UniProtKB - Q04688 (ELG_DROME)
Protein
DNA-binding protein Ets97D
Gene
Ets97D
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
May have a role in germline development.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 346 – 426 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- cell differentiation Source: GO_Central
- cellular response to starvation Source: FlyBase
- positive regulation of oxidative phosphorylation Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of glutamine family amino acid metabolic process Source: FlyBase
- regulation of mitochondrion organization Source: FlyBase
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-DME-2151201, Transcriptional activation of mitochondrial biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-binding protein Ets97DShort name: D-elg |
Gene namesi | Name:Ets97D Synonyms:elg ORF Names:CG6338 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004510, Ets97D |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204094 | 1 – 464 | DNA-binding protein Ets97DAdd BLAST | 464 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 153 | Phosphoserine1 Publication | 1 | |
Modified residuei | 157 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 167 | Phosphoserine1 Publication | 1 | |
Modified residuei | 171 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q04688 |
PRIDEi | Q04688 |
PTM databases
iPTMneti | Q04688 |
Expressioni
Tissue specificityi
Uniform distribution throughout embryonic development, with slightly higher expression in pole cells.1 Publication
Developmental stagei
Expressed throughout development with lower levels during larval development.1 Publication
Gene expression databases
Bgeei | FBgn0004510, Expressed in female gonad and 25 other tissues |
ExpressionAtlasi | Q04688, baseline and differential |
Genevisiblei | Q04688, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 68127, 13 interactors |
IntActi | Q04688, 2 interactors |
STRINGi | 7227.FBpp0084458 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 184 – 269 | PNTPROSITE-ProRule annotationAdd BLAST | 86 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000155799 |
HOGENOMi | CLU_037064_1_0_1 |
InParanoidi | Q04688 |
OMAi | QELEPHK |
OrthoDBi | 526256at2759 |
PhylomeDBi | Q04688 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR024668, GABP_asu_N IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR016312, TF_GA-bd_asu IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF11620, GABP-alpha, 1 hit PF02198, SAM_PNT, 1 hit |
PIRSFi | PIRSF001703, GABP_alpha, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q04688-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSSNDLSDE LIRRLSVGGA LEEVIASEMF EDSIDVETEA EPDDIIIVHM
60 70 80 90 100
DIREPLSMLK SLVEQKIGVC LNYYTFWLQD AQELESHKNL VDQCVKGEGL
110 120 130 140 150
VQINVQIQTI RKRINIADVL KPTEAALAAL AEEVVGQLSP PETASQKSSS
160 170 180 190 200
SESPIKTPLK RMHKEDSEEE SVEGKDVKPV LNWVLDSKFK REQIRLKIPE
210 220 230 240 250
AANEWTHAHV TYWLEWAVKQ FELVGINMSD WQMNGQELCA MTHEEFNQKL
260 270 280 290 300
PRDPGNIFWT HLQLLKECNF VSVVHKRAEE QRKPKQPRIM SANSISTNSG
310 320 330 340 350
GSLSLEQRIM RKSYQSVKSS DSVESTTSSM NPSNYTTIGS GNNGQVQLWQ
360 370 380 390 400
FLLEILTDCE HTDVIEWVGT EGEFKLTDPD RVARLWGEKK NKPAMNYEKL
410 420 430 440 450
SRALRYYYDG DMISKVSGKR FAYKFDCDLK LLIGYDANEL STLVSEGKTA
460
PERVAATETI TEDT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KHY6 | A0A0B4KHY6_DROME | Ets at 97D, isoform B | Ets97D D-Elg, D-elg, d-elg, DELG, Delg | 484 | Annotation score: |
Sequence cautioni
The sequence AAL48582 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 454 | V → L in CAA48327 (PubMed:1461651).Curated | 1 | |
Sequence conflicti | 454 | V → L in CAA41390 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68259 Genomic DNA Translation: CAA48327.1 AE014297 Genomic DNA Translation: AAF56638.1 AY070960 mRNA Translation: AAL48582.1 Frameshift. BT025224 mRNA Translation: ABF17915.1 M88471 mRNA Translation: AAC34199.1 X58481 mRNA Translation: CAA41390.1 Sequence problems. |
PIRi | S24300 S37616 |
RefSeqi | NP_524523.2, NM_079799.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0085088; FBpp0084458; FBgn0004510 |
GeneIDi | 43236 |
KEGGi | dme:Dmel_CG6338 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X68259 Genomic DNA Translation: CAA48327.1 AE014297 Genomic DNA Translation: AAF56638.1 AY070960 mRNA Translation: AAL48582.1 Frameshift. BT025224 mRNA Translation: ABF17915.1 M88471 mRNA Translation: AAC34199.1 X58481 mRNA Translation: CAA41390.1 Sequence problems. |
PIRi | S24300 S37616 |
RefSeqi | NP_524523.2, NM_079799.3 |
3D structure databases
SMRi | Q04688 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 68127, 13 interactors |
IntActi | Q04688, 2 interactors |
STRINGi | 7227.FBpp0084458 |
PTM databases
iPTMneti | Q04688 |
Proteomic databases
PaxDbi | Q04688 |
PRIDEi | Q04688 |
Genome annotation databases
EnsemblMetazoai | FBtr0085088; FBpp0084458; FBgn0004510 |
GeneIDi | 43236 |
KEGGi | dme:Dmel_CG6338 |
Organism-specific databases
CTDi | 43236 |
FlyBasei | FBgn0004510, Ets97D |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000155799 |
HOGENOMi | CLU_037064_1_0_1 |
InParanoidi | Q04688 |
OMAi | QELEPHK |
OrthoDBi | 526256at2759 |
PhylomeDBi | Q04688 |
Enzyme and pathway databases
Reactomei | R-DME-2151201, Transcriptional activation of mitochondrial biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 43236, 0 hits in 1 CRISPR screen |
ChiTaRSi | Ets97D, fly |
GenomeRNAii | 43236 |
PROi | PR:Q04688 |
Gene expression databases
Bgeei | FBgn0004510, Expressed in female gonad and 25 other tissues |
ExpressionAtlasi | Q04688, baseline and differential |
Genevisiblei | Q04688, DM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR024668, GABP_asu_N IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR016312, TF_GA-bd_asu IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF11620, GABP-alpha, 1 hit PF02198, SAM_PNT, 1 hit |
PIRSFi | PIRSF001703, GABP_alpha, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELG_DROME | |
Accessioni | Q04688Primary (citable) accession number: Q04688 Secondary accession number(s): Q1LZ02, Q8SZC7, Q9VBA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | October 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families