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Entry version 196 (16 Oct 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Keratin, type I cytoskeletal 17

Gene

KRT17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.By similarity3 Publications

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • MHC class II protein binding Source: UniProtKB
  • MHC class II receptor activity Source: UniProtKB
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q04695

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 17
Alternative name(s):
39.1
Cytokeratin-17
Short name:
CK-17
Keratin-17
Short name:
K17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6427 KRT17

Online Mendelian Inheritance in Man (OMIM)

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MIMi
148069 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q04695

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pachyonychia congenita 2 (PC2)18 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07244188M → K in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928898EnsemblClinVar.1
Natural variantiVAR_01051288M → T in PC2 and SM. 2 PublicationsCorresponds to variant dbSNP:rs28928898EnsemblClinVar.1
Natural variantiVAR_07244291L → P in PC2. 1 Publication1
Natural variantiVAR_07244392 – 99Missing in PC2. 1 Publication8
Natural variantiVAR_00384792N → D in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928896EnsemblClinVar.1
Natural variantiVAR_00384992N → S in PC2. 6 PublicationsCorresponds to variant dbSNP:rs59151893EnsemblClinVar.1
Natural variantiVAR_01706994 – 98Missing in PC2. 5
Natural variantiVAR_01051394R → C in PC2 and SM. 1 PublicationCorresponds to variant dbSNP:rs58730926EnsemblClinVar.1
Natural variantiVAR_00385094R → H in SM AND PC2. 2 PublicationsCorresponds to variant dbSNP:rs28928897EnsemblClinVar.1
Natural variantiVAR_01706894R → P in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928897EnsemblClinVar.1
Natural variantiVAR_01707195L → P in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928899EnsemblClinVar.1
Natural variantiVAR_01707095L → Q in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928899EnsemblClinVar.1
Natural variantiVAR_01707297Missing in PC2. 1 Publication1
Natural variantiVAR_00385198Y → D in PC2. 1 PublicationCorresponds to variant dbSNP:rs28933088EnsemblClinVar.1
Natural variantiVAR_01707399L → P in PC2. 1 PublicationCorresponds to variant dbSNP:rs28933089EnsemblClinVar.1
Natural variantiVAR_017074102V → M in PC2. 2 PublicationsCorresponds to variant dbSNP:rs59977263EnsemblClinVar.1
Natural variantiVAR_037083109N → D in PC2. 2 PublicationsCorresponds to variant dbSNP:rs267607412EnsemblClinVar.1
Natural variantiVAR_072444388L → P in PC2. 1 PublicationCorresponds to variant dbSNP:rs56690581EnsemblClinVar.1
Natural variantiVAR_072445388L → R in PC2. 1 Publication1
Steatocystoma multiplex (SM)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDisease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01051288M → T in PC2 and SM. 2 PublicationsCorresponds to variant dbSNP:rs28928898EnsemblClinVar.1
Natural variantiVAR_00384892N → H in SM. 1 PublicationCorresponds to variant dbSNP:rs28928896EnsemblClinVar.1
Natural variantiVAR_01051394R → C in PC2 and SM. 1 PublicationCorresponds to variant dbSNP:rs58730926EnsemblClinVar.1
Natural variantiVAR_00385094R → H in SM AND PC2. 2 PublicationsCorresponds to variant dbSNP:rs28928897EnsemblClinVar.1
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi103R → A: Down-regulates both proliferation of psoriatic T-cells and IFN-gamma production; suppresses keratinocyte growth when part of the altered peptide epitope S1. 1 Publication1
Mutagenesisi106E → A: Down-regulates proliferation of psoriatic T-cells and IFN-gamma production when part of the altered peptide epitope S1. 1 Publication1
Mutagenesisi109N → A: No significant effect on T-cell proliferation or IFN-gamma production when part of the altered peptide epitope S1. 1 Publication1
Mutagenesisi154N → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi155I → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi157L → A: Down-regulates proliferation of psoriatic T-cells and IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi160D → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S4. 1 Publication1
Mutagenesisi333N → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S4. 1 Publication1
Mutagenesisi334R → A: No significant effect on T-cell proliferation but can induce IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi336C → A: No significant effect on T-cell proliferation but reduces IFN-gamma production when part of the altered peptide epitope S2. 1 Publication1
Mutagenesisi339L → A: Down-regulates both proliferation of psoriatic T-cells and IFN-gamma production; suppresses keratinocyte growth when part of the altered peptide epitope S4. 1 Publication1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
3872

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
KRT17

MalaCards human disease database

More...
MalaCardsi
KRT17
MIMi167210 phenotype
184500 phenotype

Open Targets

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OpenTargetsi
ENSG00000128422

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2309 Pachyonychia congenita
841 Sebocystomatosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30214

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q04695

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT17

Domain mapping of disease mutations (DMDM)

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DMDMi
547751

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636641 – 432Keratin, type I cytoskeletal 17Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei25PhosphoserineBy similarity1
Modified residuei32PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei44Phosphoserine; by RPS6KA11 Publication1
Modified residuei110PhosphothreonineCombined sources1
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei279PhosphothreonineBy similarity1
Modified residuei323PhosphoserineCombined sources1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q04695

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q04695

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q04695

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04695

PeptideAtlas

More...
PeptideAtlasi
Q04695

PRoteomics IDEntifications database

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PRIDEi
Q04695

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
58264

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q04695

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q04695

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04695

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q04695

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q04695

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q04695

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).4 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in damaged or stressed epidermis. Induced by the cytokines interferon-gamma (IFN-gamma), tumor necrosis factor alpha (TNF-alpha) and transforming growth factor-alpha (TGF-alpha), and by the potent NF-kappa B inhibitor compounds Bay 11-7082 and Bay 11-7085. Down-regulated by the drug Imatinib.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128422 Expressed in 179 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q04695 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q04695 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000029
HPA000452
HPA000453
HPA000539
HPA045062

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B).

Interacts with TRADD and SFN (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110070, 183 interactors

Database of interacting proteins

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DIPi
DIP-33093N

Protein interaction database and analysis system

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IntActi
Q04695, 26 interactors

Molecular INTeraction database

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MINTi
Q04695

STRING: functional protein association networks

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STRINGi
9606.ENSP00000308452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q04695

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini84 – 395IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 83HeadAdd BLAST83
Regioni84 – 120Coil 1AAdd BLAST37
Regioni102 – 116Peptide epitope S1; induces T-cell and keratinocyte proliferation and IFN-gamma productionAdd BLAST15
Regioni121 – 138Linker 1Add BLAST18
Regioni139 – 230Coil 1BAdd BLAST92
Regioni153 – 167Peptide epitope S2; induces T-cell proliferation and IFN-gamma productionAdd BLAST15
Regioni231 – 250Linker 12Add BLAST20
Regioni251 – 392Coil 2Add BLAST142
Regioni332 – 346Peptide epitope S4; induces T-cell and keratinocyte proliferation and IFN-gamma productionAdd BLAST15
Regioni393 – 432TailAdd BLAST40

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFTF Eukaryota
ENOG410Y9IV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160681

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q04695

KEGG Orthology (KO)

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KOi
K07604

Identification of Orthologs from Complete Genome Data

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OMAi
YYHTIED

Database of Orthologous Groups

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OrthoDBi
939331at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q04695

TreeFam database of animal gene trees

More...
TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q04695-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTSIRQFTS SSSIKGSSGL GGGSSRTSCR LSGGLGAGSC RLGSAGGLGS
60 70 80 90 100
TLGGSSYSSC YSFGSGGGYG SSFGGVDGLL AGGEKATMQN LNDRLASYLD
110 120 130 140 150
KVRALEEANT ELEVKIRDWY QRQAPGPARD YSQYYRTIEE LQNKILTATV
160 170 180 190 200
DNANILLQID NARLAADDFR TKFETEQALR LSVEADINGL RRVLDELTLA
210 220 230 240 250
RADLEMQIEN LKEELAYLKK NHEEEMNALR GQVGGEINVE MDAAPGVDLS
260 270 280 290 300
RILNEMRDQY EKMAEKNRKD AEDWFFSKTE ELNREVATNS ELVQSGKSEI
310 320 330 340 350
SELRRTMQAL EIELQSQLSM KASLEGNLAE TENRYCVQLS QIQGLIGSVE
360 370 380 390 400
EQLAQLRCEM EQQNQEYKIL LDVKTRLEQE IATYRRLLEG EDAHLTQYKK
410 420 430
EPVTTRQVRT IVEEVQDGKV ISSREQVHQT TR
Length:432
Mass (Da):48,106
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35B429243F47EB5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GWP8F5GWP8_HUMAN
Keratin, type I cytoskeletal 17
KRT17
349Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPJ9K7EPJ9_HUMAN
Keratin, type I cytoskeletal 17
KRT17
231Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESE1K7ESE1_HUMAN
Keratin, type I cytoskeletal 17
KRT17
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS58A0A3B3IS58_HUMAN
Keratin, type I cytoskeletal 17
KRT17
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH72018 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30R → Q in AL353997 (PubMed:16625196).Curated1
Sequence conflicti30R → Q in AC022596 (PubMed:16625196).Curated1
Sequence conflicti42L → P in AL353997 (PubMed:16625196).Curated1
Sequence conflicti42L → P in AC022596 (PubMed:16625196).Curated1
Sequence conflicti51 – 56Missing in BAC04534 (PubMed:14702039).Curated6
Sequence conflicti51T → A in AL353997 (PubMed:16625196).Curated1
Sequence conflicti51T → A in AC022596 (PubMed:16625196).Curated1
Sequence conflicti72S → SS in AL353997 (PubMed:16625196).Curated1
Sequence conflicti73 – 74FG → SFE in AC022596 (PubMed:16625196).Curated2
Sequence conflicti74G → E in AL353997 (PubMed:16625196).Curated1
Sequence conflicti81A → V in AL353997 (PubMed:16625196).Curated1
Sequence conflicti81A → V in AC022596 (PubMed:16625196).Curated1
Sequence conflicti94 – 108Missing in AAH72018 (PubMed:15489334).CuratedAdd BLAST15
Sequence conflicti137T → I in AL353997 (PubMed:16625196).Curated1
Sequence conflicti137T → I in AC022596 (PubMed:16625196).Curated1
Sequence conflicti145 – 147ILT → VGPA in AL353997 (PubMed:16625196).Curated3
Sequence conflicti158Q → H in AC022596 (PubMed:16625196).Curated1
Sequence conflicti159I → N in AL353997 (PubMed:16625196).Curated1
Sequence conflicti163R → H in AL353997 (PubMed:16625196).Curated1
Sequence conflicti163R → H in AC022596 (PubMed:16625196).Curated1
Sequence conflicti167D → A in AL353997 (PubMed:16625196).Curated1
Sequence conflicti167D → A in AC022596 (PubMed:16625196).Curated1
Sequence conflicti180R → C in AL353997 (PubMed:16625196).Curated1
Sequence conflicti180R → C in AC022596 (PubMed:16625196).Curated1
Sequence conflicti190 – 191LR → PC in AL353997 (PubMed:16625196).Curated2
Sequence conflicti190 – 191LR → PC in AC022596 (PubMed:16625196).Curated2
Sequence conflicti204L → P in AL353997 (PubMed:16625196).Curated1
Sequence conflicti207Q → H in AL353997 (PubMed:16625196).Curated1
Sequence conflicti207Q → H in AC022596 (PubMed:16625196).Curated1
Sequence conflicti225Missing in AL353997 (PubMed:16625196).Curated1
Sequence conflicti225Missing in AC022596 (PubMed:16625196).Curated1
Sequence conflicti229L → P in AL353997 (PubMed:16625196).Curated1
Sequence conflicti229L → P in AC022596 (PubMed:16625196).Curated1
Sequence conflicti242D → G in AL353997 (PubMed:16625196).Curated1
Sequence conflicti242D → G in AC022596 (PubMed:16625196).Curated1
Sequence conflicti258D → E in AL353997 (PubMed:16625196).Curated1
Sequence conflicti258D → E in AC022596 (PubMed:16625196).Curated1
Sequence conflicti305R → C in AL353997 (PubMed:16625196).Curated1
Sequence conflicti305R → C in AC022596 (PubMed:16625196).Curated1
Sequence conflicti337V → M in AL353997 (PubMed:16625196).Curated1
Sequence conflicti337V → M in AC022596 (PubMed:16625196).Curated1
Sequence conflicti352Q → R in AL353997 (PubMed:16625196).Curated1
Sequence conflicti352Q → R in AC022596 (PubMed:16625196).Curated1
Sequence conflicti357R → L in AL353997 (PubMed:16625196).Curated1
Sequence conflicti357R → L in AC022596 (PubMed:16625196).Curated1
Sequence conflicti373 – 375VKT → MKM in AL353997 (PubMed:16625196).Curated3
Sequence conflicti373 – 375VKT → MKM in AC022596 (PubMed:16625196).Curated3
Sequence conflicti379Q → L in AL353997 (PubMed:16625196).Curated1
Sequence conflicti379Q → L in AC022596 (PubMed:16625196).Curated1
Sequence conflicti382A → T in AL353997 (PubMed:16625196).Curated1
Sequence conflicti382A → T in AC022596 (PubMed:16625196).Curated1
Sequence conflicti385R → H in AL353997 (PubMed:16625196).Curated1
Sequence conflicti385R → H in AC022596 (PubMed:16625196).Curated1
Sequence conflicti395 – 404LTQYKKEPVT → FRMSESSPVS in AC022596 (PubMed:16625196).Curated10
Sequence conflicti406R → C in AL353997 (PubMed:16625196).Curated1
Sequence conflicti409R → P in AL353997 (PubMed:16625196).Curated1
Sequence conflicti428H → R in AL353997 (PubMed:16625196).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07244188M → K in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928898EnsemblClinVar.1
Natural variantiVAR_01051288M → T in PC2 and SM. 2 PublicationsCorresponds to variant dbSNP:rs28928898EnsemblClinVar.1
Natural variantiVAR_07244291L → P in PC2. 1 Publication1
Natural variantiVAR_07244392 – 99Missing in PC2. 1 Publication8
Natural variantiVAR_00384792N → D in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928896EnsemblClinVar.1
Natural variantiVAR_00384892N → H in SM. 1 PublicationCorresponds to variant dbSNP:rs28928896EnsemblClinVar.1
Natural variantiVAR_00384992N → S in PC2. 6 PublicationsCorresponds to variant dbSNP:rs59151893EnsemblClinVar.1
Natural variantiVAR_01706994 – 98Missing in PC2. 5
Natural variantiVAR_01051394R → C in PC2 and SM. 1 PublicationCorresponds to variant dbSNP:rs58730926EnsemblClinVar.1
Natural variantiVAR_00385094R → H in SM AND PC2. 2 PublicationsCorresponds to variant dbSNP:rs28928897EnsemblClinVar.1
Natural variantiVAR_01706894R → P in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928897EnsemblClinVar.1
Natural variantiVAR_01707195L → P in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928899EnsemblClinVar.1
Natural variantiVAR_01707095L → Q in PC2. 1 PublicationCorresponds to variant dbSNP:rs28928899EnsemblClinVar.1
Natural variantiVAR_01707297Missing in PC2. 1 Publication1
Natural variantiVAR_00385198Y → D in PC2. 1 PublicationCorresponds to variant dbSNP:rs28933088EnsemblClinVar.1
Natural variantiVAR_01707399L → P in PC2. 1 PublicationCorresponds to variant dbSNP:rs28933089EnsemblClinVar.1
Natural variantiVAR_017074102V → M in PC2. 2 PublicationsCorresponds to variant dbSNP:rs59977263EnsemblClinVar.1
Natural variantiVAR_037083109N → D in PC2. 2 PublicationsCorresponds to variant dbSNP:rs267607412EnsemblClinVar.1
Natural variantiVAR_072444388L → P in PC2. 1 PublicationCorresponds to variant dbSNP:rs56690581EnsemblClinVar.1
Natural variantiVAR_072445388L → R in PC2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z19574 Genomic DNA Translation: CAA79626.1
X62571 mRNA Translation: CAA44451.1
AK095342 mRNA Translation: BAC04534.1
AC022596 Genomic DNA No translation available.
AL353997 Genomic DNA No translation available.
BC000159 mRNA Translation: AAH00159.2
BC011901 mRNA Translation: AAH11901.1
BC056421 mRNA Translation: AAH56421.1
BC072018 mRNA Translation: AAH72018.1 Frameshift.
BC072019 mRNA Translation: AAH72019.1
S78515 Genomic DNA Translation: AAB34565.1
EF608068 mRNA Translation: ABQ96595.1
EF608069 mRNA Translation: ABQ96596.1
EF608070 mRNA Translation: ABQ96597.1
EF608071 mRNA Translation: ABQ96598.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11402.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S30433

NCBI Reference Sequences

More...
RefSeqi
NP_000413.1, NM_000422.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311208; ENSP00000308452; ENSG00000128422

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3872

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3872

UCSC genome browser

More...
UCSCi
uc002hxh.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19574 Genomic DNA Translation: CAA79626.1
X62571 mRNA Translation: CAA44451.1
AK095342 mRNA Translation: BAC04534.1
AC022596 Genomic DNA No translation available.
AL353997 Genomic DNA No translation available.
BC000159 mRNA Translation: AAH00159.2
BC011901 mRNA Translation: AAH11901.1
BC056421 mRNA Translation: AAH56421.1
BC072018 mRNA Translation: AAH72018.1 Frameshift.
BC072019 mRNA Translation: AAH72019.1
S78515 Genomic DNA Translation: AAB34565.1
EF608068 mRNA Translation: ABQ96595.1
EF608069 mRNA Translation: ABQ96596.1
EF608070 mRNA Translation: ABQ96597.1
EF608071 mRNA Translation: ABQ96598.1
CCDSiCCDS11402.1
PIRiS30433
RefSeqiNP_000413.1, NM_000422.2

3D structure databases

SMRiQ04695
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110070, 183 interactors
DIPiDIP-33093N
IntActiQ04695, 26 interactors
MINTiQ04695
STRINGi9606.ENSP00000308452

PTM databases

iPTMnetiQ04695
PhosphoSitePlusiQ04695
SwissPalmiQ04695

Polymorphism and mutation databases

BioMutaiKRT17
DMDMi547751

2D gel databases

SWISS-2DPAGEiQ04695

Proteomic databases

EPDiQ04695
jPOSTiQ04695
MassIVEiQ04695
PaxDbiQ04695
PeptideAtlasiQ04695
PRIDEiQ04695
ProteomicsDBi58264
TopDownProteomicsiQ04695

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q04695

The DNASU plasmid repository

More...
DNASUi
3872

Genome annotation databases

EnsembliENST00000311208; ENSP00000308452; ENSG00000128422
GeneIDi3872
KEGGihsa:3872
UCSCiuc002hxh.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3872
DisGeNETi3872

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT17
GeneReviewsiKRT17
HGNCiHGNC:6427 KRT17
HPAiCAB000029
HPA000452
HPA000453
HPA000539
HPA045062
MalaCardsiKRT17
MIMi148069 gene
167210 phenotype
184500 phenotype
neXtProtiNX_Q04695
OpenTargetsiENSG00000128422
Orphaneti2309 Pachyonychia congenita
841 Sebocystomatosis
PharmGKBiPA30214

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00940000160681
InParanoidiQ04695
KOiK07604
OMAiYYHTIED
OrthoDBi939331at2759
PhylomeDBiQ04695
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiQ04695

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRT17 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Keratin_17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3872
PharosiQ04695
PMAP-CutDBiQ04695

Protein Ontology

More...
PROi
PR:Q04695

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128422 Expressed in 179 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ04695 baseline and differential
GenevisibleiQ04695 HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04695
Secondary accession number(s): A5Z1M9
, A5Z1N0, A5Z1N1, A5Z1N2, A6NDV6, A6NKQ2, Q6IP98, Q8N1P6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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