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Protein

Transducin-like enhancer protein 3

Gene

TLE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).By similarity

GO - Molecular functioni

  • repressing transcription factor binding Source: GO_Central
  • transcription corepressor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-4641265 Repression of WNT target genes
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiQ04726

Names & Taxonomyi

Protein namesi
Recommended name:
Transducin-like enhancer protein 3
Alternative name(s):
Enhancer of split groucho-like protein 3
Short name:
ESG3
Gene namesi
Name:TLE3
Synonyms:KIAA1547
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140332.15
HGNCiHGNC:11839 TLE3
MIMi600190 gene
neXtProtiNX_Q04726

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7090
OpenTargetsiENSG00000140332
PharmGKBiPA36541

Polymorphism and mutation databases

DMDMi20532417

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512801 – 772Transducin-like enhancer protein 3Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei232N6-acetyllysineBy similarity1
Modified residuei240PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei259PhosphothreonineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei275N6-acetyllysineBy similarity1
Modified residuei286PhosphoserineCombined sources1
Modified residuei312PhosphothreonineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei319PhosphothreonineCombined sources1
Modified residuei321PhosphothreonineCombined sources1
Modified residuei328PhosphothreonineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Isoform 7 (identifier: Q04726-7)
Modified residuei336N6-acetyllysineCombined sources1
Isoform 3 (identifier: Q04726-3)
Modified residuei343N6-acetyllysineCombined sources1
Isoform 5 (identifier: Q04726-5)
Modified residuei343N6-acetyllysineCombined sources1

Post-translational modificationi

Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ04726
MaxQBiQ04726
PaxDbiQ04726
PeptideAtlasiQ04726
PRIDEiQ04726
ProteomicsDBi58268
58269 [Q04726-2]
58270 [Q04726-3]
58271 [Q04726-4]

PTM databases

iPTMnetiQ04726
PhosphoSitePlusiQ04726

Expressioni

Tissue specificityi

Placenta and lung.

Gene expression databases

BgeeiENSG00000140332 Expressed in 203 organ(s), highest expression level in blood
CleanExiHS_TLE3
ExpressionAtlasiQ04726 baseline and differential
GenevisibleiQ04726 HS

Organism-specific databases

HPAiHPA054116

Interactioni

Subunit structurei

Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4. Interacts with TBX18 (via engrailed homology 1 repressor motif), leading to decreased of TBX18 transcriptional activity.By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112945, 87 interactors
CORUMiQ04726
DIPiDIP-36666N
IntActiQ04726, 22 interactors
MINTiQ04726
STRINGi9606.ENSP00000452871

Structurei

3D structure databases

ProteinModelPortaliQ04726
SMRiQ04726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati484 – 522WD 1Add BLAST39
Repeati530 – 569WD 2Add BLAST40
Repeati574 – 613WD 3Add BLAST40
Repeati616 – 655WD 4Add BLAST40
Repeati657 – 696WD 5Add BLAST40
Repeati698 – 737WD 6Add BLAST40
Repeati739 – 771WD 7Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 131Q domainBy similarityAdd BLAST131
Regioni132 – 199GP domainBy similarityAdd BLAST68
Regioni200 – 268CcN domainBy similarityAdd BLAST69
Regioni269 – 452SP domainBy similarityAdd BLAST184

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi225 – 228Nuclear localization signalSequence analysis4

Domaini

WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.1 Publication

Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465
HOGENOMiHOG000293211
HOVERGENiHBG004689
InParanoidiQ04726
PhylomeDBiQ04726
TreeFamiTF314167

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 7 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q04726-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL
60 70 80 90 100
ANEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH
110 120 130 140 150
QQQVAQAVER AKQVTMTELN AIIGQQQLQA QHLSHATHGP PVQLPPHPSG
160 170 180 190 200
LQPPGIPPVT GSSSGLLALG ALGSQAHLTV KDEKNHHELD HRERESSANN
210 220 230 240 250
SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS DGDKSDDLVV
260 270 280 290 300
DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK
310 320 330 340 350
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI
360 370 380 390 400
GIMASALRTP ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS
410 420 430 440 450
AAAAAAAAAY GRSPMVSFGA VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF
460 470 480 490 500
HVSADGQMQP VPFPHDALAG PGIPRHARQI NTLSHGEVVC AVTISNPTRH
510 520 530 540 550
VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL LPDGRTLIVG
560 570 580 590 600
GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI
610 620 630 640 650
AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG
660 670 680 690 700
RQLQQHDFTS QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE
710 720 730 740 750
SCVLSLKFAY CGKWFVSTGK DNLLNAWRTP YGASIFQSKE SSSVLSCDIS
760 770
ADDKYIVTGS GDKKATVYEV IY
Length:772
Mass (Da):83,417
Last modified:May 10, 2002 - v2
Checksum:iA2A469D73BF04A43
GO
Isoform 2 (identifier: Q04726-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-353: Missing.

Show »
Length:760
Mass (Da):82,222
Checksum:i5CA1DDAE26C00E19
GO
Isoform 3 (identifier: Q04726-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-353: Missing.
     417-421: Missing.

Show »
Length:764
Mass (Da):82,654
Checksum:iEF5606A1D9C7C2BA
GO
Isoform 4 (identifier: Q04726-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MYPQGRHP → MPPPPPLSCLRGLQ
     127-127: Missing.
     417-421: Missing.

Show »
Length:772
Mass (Da):83,348
Checksum:iF10C1C00DE38D280
GO
Isoform 5 (identifier: Q04726-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-353: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:769
Mass (Da):83,115
Checksum:i9E7895DE647F9D9E
GO
Isoform 6 (identifier: Q04726-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-420: Missing.

Note: No experimental confirmation available.
Show »
Length:767
Mass (Da):82,955
Checksum:i7081DB8CE8BF2EAD
GO
Isoform 7 (identifier: Q04726-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MYPQGRHP → M
     351-353: Missing.

Show »
Length:762
Mass (Da):82,279
Checksum:iE82ECE78C54894E1
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YL70H0YL70_HUMAN
Transducin-like enhancer protein 3
TLE3
782Annotation score:
H0YKT5H0YKT5_HUMAN
Transducin-like enhancer protein 3
TLE3
774Annotation score:
H0YKN8H0YKN8_HUMAN
Transducin-like enhancer protein 3
TLE3
778Annotation score:
A0A0D9SES8A0A0D9SES8_HUMAN
Transducin-like enhancer protein 3
TLE3
772Annotation score:
F5H7D6F5H7D6_HUMAN
Transducin-like enhancer protein 3
TLE3
699Annotation score:
H0YNT2H0YNT2_HUMAN
Transducin-like enhancer protein 3
TLE3
716Annotation score:
H0YNI7H0YNI7_HUMAN
Transducin-like enhancer protein 3
TLE3
353Annotation score:
H0YLI3H0YLI3_HUMAN
Transducin-like enhancer protein 3
TLE3
611Annotation score:
H0YKH0H0YKH0_HUMAN
Transducin-like enhancer protein 3
TLE3
445Annotation score:
H0YLW9H0YLW9_HUMAN
Transducin-like enhancer protein 3
TLE3
448Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAB13373 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358R → C in BAG60692 (PubMed:14702039).Curated1
Sequence conflicti365S → G in BAG60692 (PubMed:14702039).Curated1
Sequence conflicti409A → T in AAH41831 (PubMed:15489334).Curated1
Sequence conflicti487E → G in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti498T → S in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti535I → M in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti541L → H in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti549V → E in BAG60692 (PubMed:14702039).Curated1
Sequence conflicti553A → G in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti692D → H in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti736F → S in AAA61194 (PubMed:1303260).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053421229A → V1 PublicationCorresponds to variant dbSNP:rs1057864Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0070231 – 8MYPQGRHP → MPPPPPLSCLRGLQ in isoform 4. 1 Publication8
Alternative sequenceiVSP_0551681 – 8MYPQGRHP → M in isoform 7. 1 Publication8
Alternative sequenceiVSP_007024127Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_006788342 – 353Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_006789351 – 353Missing in isoform 3, isoform 5 and isoform 7. 2 Publications3
Alternative sequenceiVSP_054598416 – 420Missing in isoform 6. 1 Publication5
Alternative sequenceiVSP_006790417 – 421Missing in isoform 3 and isoform 4. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99438 mRNA Translation: AAA61194.1
AB046767 mRNA Translation: BAB13373.1 Different initiation.
AK315058 mRNA No translation available.
AK298482 mRNA Translation: BAG60692.1
AC026583 Genomic DNA No translation available.
AC068327 Genomic DNA No translation available.
BC015729 mRNA No translation available.
BC041831 mRNA Translation: AAH41831.1
BC043247 mRNA Translation: AAH43247.1
CCDSiCCDS45293.1 [Q04726-1]
CCDS45294.1 [Q04726-5]
CCDS58375.1 [Q04726-2]
CCDS61689.1 [Q04726-7]
CCDS61691.1 [Q04726-6]
CCDS61692.1 [Q04726-3]
PIRiD56695
RefSeqiNP_001098662.1, NM_001105192.2 [Q04726-5]
NP_001269908.1, NM_001282979.1 [Q04726-3]
NP_001269909.1, NM_001282980.1 [Q04726-6]
NP_001269910.1, NM_001282981.1 [Q04726-7]
NP_001269911.1, NM_001282982.1
NP_005069.2, NM_005078.3 [Q04726-1]
NP_065959.1, NM_020908.2 [Q04726-2]
UniGeneiHs.287362

Genome annotation databases

EnsembliENST00000317509; ENSP00000319233; ENSG00000140332 [Q04726-2]
ENST00000440567; ENSP00000415057; ENSG00000140332 [Q04726-7]
ENST00000451782; ENSP00000394717; ENSG00000140332 [Q04726-5]
ENST00000557907; ENSP00000453107; ENSG00000140332 [Q04726-3]
ENST00000557997; ENSP00000453083; ENSG00000140332 [Q04726-3]
ENST00000558379; ENSP00000453435; ENSG00000140332 [Q04726-6]
ENST00000558939; ENSP00000452871; ENSG00000140332 [Q04726-1]
ENST00000559048; ENSP00000453760; ENSG00000140332 [Q04726-4]
GeneIDi7090
KEGGihsa:7090
UCSCiuc002asl.4 human [Q04726-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99438 mRNA Translation: AAA61194.1
AB046767 mRNA Translation: BAB13373.1 Different initiation.
AK315058 mRNA No translation available.
AK298482 mRNA Translation: BAG60692.1
AC026583 Genomic DNA No translation available.
AC068327 Genomic DNA No translation available.
BC015729 mRNA No translation available.
BC041831 mRNA Translation: AAH41831.1
BC043247 mRNA Translation: AAH43247.1
CCDSiCCDS45293.1 [Q04726-1]
CCDS45294.1 [Q04726-5]
CCDS58375.1 [Q04726-2]
CCDS61689.1 [Q04726-7]
CCDS61691.1 [Q04726-6]
CCDS61692.1 [Q04726-3]
PIRiD56695
RefSeqiNP_001098662.1, NM_001105192.2 [Q04726-5]
NP_001269908.1, NM_001282979.1 [Q04726-3]
NP_001269909.1, NM_001282980.1 [Q04726-6]
NP_001269910.1, NM_001282981.1 [Q04726-7]
NP_001269911.1, NM_001282982.1
NP_005069.2, NM_005078.3 [Q04726-1]
NP_065959.1, NM_020908.2 [Q04726-2]
UniGeneiHs.287362

3D structure databases

ProteinModelPortaliQ04726
SMRiQ04726
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112945, 87 interactors
CORUMiQ04726
DIPiDIP-36666N
IntActiQ04726, 22 interactors
MINTiQ04726
STRINGi9606.ENSP00000452871

PTM databases

iPTMnetiQ04726
PhosphoSitePlusiQ04726

Polymorphism and mutation databases

DMDMi20532417

Proteomic databases

EPDiQ04726
MaxQBiQ04726
PaxDbiQ04726
PeptideAtlasiQ04726
PRIDEiQ04726
ProteomicsDBi58268
58269 [Q04726-2]
58270 [Q04726-3]
58271 [Q04726-4]

Protocols and materials databases

DNASUi7090
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317509; ENSP00000319233; ENSG00000140332 [Q04726-2]
ENST00000440567; ENSP00000415057; ENSG00000140332 [Q04726-7]
ENST00000451782; ENSP00000394717; ENSG00000140332 [Q04726-5]
ENST00000557907; ENSP00000453107; ENSG00000140332 [Q04726-3]
ENST00000557997; ENSP00000453083; ENSG00000140332 [Q04726-3]
ENST00000558379; ENSP00000453435; ENSG00000140332 [Q04726-6]
ENST00000558939; ENSP00000452871; ENSG00000140332 [Q04726-1]
ENST00000559048; ENSP00000453760; ENSG00000140332 [Q04726-4]
GeneIDi7090
KEGGihsa:7090
UCSCiuc002asl.4 human [Q04726-1]

Organism-specific databases

CTDi7090
DisGeNETi7090
EuPathDBiHostDB:ENSG00000140332.15
GeneCardsiTLE3
HGNCiHGNC:11839 TLE3
HPAiHPA054116
MIMi600190 gene
neXtProtiNX_Q04726
OpenTargetsiENSG00000140332
PharmGKBiPA36541
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465
HOGENOMiHOG000293211
HOVERGENiHBG004689
InParanoidiQ04726
PhylomeDBiQ04726
TreeFamiTF314167

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-4641265 Repression of WNT target genes
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiQ04726

Miscellaneous databases

ChiTaRSiTLE3 human
GeneWikiiTLE3
GenomeRNAii7090
PROiPR:Q04726
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140332 Expressed in 203 organ(s), highest expression level in blood
CleanExiHS_TLE3
ExpressionAtlasiQ04726 baseline and differential
GenevisibleiQ04726 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10814 PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTLE3_HUMAN
AccessioniPrimary (citable) accession number: Q04726
Secondary accession number(s): B4DPT0
, E9PD64, F8W964, Q6PI57, Q8IVV6, Q8WVR2, Q9HCM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 10, 2002
Last modified: November 7, 2018
This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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