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Entry version 154 (18 Sep 2019)
Sequence version 1 (01 Nov 1997)
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Protein

Pre-mRNA-splicing factor RSE1

Gene

RSE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in G2/M transition (By similarity). Required for pre-mRNA splicing and endoplasmic reticulum (ER) to Golgi secretion pathway. U2 snRNPs associated protein required for the pre-spliceosome assembly. The involvement in ER to Golgi secretion is probably indirect and due to the splicing of the pre-mRNA coding for SAR1, a small GTP-binding protein required for COPII vesicle formation from the ER.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • U2 snRNA binding Source: SGD

GO - Biological processi

  • mRNA splicing, via spliceosome Source: SGD
  • spliceosomal complex assembly Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32646-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing factor RSE1
Alternative name(s):
RNA splicing and ER to Golgi transport factor 1
Spliceosome-associated protein 130
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RSE1
Synonyms:SAP130
Ordered Locus Names:YML049C
ORF Names:YM9827.03C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YML049C

Saccharomyces Genome Database

More...
SGDi
S000004513 RSE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002186381 – 1361Pre-mRNA-splicing factor RSE1Add BLAST1361

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q04693

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q04693

PRoteomics IDEntifications database

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PRIDEi
Q04693

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q04693

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04693

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the SF3B complex, a U2 associated sub-complex of the spliceosome. The SF3B complex is composed of at least CUS1, HSH49, HSH155, RDS3 and RSE1. Belongs also to the CWC complex (or CEF1-associated complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least BUD13, BUD31, BRR2, CDC40, CEF1, CLF1, CUS1, CWC2, CWC15, CWC21, CWC22, CWC23, CWC24, CWC25, CWC27, ECM2, HSH155, IST3, ISY1, LEA1, MSL1, NTC20, PRP8, PRP9, PRP11, PRP19, PRP21, PRP22, PRP45, PRP46, SLU7, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, SNT309, SNU114, SPP2, SYF1, SYF2, RSE1 and YJU2.

Interacts with RDS3.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HSH155P499553EBI-519,EBI-664

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
35119, 200 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1647 SF3B complex
CPX-1651 PRP19-associated complex
CPX-26 U2 snRNP

Database of interacting proteins

More...
DIPi
DIP-856N

Protein interaction database and analysis system

More...
IntActi
Q04693, 32 interactors

Molecular INTeraction database

More...
MINTi
Q04693

STRING: functional protein association networks

More...
STRINGi
4932.YML049C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q04693

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RSE1 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000066036

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q04693

KEGG Orthology (KO)

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KOi
K12830

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWKAPGK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004871 Cleavage/polyA-sp_fac_asu_C
IPR015943 WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03178 CPSF_A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q04693-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGGGKMAVV SLSPHTAKMR KLFGQASTTM AYDGLKREAE RRTRSDHNIT
60 70 80 90 100
MVAKDDELYL YHLTLKKQTN FVHSCIGHFV DLEAGSKREQ SQLCVATETH
110 120 130 140 150
LELYDTADGE LKLIAKFQNL FATITSMKSL DLPHSGSRAK ASNWPTFLAL
160 170 180 190 200
TSDSGNLSIV QIIMHAGALR LKTLVNQPLT RTTLRRVSPI SYMEIDPNGR
210 220 230 240 250
CIILSSVEQN KLCFLVDYAQ KLRISSPLEI IRPHMVTLDM AVVDVNFNNP
260 270 280 290 300
CFVTLEIDNA ATQLSVHLIF YVLELGLNHI VKKADYLVNP SANFVLSLPD
310 320 330 340 350
LSRYNITTSL SDNNYDADYD TLFNPFVVIG FENHILVKDM NGFFSLKVEI
360 370 380 390 400
PKRSITNSRH KNVTIISGIV QKLKNDFFVL LQSNHGDLFK LTVSPDTNDR
410 420 430 440 450
NRPLVQLSYF DTIQNSHQLH IFKNGYLFAL SEMNNNFLFQ FEKLGVEKND
460 470 480 490 500
FSNVLTSKDP NKSLVFEPSI KLQNLSILSQ QLNLNPSIKS QIVSDSPLSI
510 520 530 540 550
ATKHFTNNKI ITLTNAVNYS NLISTSLPPN ATKLWLIPDP ATTGDNNTLL
560 570 580 590 600
FITFPKKTMI LQIDNESMEE LTPDEATRSA FKLSQDTTIH TCLMGSHSII
610 620 630 640 650
QVCTAELRHI VPTGKSRYSN KLTWVPPAGI RIVCATSSKT QLIISLSNYE
660 670 680 690 700
LVYFKIDVSS DSLIELTTHP ELDTMPSKVA IVQDTQHADL LAIADNEGMI
710 720 730 740 750
KIMSLKDQKE DFLTVISLQL VSEKISDMIM VRDSSIGQLN LHVGLENGVY
760 770 780 790 800
MKFHIGDVDG SFTDIKRRFL GLKPVSLSYL REISVSLNNE EEEEEEEDDD
810 820 830 840 850
DEKEEEEINS SGAKWMSCVV CHSSSTWVSY TWKNVWTIRQ LKDQNMLSCS
860 870 880 890 900
KFVNADVAIN GVCSISSSGR LNIGRVSNFP TLDNWFHVHE SSVNKQENGG
910 920 930 940 950
GDESNEEEED EMEEEMEMLQ ISTFRPRTIL SFPNNPKSIL FIDNHSGKKQ
960 970 980 990 1000
CRISLQIDGE CLKFGSSDHL YKILDDIDCV SAAIIDFTRQ ADHLIICAGD
1010 1020 1030 1040 1050
KRLLTYKILV NKDKLSFDIE LLHQTEIISP IHAMLKFKNF LLTAMGSTIV
1060 1070 1080 1090 1100
LYGLGKKQLL RRSVTQTPVS ITKIVSMHQW NYERLAVGDI HESVTLFIWD
1110 1120 1130 1140 1150
PAGNVFIPYV DDSVKRHVTV LKFLDEATVI GADRYGNAWT LRSPPECEKI
1160 1170 1180 1190 1200
MSNHDPSELS NGAIKYPLDV ITLQQKLPNT YDCKFKFQLL NHFFVNDIIT
1210 1220 1230 1240 1250
DFHILDSLSN SDRPGCIYMG LQGTVGCFIP LLSKGNVFMM GNIENIMAEA
1260 1270 1280 1290 1300
DDTFYLDYES RKKNNNMRKE DDEEESGSVV LQGRHGIEDE IICEGSCSIL
1310 1320 1330 1340 1350
GRDHQEYRSY YAPVRKVIDG DLCENFLRLS LNEQEFLAKN LKSVQVEDII
1360
QTINEVRTNY M
Length:1,361
Mass (Da):153,784
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D92837F5C267D67
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z47816 Genomic DNA Translation: CAA87825.1
BK006946 Genomic DNA Translation: DAA09850.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50943

NCBI Reference Sequences

More...
RefSeqi
NP_013663.1, NM_001182407.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YML049C_mRNA; YML049C; YML049C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854956

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YML049C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47816 Genomic DNA Translation: CAA87825.1
BK006946 Genomic DNA Translation: DAA09850.1
PIRiS50943
RefSeqiNP_013663.1, NM_001182407.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GM6electron microscopy3.50F1-1361[»]
5LQWelectron microscopy5.80X1-1361[»]
5NRLelectron microscopy7.20P1-1361[»]
5ZWMelectron microscopy3.4031-1361[»]
5ZWOelectron microscopy3.9031-1361[»]
6G90electron microscopy4.00P1-1361[»]
SMRiQ04693
ModBaseiSearch...

Protein-protein interaction databases

BioGridi35119, 200 interactors
ComplexPortaliCPX-1647 SF3B complex
CPX-1651 PRP19-associated complex
CPX-26 U2 snRNP
DIPiDIP-856N
IntActiQ04693, 32 interactors
MINTiQ04693
STRINGi4932.YML049C

PTM databases

iPTMnetiQ04693

Proteomic databases

MaxQBiQ04693
PaxDbiQ04693
PRIDEiQ04693
TopDownProteomicsiQ04693

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML049C_mRNA; YML049C; YML049C
GeneIDi854956
KEGGisce:YML049C

Organism-specific databases

EuPathDBiFungiDB:YML049C
SGDiS000004513 RSE1

Phylogenomic databases

HOGENOMiHOG000066036
InParanoidiQ04693
KOiK12830
OMAiEWKAPGK

Enzyme and pathway databases

BioCyciYEAST:G3O-32646-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q04693

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR004871 Cleavage/polyA-sp_fac_asu_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF03178 CPSF_A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSE1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04693
Secondary accession number(s): D6VZC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 18, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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