Yes1

Functionⁱ

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity).By similarity

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	303	ATPPROSITE-ProRule annotation		1
Active siteⁱ	394	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	281 – 289	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
enzyme binding Source: MGI
epidermal growth factor receptor binding Source: MGI
ion channel binding Source: MGI
non-membrane spanning protein tyrosine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphotyrosine residue binding Source: MGI
protein tyrosine kinase activity Source: MGI
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to platelet-derived growth factor stimulus
Source: MGI
Inferred from direct assayⁱ
- 17623777
cellular response to retinoic acid
Source: MGI
Inferred from direct assayⁱ
- 21385842
cellular response to transforming growth factor beta stimulus
Source: MGI
Inferred from genetic interactionⁱ
- 21829547
peptidyl-tyrosine autophosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of peptidyl-tyrosine phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 21385842
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 21385842
protein autophosphorylation Source: MGI
regulation of glucose transmembrane transport
Source: MGI
Inferred from direct assayⁱ
- 11546805
transmembrane receptor protein tyrosine kinase signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 3474
Reactomeⁱ	R-MMU-1227986 Signaling by ERBB2 R-MMU-1433557 Signaling by SCF-KIT R-MMU-1433559 Regulation of KIT signaling R-MMU-2029481 FCGR activation R-MMU-389356 CD28 co-stimulation R-MMU-389513 CTLA4 inhibitory signaling R-MMU-3928662 EPHB-mediated forward signaling R-MMU-3928663 EPHA-mediated growth cone collapse R-MMU-3928665 EPH-ephrin mediated repulsion of cells R-MMU-912631 Regulation of signaling by CBL

BRENDAⁱ

2.7.10.2 3474

Reactomeⁱ

R-MMU-1227986 Signaling by ERBB2
R-MMU-1433557 Signaling by SCF-KIT
R-MMU-1433559 Regulation of KIT signaling
R-MMU-2029481 FCGR activation
R-MMU-389356 CD28 co-stimulation
R-MMU-389513 CTLA4 inhibitory signaling
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells
R-MMU-912631 Regulation of signaling by CBL

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinase Yes (EC:2.7.10.2) Alternative name(s): Proto-oncogene c-Yes p61-Yes
Gene namesⁱ	Name:Yes1 Synonyms:Yes
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:99147 Yes1

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are viable, fertile, and display no apparent phenotypes. This lack of phenotype may be attributable to compensatory roles of the other SRC-family members.1 Publication

Keywords - Diseaseⁱ

Proto-oncogene

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000088182	2 – 541	Tyrosine-protein kinase YesAdd BLAST		540

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycineBy similarity	1
Lipidationⁱ	3	S-palmitoyl cysteine; in membrane formBy similarity	1
Modified residueⁱ	32	Phosphotyrosine1 Publication	1
Modified residueⁱ	334	PhosphotyrosineBy similarity	1
Modified residueⁱ	343	PhosphotyrosineBy similarity	1
Modified residueⁱ	424	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	535	PhosphotyrosineCombined sources	1

Post-translational modificationⁱ

Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-424 maintains enzyme activity by blocking CSK-mediated inhibition (By similarity).By similarity

Palmitoylation at Cys-3 promotes membrane localization.By similarity

Keywords - PTMⁱ

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q04736
PeptideAtlas More...PeptideAtlasⁱ	Q04736
PRIDEⁱ	Q04736

PTM databases

iPTMnetⁱ	Q04736
PhosphoSitePlusⁱ	Q04736
SwissPalmⁱ	Q04736

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000014932 Expressed in 272 organ(s), highest expression level in cumulus cell
ExpressionAtlasⁱ	Q04736 baseline and differential
Genevisibleⁱ	Q04736 MM

Interactionⁱ

Subunit structureⁱ

Interacts with YAP1. Interacts with FASLG. Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with CSF1R.By similarity1 Publication

GO - Molecular functionⁱ

enzyme binding Source: MGI
epidermal growth factor receptor binding Source: MGI
ion channel binding Source: MGI
phosphotyrosine residue binding Source: MGI
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204615, 6 interactors
IntActⁱ	Q04736, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q04736
STRINGⁱ	10090.ENSMUSP00000072154

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	93 – 98	Combined sources	6
Beta strandⁱ	115 – 120	Combined sources	6
Beta strandⁱ	127 – 134	Combined sources	8
Beta strandⁱ	137 – 140	Combined sources	4
Turnⁱ	142 – 144	Combined sources	3
Beta strandⁱ	145 – 150	Combined sources	6
Turnⁱ	152 – 154	Combined sources	3
Beta strandⁱ	157 – 160	Combined sources	4
Helixⁱ	163 – 170	Combined sources	8
Beta strandⁱ	180 – 184	Combined sources	5
Beta strandⁱ	186 – 188	Combined sources	3
Beta strandⁱ	192 – 200	Combined sources	9
Turnⁱ	201 – 203	Combined sources	3
Beta strandⁱ	204 – 214	Combined sources	11
Beta strandⁱ	216 – 218	Combined sources	3
Beta strandⁱ	220 – 223	Combined sources	4
Beta strandⁱ	226 – 230	Combined sources	5
Helixⁱ	231 – 240	Combined sources	10
Beta strandⁱ	245 – 247	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q04736
SMRⁱ	Q04736
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q04736

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	89 – 150	SH3PROSITE-ProRule annotationAdd BLAST	62
Domainⁱ	156 – 253	SH2PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	275 – 528	Protein kinasePROSITE-ProRule annotationAdd BLAST	254

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG0197 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118938
HOGENOMⁱ	HOG000233858
HOVERGENⁱ	HBG008761
InParanoidⁱ	Q04736
KEGG Orthology (KO) More...KOⁱ	K05705
OMAⁱ	IKYRTEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D46
PhylomeDBⁱ	Q04736
TreeFamⁱ	TF351634

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12007 SH3_Yes, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR035751 Yes_SH3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00452 SH3DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit PS50002 SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q04736-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGCIKSKENK SPAIKYTPEN LTEPVSPSAS HYGVEHATVA PTSSTKGASV 
        60         70         80         90        100
NFNSLSMTPF GGSSGVTPFG GASSSFSVVS SSYPTGLTGG VTIFVALYDY 
       110        120        130        140        150
EARTTEDLSF KKGERFQIIN NTEGDWWEAR SIATGKSGYI PSNYVVPADS 
       160        170        180        190        200
IQAEEWYFGK MGRKDAERLL LNPGNQRGIF LVRESETTKG AYSLSIRDWD 
       210        220        230        240        250
EVRGDNVKHY KIRKLDNGGY YITTRAQFDT LQKLVKHYTE HADGLCHKLT 
       260        270        280        290        300
TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 
       310        320        330        340        350
AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMS 
       360        370        380        390        400
KGSLLDFLKE GDGKYLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI 
       410        420        430        440        450
LVGENLICKI ADFGLARLIE DNEYTARQGA KFPIKWTAPE AALYGRFTIK 
       460        470        480        490        500
SDVWSFGILQ TELVTKGRVP YPGMVNREVL EQVERGYRMP CPQGCPESLH 
       510        520        530        540 
ELMNLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGEN L

Length:541

Mass (Da):60,630

Last modified:January 23, 2007 - v3

Checksum:ⁱ9A773C39D2119EA6

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0J9YUV2	A0A0J9YUV2_MOUSE		Tyrosine-protein kinase Yes Tyrosine-protein kinase Yes	Yes1	198	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X67677 mRNA Translation: CAA47909.1 BC010594 mRNA Translation: AAH10594.1 L25762 mRNA Translation: AAA40020.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39061.1
PIRⁱ	I48318 S31645
NCBI Reference Sequences More...RefSeqⁱ	NP_001192061.1, NM_001205132.1 NP_001192062.1, NM_001205133.1 NP_033561.1, NM_009535.3
UniGeneⁱ	Mm.4558

Genome annotation databases

Ensemblⁱ	ENSMUST00000072311; ENSMUSP00000072154; ENSMUSG00000014932 ENSMUST00000168707; ENSMUSP00000132161; ENSMUSG00000014932 ENSMUST00000202543; ENSMUSP00000144001; ENSMUSG00000014932
GeneIDⁱ	22612
KEGGⁱ	mmu:22612
UCSC genome browser More...UCSCⁱ	uc008wzs.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q04736	Tyrosine-protein kinase		MOUSE		541	UniRef100_Q04736
Tyrosine-protein kinase Yes (Fragment)		MOUSE		198

Protein	Similar proteins		Species	Score	Length	Source
Q04736	Tyrosine-protein kinase Yes	)	HUMAN		543	UniRef90_P07947
Tyrosine-protein kinase Yes		RAT		541
Tyrosine-protein kinase Yes		CHICK		541
Tyrosine-protein kinase Yes		CANLF		539
Tyrosine-protein kinase Yes		XENLA		537
+195

Protein	Similar proteins		Species	Score	Length	Source
Q04736	Proto-oncogene tyrosine-protein kinase Src	)	HUMAN		536	UniRef50_P12931
Neuronal proto-oncogene tyrosine-protein kinase Src	)	MOUSE		541
Proto-oncogene tyrosine-protein kinase Src		RAT		536
Proto-oncogene tyrosine-protein kinase Src	)	CHICK		533
Tyrosine-protein kinase transforming protein Src	)	RSVSE		526
+841

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X67677 mRNA Translation: CAA47909.1 BC010594 mRNA Translation: AAH10594.1 L25762 mRNA Translation: AAA40020.1
CCDSⁱ	CCDS39061.1
PIRⁱ	I48318 S31645
RefSeqⁱ	NP_001192061.1, NM_001205132.1 NP_001192062.1, NM_001205133.1 NP_033561.1, NM_009535.3
UniGeneⁱ	Mm.4558

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2YT6	NMR	-	A	71-167	[»]
	5MTJ	X-ray	1.95	A	147-260	[»]
ProteinModelPortalⁱ	Q04736
SMRⁱ	Q04736
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204615, 6 interactors
IntActⁱ	Q04736, 4 interactors
MINTⁱ	Q04736
STRINGⁱ	10090.ENSMUSP00000072154

PTM databases

iPTMnetⁱ	Q04736
PhosphoSitePlusⁱ	Q04736
SwissPalmⁱ	Q04736

Proteomic databases

PaxDbⁱ	Q04736
PeptideAtlasⁱ	Q04736
PRIDEⁱ	Q04736

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000072311; ENSMUSP00000072154; ENSMUSG00000014932 ENSMUST00000168707; ENSMUSP00000132161; ENSMUSG00000014932 ENSMUST00000202543; ENSMUSP00000144001; ENSMUSG00000014932
GeneIDⁱ	22612
KEGGⁱ	mmu:22612
UCSCⁱ	uc008wzs.2 mouse

Organism-specific databases

CTDⁱ	7525
MGIⁱ	MGI:99147 Yes1

Phylogenomic databases

eggNOGⁱ	KOG0197 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00760000118938
HOGENOMⁱ	HOG000233858
HOVERGENⁱ	HBG008761
InParanoidⁱ	Q04736
KOⁱ	K05705
OMAⁱ	IKYRTEN
OrthoDBⁱ	EOG091G0D46
PhylomeDBⁱ	Q04736
TreeFamⁱ	TF351634

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 3474
Reactomeⁱ	R-MMU-1227986 Signaling by ERBB2 R-MMU-1433557 Signaling by SCF-KIT R-MMU-1433559 Regulation of KIT signaling R-MMU-2029481 FCGR activation R-MMU-389356 CD28 co-stimulation R-MMU-389513 CTLA4 inhibitory signaling R-MMU-3928662 EPHB-mediated forward signaling R-MMU-3928663 EPHA-mediated growth cone collapse R-MMU-3928665 EPH-ephrin mediated repulsion of cells R-MMU-912631 Regulation of signaling by CBL

BRENDAⁱ

2.7.10.2 3474

Reactomeⁱ

R-MMU-1227986 Signaling by ERBB2
R-MMU-1433557 Signaling by SCF-KIT
R-MMU-1433559 Regulation of KIT signaling
R-MMU-2029481 FCGR activation
R-MMU-389356 CD28 co-stimulation
R-MMU-389513 CTLA4 inhibitory signaling
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-3928663 EPHA-mediated growth cone collapse
R-MMU-3928665 EPH-ephrin mediated repulsion of cells
R-MMU-912631 Regulation of signaling by CBL

Miscellaneous databases

EvolutionaryTraceⁱ	Q04736
Protein Ontology More...PROⁱ	PR:Q04736
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000014932 Expressed in 272 organ(s), highest expression level in cumulus cell
ExpressionAtlasⁱ	Q04736 baseline and differential
Genevisibleⁱ	Q04736 MM

Family and domain databases

CDDⁱ	cd12007 SH3_Yes, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR035751 Yes_SH3
Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00452 SH3DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YES_MOUSE
Accessionⁱ	Q04736Primary (citable) accession number: Q04736
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q04736 (YES_MOUSE)

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Tyrosine-protein kinase Yes

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Plasma membrane

Cytosol

Cytoskeleton

Cytosol

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ