UniProtKB - Q04721 (NOTC2_HUMAN)
Neurogenic locus notch homolog protein 2
NOTCH2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 614 | Essential for O-xylosylationBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- enzyme binding Source: Ensembl
- NF-kappaB binding Source: Ensembl
- signaling receptor activity Source: UniProtKB
GO - Biological processi
- animal organ morphogenesis Source: UniProtKB
- apoptotic process Source: UniProtKB
- atrial septum morphogenesis Source: BHF-UCL
- axon guidance Source: GO_Central
- bone remodeling Source: UniProtKB
- cell cycle arrest Source: UniProtKB
- cell fate determination Source: UniProtKB
- cholangiocyte proliferation Source: Ensembl
- ciliary body morphogenesis Source: Ensembl
- defense response to bacterium Source: Ensembl
- embryonic limb morphogenesis Source: Ensembl
- glomerular capillary formation Source: Ensembl
- glomerular visceral epithelial cell development Source: Ensembl
- heart looping Source: Ensembl
- hemopoiesis Source: UniProtKB
- hepatocyte proliferation Source: Ensembl
- humoral immune response Source: Ensembl
- inflammatory response to antigenic stimulus Source: Ensembl
- intrahepatic bile duct development Source: Ensembl
- in utero embryonic development Source: Ensembl
- left/right axis specification Source: Ensembl
- marginal zone B cell differentiation Source: UniProtKB
- morphogenesis of an epithelial sheet Source: Ensembl
- multicellular organism development Source: UniProtKB
- multicellular organism growth Source: Ensembl
- myeloid dendritic cell differentiation Source: Ensembl
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- negative regulation of growth rate Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- nervous system development Source: UniProtKB
- Notch signaling involved in heart development Source: BHF-UCL
- Notch signaling pathway Source: UniProtKB
- placenta blood vessel development Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of BMP signaling pathway Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of keratinocyte proliferation Source: UniProtKB
- positive regulation of osteoclast differentiation Source: Ensembl
- positive regulation of Ras protein signal transduction Source: UniProtKB
- proximal tubule development Source: Ensembl
- pulmonary valve morphogenesis Source: BHF-UCL
- regulation of actin cytoskeleton reorganization Source: UniProtKB
- regulation of osteoclast development Source: UniProtKB
- stem cell population maintenance Source: UniProtKB
- transcription initiation from RNA polymerase II promoter Source: Reactome
- wound healing Source: Ensembl
Keywordsi
Molecular function | Activator, Developmental protein, Receptor |
Biological process | Differentiation, Notch signaling pathway, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q04721 |
Reactomei | R-HSA-1912399, Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-1912420, Pre-NOTCH Processing in Golgi R-HSA-2197563, NOTCH2 intracellular domain regulates transcription R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-350054, Notch-HLH transcription pathway R-HSA-5083630, Defective LFNG causes SCDO3 R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription |
SignaLinki | Q04721 |
SIGNORi | Q04721 |
Names & Taxonomyi
Protein namesi | Recommended name: Neurogenic locus notch homolog protein 2CuratedShort name: Notch 2 Short name: hN2 Cleaved into the following 2 chains: |
Gene namesi | Name:NOTCH2Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7882, NOTCH2 |
MIMi | 600275, gene |
neXtProti | NX_Q04721 |
VEuPathDBi | HostDB:ENSG00000134250.17 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
Golgi apparatus
- Golgi membrane Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- cilium Source: Ensembl
- membrane Source: UniProtKB
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 1677 | ExtracellularSequence analysisAdd BLAST | 1652 | |
Transmembranei | 1678 – 1698 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1699 – 2471 | CytoplasmicSequence analysisAdd BLAST | 773 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Alagille syndrome 2 (ALGS2)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029361 | 444 | C → Y in ALGS2. 1 PublicationCorresponds to variant dbSNP:rs111033632EnsemblClinVar. | 1 |
Hajdu-Cheney syndrome (HJCYS)7 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080195 | 2140 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 332 | |
Natural variantiVAR_080196 | 2196 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 276 | |
Natural variantiVAR_080197 | 2208 – 2471 | Missing in HJCYS. 2 PublicationsAdd BLAST | 264 | |
Natural variantiVAR_080198 | 2223 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 249 | |
Natural variantiVAR_080199 | 2285 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 187 | |
Natural variantiVAR_080200 | 2299 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 173 | |
Natural variantiVAR_080201 | 2317 – 2471 | Missing in HJCYS; loss of interaction with FBW7; decreased ubiquitination. 2 PublicationsAdd BLAST | 155 | |
Natural variantiVAR_080202 | 2325 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 147 | |
Natural variantiVAR_080203 | 2360 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 112 | |
Natural variantiVAR_080204 | 2373 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 99 | |
Natural variantiVAR_080205 | 2389 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 83 | |
Natural variantiVAR_080206 | 2400 – 2471 | Missing in HJCYS. 3 PublicationsAdd BLAST | 72 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2416 | T → A: Loss of interaction with FBW7. Results in decreased ubiquitination and degradation. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 4853 |
GeneReviewsi | NOTCH2 |
MalaCardsi | NOTCH2 |
MIMi | 102500, phenotype 610205, phenotype |
OpenTargetsi | ENSG00000134250 |
Orphaneti | 955, Acroosteolysis dominant type 261629, Alagille syndrome due to a NOTCH2 point mutation |
PharmGKBi | PA31684 |
Miscellaneous databases
Pharosi | Q04721, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3407320 |
GuidetoPHARMACOLOGYi | 2859 |
Genetic variation databases
BioMutai | NOTCH2 |
DMDMi | 143811429 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000007683 | 26 – 2471 | Neurogenic locus notch homolog protein 2Add BLAST | 2446 | |
ChainiPRO_0000007684 | 1666 – 2471 | Notch 2 extracellular truncationBy similarityAdd BLAST | 806 | |
ChainiPRO_0000007685 | 1697 – 2471 | Notch 2 intracellular domainBy similarityAdd BLAST | 775 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 41 | By similarity | ||
Disulfide bondi | 35 ↔ 51 | By similarity | ||
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 53 ↔ 62 | By similarity | ||
Disulfide bondi | 68 ↔ 79 | By similarity | ||
Disulfide bondi | 73 ↔ 90 | By similarity | ||
Disulfide bondi | 92 ↔ 101 | By similarity | ||
Disulfide bondi | 109 ↔ 121 | By similarity | ||
Disulfide bondi | 115 ↔ 131 | By similarity | ||
Disulfide bondi | 133 ↔ 142 | By similarity | ||
Disulfide bondi | 148 ↔ 159 | By similarity | ||
Disulfide bondi | 153 ↔ 168 | By similarity | ||
Glycosylationi | 155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 170 ↔ 179 | By similarity | ||
Disulfide bondi | 186 ↔ 198 | By similarity | ||
Disulfide bondi | 192 ↔ 207 | By similarity | ||
Disulfide bondi | 209 ↔ 218 | By similarity | ||
Disulfide bondi | 225 ↔ 236 | By similarity | ||
Disulfide bondi | 230 ↔ 246 | By similarity | ||
Disulfide bondi | 248 ↔ 257 | By similarity | ||
Disulfide bondi | 264 ↔ 275 | By similarity | ||
Disulfide bondi | 269 ↔ 284 | By similarity | ||
Disulfide bondi | 286 ↔ 295 | By similarity | ||
Disulfide bondi | 302 ↔ 315 | By similarity | ||
Disulfide bondi | 309 ↔ 324 | By similarity | ||
Disulfide bondi | 326 ↔ 335 | By similarity | ||
Disulfide bondi | 342 ↔ 353 | By similarity | ||
Disulfide bondi | 347 ↔ 362 | By similarity | ||
Disulfide bondi | 364 ↔ 373 | By similarity | ||
Disulfide bondi | 379 ↔ 390 | By similarity | ||
Disulfide bondi | 384 ↔ 401 | By similarity | ||
Disulfide bondi | 403 ↔ 412 | By similarity | ||
Disulfide bondi | 419 ↔ 433 | By similarity | ||
Disulfide bondi | 427 ↔ 442 | By similarity | ||
Disulfide bondi | 444 ↔ 453 | By similarity | ||
Disulfide bondi | 460 ↔ 471 | By similarity | ||
Disulfide bondi | 465 ↔ 480 | By similarity | ||
Disulfide bondi | 482 ↔ 491 | By similarity | ||
Disulfide bondi | 498 ↔ 509 | By similarity | ||
Disulfide bondi | 503 ↔ 518 | By similarity | ||
Disulfide bondi | 520 ↔ 529 | By similarity | ||
Disulfide bondi | 536 ↔ 547 | By similarity | ||
Disulfide bondi | 541 ↔ 556 | By similarity | ||
Disulfide bondi | 558 ↔ 567 | By similarity | ||
Disulfide bondi | 574 ↔ 584 | By similarity | ||
Disulfide bondi | 579 ↔ 593 | By similarity | ||
Disulfide bondi | 595 ↔ 604 | By similarity | ||
Disulfide bondi | 611 ↔ 622 | By similarity | ||
Glycosylationi | 613 | O-linked (Glc...) serine; alternateBy similarity | 1 | |
Glycosylationi | 613 | O-linked (Xyl...) serine; alternateBy similarity | 1 | |
Disulfide bondi | 616 ↔ 631 | By similarity | ||
Disulfide bondi | 633 ↔ 642 | By similarity | ||
Disulfide bondi | 649 ↔ 659 | By similarity | ||
Disulfide bondi | 654 ↔ 668 | By similarity | ||
Disulfide bondi | 670 ↔ 679 | By similarity | ||
Disulfide bondi | 686 ↔ 697 | By similarity | ||
Disulfide bondi | 691 ↔ 706 | By similarity | ||
Disulfide bondi | 708 ↔ 717 | By similarity | ||
Disulfide bondi | 724 ↔ 734 | By similarity | ||
Disulfide bondi | 729 ↔ 743 | By similarity | ||
Glycosylationi | 733 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 745 ↔ 754 | By similarity | ||
Disulfide bondi | 761 ↔ 772 | By similarity | ||
Disulfide bondi | 766 ↔ 781 | By similarity | ||
Disulfide bondi | 783 ↔ 792 | By similarity | ||
Disulfide bondi | 799 ↔ 810 | By similarity | ||
Disulfide bondi | 804 ↔ 819 | By similarity | ||
Disulfide bondi | 821 ↔ 830 | By similarity | ||
Disulfide bondi | 837 ↔ 848 | By similarity | ||
Disulfide bondi | 842 ↔ 859 | By similarity | ||
Disulfide bondi | 861 ↔ 870 | By similarity | ||
Disulfide bondi | 877 ↔ 888 | By similarity | ||
Disulfide bondi | 882 ↔ 897 | By similarity | ||
Disulfide bondi | 899 ↔ 908 | By similarity | ||
Disulfide bondi | 915 ↔ 926 | By similarity | ||
Disulfide bondi | 920 ↔ 935 | By similarity | ||
Disulfide bondi | 937 ↔ 946 | By similarity | ||
Disulfide bondi | 953 ↔ 964 | By similarity | ||
Disulfide bondi | 958 ↔ 973 | By similarity | ||
Disulfide bondi | 975 ↔ 984 | By similarity | ||
Disulfide bondi | 991 ↔ 1002 | By similarity | ||
Disulfide bondi | 996 ↔ 1011 | By similarity | ||
Disulfide bondi | 1013 ↔ 1022 | By similarity | ||
Disulfide bondi | 1029 ↔ 1040 | By similarity | ||
Disulfide bondi | 1034 ↔ 1049 | By similarity | ||
Disulfide bondi | 1051 ↔ 1060 | By similarity | ||
Disulfide bondi | 1067 ↔ 1078 | By similarity | ||
Disulfide bondi | 1072 ↔ 1087 | By similarity | ||
Disulfide bondi | 1089 ↔ 1098 | By similarity | ||
Glycosylationi | 1102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1105 ↔ 1126 | Curated | ||
Disulfide bondi | 1120 ↔ 1135 | By similarity | ||
Disulfide bondi | 1137 ↔ 1146 | By similarity | ||
Disulfide bondi | 1153 ↔ 1164 | By similarity | ||
Disulfide bondi | 1158 ↔ 1173 | By similarity | ||
Disulfide bondi | 1175 ↔ 1184 | By similarity | ||
Disulfide bondi | 1191 ↔ 1202 | By similarity | ||
Disulfide bondi | 1196 ↔ 1211 | By similarity | ||
Disulfide bondi | 1213 ↔ 1222 | By similarity | ||
Disulfide bondi | 1229 ↔ 1241 | By similarity | ||
Disulfide bondi | 1235 ↔ 1250 | By similarity | ||
Disulfide bondi | 1252 ↔ 1261 | By similarity | ||
Disulfide bondi | 1268 ↔ 1281 | By similarity | ||
Disulfide bondi | 1273 ↔ 1290 | By similarity | ||
Disulfide bondi | 1292 ↔ 1301 | By similarity | ||
Disulfide bondi | 1308 ↔ 1319 | By similarity | ||
Disulfide bondi | 1313 ↔ 1331 | By similarity | ||
Disulfide bondi | 1333 ↔ 1342 | By similarity | ||
Disulfide bondi | 1378 ↔ 1389 | By similarity | ||
Disulfide bondi | 1383 ↔ 1400 | By similarity | ||
Disulfide bondi | 1402 ↔ 1411 | By similarity | ||
Disulfide bondi | 1425 ↔ 1448 | 1 Publication | ||
Disulfide bondi | 1430 ↔ 1443 | 1 Publication | ||
Disulfide bondi | 1439 ↔ 1455 | 1 Publication | ||
Glycosylationi | 1465 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1466 ↔ 1489 | 1 Publication | ||
Disulfide bondi | 1472 ↔ 1484 | 1 Publication | ||
Disulfide bondi | 1480 ↔ 1496 | 1 Publication | ||
Disulfide bondi | 1503 ↔ 1527 | 1 Publication | ||
Disulfide bondi | 1509 ↔ 1522 | 1 Publication | ||
Disulfide bondi | 1518 ↔ 1534 | 1 Publication | ||
Disulfide bondi | 1632 ↔ 1639 | 1 Publication | ||
Modified residuei | 1716 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1778 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1802 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1804 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1808 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1842 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1845 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2070 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2078 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2081 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2097 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q04721 |
jPOSTi | Q04721 |
MassIVEi | Q04721 |
MaxQBi | Q04721 |
PaxDbi | Q04721 |
PeptideAtlasi | Q04721 |
PRIDEi | Q04721 |
ProteomicsDBi | 58265 |
PTM databases
GlyConnecti | 1553, 2 N-Linked glycans (1 site) |
GlyGeni | Q04721, 8 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q04721 |
PhosphoSitePlusi | Q04721 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000134250, Expressed in testis and 248 other tissues |
ExpressionAtlasi | Q04721, baseline and differential |
Genevisiblei | Q04721, HS |
Organism-specific databases
HPAi | ENSG00000134250, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity).
Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2.
Interacts with RELA/p65 (By similarity).
Interacts with HIF1AN.
Interacts (via ANK repeats) with TCIM, the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (PubMed:25985737).
Interacts with CUL1, RBX1, SKP1 and FBXW7 that are SCF(FBXW7) E3 ubiquitin-protein ligase complex components (PubMed:29149593).
Interacts with MINAR1; this interaction increases MINAR1 stability and function (PubMed:29329397).
Interacts with NOTCH2NL (NOTCH2NLA, NOTCH2NLB and/or NOTCH2NLC); leading to enhance Notch signaling pathway in a non-cell-autonomous manner (PubMed:29856954).
Interacts with MDK; this interaction mediates a nuclear accumulation of NOTCH2 and therefore activation of NOTCH2 signaling leading to interaction between HES1 and STAT3 (PubMed:18469519).
By similarity8 PublicationsGO - Molecular functioni
- enzyme binding Source: Ensembl
- NF-kappaB binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 110915, 91 interactors |
CORUMi | Q04721 |
ELMi | Q04721 |
IntActi | Q04721, 47 interactors |
MINTi | Q04721 |
STRINGi | 9606.ENSP00000256646 |
Chemistry databases
BindingDBi | Q04721 |
Miscellaneous databases
RNActi | Q04721, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q04721 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q04721 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 63 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 64 – 102 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 105 – 143 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 144 – 180 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 182 – 219 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 221 – 258 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 260 – 296 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 298 – 336 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 338 – 374 | EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 375 – 413 | EGF-like 10PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 415 – 454 | EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 456 – 492 | EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 494 – 530 | EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 532 – 568 | EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 570 – 605 | EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 607 – 643 | EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 645 – 680 | EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 682 – 718 | EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 720 – 755 | EGF-like 19PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 757 – 793 | EGF-like 20; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 795 – 831 | EGF-like 21; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 833 – 871 | EGF-like 22PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 873 – 909 | EGF-like 23; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 911 – 947 | EGF-like 24; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 949 – 985 | EGF-like 25; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 987 – 1023 | EGF-like 26; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1025 – 1061 | EGF-like 27; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1063 – 1099 | EGF-like 28PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1101 – 1147 | EGF-like 29CuratedAdd BLAST | 47 | |
Domaini | 1149 – 1185 | EGF-like 30; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1187 – 1223 | EGF-like 31; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1225 – 1262 | EGF-like 32; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1264 – 1302 | EGF-like 33PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1304 – 1343 | EGF-like 34PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 1374 – 1412 | EGF-like 35PROSITE-ProRule annotationAdd BLAST | 39 | |
Repeati | 1425 – 1465 | LNR 1Add BLAST | 41 | |
Repeati | 1466 – 1502 | LNR 2Add BLAST | 37 | |
Repeati | 1503 – 1544 | LNR 3Add BLAST | 42 | |
Repeati | 1827 – 1871 | ANK 1Add BLAST | 45 | |
Repeati | 1876 – 1905 | ANK 2Add BLAST | 30 | |
Repeati | 1909 – 1939 | ANK 3Add BLAST | 31 | |
Repeati | 1943 – 1972 | ANK 4Add BLAST | 30 | |
Repeati | 1976 – 2005 | ANK 5Add BLAST | 30 | |
Repeati | 2009 – 2038 | ANK 6Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1425 – 1677 | Negative regulatory region (NRR)Add BLAST | 253 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1645 – 1648 | Poly-Ala | 4 | |
Compositional biasi | 1994 – 1997 | Poly-Leu | 4 | |
Compositional biasi | 2426 – 2429 | Poly-Ser | 4 |
Sequence similaritiesi
Keywords - Domaini
ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000155030 |
HOGENOMi | CLU_000576_0_0_1 |
InParanoidi | Q04721 |
OMAi | VSKPCLN |
OrthoDBi | 7525at2759 |
PhylomeDBi | Q04721 |
TreeFami | TF351641 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
IDEALi | IID00463 |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR024600, DUF3454_notch IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR008297, Notch IPR035993, Notch-like_dom_sf IPR022336, Notch_2 IPR000800, Notch_dom IPR010660, Notch_NOD_dom IPR011656, Notch_NODP_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF11936, DUF3454, 1 hit PF00008, EGF, 24 hits PF07645, EGF_CA, 4 hits PF12661, hEGF, 3 hits PF06816, NOD, 1 hit PF07684, NODP, 1 hit PF00066, Notch, 3 hits |
PIRSFi | PIRSF002279, Notch, 1 hit |
PRINTSi | PR01452, LNOTCHREPEAT PR01985, NOTCH2 |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM01334, DUF3454, 1 hit SM00181, EGF, 36 hits SM00179, EGF_CA, 34 hits SM00004, NL, 3 hits SM01338, NOD, 1 hit SM01339, NODP, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57184, SSF57184, 6 hits SSF90193, SSF90193, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS00010, ASX_HYDROXYL, 22 hits PS00022, EGF_1, 34 hits PS01186, EGF_2, 29 hits PS50026, EGF_3, 35 hits PS01187, EGF_CA, 22 hits PS50258, LNR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPALRPALLW ALLALWLCCA APAHALQCRD GYEPCVNEGM CVTYHNGTGY
60 70 80 90 100
CKCPEGFLGE YCQHRDPCEK NRCQNGGTCV AQAMLGKATC RCASGFTGED
110 120 130 140 150
CQYSTSHPCF VSRPCLNGGT CHMLSRDTYE CTCQVGFTGK ECQWTDACLS
160 170 180 190 200
HPCANGSTCT TVANQFSCKC LTGFTGQKCE TDVNECDIPG HCQHGGTCLN
210 220 230 240 250
LPGSYQCQCP QGFTGQYCDS LYVPCAPSPC VNGGTCRQTG DFTFECNCLP
260 270 280 290 300
GFEGSTCERN IDDCPNHRCQ NGGVCVDGVN TYNCRCPPQW TGQFCTEDVD
310 320 330 340 350
ECLLQPNACQ NGGTCANRNG GYGCVCVNGW SGDDCSENID DCAFASCTPG
360 370 380 390 400
STCIDRVASF SCMCPEGKAG LLCHLDDACI SNPCHKGALC DTNPLNGQYI
410 420 430 440 450
CTCPQGYKGA DCTEDVDECA MANSNPCEHA GKCVNTDGAF HCECLKGYAG
460 470 480 490 500
PRCEMDINEC HSDPCQNDAT CLDKIGGFTC LCMPGFKGVH CELEINECQS
510 520 530 540 550
NPCVNNGQCV DKVNRFQCLC PPGFTGPVCQ IDIDDCSSTP CLNGAKCIDH
560 570 580 590 600
PNGYECQCAT GFTGVLCEEN IDNCDPDPCH HGQCQDGIDS YTCICNPGYM
610 620 630 640 650
GAICSDQIDE CYSSPCLNDG RCIDLVNGYQ CNCQPGTSGV NCEINFDDCA
660 670 680 690 700
SNPCIHGICM DGINRYSCVC SPGFTGQRCN IDIDECASNP CRKGATCING
710 720 730 740 750
VNGFRCICPE GPHHPSCYSQ VNECLSNPCI HGNCTGGLSG YKCLCDAGWV
760 770 780 790 800
GINCEVDKNE CLSNPCQNGG TCDNLVNGYR CTCKKGFKGY NCQVNIDECA
810 820 830 840 850
SNPCLNQGTC FDDISGYTCH CVLPYTGKNC QTVLAPCSPN PCENAAVCKE
860 870 880 890 900
SPNFESYTCL CAPGWQGQRC TIDIDECISK PCMNHGLCHN TQGSYMCECP
910 920 930 940 950
PGFSGMDCEE DIDDCLANPC QNGGSCMDGV NTFSCLCLPG FTGDKCQTDM
960 970 980 990 1000
NECLSEPCKN GGTCSDYVNS YTCKCQAGFD GVHCENNINE CTESSCFNGG
1010 1020 1030 1040 1050
TCVDGINSFS CLCPVGFTGS FCLHEINECS SHPCLNEGTC VDGLGTYRCS
1060 1070 1080 1090 1100
CPLGYTGKNC QTLVNLCSRS PCKNKGTCVQ KKAESQCLCP SGWAGAYCDV
1110 1120 1130 1140 1150
PNVSCDIAAS RRGVLVEHLC QHSGVCINAG NTHYCQCPLG YTGSYCEEQL
1160 1170 1180 1190 1200
DECASNPCQH GATCSDFIGG YRCECVPGYQ GVNCEYEVDE CQNQPCQNGG
1210 1220 1230 1240 1250
TCIDLVNHFK CSCPPGTRGL LCEENIDDCA RGPHCLNGGQ CMDRIGGYSC
1260 1270 1280 1290 1300
RCLPGFAGER CEGDINECLS NPCSSEGSLD CIQLTNDYLC VCRSAFTGRH
1310 1320 1330 1340 1350
CETFVDVCPQ MPCLNGGTCA VASNMPDGFI CRCPPGFSGA RCQSSCGQVK
1360 1370 1380 1390 1400
CRKGEQCVHT ASGPRCFCPS PRDCESGCAS SPCQHGGSCH PQRQPPYYSC
1410 1420 1430 1440 1450
QCAPPFSGSR CELYTAPPST PPATCLSQYC ADKARDGVCD EACNSHACQW
1460 1470 1480 1490 1500
DGGDCSLTME NPWANCSSPL PCWDYINNQC DELCNTVECL FDNFECQGNS
1510 1520 1530 1540 1550
KTCKYDKYCA DHFKDNHCDQ GCNSEECGWD GLDCAADQPE NLAEGTLVIV
1560 1570 1580 1590 1600
VLMPPEQLLQ DARSFLRALG TLLHTNLRIK RDSQGELMVY PYYGEKSAAM
1610 1620 1630 1640 1650
KKQRMTRRSL PGEQEQEVAG SKVFLEIDNR QCVQDSDHCF KNTDAAAALL
1660 1670 1680 1690 1700
ASHAIQGTLS YPLVSVVSES LTPERTQLLY LLAVAVVIIL FIILLGVIMA
1710 1720 1730 1740 1750
KRKRKHGSLW LPEGFTLRRD ASNHKRREPV GQDAVGLKNL SVQVSEANLI
1760 1770 1780 1790 1800
GTGTSEHWVD DEGPQPKKVK AEDEALLSEE DDPIDRRPWT QQHLEAADIR
1810 1820 1830 1840 1850
RTPSLALTPP QAEQEVDVLD VNVRGPDGCT PLMLASLRGG SSDLSDEDED
1860 1870 1880 1890 1900
AEDSSANIIT DLVYQGASLQ AQTDRTGEMA LHLAARYSRA DAAKRLLDAG
1910 1920 1930 1940 1950
ADANAQDNMG RCPLHAAVAA DAQGVFQILI RNRVTDLDAR MNDGTTPLIL
1960 1970 1980 1990 2000
AARLAVEGMV AELINCQADV NAVDDHGKSA LHWAAAVNNV EATLLLLKNG
2010 2020 2030 2040 2050
ANRDMQDNKE ETPLFLAARE GSYEAAKILL DHFANRDITD HMDRLPRDVA
2060 2070 2080 2090 2100
RDRMHHDIVR LLDEYNVTPS PPGTVLTSAL SPVICGPNRS FLSLKHTPMG
2110 2120 2130 2140 2150
KKSRRPSAKS TMPTSLPNLA KEAKDAKGSR RKKSLSEKVQ LSESSVTLSP
2160 2170 2180 2190 2200
VDSLESPHTY VSDTTSSPMI TSPGILQASP NPMLATAAPP APVHAQHALS
2210 2220 2230 2240 2250
FSNLHEMQPL AHGASTVLPS VSQLLSHHHI VSPGSGSAGS LSRLHPVPVP
2260 2270 2280 2290 2300
ADWMNRMEVN ETQYNEMFGM VLAPAEGTHP GIAPQSRPPE GKHITTPREP
2310 2320 2330 2340 2350
LPPIVTFQLI PKGSIAQPAG APQPQSTCPP AVAGPLPTMY QIPEMARLPS
2360 2370 2380 2390 2400
VAFPTAMMPQ QDGQVAQTIL PAYHPFPASV GKYPTPPSQH SYASSNAAER
2410 2420 2430 2440 2450
TPSHSGHLQG EHPYLTPSPE SPDQWSSSSP HSASDWSDVT TSPTPGGAGG
2460 2470
GQRGPGTHMS EPPHNNMQVY A
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494C1U9 | A0A494C1U9_HUMAN | Neurogenic locus notch homolog prot... | NOTCH2 | 274 | Annotation score: | ||
D2WEZ3 | D2WEZ3_HUMAN | Neurogenic locus notch homolog prot... | NOTCH2 | 863 | Annotation score: | ||
A0A494C1F1 | A0A494C1F1_HUMAN | Neurogenic locus notch homolog prot... | NOTCH2 | 114 | Annotation score: | ||
R4GN02 | R4GN02_HUMAN | Neurogenic locus notch homolog prot... | NOTCH2 | 236 | Annotation score: | ||
A0A1W2PQQ5 | A0A1W2PQQ5_HUMAN | Neurogenic locus notch homolog prot... | NOTCH2 | 31 | Annotation score: | ||
A0A494C1H8 | A0A494C1H8_HUMAN | Neurogenic locus notch homolog prot... | NOTCH2 | 12 | Annotation score: | ||
A0A494C049 | A0A494C049_HUMAN | Neurogenic locus notch homolog prot... | NOTCH2 | 25 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | A → T in AAG37073 (Ref. 2) Curated | 1 | |
Sequence conflicti | 210 | P → L in AAG37073 (Ref. 2) Curated | 1 | |
Sequence conflicti | 1037 | E → D in AAB19224 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1084 – 1085 | ES → SP in AAB19224 (Ref. 4) Curated | 2 | |
Sequence conflicti | 1094 | A → V in AAB19224 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1139 | L → V in AAB19224 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1519 | D → N in AAA36377 (Ref. 1) Curated | 1 | |
Sequence conflicti | 2053 | R → H in AAG37073 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029361 | 444 | C → Y in ALGS2. 1 PublicationCorresponds to variant dbSNP:rs111033632EnsemblClinVar. | 1 | |
Natural variantiVAR_031463 | 1667 | V → F. Corresponds to variant dbSNP:rs17024517EnsemblClinVar. | 1 | |
Natural variantiVAR_080195 | 2140 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 332 | |
Natural variantiVAR_080196 | 2196 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 276 | |
Natural variantiVAR_080197 | 2208 – 2471 | Missing in HJCYS. 2 PublicationsAdd BLAST | 264 | |
Natural variantiVAR_080198 | 2223 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 249 | |
Natural variantiVAR_080199 | 2285 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 187 | |
Natural variantiVAR_080200 | 2299 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 173 | |
Natural variantiVAR_080201 | 2317 – 2471 | Missing in HJCYS; loss of interaction with FBW7; decreased ubiquitination. 2 PublicationsAdd BLAST | 155 | |
Natural variantiVAR_080202 | 2325 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 147 | |
Natural variantiVAR_080203 | 2360 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 112 | |
Natural variantiVAR_080204 | 2373 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 99 | |
Natural variantiVAR_080205 | 2389 – 2471 | Missing in HJCYS. 1 PublicationAdd BLAST | 83 | |
Natural variantiVAR_080206 | 2400 – 2471 | Missing in HJCYS. 3 PublicationsAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF308601 mRNA Translation: AAA36377.2 AF315356 mRNA Translation: AAG37073.1 AL359752, AL512503, AL596222 Genomic DNA Translation: CAI18974.1 AL512503, AL359752, AL596222 Genomic DNA Translation: CAH72483.1 AL596222, AL359752, AL512503 Genomic DNA Translation: CAH70182.1 U77493 mRNA Translation: AAB19224.1 |
CCDSi | CCDS908.1 |
RefSeqi | NP_001186930.1, NM_001200001.1 NP_077719.2, NM_024408.3 |
Genome annotation databases
Ensembli | ENST00000256646; ENSP00000256646; ENSG00000134250 |
GeneIDi | 4853 |
KEGGi | hsa:4853 |
UCSCi | uc001eik.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF308601 mRNA Translation: AAA36377.2 AF315356 mRNA Translation: AAG37073.1 AL359752, AL512503, AL596222 Genomic DNA Translation: CAI18974.1 AL512503, AL359752, AL596222 Genomic DNA Translation: CAH72483.1 AL596222, AL359752, AL512503 Genomic DNA Translation: CAH70182.1 U77493 mRNA Translation: AAB19224.1 |
CCDSi | CCDS908.1 |
RefSeqi | NP_001186930.1, NM_001200001.1 NP_077719.2, NM_024408.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2OO4 | X-ray | 2.00 | A/B | 1423-1677 | [»] | |
5MWB | X-ray | 1.86 | A | 414-532 | [»] | |
SMRi | Q04721 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110915, 91 interactors |
CORUMi | Q04721 |
ELMi | Q04721 |
IntActi | Q04721, 47 interactors |
MINTi | Q04721 |
STRINGi | 9606.ENSP00000256646 |
Chemistry databases
BindingDBi | Q04721 |
ChEMBLi | CHEMBL3407320 |
GuidetoPHARMACOLOGYi | 2859 |
PTM databases
GlyConnecti | 1553, 2 N-Linked glycans (1 site) |
GlyGeni | Q04721, 8 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q04721 |
PhosphoSitePlusi | Q04721 |
Genetic variation databases
BioMutai | NOTCH2 |
DMDMi | 143811429 |
Proteomic databases
EPDi | Q04721 |
jPOSTi | Q04721 |
MassIVEi | Q04721 |
MaxQBi | Q04721 |
PaxDbi | Q04721 |
PeptideAtlasi | Q04721 |
PRIDEi | Q04721 |
ProteomicsDBi | 58265 |
Protocols and materials databases
ABCDi | Q04721, 25 sequenced antibodies |
Antibodypediai | 20208, 635 antibodies |
Genome annotation databases
Ensembli | ENST00000256646; ENSP00000256646; ENSG00000134250 |
GeneIDi | 4853 |
KEGGi | hsa:4853 |
UCSCi | uc001eik.4, human |
Organism-specific databases
CTDi | 4853 |
DisGeNETi | 4853 |
GeneCardsi | NOTCH2 |
GeneReviewsi | NOTCH2 |
HGNCi | HGNC:7882, NOTCH2 |
HPAi | ENSG00000134250, Low tissue specificity |
MalaCardsi | NOTCH2 |
MIMi | 102500, phenotype 600275, gene 610205, phenotype |
neXtProti | NX_Q04721 |
OpenTargetsi | ENSG00000134250 |
Orphaneti | 955, Acroosteolysis dominant type 261629, Alagille syndrome due to a NOTCH2 point mutation |
PharmGKBi | PA31684 |
VEuPathDBi | HostDB:ENSG00000134250.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000155030 |
HOGENOMi | CLU_000576_0_0_1 |
InParanoidi | Q04721 |
OMAi | VSKPCLN |
OrthoDBi | 7525at2759 |
PhylomeDBi | Q04721 |
TreeFami | TF351641 |
Enzyme and pathway databases
PathwayCommonsi | Q04721 |
Reactomei | R-HSA-1912399, Pre-NOTCH Processing in the Endoplasmic Reticulum R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-1912420, Pre-NOTCH Processing in Golgi R-HSA-2197563, NOTCH2 intracellular domain regulates transcription R-HSA-2979096, NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-350054, Notch-HLH transcription pathway R-HSA-5083630, Defective LFNG causes SCDO3 R-HSA-9013695, NOTCH4 Intracellular Domain Regulates Transcription |
SignaLinki | Q04721 |
SIGNORi | Q04721 |
Miscellaneous databases
BioGRID-ORCSi | 4853, 9 hits in 992 CRISPR screens |
ChiTaRSi | NOTCH2, human |
EvolutionaryTracei | Q04721 |
GeneWikii | Notch-2 |
GenomeRNAii | 4853 |
Pharosi | Q04721, Tchem |
PROi | PR:Q04721 |
RNActi | Q04721, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134250, Expressed in testis and 248 other tissues |
ExpressionAtlasi | Q04721, baseline and differential |
Genevisiblei | Q04721, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
IDEALi | IID00463 |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR024600, DUF3454_notch IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR008297, Notch IPR035993, Notch-like_dom_sf IPR022336, Notch_2 IPR000800, Notch_dom IPR010660, Notch_NOD_dom IPR011656, Notch_NODP_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF11936, DUF3454, 1 hit PF00008, EGF, 24 hits PF07645, EGF_CA, 4 hits PF12661, hEGF, 3 hits PF06816, NOD, 1 hit PF07684, NODP, 1 hit PF00066, Notch, 3 hits |
PIRSFi | PIRSF002279, Notch, 1 hit |
PRINTSi | PR01452, LNOTCHREPEAT PR01985, NOTCH2 |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM01334, DUF3454, 1 hit SM00181, EGF, 36 hits SM00179, EGF_CA, 34 hits SM00004, NL, 3 hits SM01338, NOD, 1 hit SM01339, NODP, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57184, SSF57184, 6 hits SSF90193, SSF90193, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 4 hits PS00010, ASX_HYDROXYL, 22 hits PS00022, EGF_1, 34 hits PS01186, EGF_2, 29 hits PS50026, EGF_3, 35 hits PS01187, EGF_CA, 22 hits PS50258, LNR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOTC2_HUMAN | |
Accessioni | Q04721Primary (citable) accession number: Q04721 Secondary accession number(s): Q5T3X7, Q99734, Q9H240 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | April 3, 2007 | |
Last modified: | April 7, 2021 | |
This is version 236 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families