UniProtKB - Q04751 (NAA40_YEAST)
Protein
N-alpha-acetyltransferase 40
Gene
NAT4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A.1 Publication
Catalytic activityi
- acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H+ + N-terminal Nα-acetyl-L-seryl-[histone H4]1 PublicationEC:2.3.1.2571 Publication
- acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H+ + N-terminal Nα-acetyl-L-seryl-[histone H2A]1 PublicationEC:2.3.1.2571 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | SubstrateBy similarity | 1 | |
Binding sitei | 185 | SubstrateBy similarity | 1 | |
Sitei | 186 | Essential for catalytic activityBy similarity | 1 | |
Binding sitei | 228 | SubstrateBy similarity | 1 | |
Binding sitei | 233 | Acetyl-CoABy similarity | 1 |
GO - Molecular functioni
- H2A histone acetyltransferase activity Source: GO_Central
- H4 histone acetyltransferase activity Source: GO_Central
- histone acetyltransferase activity Source: SGD
- peptide-serine-N-acetyltransferase activity Source: GO_Central
GO - Biological processi
- histone acetylation Source: SGD
- N-terminal protein amino acid acetylation Source: GO_Central
- regulation of ribosomal DNA heterochromatin assembly Source: SGD
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | YEAST:G3O-32771-MONOMER |
BRENDAi | 2.3.1.48, 984 |
Names & Taxonomyi
Protein namesi | Recommended name: N-alpha-acetyltransferase 40By similarity (EC:2.3.1.2571 Publication)Alternative name(s): Histone-specific N-acetyltransferase NAT4Curated |
Gene namesi | Name:NAT4Imported Ordered Locus Names:YMR069W ORF Names:YM9916.08 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004673, NAT4 |
VEuPathDBi | FungiDB:YMR069W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074636 | 1 – 285 | N-alpha-acetyltransferase 40Add BLAST | 285 |
Proteomic databases
PaxDbi | Q04751 |
PRIDEi | Q04751 |
PTM databases
iPTMneti | Q04751 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 35244, 92 interactors |
DIPi | DIP-2745N |
IntActi | Q04751, 2 interactors |
MINTi | Q04751 |
STRINGi | 4932.YMR069W |
Miscellaneous databases
RNActi | Q04751, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 88 – 274 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 187 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 163 – 165 | Substrate bindingBy similarity | 3 | |
Regioni | 187 – 189 | Acetyl-CoA bindingBy similarity | 3 | |
Regioni | 195 – 200 | Acetyl-CoA bindingBy similarity | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2488, Eukaryota |
HOGENOMi | CLU_087674_0_0_1 |
InParanoidi | Q04751 |
OMAi | DIPLRSX |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR039949, NAA40 |
PANTHERi | PTHR20531, PTHR20531, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSSVYSENT YNCIRTSKEH LTERRRVAMA PMFQHFLNLC VEKFPESIEH
60 70 80 90 100
KDTDGNGNFT TAILEREIIY IPEDDTDSID SVDSLKCINY KLHKSRGDQV
110 120 130 140 150
LDACVQLIDK HLGAKYRRAS RIMYGNRKPW KANKLAEMKS AGLVYVCYWD
160 170 180 190 200
NGVLGAFTSF MLTEETGLVE GDALHEVSVP VIYLYEVHVA SAHRGHGIGR
210 220 230 240 250
RLLEHALCDG VARHTRRMCD NFFGVALTVF SDNTRARRLY EALGFYRAPG
260 270 280
SPAPASPTIR HTRHGGGRVV VPCDPLYYVY CLHMP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48952 Genomic DNA Translation: CAA88794.1 AY557984 Genomic DNA Translation: AAS56310.1 BK006946 Genomic DNA Translation: DAA09967.1 |
PIRi | S52829 |
RefSeqi | NP_013785.1, NM_001182567.1 |
Genome annotation databases
EnsemblFungii | YMR069W_mRNA; YMR069W; YMR069W |
GeneIDi | 855091 |
KEGGi | sce:YMR069W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z48952 Genomic DNA Translation: CAA88794.1 AY557984 Genomic DNA Translation: AAS56310.1 BK006946 Genomic DNA Translation: DAA09967.1 |
PIRi | S52829 |
RefSeqi | NP_013785.1, NM_001182567.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35244, 92 interactors |
DIPi | DIP-2745N |
IntActi | Q04751, 2 interactors |
MINTi | Q04751 |
STRINGi | 4932.YMR069W |
PTM databases
iPTMneti | Q04751 |
Proteomic databases
PaxDbi | Q04751 |
PRIDEi | Q04751 |
Genome annotation databases
EnsemblFungii | YMR069W_mRNA; YMR069W; YMR069W |
GeneIDi | 855091 |
KEGGi | sce:YMR069W |
Organism-specific databases
SGDi | S000004673, NAT4 |
VEuPathDBi | FungiDB:YMR069W |
Phylogenomic databases
eggNOGi | KOG2488, Eukaryota |
HOGENOMi | CLU_087674_0_0_1 |
InParanoidi | Q04751 |
OMAi | DIPLRSX |
Enzyme and pathway databases
BioCyci | YEAST:G3O-32771-MONOMER |
BRENDAi | 2.3.1.48, 984 |
Miscellaneous databases
PROi | PR:Q04751 |
RNActi | Q04751, protein |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR039949, NAA40 |
PANTHERi | PTHR20531, PTHR20531, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAA40_YEAST | |
Accessioni | Q04751Primary (citable) accession number: Q04751 Secondary accession number(s): D6VZP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - SIMILARITY comments
Index of protein domains and families