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Entry version 204 (12 Aug 2020)
Sequence version 2 (10 May 2002)
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Protein

Transducin-like enhancer protein 3

Gene

TLE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q04726

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex
R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription [Q04726-3]
R-HSA-3769402, Deactivation of the beta-catenin transactivating complex
R-HSA-4641265, Repression of WNT target genes
R-HSA-9018519, Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q04726

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transducin-like enhancer protein 3
Alternative name(s):
Enhancer of split groucho-like protein 3
Short name:
ESG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLE3
Synonyms:KIAA1547
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140332.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11839, TLE3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600190, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q04726

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7090

Open Targets

More...
OpenTargetsi
ENSG00000140332

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36541

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q04726, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TLE3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20532417

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000512801 – 772Transducin-like enhancer protein 3Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei203PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei232N6-acetyllysineBy similarity1
Modified residuei240PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei259PhosphothreonineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei275N6-acetyllysineBy similarity1
Modified residuei286PhosphoserineCombined sources1
Modified residuei312PhosphothreonineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei319PhosphothreonineCombined sources1
Modified residuei321PhosphothreonineCombined sources1
Modified residuei328PhosphothreonineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Isoform 7 (identifier: Q04726-7)
Modified residuei336N6-acetyllysineCombined sources1
Isoform 3 (identifier: Q04726-3)
Modified residuei343N6-acetyllysineCombined sources1
Isoform 5 (identifier: Q04726-5)
Modified residuei343N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q04726

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q04726

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q04726

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q04726

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04726

PeptideAtlas

More...
PeptideAtlasi
Q04726

PRoteomics IDEntifications database

More...
PRIDEi
Q04726

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19592
30271
58268 [Q04726-1]
58269 [Q04726-2]
58270 [Q04726-3]
58271 [Q04726-4]
67140

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04726

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q04726

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140332, Expressed in blood and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q04726, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q04726, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000140332, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2.

Interacts with XIAP/BIRC4 and TCF7L2/TCF4.

Interacts with TBX18 (via engrailed homology 1 repressor motif), leading to decreased of TBX18 transcriptional activity.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112945, 98 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q04726

Database of interacting proteins

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DIPi
DIP-36666N

Protein interaction database and analysis system

More...
IntActi
Q04726, 46 interactors

Molecular INTeraction database

More...
MINTi
Q04726

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000452871

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q04726, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q04726

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati484 – 522WD 1Add BLAST39
Repeati530 – 569WD 2Add BLAST40
Repeati574 – 613WD 3Add BLAST40
Repeati616 – 655WD 4Add BLAST40
Repeati657 – 696WD 5Add BLAST40
Repeati698 – 737WD 6Add BLAST40
Repeati739 – 771WD 7Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 131Q domainBy similarityAdd BLAST131
Regioni132 – 199GP domainBy similarityAdd BLAST68
Regioni200 – 268CcN domainBy similarityAdd BLAST69
Regioni269 – 452SP domainBy similarityAdd BLAST184

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi225 – 228Nuclear localization signalSequence analysis4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0639, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007612_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q04726

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q04726

TreeFam database of animal gene trees

More...
TreeFami
TF314167

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005617, Groucho/TLE_N
IPR009146, Groucho_enhance
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10814, PTHR10814, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03920, TLE_N, 1 hit
PF00400, WD40, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01850, GROUCHOFAMLY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 2 hits
PS50294, WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 7 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q04726-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL
60 70 80 90 100
ANEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH
110 120 130 140 150
QQQVAQAVER AKQVTMTELN AIIGQQQLQA QHLSHATHGP PVQLPPHPSG
160 170 180 190 200
LQPPGIPPVT GSSSGLLALG ALGSQAHLTV KDEKNHHELD HRERESSANN
210 220 230 240 250
SVSPSESLRA SEKHRGSADY SMEAKKRKAE EKDSLSRYDS DGDKSDDLVV
260 270 280 290 300
DVSNEDPATP RVSPAHSPPE NGLDKARSLK KDAPTSPASV ASSSSTPSSK
310 320 330 340 350
TKDLGHNDKS STPGLKSNTP TPRNDAPTPG TSTTPGLRSM PGKPPGMDPI
360 370 380 390 400
GIMASALRTP ISITSSYAAP FAMMSHHEMN GSLTSPGAYA GLHNIPPQMS
410 420 430 440 450
AAAAAAAAAY GRSPMVSFGA VGFDPHPPMR ATGLPSSLAS IPGGKPAYSF
460 470 480 490 500
HVSADGQMQP VPFPHDALAG PGIPRHARQI NTLSHGEVVC AVTISNPTRH
510 520 530 540 550
VYTGGKGCVK IWDISQPGSK SPISQLDCLN RDNYIRSCKL LPDGRTLIVG
560 570 580 590 600
GEASTLTIWD LASPTPRIKA ELTSSAPACY ALAISPDAKV CFSCCSDGNI
610 620 630 640 650
AVWDLHNQTL VRQFQGHTDG ASCIDISHDG TKLWTGGLDN TVRSWDLREG
660 670 680 690 700
RQLQQHDFTS QIFSLGYCPT GEWLAVGMES SNVEVLHHTK PDKYQLHLHE
710 720 730 740 750
SCVLSLKFAY CGKWFVSTGK DNLLNAWRTP YGASIFQSKE SSSVLSCDIS
760 770
ADDKYIVTGS GDKKATVYEV IY
Length:772
Mass (Da):83,417
Last modified:May 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2A469D73BF04A43
GO
Isoform 2 (identifier: Q04726-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-353: Missing.

Show »
Length:760
Mass (Da):82,222
Checksum:i5CA1DDAE26C00E19
GO
Isoform 3 (identifier: Q04726-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-353: Missing.
     417-421: Missing.

Show »
Length:764
Mass (Da):82,654
Checksum:iEF5606A1D9C7C2BA
GO
Isoform 4 (identifier: Q04726-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MYPQGRHP → MPPPPPLSCLRGLQ
     127-127: Missing.
     417-421: Missing.

Show »
Length:772
Mass (Da):83,348
Checksum:iF10C1C00DE38D280
GO
Isoform 5 (identifier: Q04726-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-353: Missing.

Show »
Length:769
Mass (Da):83,115
Checksum:i9E7895DE647F9D9E
GO
Isoform 6 (identifier: Q04726-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-420: Missing.

Show »
Length:767
Mass (Da):82,955
Checksum:i7081DB8CE8BF2EAD
GO
Isoform 7 (identifier: Q04726-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MYPQGRHP → M
     351-353: Missing.

Show »
Length:762
Mass (Da):82,279
Checksum:iE82ECE78C54894E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YL70H0YL70_HUMAN
Transducin-like enhancer protein 3
TLE3
782Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKT5H0YKT5_HUMAN
Transducin-like enhancer protein 3
TLE3
774Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKN8H0YKN8_HUMAN
Transducin-like enhancer protein 3
TLE3
778Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SES8A0A0D9SES8_HUMAN
Transducin-like enhancer protein 3
TLE3
772Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNT2H0YNT2_HUMAN
Transducin-like enhancer protein 3
TLE3
716Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKH0H0YKH0_HUMAN
Transducin-like enhancer protein 3
TLE3
445Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLI3H0YLI3_HUMAN
Transducin-like enhancer protein 3
TLE3
537Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLW9H0YLW9_HUMAN
Transducin-like enhancer protein 3
TLE3
448Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNI7H0YNI7_HUMAN
Transducin-like enhancer protein 3
TLE3
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKH5H0YKH5_HUMAN
Transducin-like enhancer protein 3
TLE3
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13373 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti358R → C in BAG60692 (PubMed:14702039).Curated1
Sequence conflicti365S → G in BAG60692 (PubMed:14702039).Curated1
Sequence conflicti409A → T in AAH41831 (PubMed:15489334).Curated1
Sequence conflicti487E → G in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti498T → S in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti535I → M in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti541L → H in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti549V → E in BAG60692 (PubMed:14702039).Curated1
Sequence conflicti553A → G in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti692D → H in AAA61194 (PubMed:1303260).Curated1
Sequence conflicti736F → S in AAA61194 (PubMed:1303260).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053421229A → V1 PublicationCorresponds to variant dbSNP:rs1057864Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0070231 – 8MYPQGRHP → MPPPPPLSCLRGLQ in isoform 4. 1 Publication8
Alternative sequenceiVSP_0551681 – 8MYPQGRHP → M in isoform 7. 1 Publication8
Alternative sequenceiVSP_007024127Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_006788342 – 353Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_006789351 – 353Missing in isoform 3, isoform 5 and isoform 7. 2 Publications3
Alternative sequenceiVSP_054598416 – 420Missing in isoform 6. 1 Publication5
Alternative sequenceiVSP_006790417 – 421Missing in isoform 3 and isoform 4. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M99438 mRNA Translation: AAA61194.1
AB046767 mRNA Translation: BAB13373.1 Different initiation.
AK315058 mRNA No translation available.
AK298482 mRNA Translation: BAG60692.1
AC026583 Genomic DNA No translation available.
AC068327 Genomic DNA No translation available.
BC015729 mRNA No translation available.
BC041831 mRNA Translation: AAH41831.1
BC043247 mRNA Translation: AAH43247.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45293.1 [Q04726-1]
CCDS45294.1 [Q04726-5]
CCDS58375.1 [Q04726-2]
CCDS61689.1 [Q04726-7]
CCDS61691.1 [Q04726-6]
CCDS61692.1 [Q04726-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
D56695

NCBI Reference Sequences

More...
RefSeqi
NP_001098662.1, NM_001105192.2 [Q04726-5]
NP_001269908.1, NM_001282979.1 [Q04726-3]
NP_001269909.1, NM_001282980.1 [Q04726-6]
NP_001269910.1, NM_001282981.1 [Q04726-7]
NP_001269911.1, NM_001282982.1
NP_005069.2, NM_005078.3 [Q04726-1]
NP_065959.1, NM_020908.2 [Q04726-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317509; ENSP00000319233; ENSG00000140332 [Q04726-2]
ENST00000440567; ENSP00000415057; ENSG00000140332 [Q04726-7]
ENST00000451782; ENSP00000394717; ENSG00000140332 [Q04726-5]
ENST00000557907; ENSP00000453107; ENSG00000140332 [Q04726-3]
ENST00000557997; ENSP00000453083; ENSG00000140332 [Q04726-3]
ENST00000558379; ENSP00000453435; ENSG00000140332 [Q04726-6]
ENST00000558939; ENSP00000452871; ENSG00000140332 [Q04726-1]
ENST00000559048; ENSP00000453760; ENSG00000140332 [Q04726-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7090

UCSC genome browser

More...
UCSCi
uc002asl.4, human [Q04726-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99438 mRNA Translation: AAA61194.1
AB046767 mRNA Translation: BAB13373.1 Different initiation.
AK315058 mRNA No translation available.
AK298482 mRNA Translation: BAG60692.1
AC026583 Genomic DNA No translation available.
AC068327 Genomic DNA No translation available.
BC015729 mRNA No translation available.
BC041831 mRNA Translation: AAH41831.1
BC043247 mRNA Translation: AAH43247.1
CCDSiCCDS45293.1 [Q04726-1]
CCDS45294.1 [Q04726-5]
CCDS58375.1 [Q04726-2]
CCDS61689.1 [Q04726-7]
CCDS61691.1 [Q04726-6]
CCDS61692.1 [Q04726-3]
PIRiD56695
RefSeqiNP_001098662.1, NM_001105192.2 [Q04726-5]
NP_001269908.1, NM_001282979.1 [Q04726-3]
NP_001269909.1, NM_001282980.1 [Q04726-6]
NP_001269910.1, NM_001282981.1 [Q04726-7]
NP_001269911.1, NM_001282982.1
NP_005069.2, NM_005078.3 [Q04726-1]
NP_065959.1, NM_020908.2 [Q04726-2]

3D structure databases

SMRiQ04726
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112945, 98 interactors
CORUMiQ04726
DIPiDIP-36666N
IntActiQ04726, 46 interactors
MINTiQ04726
STRINGi9606.ENSP00000452871

PTM databases

iPTMnetiQ04726
PhosphoSitePlusiQ04726

Polymorphism and mutation databases

BioMutaiTLE3
DMDMi20532417

Proteomic databases

EPDiQ04726
jPOSTiQ04726
MassIVEiQ04726
MaxQBiQ04726
PaxDbiQ04726
PeptideAtlasiQ04726
PRIDEiQ04726
ProteomicsDBi19592
30271
58268 [Q04726-1]
58269 [Q04726-2]
58270 [Q04726-3]
58271 [Q04726-4]
67140

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
7320, 91 antibodies

The DNASU plasmid repository

More...
DNASUi
7090

Genome annotation databases

EnsembliENST00000317509; ENSP00000319233; ENSG00000140332 [Q04726-2]
ENST00000440567; ENSP00000415057; ENSG00000140332 [Q04726-7]
ENST00000451782; ENSP00000394717; ENSG00000140332 [Q04726-5]
ENST00000557907; ENSP00000453107; ENSG00000140332 [Q04726-3]
ENST00000557997; ENSP00000453083; ENSG00000140332 [Q04726-3]
ENST00000558379; ENSP00000453435; ENSG00000140332 [Q04726-6]
ENST00000558939; ENSP00000452871; ENSG00000140332 [Q04726-1]
ENST00000559048; ENSP00000453760; ENSG00000140332 [Q04726-4]
GeneIDi7090
KEGGihsa:7090
UCSCiuc002asl.4, human [Q04726-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7090
DisGeNETi7090
EuPathDBiHostDB:ENSG00000140332.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TLE3
HGNCiHGNC:11839, TLE3
HPAiENSG00000140332, Low tissue specificity
MIMi600190, gene
neXtProtiNX_Q04726
OpenTargetsiENSG00000140332
PharmGKBiPA36541

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0639, Eukaryota
GeneTreeiENSGT00990000203542
HOGENOMiCLU_007612_3_0_1
InParanoidiQ04726
PhylomeDBiQ04726
TreeFamiTF314167

Enzyme and pathway databases

PathwayCommonsiQ04726
ReactomeiR-HSA-201722, Formation of the beta-catenin:TCF transactivating complex
R-HSA-2122947, NOTCH1 Intracellular Domain Regulates Transcription [Q04726-3]
R-HSA-3769402, Deactivation of the beta-catenin transactivating complex
R-HSA-4641265, Repression of WNT target genes
R-HSA-9018519, Estrogen-dependent gene expression
SignaLinkiQ04726

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7090, 23 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TLE3, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TLE3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7090
PharosiQ04726, Tbio

Protein Ontology

More...
PROi
PR:Q04726
RNActiQ04726, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140332, Expressed in blood and 214 other tissues
ExpressionAtlasiQ04726, baseline and differential
GenevisibleiQ04726, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617, Groucho/TLE_N
IPR009146, Groucho_enhance
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR10814, PTHR10814, 1 hit
PfamiView protein in Pfam
PF03920, TLE_N, 1 hit
PF00400, WD40, 2 hits
PRINTSiPR01850, GROUCHOFAMLY
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 2 hits
PS50294, WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLE3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04726
Secondary accession number(s): B4DPT0
, E9PD64, F8W964, Q6PI57, Q8IVV6, Q8WVR2, Q9HCM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 10, 2002
Last modified: August 12, 2020
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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