UniProtKB - Q04759 (KPCT_HUMAN)
Protein kinase C theta type
PRKCQ
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 409 | ATP | 1 | |
Active sitei | 504 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 159 – 209 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 231 – 281 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 51 | |
Nucleotide bindingi | 386 – 394 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium-dependent protein kinase C activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
- protein kinase activity Source: Reactome
- protein serine/threonine kinase activity Source: Reactome
GO - Biological processi
- axon guidance Source: Reactome
- cell chemotaxis Source: UniProtKB
- Fc-epsilon receptor signaling pathway Source: Reactome
- inflammatory response Source: UniProtKB-KW
- intracellular signal transduction Source: GO_Central
- membrane protein ectodomain proteolysis Source: BHF-UCL
- negative regulation of insulin receptor signaling pathway Source: UniProtKB
- negative regulation of T cell apoptotic process Source: UniProtKB
- peptidyl-serine phosphorylation Source: GO_Central
- platelet activation Source: Reactome
- positive regulation of interleukin-17 production Source: UniProtKB
- positive regulation of interleukin-2 production Source: Ensembl
- positive regulation of interleukin-4 production Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of T cell activation Source: UniProtKB
- positive regulation of T cell proliferation Source: Ensembl
- positive regulation of telomerase activity Source: BHF-UCL
- positive regulation of telomere capping Source: BHF-UCL
- positive regulation of telomere maintenance via telomerase Source: BHF-UCL
- positive regulation of T-helper 17 type immune response Source: UniProtKB
- positive regulation of T-helper 2 cell activation Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- regulation of megakaryocyte differentiation Source: Reactome
- regulation of platelet aggregation Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- T cell receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Immunity, Inflammatory response |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | Q04759 |
Reactomei | R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-114508, Effects of PIP2 hydrolysis R-HSA-202424, Downstream TCR signaling R-HSA-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-373752, Netrin-1 signaling R-HSA-418597, G alpha (z) signalling events R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-9648002, RAS processing |
SABIO-RKi | Q04759 |
SignaLinki | Q04759 |
SIGNORi | Q04759 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase C theta type (EC:2.7.11.131 Publication)Alternative name(s): nPKC-theta |
Gene namesi | Name:PRKCQ Synonyms:PRKCT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000065675.14 |
HGNCi | HGNC:9410, PRKCQ |
MIMi | 600448, gene |
neXtProti | NX_Q04759 |
Subcellular locationi
Plasma membrane
Other locations
Note: In resting T-cells, mostly localized in cytoplasm. In response to TCR stimulation, associates with lipid rafts and then localizes in the immunological synapse.
Cytoskeleton
- centriolar satellite Source: HPA
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- immunological synapse Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- aggresome Source: HPA
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 90 | Y → F: Loss of function in T-cells proliferation. No effect on kinase activity. 1 Publication | 1 | |
Mutagenesisi | 148 | A → E: Constitutively active form. 1 Publication | 1 | |
Mutagenesisi | 219 | T → A: Loss of transactivation of the IL2 promoter and translocation to the plasma membrane. No effect on kinase activity. 1 Publication | 1 | |
Mutagenesisi | 409 | K → A or E: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 538 | T → A: Loss of kinase activity. 2 Publications | 1 | |
Mutagenesisi | 676 | S → A: Reduction in kinase activity. 1 Publication | 1 | |
Mutagenesisi | 695 | S → A: Reduction in kinase activity. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 5588 |
MalaCardsi | PRKCQ |
OpenTargetsi | ENSG00000065675 |
PharmGKBi | PA33773 |
Miscellaneous databases
Pharosi | Q04759, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3920 |
DrugBanki | DB04522, Dexfosfoserine DB12010, Fostamatinib DB02482, Phosphonothreonine DB02010, Staurosporine DB00675, Tamoxifen |
DrugCentrali | Q04759 |
GuidetoPHARMACOLOGYi | 1488 |
Polymorphism and mutation databases
BioMutai | PRKCQ |
DMDMi | 20141582 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055708 | 1 – 706 | Protein kinase C theta typeAdd BLAST | 706 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 90 | Phosphotyrosine; by LCK1 Publication | 1 | |
Modified residuei | 219 | Phosphothreonine; by autocatalysis1 Publication | 1 | |
Modified residuei | 348 | PhosphoserineCombined sources | 1 | |
Modified residuei | 538 | Phosphothreonine; by PDPK13 Publications | 1 | |
Modified residuei | 676 | PhosphoserineCombined sources3 Publications | 1 | |
Modified residuei | 685 | PhosphoserineCombined sources | 1 | |
Modified residuei | 695 | PhosphoserineCombined sources4 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q04759 |
jPOSTi | Q04759 |
MassIVEi | Q04759 |
MaxQBi | Q04759 |
PaxDbi | Q04759 |
PeptideAtlasi | Q04759 |
PRIDEi | Q04759 |
ProteomicsDBi | 4008 58279 [Q04759-1] 58280 [Q04759-2] |
PTM databases
CarbonylDBi | Q04759 |
iPTMneti | Q04759 |
PhosphoSitePlusi | Q04759 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000065675, Expressed in vastus lateralis and 190 other tissues |
ExpressionAtlasi | Q04759, baseline and differential |
Genevisiblei | Q04759, HS |
Organism-specific databases
HPAi | ENSG00000065675, Group enriched (blood, lymphoid tissue, skeletal muscle) |
Interactioni
Subunit structurei
Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB (PubMed:16356855).
Interacts with GLRX3 (via N-terminus) (PubMed:10636891).
Interacts with ECT2 (PubMed:15254234).
Interacts with CCDC88A/GIV; the interaction leads to phosphorylation of CCDC88A and inhibition of its guanine nucleotide exchange factor activity (PubMed:23509302).
4 PublicationsBinary interactionsi
Hide detailsQ04759
Protein-protein interaction databases
BioGRIDi | 111574, 32 interactors |
IntActi | Q04759, 23 interactors |
MINTi | Q04759 |
STRINGi | 9606.ENSP00000263125 |
Chemistry databases
BindingDBi | Q04759 |
Miscellaneous databases
RNActi | Q04759, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q04759 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q04759 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 107 | C2PROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 380 – 634 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 255 | |
Domaini | 635 – 706 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 72 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 159 – 209 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 231 – 281 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 51 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0694, Eukaryota |
GeneTreei | ENSGT00940000157638 |
HOGENOMi | CLU_000288_54_4_1 |
InParanoidi | Q04759 |
OMAi | MFHIQNC |
OrthoDBi | 222529at2759 |
PhylomeDBi | Q04759 |
TreeFami | TF102004 |
Family and domain databases
CDDi | cd00029, C1, 2 hits cd05619, STKc_nPKC_theta, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR034668, nPKC_theta IPR002219, PE/DAG-bd IPR027264, PKC_theta IPR017892, Pkinase_C IPR014376, Prot_kin_PKC_delta IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000551, PKC_delta, 1 hit PIRSF501105, Protein_kin_C_theta, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP
60 70 80 90 100
TMYPPWDSTF DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN
110 120 130 140 150
GKTEIWLELK PQGRMLMNAR YFLEMSDTKD MNEFETEGFF ALHQRRGAIK
160 170 180 190 200
QAKVHHVKCH EFTATFFPQP TFCSVCHEFV WGLNKQGYQC RQCNAAIHKK
210 220 230 240 250
CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK SPTFCEHCGT
260 270 280 290 300
LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ
310 320 330 340 350
ARCLRDTEQI FREGPVEIGL PCSIKNEARP PCLPTPGKRE PQGISWESPL
360 370 380 390 400
DEVDKMCHLP EPELNKERPS LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK
410 420 430 440 450
KTNQFFAIKA LKKDVVLMDD DVECTMVEKR VLSLAWEHPF LTHMFCTFQT
460 470 480 490 500
KENLFFVMEY LNGGDLMYHI QSCHKFDLSR ATFYAAEIIL GLQFLHSKGI
510 520 530 540 550
VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC GTPDYIAPEI
560 570 580 590 600
LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR
610 620 630 640 650
WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP
660 670 680 690 700
FRPKVKSPFD CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG
MERLIS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X0I9 | A0A087X0I9_HUMAN | Protein kinase C | PRKCQ | 670 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 700 | G → R in AAA75571 (PubMed:7686153).Curated | 1 | |
Sequence conflicti | 700 | G → R in AAU29340 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042319 | 240 | K → N in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042320 | 306 | D → V1 PublicationCorresponds to variant dbSNP:rs45590231Ensembl. | 1 | |
Natural variantiVAR_020401 | 330 | P → L3 PublicationsCorresponds to variant dbSNP:rs2236379EnsemblClinVar. | 1 | |
Natural variantiVAR_042321 | 354 | D → N1 PublicationCorresponds to variant dbSNP:rs34524148Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054550 | 2 – 126 | Missing in isoform 3. 1 PublicationAdd BLAST | 125 | |
Alternative sequenceiVSP_017294 | 550 – 612 | Missing in isoform 2. 1 PublicationAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01087 mRNA Translation: AAA75571.1 L07032 mRNA Translation: AAA60101.1 AY702977 mRNA Translation: AAU29340.1 AK293935 mRNA Translation: BAG57313.1 AL158043 Genomic DNA No translation available. AL137145 Genomic DNA No translation available. BC101465 mRNA Translation: AAI01466.1 BC113359 mRNA Translation: AAI13360.1 |
CCDSi | CCDS55701.1 [Q04759-2] CCDS60482.1 [Q04759-3] CCDS7079.1 [Q04759-1] |
PIRi | A45416 |
RefSeqi | NP_001229342.1, NM_001242413.2 [Q04759-2] NP_001269573.1, NM_001282644.1 NP_001269574.1, NM_001282645.1 [Q04759-3] NP_001310194.1, NM_001323265.1 [Q04759-1] NP_001310195.1, NM_001323266.1 [Q04759-3] NP_006248.1, NM_006257.4 [Q04759-1] XP_006717528.1, XM_006717465.3 XP_016871899.1, XM_017016410.1 XP_016871900.1, XM_017016411.1 |
Genome annotation databases
Ensembli | ENST00000263125; ENSP00000263125; ENSG00000065675 [Q04759-1] ENST00000397176; ENSP00000380361; ENSG00000065675 [Q04759-2] ENST00000539722; ENSP00000441752; ENSG00000065675 [Q04759-3] |
GeneIDi | 5588 |
KEGGi | hsa:5588 |
UCSCi | uc001ijj.3, human [Q04759-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01087 mRNA Translation: AAA75571.1 L07032 mRNA Translation: AAA60101.1 AY702977 mRNA Translation: AAU29340.1 AK293935 mRNA Translation: BAG57313.1 AL158043 Genomic DNA No translation available. AL137145 Genomic DNA No translation available. BC101465 mRNA Translation: AAI01466.1 BC113359 mRNA Translation: AAI13360.1 |
CCDSi | CCDS55701.1 [Q04759-2] CCDS60482.1 [Q04759-3] CCDS7079.1 [Q04759-1] |
PIRi | A45416 |
RefSeqi | NP_001229342.1, NM_001242413.2 [Q04759-2] NP_001269573.1, NM_001282644.1 NP_001269574.1, NM_001282645.1 [Q04759-3] NP_001310194.1, NM_001323265.1 [Q04759-1] NP_001310195.1, NM_001323266.1 [Q04759-3] NP_006248.1, NM_006257.4 [Q04759-1] XP_006717528.1, XM_006717465.3 XP_016871899.1, XM_017016410.1 XP_016871900.1, XM_017016411.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XJD | X-ray | 2.00 | A | 362-706 | [»] | |
2ENJ | NMR | - | A | 1-125 | [»] | |
2ENN | NMR | - | A | 144-213 | [»] | |
2ENZ | NMR | - | A | 227-284 | [»] | |
2JED | X-ray | 2.32 | A/B | 361-706 | [»] | |
4Q9Z | X-ray | 2.60 | A/B | 374-706 | [»] | |
4RA5 | X-ray | 2.61 | A/B | 374-706 | [»] | |
5F9E | X-ray | 2.00 | A/B | 361-706 | [»] | |
SMRi | Q04759 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111574, 32 interactors |
IntActi | Q04759, 23 interactors |
MINTi | Q04759 |
STRINGi | 9606.ENSP00000263125 |
Chemistry databases
BindingDBi | Q04759 |
ChEMBLi | CHEMBL3920 |
DrugBanki | DB04522, Dexfosfoserine DB12010, Fostamatinib DB02482, Phosphonothreonine DB02010, Staurosporine DB00675, Tamoxifen |
DrugCentrali | Q04759 |
GuidetoPHARMACOLOGYi | 1488 |
PTM databases
CarbonylDBi | Q04759 |
iPTMneti | Q04759 |
PhosphoSitePlusi | Q04759 |
Polymorphism and mutation databases
BioMutai | PRKCQ |
DMDMi | 20141582 |
Proteomic databases
EPDi | Q04759 |
jPOSTi | Q04759 |
MassIVEi | Q04759 |
MaxQBi | Q04759 |
PaxDbi | Q04759 |
PeptideAtlasi | Q04759 |
PRIDEi | Q04759 |
ProteomicsDBi | 4008 58279 [Q04759-1] 58280 [Q04759-2] |
Protocols and materials databases
Antibodypediai | 10940, 802 antibodies |
DNASUi | 5588 |
Genome annotation databases
Ensembli | ENST00000263125; ENSP00000263125; ENSG00000065675 [Q04759-1] ENST00000397176; ENSP00000380361; ENSG00000065675 [Q04759-2] ENST00000539722; ENSP00000441752; ENSG00000065675 [Q04759-3] |
GeneIDi | 5588 |
KEGGi | hsa:5588 |
UCSCi | uc001ijj.3, human [Q04759-1] |
Organism-specific databases
CTDi | 5588 |
DisGeNETi | 5588 |
EuPathDBi | HostDB:ENSG00000065675.14 |
GeneCardsi | PRKCQ |
HGNCi | HGNC:9410, PRKCQ |
HPAi | ENSG00000065675, Group enriched (blood, lymphoid tissue, skeletal muscle) |
MalaCardsi | PRKCQ |
MIMi | 600448, gene |
neXtProti | NX_Q04759 |
OpenTargetsi | ENSG00000065675 |
PharmGKBi | PA33773 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0694, Eukaryota |
GeneTreei | ENSGT00940000157638 |
HOGENOMi | CLU_000288_54_4_1 |
InParanoidi | Q04759 |
OMAi | MFHIQNC |
OrthoDBi | 222529at2759 |
PhylomeDBi | Q04759 |
TreeFami | TF102004 |
Enzyme and pathway databases
BRENDAi | 2.7.11.13, 2681 |
PathwayCommonsi | Q04759 |
Reactomei | R-HSA-111465, Apoptotic cleavage of cellular proteins R-HSA-114508, Effects of PIP2 hydrolysis R-HSA-202424, Downstream TCR signaling R-HSA-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-373752, Netrin-1 signaling R-HSA-418597, G alpha (z) signalling events R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-9648002, RAS processing |
SABIO-RKi | Q04759 |
SignaLinki | Q04759 |
SIGNORi | Q04759 |
Miscellaneous databases
BioGRID-ORCSi | 5588, 6 hits in 873 CRISPR screens |
ChiTaRSi | PRKCQ, human |
EvolutionaryTracei | Q04759 |
GeneWikii | PRKCQ |
GenomeRNAii | 5588 |
Pharosi | Q04759, Tchem |
PROi | PR:Q04759 |
RNActi | Q04759, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000065675, Expressed in vastus lateralis and 190 other tissues |
ExpressionAtlasi | Q04759, baseline and differential |
Genevisiblei | Q04759, HS |
Family and domain databases
CDDi | cd00029, C1, 2 hits cd05619, STKc_nPKC_theta, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR035892, C2_domain_sf IPR020454, DAG/PE-bd IPR011009, Kinase-like_dom_sf IPR034668, nPKC_theta IPR002219, PE/DAG-bd IPR027264, PKC_theta IPR017892, Pkinase_C IPR014376, Prot_kin_PKC_delta IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000551, PKC_delta, 1 hit PIRSF501105, Protein_kin_C_theta, 1 hit |
PRINTSi | PR00008, DAGPEDOMAIN |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50004, C2, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KPCT_HUMAN | |
Accessioni | Q04759Primary (citable) accession number: Q04759 Secondary accession number(s): B4DF52 Q9H549 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | March 27, 2002 | |
Last modified: | December 2, 2020 | |
This is version 223 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index