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Protein

cAMP-dependent protein kinase inhibitor beta

Gene

Pkib

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37Important for inhibitionBy similarity1
Sitei40Important for inhibitionBy similarity1
Sitei41Important for inhibitionBy similarity1

GO - Molecular functioni

  • cAMP-dependent protein kinase inhibitor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor beta
Alternative name(s):
PKI-beta
cAMP-dependent protein kinase inhibitor, testis isoform
Gene namesi
Name:Pkib
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:101937 Pkib

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545391 – 92cAMP-dependent protein kinase inhibitor betaAdd BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ04758
PaxDbiQ04758
PeptideAtlasiQ04758
PRIDEiQ04758

PTM databases

PhosphoSitePlusiQ04758

Structurei

3D structure databases

SMRiQ04758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiENOG410JF7B Eukaryota
ENOG410Y067 LUCA
HOGENOMiHOG000059641
HOVERGENiHBG003541
InParanoidiQ04758
PhylomeDBiQ04758

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q04758-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGGTSPEAQ QDSVMRTDSS EMTDVESVIT SFASSARAGR RNALPDIQSS
60 70 80 90
LATSGSSDLP LKLEALAVKE DAKTKNEEKD QGQPKTPLNE GK
Length:92
Mass (Da):9,682
Last modified:October 1, 1993 - v1
Checksum:iF0D537A4AED29956
GO
Isoform 1 (identifier: Q04758-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.

Show »
Length:71
Mass (Da):7,529
Checksum:iCDE35771343C4158
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TZU5Q3TZU5_MOUSE
cAMP-dependent protein kinase inhib...
Pkib mCG_10843
78Annotation score:
F7D7A9F7D7A9_MOUSE
cAMP-dependent protein kinase inhib...
Pkib
110Annotation score:
H3BLG2H3BLG2_MOUSE
cAMP-dependent protein kinase inhib...
Pkib
24Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0027541 – 21Missing in isoform 1. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02241 mRNA Translation: AAB59678.1
PIRiB46707
UniGeneiMm.262135

Genome annotation databases

UCSCiuc007fcq.2 mouse [Q04758-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02241 mRNA Translation: AAB59678.1
PIRiB46707
UniGeneiMm.262135

3D structure databases

SMRiQ04758
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ04758

Proteomic databases

MaxQBiQ04758
PaxDbiQ04758
PeptideAtlasiQ04758
PRIDEiQ04758

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007fcq.2 mouse [Q04758-1]

Organism-specific databases

MGIiMGI:101937 Pkib

Phylogenomic databases

eggNOGiENOG410JF7B Eukaryota
ENOG410Y067 LUCA
HOGENOMiHOG000059641
HOVERGENiHBG003541
InParanoidiQ04758
PhylomeDBiQ04758

Miscellaneous databases

ChiTaRSiPkib mouse
PROiPR:Q04758
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPKB_MOUSE
AccessioniPrimary (citable) accession number: Q04758
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 22, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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