PRKCQ

Functionⁱ

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in 'outside-in' signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at 'Ser-504' and 'Ser-532' and negatively regulates its ability to phosphorylate PKB/AKT1.8 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺

Activity regulationⁱ

Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-538 (activation loop of the kinase domain), Ser-676 (turn motif) and Ser-695 (hydrophobic region), need to be phosphorylated for its full activation.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	409	ATP		1
Active siteⁱ	504	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	159 – 209	Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST	51
Zinc fingerⁱ	231 – 281	Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST	51
Nucleotide bindingⁱ	386 – 394	ATPPROSITE-ProRule annotation	9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
protein kinase activity Source: Reactome
protein kinase C activity Source: UniProtKB-EC
protein serine/threonine kinase activity
Source: Reactome
Inferred from experimentⁱ
- 16356856

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance Source: Reactome
cell chemotaxis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24008408
Fc-epsilon receptor signaling pathway Source: Reactome
inflammatory response Source: UniProtKB-KW
intracellular signal transduction Source: GO_Central
membrane protein ectodomain proteolysis Source: BHF-UCL
negative regulation of insulin receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15364919
negative regulation of T cell apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11342610
- 16709830
peptidyl-serine phosphorylation Source: GO_Central
platelet activation Source: Reactome
positive regulation of interleukin-17 production Source: UniProtKB
positive regulation of interleukin-2 biosynthetic process Source: Ensembl
positive regulation of interleukin-4 production Source: UniProtKB
positive regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16356855
positive regulation of T cell activation Source: UniProtKB
positive regulation of T cell proliferation Source: Ensembl
positive regulation of telomerase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
positive regulation of telomere capping
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
positive regulation of telomere maintenance via telomerase
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
positive regulation of T-helper 17 type immune response Source: UniProtKB
positive regulation of T-helper 2 cell activation Source: UniProtKB
regulation of cell growth
Source: UniProtKB
Non-traceable author statementⁱ
- 8444877
regulation of megakaryocyte differentiation Source: Reactome
regulation of platelet aggregation Source: UniProtKB
regulation of transcription, DNA-templated Source: UniProtKB
T cell receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Immunity, Inflammatory response
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	2.7.11.13 2681
Reactomeⁱ	R-HSA-111465 Apoptotic cleavage of cellular proteins R-HSA-114508 Effects of PIP2 hydrolysis R-HSA-202424 Downstream TCR signaling R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-373752 Netrin-1 signaling R-HSA-418597 G alpha (z) signalling events R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
SABIO-RKⁱ	Q04759
SignaLinkⁱ	Q04759
SIGNORⁱ	Q04759

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein kinase C theta type (EC:2.7.11.13) Alternative name(s): nPKC-theta
Gene namesⁱ	Name:PRKCQ Synonyms:PRKCT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000065675.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9410 PRKCQ
MIMⁱ	600448 gene
neXtProtⁱ	NX_Q04759

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	90	Y → F: Loss of function in T-cells proliferation. No effect on kinase activity. 1 Publication	1
Mutagenesisⁱ	148	A → E: Constitutively active form. 1 Publication	1
Mutagenesisⁱ	219	T → A: Loss of transactivation of the IL2 promoter and translocation to the plasma membrane. No effect on kinase activity. 1 Publication	1
Mutagenesisⁱ	409	K → A or E: Loss of kinase activity. 1 Publication	1
Mutagenesisⁱ	538	T → A: Loss of kinase activity. 2 Publications	1
Mutagenesisⁱ	676	S → A: Reduction in kinase activity. 1 Publication	1
Mutagenesisⁱ	695	S → A: Reduction in kinase activity. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5588
Open Targets More...OpenTargetsⁱ	ENSG00000065675
PharmGKBⁱ	PA33773

Chemistry databases

ChEMBLⁱ	CHEMBL3920
Drug and drug target database More...DrugBankⁱ	DB04522 Phosphonoserine DB02482 Phosphonothreonine DB02010 Staurosporine DB00675 Tamoxifen
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1488

Polymorphism and mutation databases

BioMutaⁱ	PRKCQ
DMDMⁱ	20141582

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000055708	1 – 706	Protein kinase C theta typeAdd BLAST		706

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	90	Phosphotyrosine; by LCK1 Publication	1
Modified residueⁱ	219	Phosphothreonine; by autocatalysis1 Publication	1
Modified residueⁱ	348	PhosphoserineCombined sources	1
Modified residueⁱ	538	Phosphothreonine; by PDPK13 Publications	1
Modified residueⁱ	676	PhosphoserineCombined sources3 Publications	1
Modified residueⁱ	685	PhosphoserineCombined sources	1
Modified residueⁱ	695	PhosphoserineCombined sources4 Publications	1

Post-translational modificationⁱ

Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PRKCQ upon antigen receptor ligation. Following TCR stimulation, phosphorylated at Tyr-90 and Ser-685.5 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q04759
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04759
PaxDbⁱ	Q04759
PeptideAtlas More...PeptideAtlasⁱ	Q04759
PRIDEⁱ	Q04759
ProteomicsDBⁱ	58279 58280 [Q04759-2]

PTM databases

CarbonylDBⁱ	Q04759
iPTMnetⁱ	Q04759
PhosphoSitePlusⁱ	Q04759

Miscellaneous databases

PMAP-CutDBⁱ	Q04759

PMAP-CutDBⁱ

Q04759

Expressionⁱ

Tissue specificityⁱ

Expressed in skeletal muscle, T-cells, megakaryoblastic cells and platelets.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000065675 Expressed in 173 organ(s), highest expression level in vastus lateralis
CleanExⁱ	HS_PRKCQ
ExpressionAtlasⁱ	Q04759 baseline and differential
Genevisibleⁱ	Q04759 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA065279 HPA073098

HPAⁱ

HPA065279
HPA073098

Interactionⁱ

Subunit structureⁱ

Interacts with GLRX3 (via N-terminus). Interacts with ECT2. Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BTK	Q06187	2	EBI-374762,EBI-624835
FYN	P06241	7	EBI-374762,EBI-515315
GLRX3	O76003	5	EBI-374762,EBI-374781
HSF1	Q00613	2	EBI-374762,EBI-719620
Irs1	P35570	2	EBI-374762,EBI-520230	From Rattus norvegicus.
LCK	P06239	2	EBI-374762,EBI-1348
MAP4K3	Q8IVH8	4	EBI-374762,EBI-1758170
PRKCZ	Q05513	3	EBI-374762,EBI-295351

Protein-protein interaction databases

BioGridⁱ	111574, 31 interactors
IntActⁱ	Q04759, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q04759
STRINGⁱ	9606.ENSP00000263125

Chemistry databases

BindingDBⁱ

Q04759

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	5 – 13	Combined sources	9
Beta strandⁱ	28 – 39	Combined sources	12
Beta strandⁱ	42 – 52	Combined sources	11
Beta strandⁱ	56 – 62	Combined sources	7
Beta strandⁱ	69 – 75	Combined sources	7
Beta strandⁱ	83 – 89	Combined sources	7
Helixⁱ	90 – 98	Combined sources	9
Turnⁱ	99 – 101	Combined sources	3
Beta strandⁱ	103 – 108	Combined sources	6
Beta strandⁱ	110 – 112	Combined sources	3
Beta strandⁱ	114 – 121	Combined sources	8
Beta strandⁱ	155 – 159	Combined sources	5
Beta strandⁱ	161 – 165	Combined sources	5
Beta strandⁱ	174 – 176	Combined sources	3
Beta strandⁱ	187 – 189	Combined sources	3
Beta strandⁱ	191 – 193	Combined sources	3
Beta strandⁱ	196 – 199	Combined sources	4
Helixⁱ	200 – 202	Combined sources	3
Beta strandⁱ	234 – 236	Combined sources	3
Beta strandⁱ	246 – 248	Combined sources	3
Beta strandⁱ	255 – 257	Combined sources	3
Beta strandⁱ	259 – 265	Combined sources	7
Turnⁱ	271 – 276	Combined sources	6
Turnⁱ	281 – 283	Combined sources	3
Helixⁱ	377 – 379	Combined sources	3
Beta strandⁱ	380 – 388	Combined sources	9
Beta strandⁱ	390 – 399	Combined sources	10
Turnⁱ	400 – 402	Combined sources	3
Beta strandⁱ	405 – 412	Combined sources	8
Helixⁱ	413 – 418	Combined sources	6
Helixⁱ	422 – 435	Combined sources	14
Beta strandⁱ	444 – 449	Combined sources	6
Beta strandⁱ	451 – 459	Combined sources	9
Beta strandⁱ	463 – 465	Combined sources	3
Helixⁱ	466 – 473	Combined sources	8
Helixⁱ	478 – 497	Combined sources	20
Helixⁱ	507 – 509	Combined sources	3
Beta strandⁱ	510 – 512	Combined sources	3
Beta strandⁱ	518 – 520	Combined sources	3
Helixⁱ	543 – 545	Combined sources	3
Helixⁱ	548 – 551	Combined sources	4
Helixⁱ	559 – 574	Combined sources	16
Helixⁱ	584 – 593	Combined sources	10
Helixⁱ	604 – 613	Combined sources	10
Helixⁱ	618 – 620	Combined sources	3
Helixⁱ	628 – 630	Combined sources	3
Helixⁱ	632 – 634	Combined sources	3
Helixⁱ	639 – 643	Combined sources	5
Helixⁱ	666 – 669	Combined sources	4
Helixⁱ	680 – 685	Combined sources	6
Turnⁱ	690 – 693	Combined sources	4
Helixⁱ	699 – 706	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q04759
SMRⁱ	Q04759
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q04759

EvolutionaryTraceⁱ

Q04759

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	8 – 123	C2Add BLAST	116
Domainⁱ	380 – 634	Protein kinasePROSITE-ProRule annotationAdd BLAST	255
Domainⁱ	635 – 706	AGC-kinase C-terminalAdd BLAST	72

Domainⁱ

The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	159 – 209	Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST		51
Zinc fingerⁱ	231 – 281	Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST		51

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0694 Eukaryota ENOG410XNPH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148938
HOGENOMⁱ	HOG000233022
HOVERGENⁱ	HBG108317
InParanoidⁱ	Q04759
KEGG Orthology (KO) More...KOⁱ	K18052
OMAⁱ	EPQGISW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QRS
PhylomeDBⁱ	Q04759
TreeFamⁱ	TF102004

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029 C1, 2 hits cd05619 STKc_nPKC_theta, 1 hit
Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR035892 C2_domain_sf IPR020454 DAG/PE-bd IPR011009 Kinase-like_dom_sf IPR034668 nPKC_theta IPR002219 PE/DAG-bd IPR027264 PKC_theta IPR017892 Pkinase_C IPR014376 Prot_kin_PKC_delta IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00130 C1_1, 2 hits PF00069 Pkinase, 1 hit PF00433 Pkinase_C, 1 hit
PIRSFⁱ	PIRSF000551 PKC_delta, 1 hit PIRSF501105 Protein_kin_C_theta, 1 hit
PRINTSⁱ	PR00008 DAGPEDOMAIN
SMARTⁱ	View protein in SMART SM00109 C1, 2 hits SM00133 S_TK_X, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS00479 ZF_DAG_PE_1, 2 hits PS50081 ZF_DAG_PE_2, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q04759-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP 
        60         70         80         90        100
TMYPPWDSTF DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN 
       110        120        130        140        150
GKTEIWLELK PQGRMLMNAR YFLEMSDTKD MNEFETEGFF ALHQRRGAIK 
       160        170        180        190        200
QAKVHHVKCH EFTATFFPQP TFCSVCHEFV WGLNKQGYQC RQCNAAIHKK 
       210        220        230        240        250
CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK SPTFCEHCGT 
       260        270        280        290        300
LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 
       310        320        330        340        350
ARCLRDTEQI FREGPVEIGL PCSIKNEARP PCLPTPGKRE PQGISWESPL 
       360        370        380        390        400
DEVDKMCHLP EPELNKERPS LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK 
       410        420        430        440        450
KTNQFFAIKA LKKDVVLMDD DVECTMVEKR VLSLAWEHPF LTHMFCTFQT 
       460        470        480        490        500
KENLFFVMEY LNGGDLMYHI QSCHKFDLSR ATFYAAEIIL GLQFLHSKGI 
       510        520        530        540        550
VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC GTPDYIAPEI 
       560        570        580        590        600
LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 
       610        620        630        640        650
WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP 
       660        670        680        690        700
FRPKVKSPFD CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG 

MERLIS

Length:706

Mass (Da):81,865

Last modified:March 27, 2002 - v3

Checksum:ⁱB3C53AB892D5210A

GO

Isoform 2 (identifier: Q04759-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
550-612: Missing.

« Hide

        10         20         30         40         50
MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP 
        60         70         80         90        100
TMYPPWDSTF DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN 
       110        120        130        140        150
GKTEIWLELK PQGRMLMNAR YFLEMSDTKD MNEFETEGFF ALHQRRGAIK 
       160        170        180        190        200
QAKVHHVKCH EFTATFFPQP TFCSVCHEFV WGLNKQGYQC RQCNAAIHKK 
       210        220        230        240        250
CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK SPTFCEHCGT 
       260        270        280        290        300
LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 
       310        320        330        340        350
ARCLRDTEQI FREGPVEIGL PCSIKNEARP PCLPTPGKRE PQGISWESPL 
       360        370        380        390        400
DEVDKMCHLP EPELNKERPS LQIKLKIEDF ILHKMLGKGS FGKVFLAEFK 
       410        420        430        440        450
KTNQFFAIKA LKKDVVLMDD DVECTMVEKR VLSLAWEHPF LTHMFCTFQT 
       460        470        480        490        500
KENLFFVMEY LNGGDLMYHI QSCHKFDLSR ATFYAAEIIL GLQFLHSKGI 
       510        520        530        540        550
VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC GTPDYIAPEL 
       560        570        580        590        600
FVREPEKRLG VRGDIRQHPL FREINWEELE RKEIDPPFRP KVKSPFDCSN 
       610        620        630        640 
FDKEFLNEKP RLSFADRALI NSMDQNMFRN FSFMNPGMER LIS

Show »

Length:643

Mass (Da):74,287

Checksum:ⁱA3B688EBE8809B9E

GO

Isoform 3 (identifier: Q04759-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2-126: Missing.

« Hide

        10         20         30         40         50
MDTKDMNEFE TEGFFALHQR RGAIKQAKVH HVKCHEFTAT FFPQPTFCSV 
        60         70         80         90        100
CHEFVWGLNK QGYQCRQCNA AIHKKCIDKV IAKCTGSAIN SRETMFHKER 
       110        120        130        140        150
FKIDMPHRFK VYNYKSPTFC EHCGTLLWGL ARQGLKCDAC GMNVHHRCQT 
       160        170        180        190        200
KVANLCGINQ KLMAEALAMI ESTQQARCLR DTEQIFREGP VEIGLPCSIK 
       210        220        230        240        250
NEARPPCLPT PGKREPQGIS WESPLDEVDK MCHLPEPELN KERPSLQIKL 
       260        270        280        290        300
KIEDFILHKM LGKGSFGKVF LAEFKKTNQF FAIKALKKDV VLMDDDVECT 
       310        320        330        340        350
MVEKRVLSLA WEHPFLTHMF CTFQTKENLF FVMEYLNGGD LMYHIQSCHK 
       360        370        380        390        400
FDLSRATFYA AEIILGLQFL HSKGIVYRDL KLDNILLDKD GHIKIADFGM 
       410        420        430        440        450
CKENMLGDAK TNTFCGTPDY IAPEILLGQK YNHSVDWWSF GVLLYEMLIG 
       460        470        480        490        500
QSPFHGQDEE ELFHSIRMDN PFYPRWLEKE AKDLLVKLFV REPEKRLGVR 
       510        520        530        540        550
GDIRQHPLFR EINWEELERK EIDPPFRPKV KSPFDCSNFD KEFLNEKPRL 
       560        570        580 
SFADRALINS MDQNMFRNFS FMNPGMERLI S

Note: No experimental confirmation available.

Show »

Length:581

Mass (Da):67,560

Checksum:ⁱABB524BD5B3E2898

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087X0I9	A0A087X0I9_HUMAN		Protein kinase C Protein kinase C, EC 2.7.11.13	PRKCQ	670	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	700	G → R in AAA75571 (PubMed:7686153).Curated		1
Sequence conflictⁱ	700	G → R in AAU29340 (Ref. 4) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_042319	240	K → N in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_042320	306	D → V1 PublicationCorresponds to variant dbSNP:rs45590231Ensembl.	1
Natural variantⁱVAR_020401	330	P → L3 PublicationsCorresponds to variant dbSNP:rs2236379Ensembl.	1
Natural variantⁱVAR_042321	354	D → N1 PublicationCorresponds to variant dbSNP:rs34524148Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054550	2 – 126	Missing in isoform 3. 1 PublicationAdd BLAST		125
Alternative sequenceⁱVSP_017294	550 – 612	Missing in isoform 2. 1 PublicationAdd BLAST		63

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L01087 mRNA Translation: AAA75571.1 L07032 mRNA Translation: AAA60101.1 AY702977 mRNA Translation: AAU29340.1 AK293935 mRNA Translation: BAG57313.1 AL158043 Genomic DNA No translation available. AL137145 Genomic DNA No translation available. BC101465 mRNA Translation: AAI01466.1 BC113359 mRNA Translation: AAI13360.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55701.1 [Q04759-2] CCDS60482.1 [Q04759-3] CCDS7079.1 [Q04759-1]
PIRⁱ	A45416
NCBI Reference Sequences More...RefSeqⁱ	NP_001229342.1, NM_001242413.2 [Q04759-2] NP_001269573.1, NM_001282644.1 NP_001269574.1, NM_001282645.1 [Q04759-3] NP_001310194.1, NM_001323265.1 [Q04759-1] NP_001310195.1, NM_001323266.1 [Q04759-3] NP_006248.1, NM_006257.4 [Q04759-1] XP_006717528.1, XM_006717465.3 XP_016871899.1, XM_017016410.1 XP_016871900.1, XM_017016411.1
UniGeneⁱ	Hs.498570

Genome annotation databases

Ensemblⁱ	ENST00000263125; ENSP00000263125; ENSG00000065675 [Q04759-1] ENST00000397176; ENSP00000380361; ENSG00000065675 [Q04759-2] ENST00000539722; ENSP00000441752; ENSG00000065675 [Q04759-3]
GeneIDⁱ	5588
KEGGⁱ	hsa:5588
UCSC genome browser More...UCSCⁱ	uc001ijj.3 human [Q04759-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q04759	Protein kinase C theta type	)	MOUSE		707	UniRef90_Q04759
Protein kinase C theta type		RAT		707
Protein kinase C		PANTR		845
Protein kinase C		PANPA		758
Protein kinase C		GORGO		706
+150
Q04759-2	Protein kinase C		PIG		665	UniRef90_Q04759-2
Protein kinase C		ERIEU		644
Protein kinase C		MACMU		643
Protein kinase C		MANLE		643
Protein kinase C		TARSY		643
+38
Q04759-3	Protein kinase C		LEPWE		591	UniRef90_Q04759-3
Protein kinase C		ODORO		591
Protein kinase C		TARSY		591
Protein kinase C		FELCA		581
Protein kinase C		PANTR		581
+34

Protein	Similar proteins		Species	Score	Length	Source
Q04759	Isoform 2 of Protein kinase C delta type		HUMAN		707	UniRef50_Q05655-2
Protein kinase C theta type	)	MOUSE		707
Protein kinase C theta type		RAT		707
Protein kinase C		SAIBB		720
Protein kinase C		HETGA		706
+553

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L01087 mRNA Translation: AAA75571.1 L07032 mRNA Translation: AAA60101.1 AY702977 mRNA Translation: AAU29340.1 AK293935 mRNA Translation: BAG57313.1 AL158043 Genomic DNA No translation available. AL137145 Genomic DNA No translation available. BC101465 mRNA Translation: AAI01466.1 BC113359 mRNA Translation: AAI13360.1
CCDSⁱ	CCDS55701.1 [Q04759-2] CCDS60482.1 [Q04759-3] CCDS7079.1 [Q04759-1]
PIRⁱ	A45416
RefSeqⁱ	NP_001229342.1, NM_001242413.2 [Q04759-2] NP_001269573.1, NM_001282644.1 NP_001269574.1, NM_001282645.1 [Q04759-3] NP_001310194.1, NM_001323265.1 [Q04759-1] NP_001310195.1, NM_001323266.1 [Q04759-3] NP_006248.1, NM_006257.4 [Q04759-1] XP_006717528.1, XM_006717465.3 XP_016871899.1, XM_017016410.1 XP_016871900.1, XM_017016411.1
UniGeneⁱ	Hs.498570

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1XJD	X-ray	2.00	A	362-706	[»]
	2ENJ	NMR	-	A	1-125	[»]
	2ENN	NMR	-	A	144-213	[»]
	2ENZ	NMR	-	A	227-284	[»]
	2JED	X-ray	2.32	A/B	361-706	[»]
	4Q9Z	X-ray	2.60	A/B	374-706	[»]
	4RA5	X-ray	2.61	A/B	374-706	[»]
	5F9E	X-ray	2.00	A/B	361-706	[»]
ProteinModelPortalⁱ	Q04759
SMRⁱ	Q04759
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111574, 31 interactors
IntActⁱ	Q04759, 19 interactors
MINTⁱ	Q04759
STRINGⁱ	9606.ENSP00000263125

Chemistry databases

BindingDBⁱ	Q04759
ChEMBLⁱ	CHEMBL3920
DrugBankⁱ	DB04522 Phosphonoserine DB02482 Phosphonothreonine DB02010 Staurosporine DB00675 Tamoxifen
GuidetoPHARMACOLOGYⁱ	1488

PTM databases

CarbonylDBⁱ	Q04759
iPTMnetⁱ	Q04759
PhosphoSitePlusⁱ	Q04759

Polymorphism and mutation databases

BioMutaⁱ	PRKCQ
DMDMⁱ	20141582

Proteomic databases

EPDⁱ	Q04759
MaxQBⁱ	Q04759
PaxDbⁱ	Q04759
PeptideAtlasⁱ	Q04759
PRIDEⁱ	Q04759
ProteomicsDBⁱ	58279 58280 [Q04759-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5588
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263125; ENSP00000263125; ENSG00000065675 [Q04759-1] ENST00000397176; ENSP00000380361; ENSG00000065675 [Q04759-2] ENST00000539722; ENSP00000441752; ENSG00000065675 [Q04759-3]
GeneIDⁱ	5588
KEGGⁱ	hsa:5588
UCSCⁱ	uc001ijj.3 human [Q04759-1]

Organism-specific databases

CTDⁱ	5588
DisGeNETⁱ	5588
EuPathDBⁱ	HostDB:ENSG00000065675.14
GeneCardsⁱ	PRKCQ
HGNCⁱ	HGNC:9410 PRKCQ
HPAⁱ	HPA065279 HPA073098
MIMⁱ	600448 gene
neXtProtⁱ	NX_Q04759
OpenTargetsⁱ	ENSG00000065675
PharmGKBⁱ	PA33773
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0694 Eukaryota ENOG410XNPH LUCA
GeneTreeⁱ	ENSGT00920000148938
HOGENOMⁱ	HOG000233022
HOVERGENⁱ	HBG108317
InParanoidⁱ	Q04759
KOⁱ	K18052
OMAⁱ	EPQGISW
OrthoDBⁱ	EOG091G0QRS
PhylomeDBⁱ	Q04759
TreeFamⁱ	TF102004

Enzyme and pathway databases

BRENDAⁱ	2.7.11.13 2681
Reactomeⁱ	R-HSA-111465 Apoptotic cleavage of cellular proteins R-HSA-114508 Effects of PIP2 hydrolysis R-HSA-202424 Downstream TCR signaling R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-373752 Netrin-1 signaling R-HSA-418597 G alpha (z) signalling events R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
SABIO-RKⁱ	Q04759
SignaLinkⁱ	Q04759
SIGNORⁱ	Q04759

Miscellaneous databases

ChiTaRSⁱ	PRKCQ human
EvolutionaryTraceⁱ	Q04759
GeneWikiⁱ	PRKCQ
GenomeRNAiⁱ	5588
PMAP-CutDBⁱ	Q04759
Protein Ontology More...PROⁱ	PR:Q04759
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000065675 Expressed in 173 organ(s), highest expression level in vastus lateralis
CleanExⁱ	HS_PRKCQ
ExpressionAtlasⁱ	Q04759 baseline and differential
Genevisibleⁱ	Q04759 HS

Family and domain databases

CDDⁱ	cd00029 C1, 2 hits cd05619 STKc_nPKC_theta, 1 hit
Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR035892 C2_domain_sf IPR020454 DAG/PE-bd IPR011009 Kinase-like_dom_sf IPR034668 nPKC_theta IPR002219 PE/DAG-bd IPR027264 PKC_theta IPR017892 Pkinase_C IPR014376 Prot_kin_PKC_delta IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00130 C1_1, 2 hits PF00069 Pkinase, 1 hit PF00433 Pkinase_C, 1 hit
PIRSFⁱ	PIRSF000551 PKC_delta, 1 hit PIRSF501105 Protein_kin_C_theta, 1 hit
PRINTSⁱ	PR00008 DAGPEDOMAIN
SMARTⁱ	View protein in SMART SM00109 C1, 2 hits SM00133 S_TK_X, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS00479 ZF_DAG_PE_1, 2 hits PS50081 ZF_DAG_PE_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KPCT_HUMAN
Accessionⁱ	Q04759Primary (citable) accession number: Q04759 Secondary accession number(s): B4DF52 , Q14DH6, Q3MJF1, Q64FY5, Q9H508, Q9H549
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	March 27, 2002
	Last modified:	October 10, 2018
	This is version 207 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q04759 (KPCT_HUMAN)

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Protein kinase C theta type

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

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Experimental Info

Natural variant

Alternative sequence

Sequence databases

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Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Chemistry databases

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Polymorphism and mutation databases

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Protocols and materials databases

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Enzyme and pathway databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ