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Entry version 112 (12 Aug 2020)
Sequence version 3 (17 Jan 2003)
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Protein

Galactosyl transferase CpsE

Gene

cpsE

Organism
Streptococcus agalactiae serotype III (strain NEM316)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Galactosyl transferase is essential for the assembly of the group B streptococci (GBS) type III capsular polysaccharide. May be involved in the formation of either or both galactosidic bonds by catalyzing the addition of galactose to an oligosaccharide precursor or to a lipid intermediate. Type III capsular polysaccharide consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought to be an important element in the virulence function of the capsule.

Caution

Was originally called CpsD.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processCapsule biogenesis/degradation, Exopolysaccharide synthesis, Virulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galactosyl transferase CpsE (EC:2.7.8.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cpsE
Ordered Locus Names:gbs1244
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus agalactiae serotype III (strain NEM316)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri211110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000823 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 22HelicalSequence analysisAdd BLAST18
Transmembranei27 – 46HelicalSequence analysisAdd BLAST20
Transmembranei59 – 78HelicalSequence analysisAdd BLAST20
Transmembranei88 – 107HelicalSequence analysisAdd BLAST20
Transmembranei258 – 280HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001664631 – 449Galactosyl transferase CpsEAdd BLAST449

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
211110.gbs1243

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bacterial sugar transferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2148, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024920_3_4_9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003362, Bact_transf
IPR017475, EPS_sugar_tfrase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02397, Bac_transf, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03025, EPS_sugtrans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q04664-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQTVVVYFS ASLTLTLITP NFKSNKDLLF VLLIHYIVFY LSDFYRDFWS
60 70 80 90 100
RGYLEEFKMV LKYSFYYIFI SSSLFFIFKN SFTTTRLSFF TFIAMNSILL
110 120 130 140 150
YLLNSFLKYY RKYSYAKFSR DTKVVLITNK DSLSKMTFRN KYDHNYIAVC
160 170 180 190 200
ILDSSEKDCY DLKHNSLRII NKDALTSELT CLTVDQAFIN IPIELFGKYQ
210 220 230 240 250
IQDIINDIEA MGVIVNVNVE ALSFDNIGEK RIQTFEGYSV ITYSMKFYKY
260 270 280 290 300
SHLIAKRFLD ITGAIIGLLI CGIVAIFLVP QIRKDGGPAI FSQNRVGRNG
310 320 330 340 350
RIFRFYKFRS MRVDAEQIKK DLLVHNQMTG LMFKLEDDPR ITKIGKFIRK
360 370 380 390 400
TSIDELPQFY NVLKGDMSLV GTRPPTVDEY EKYNSTQKRR LSFKPGITGL
410 420 430 440
WQISGRNNIT DFDEIVKLDV QYINEWSIWS DIKIILLTLK VVLLGTGAK
Length:449
Mass (Da):52,378
Last modified:January 17, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA958FE1E0DA01338
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD46903 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti262T → M in strain: SG96/585 / Serotype III. 1
Natural varianti370V → A in strain: COH1 / Serotype III. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF163833 Genomic DNA Translation: AAD53066.1
AF332896 Genomic DNA Translation: AAL57072.1
AF332897 Genomic DNA Translation: AAL57079.1
AF332898 Genomic DNA Translation: AAL57085.1
AF332899 Genomic DNA Translation: AAL57091.1
AF332900 Genomic DNA Translation: AAL57097.1
AF363032 Genomic DNA Translation: AAL56269.1
AF363033 Genomic DNA Translation: AAL56273.1
AF363034 Genomic DNA Translation: AAL56277.1
AF363035 Genomic DNA Translation: AAL56281.1
AF363039 Genomic DNA Translation: AAL56297.1
AF363040 Genomic DNA Translation: AAL56301.1
AF363055 Genomic DNA Translation: AAL56361.1
AF363056 Genomic DNA Translation: AAL56368.1
AF381031 Genomic DNA Translation: AAL57286.1
AF367973 Genomic DNA Translation: AAL56403.1
AL766849 Genomic DNA Translation: CAD46903.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
T44643

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAD46903; CAD46903; CAD46903

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
san:cpsE

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163833 Genomic DNA Translation: AAD53066.1
AF332896 Genomic DNA Translation: AAL57072.1
AF332897 Genomic DNA Translation: AAL57079.1
AF332898 Genomic DNA Translation: AAL57085.1
AF332899 Genomic DNA Translation: AAL57091.1
AF332900 Genomic DNA Translation: AAL57097.1
AF363032 Genomic DNA Translation: AAL56269.1
AF363033 Genomic DNA Translation: AAL56273.1
AF363034 Genomic DNA Translation: AAL56277.1
AF363035 Genomic DNA Translation: AAL56281.1
AF363039 Genomic DNA Translation: AAL56297.1
AF363040 Genomic DNA Translation: AAL56301.1
AF363055 Genomic DNA Translation: AAL56361.1
AF363056 Genomic DNA Translation: AAL56368.1
AF381031 Genomic DNA Translation: AAL57286.1
AF367973 Genomic DNA Translation: AAL56403.1
AL766849 Genomic DNA Translation: CAD46903.1 Different initiation.
PIRiT44643

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi211110.gbs1243

Genome annotation databases

EnsemblBacteriaiCAD46903; CAD46903; CAD46903
KEGGisan:cpsE

Phylogenomic databases

eggNOGiCOG2148, Bacteria
HOGENOMiCLU_024920_3_4_9

Family and domain databases

InterProiView protein in InterPro
IPR003362, Bact_transf
IPR017475, EPS_sugar_tfrase
PfamiView protein in Pfam
PF02397, Bac_transf, 1 hit
TIGRFAMsiTIGR03025, EPS_sugtrans, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPSE_STRA3
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04664
Secondary accession number(s): Q8VL98, Q8VSS5, Q9JN35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 17, 2003
Last modified: August 12, 2020
This is version 112 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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