_001347663.1 NP_001334593.1, NM_001347664.1 NP_001334594.1, NM_001347665.1 NP_001334595.1, NM_001347666.1 NP_001334596.1, NM_001347667.1 XP_006712888.1, XM_006712825.3 XP_011510410.1, XM_011512108.2
UniGeneⁱ	Hs.470316

Genome annotation databases

Ensemblⁱ	ENST00000263640; ENSP00000263640; ENSG00000115170 ENST00000409283; ENSP00000387273; ENSG00000115170 ENST00000410057; ENSP00000387127; ENSG00000115170 ENST00000434821; ENSP00000405004; ENSG00000115170
GeneIDⁱ	90
KEGGⁱ	hsa:90
UCSC genome browser More...UCSCⁱ	uc002tzm.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q04771	Serine/threonine-protein kinase receptor		HUMAN		509	UniRef100_Q04771
Serine/threonine-protein kinase receptor		PONAB		509
Serine/threonine-protein kinase receptor		COLAP		509
Serine/threonine-protein kinase receptor		NOMLE		509
Serine/threonine-protein kinase receptor		GORGO		509
+7

Protein	Similar proteins		Species	Score	Length	Source
Q04771	Activin receptor type-1		BOVIN		509	UniRef90_Q04771
Activin receptor type-1		MOUSE		509
Activin receptor type-1		RAT		509
Serine/threonine-protein kinase receptor		HUMAN		509
Serine/threonine-protein kinase receptor		PONAB		509
+160

Protein	Similar proteins		Species	Score	Length	Source
Q04771	Activin receptor type-1		RAT		509	UniRef50_Q04771
Activin receptor type-1		MOUSE		509
Activin receptor type-1		BOVIN		509
Serine/threonine-protein kinase receptor		HUMAN		509
Serine/threonine-protein kinase receptor		PONAB		509
+220

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L02911 mRNA Translation: AAA36614.1 Z22534 mRNA Translation: CAA80256.1 BC033867 mRNA Translation: AAH33867.1
CCDSⁱ	CCDS2206.1
PIRⁱ	A45992
RefSeqⁱ	NP_001096.1, NM_001105.4 NP_001104537.1, NM_001111067.2 NP_001334592.1, NM_001347663.1 NP_001334593.1, NM_001347664.1 NP_001334594.1, NM_001347665.1 NP_001334595.1, NM_001347666.1 NP_001334596.1, NM_001347667.1 XP_006712888.1, XM_006712825.3 XP_011510410.1, XM_011512108.2
UniGeneⁱ	Hs.470316

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3H9R	X-ray	2.35	A	172-499	[»]
	3MTF	X-ray	2.15	A/B	201-499	[»]
	3OOM	X-ray	2.00	A	201-499	[»]
	3Q4U	X-ray	1.82	A/B/C/D	201-499	[»]
	4BGG	X-ray	2.56	A/B/C/D	201-499	[»]
	4C02	X-ray	2.17	A	172-499	[»]
	4DYM	X-ray	2.42	A	201-499	[»]
	5OXG	X-ray	2.13	A/B/C/D	201-499	[»]
	5OY6	X-ray	2.56	A/B/C/D	201-499	[»]
	6EIX	X-ray	2.30	A	172-509	[»]
	6GI6	X-ray	1.98	A	201-499	[»]
	6GIN	X-ray	2.20	A/B	201-499	[»]
	6GIP	X-ray	2.17	A	201-499	[»]
ProteinModelPortalⁱ	Q04771
SMRⁱ	Q04771
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106605, 72 interactors
DIPⁱ	DIP-212N
IntActⁱ	Q04771, 3 interactors
MINTⁱ	Q04771
STRINGⁱ	9606.ENSP00000263640

Chemistry databases

BindingDBⁱ	Q04771
ChEMBLⁱ	CHEMBL5903
DrugBankⁱ	DB00171 Adenosine triphosphate
GuidetoPHARMACOLOGYⁱ	1785

PTM databases

iPTMnetⁱ	Q04771
PhosphoSitePlusⁱ	Q04771

Polymorphism and mutation databases

BioMutaⁱ	ACVR1
DMDMⁱ	462447

Proteomic databases

EPDⁱ	Q04771
MaxQBⁱ	Q04771
PaxDbⁱ	Q04771
PeptideAtlasⁱ	Q04771
PRIDEⁱ	Q04771
ProteomicsDBⁱ	58283

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	90
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263640; ENSP00000263640; ENSG00000115170 ENST00000409283; ENSP00000387273; ENSG00000115170 ENST00000410057; ENSP00000387127; ENSG00000115170 ENST00000434821; ENSP00000405004; ENSG00000115170
GeneIDⁱ	90
KEGGⁱ	hsa:90
UCSCⁱ	uc002tzm.4 human

Organism-specific databases

CTDⁱ	90
DisGeNETⁱ	90
EuPathDBⁱ	HostDB:ENSG00000115170.13
GeneCardsⁱ	ACVR1
HGNCⁱ	HGNC:171 ACVR1
HPAⁱ	HPA007505 HPA046514
MalaCardsⁱ	ACVR1
MIMⁱ	102576 gene 135100 phenotype
neXtProtⁱ	NX_Q04771
OpenTargetsⁱ	ENSG00000115170
Orphanetⁱ	337 Fibrodysplasia ossificans progressiva
PharmGKBⁱ	PA24492
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2052 Eukaryota ENOG410XQT0 LUCA
GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000230587
HOVERGENⁱ	HBG054502
InParanoidⁱ	Q04771
KOⁱ	K04675
OMAⁱ	GHLCNMN
OrthoDBⁱ	EOG091G0BIU
PhylomeDBⁱ	Q04771
TreeFamⁱ	TF314724

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
SignaLinkⁱ	Q04771
SIGNORⁱ	Q04771

Miscellaneous databases

ChiTaRSⁱ	ACVR1 human
EvolutionaryTraceⁱ	Q04771
GeneWikiⁱ	ACVR1
GenomeRNAiⁱ	90
Protein Ontology More...PROⁱ	PR:Q04771
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000115170 Expressed in 234 organ(s), highest expression level in cartilage tissue
CleanExⁱ	HS_ACVR1
ExpressionAtlasⁱ	Q04771 baseline and differential
Genevisibleⁱ	Q04771 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR003605 GS_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF00069 Pkinase, 1 hit PF08515 TGF_beta_GS, 1 hit
PRINTSⁱ	PR00653 ACTIVIN2R
SMARTⁱ	View protein in SMART SM00467 GS, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51256 GS, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACVR1_HUMAN
Accessionⁱ	Q04771Primary (citable) accession number: Q04771
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	October 10, 2018
	This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q04771 (ACVR1_HUMAN)

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Activin receptor type-1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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GO - Molecular functionⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

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