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UniProtKB - Q04637 (IF4G1_HUMAN)

Entry version 231 (29 Sep 2021)
Sequence version 4 (20 Apr 2010)
Previous versions | rss
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Protein

Eukaryotic translation initiation factor 4 gamma 1

Gene

EIF4G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding, Translational shunt
Biological processHost-virus interaction, Protein biosynthesis, Translation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q04637

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1169408, ISG15 antiviral mechanism
R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-166208, mTORC1-mediated signalling
R-HSA-429947, Deadenylation of mRNA
R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649, Translation initiation complex formation
R-HSA-72662, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q04637

Protein family/group databases

MoonProt database of moonlighting proteins

More...MoonProti		Q04637

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 1
Short name:
eIF-4-gamma 1
Short name:
eIF-4G 1
Short name:
eIF-4G1
Alternative name(s):
p220
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4G1
Synonyms:EIF4F, EIF4G, EIF4GI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3296, EIF4G1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600495, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q04637

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114867

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parkinson disease 18 (PARK18)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066573502A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar.1
Natural variantiVAR_0665791205R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi174 – 178KRERK → AAAAA: Loss of PABPC1 binding; when associated with 184-AAAA-187. 1 Publication5
Mutagenesisi180I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi182I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi184 – 187DPNQ → AAAA: Loss of PABPC1 binding; when associated with 174-AAAAA-178. 4
Mutagenesisi192I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi196I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi612Y → A or F: Abolishes binding to EIF4E. 1 Publication1
Mutagenesisi617 – 618LL → AA: Abolishes binding to EIF4E. 1 Publication2
Mutagenesisi682G → A, V, W, R or E: Reduced cleavage by protease 2A from human rhinovirus 2. 1 Publication1
Mutagenesisi768L → A: Abolishes binding to EIF4A; when associated with A-770 and A-775. 1 Publication1
Mutagenesisi771L → A: Abolishes binding to EIF4A; when associated with A-767 and A-775. 1 Publication1
Mutagenesisi776F → A: Abolishes binding to EIF4A; when associated with A-767 and A-770. 1 Publication1
Mutagenesisi842 – 843LL → AA: Abolishes binding to EIF4A; when associated with A-850 and K-851. 1 Publication2
Mutagenesisi851 – 852FE → AK: Abolishes binding to EIF4A; when associated with A-841 and A-842. 1 Publication2
Mutagenesisi896L → A: Abolishes binding to EIF4A; when associated with A-92 and A-95. 1 Publication1
Mutagenesisi902I → A: Abolishes binding to EIF4A; when associated with A-895 and A-95. 1 Publication1
Mutagenesisi905L → A: Abolishes binding to EIF4A; when associated with A-895 and A-92. 1 Publication1
Mutagenesisi974R → A: Abolishes binding to EIF4A; when associated with A-976. 1 Publication1
Mutagenesisi977F → A: Abolishes binding to EIF4A; when associated with A-973. 1 Publication1
Mutagenesisi985L → A: Slightly reduced binding to EIF4A; when associated with A-989. 1 Publication1
Mutagenesisi990W → A: Slightly reduced binding to EIF4A; when associated with A-984. 1 Publication1

Keywords - Diseasei

Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNET

More...DisGeNETi		1981

MalaCards human disease database

More...MalaCardsi		EIF4G1
MIMi614251, phenotype

Open Targets

More...OpenTargetsi		ENSG00000114867

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		411602, Hereditary late-onset Parkinson disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27722

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q04637, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523621

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EIF4G1

Domain mapping of disease mutations (DMDM)

More...DMDMi		294862538

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000077861 – 1599Eukaryotic translation initiation factor 4 gamma 1Add BLAST1599
Isoform C (identifier: Q04637-4)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineBy similarity1
Modified residuei73Omega-N-methylarginineCombined sources1
Modified residuei110Omega-N-methylarginineCombined sources1
Modified residuei207PhosphothreonineCombined sources1
Modified residuei223PhosphothreonineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei602N6-acetyllysineBy similarity1
Modified residuei647PhosphothreonineCombined sources1
Modified residuei685Omega-N-methylarginineCombined sources1
Modified residuei694Omega-N-methylarginineCombined sources1
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1032Omega-N-methylarginineCombined sources1
Modified residuei1042Omega-N-methylarginineCombined sources1
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1
Modified residuei1095N6-acetyllysineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1185Phosphoserine; by PKC/PRKCACombined sources1 Publication1
Modified residuei1187PhosphoserineCombined sources1
Modified residuei1194PhosphoserineCombined sources1
Modified residuei1209PhosphoserineCombined sources1
Modified residuei1211PhosphothreonineCombined sources1
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1238PhosphoserineCombined sources1
Modified residuei1596PhosphoserineCombined sources1
Isoform C (identifier: Q04637-4)
Modified residuei2N-acetylmethionineCombined sources1
Isoform 7 (identifier: Q04637-7)
Modified residuei489Omega-N-methylarginineCombined sources1
Modified residuei498Omega-N-methylarginineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Isoform 8 (identifier: Q04637-8)
Modified residuei685Omega-N-methylarginineCombined sources1
Modified residuei694Omega-N-methylarginineCombined sources1
Modified residuei705PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.1 Publication
Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei674 – 675Cleavage; by foot-and-mouth disease virus leader protease2
Sitei681 – 682Cleavage; by enterovirus/rhinovirus protease 2A2

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q04637

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q04637

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q04637

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q04637

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q04637

PeptideAtlas

More...PeptideAtlasi		Q04637

PRoteomics IDEntifications database

More...PRIDEi		Q04637

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20132
34026
58250 [Q04637-1]
58251 [Q04637-3]
58252 [Q04637-4]
58253 [Q04637-5]
58254 [Q04637-6]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2847, 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q04637, 6 sites, 1 O-linked glycan (6 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q04637

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q04637

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q04637

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q04637

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114867, Expressed in gastrocnemius and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q04637, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q04637, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114867, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3.

Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1.

Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs.

Interacts with EIF4E3.

Interacts with CIRBP and MIF4GD.

Interacts with RBM4.

Interacts with HNRNPD/AUF1; the interaction requires RNA. Directly interacts with EIF4G1 in an RNA-independent manner (PubMed:22872150).

16 Publications

(Microbial infection) Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis.

1 Publication

(Microbial infection) Interacts with human adenovirus 5 protein 100K; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108296, 209 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2666, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G1 variant
CPX-5634, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G1 variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q04637

Database of interacting proteins

More...DIPi		DIP-1161N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q04637

Protein interaction database and analysis system

More...IntActi		Q04637, 91 interactors

Molecular INTeraction database

More...MINTi		Q04637

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000416255

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q04637

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q04637, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q04637

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q04637

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q04637

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini565 – 792MIF4GPROSITE-ProRule annotationAdd BLAST228
Domaini1241 – 1363MIPROSITE-ProRule annotationAdd BLAST123
Domaini1433 – 1599W2PROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 77DisorderedSequence analysisAdd BLAST77
Regioni166 – 222DisorderedSequence analysisAdd BLAST57
Regioni172 – 200PABPC1-bindingAdd BLAST29
Regioni234 – 319DisorderedSequence analysisAdd BLAST86
Regioni332 – 600DisorderedSequence analysisAdd BLAST269
Regioni607 – 618EIF4E-bindingAdd BLAST12
Regioni667 – 713DisorderedSequence analysisAdd BLAST47
Regioni682 – 1085eIF3/EIF4A-bindingAdd BLAST404
Regioni731 – 757DisorderedSequence analysisAdd BLAST27
Regioni1024 – 1227DisorderedSequence analysisAdd BLAST204
Regioni1450 – 1599EIF4A-bindingAdd BLAST150
Regioni1585 – 1599Necessary but not sufficient for MKNK1-bindingAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 26Pro residuesSequence analysisAdd BLAST20
Compositional biasi30 – 67Polar residuesSequence analysisAdd BLAST38
Compositional biasi174 – 190Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi198 – 218Polar residuesSequence analysisAdd BLAST21
Compositional biasi255 – 273Pro residuesSequence analysisAdd BLAST19
Compositional biasi285 – 303Polar residuesSequence analysisAdd BLAST19
Compositional biasi335 – 350Polar residuesSequence analysisAdd BLAST16
Compositional biasi377 – 394Pro residuesSequence analysisAdd BLAST18
Compositional biasi434 – 451Polar residuesSequence analysisAdd BLAST18
Compositional biasi453 – 471Acidic residuesSequence analysisAdd BLAST19
Compositional biasi490 – 504Polar residuesSequence analysisAdd BLAST15
Compositional biasi564 – 586Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1059 – 1087Polar residuesSequence analysisAdd BLAST29
Compositional biasi1112 – 1141Polar residuesSequence analysisAdd BLAST30
Compositional biasi1142 – 1223Basic and acidic residuesSequence analysisAdd BLAST82

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4G family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0401, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154648

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001519_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q04637

Identification of Orthologs from Complete Genome Data

More...OMAi		PRGGPNM

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q04637

TreeFam database of animal gene trees

More...TreeFami		TF101527

Family and domain databases

Database of protein disorder

More...DisProti		DP02398

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR037584, EIF4G1
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain

The PANTHER Classification System

More...PANTHERi		PTHR23253:SF10, PTHR23253:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 8 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q04637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH 
        60         70         80         90        100
FYPSRAQPPS SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ 
       110        120        130        140        150
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQG 
       160        170        180        190        200
VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA 
       210        220        230        240        250
RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI IADRPGLPGP 
       260        270        280        290        300
EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM TTIQMSVEES 
       310        320        330        340        350
TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF SSSPLQAPTP 
       360        370        380        390        400
LASHTVEIHE PNGMVPSEDL EPEVESSPEL APPPACPSES PVPIAPTAQP 
       410        420        430        440        450
EELLNGAPSP PAVDLSPVSE PEEQAKEVTA SMAPPTIPSA TPATAPSATS 
       460        470        480        490        500
PAQEEEMEEE EEEEEGEAGE AGEAESEKGG EELLPPESTP IPANLSQNLE 
       510        520        530        540        550
AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA VPEVENQPPA 
       560        570        580        590        600
GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG EQKYEYKSDQ 
       610        620        630        640        650
WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV LDKANKTPLR 
       660        670        680        690        700
PLDPTRLQGI NCGPDFTPSF ANLGRTTLST RGPPRGGPGG ELPRGPAGLG 
       710        720        730        740        750
PRRSQQGPRK EPRKIIATVL MTEDIKLNKA EKAWKPSSKR TAADKDRGEE 
       760        770        780        790        800
DADGSKTQDL FRRVRSILNK LTPQMFQQLM KQVTQLAIDT EERLKGVIDL 
       810        820        830        840        850
IFEKAISEPN FSVAYANMCR CLMALKVPTT EKPTVTVNFR KLLLNRCQKE 
       860        870        880        890        900
FEKDKDDDEV FEKKQKEMDE AATAEERGRL KEELEEARDI ARRRSLGNIK 
       910        920        930        940        950
FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK 
       960        970        980        990       1000
AKPRMDQYFN QMEKIIKEKK TSSRIRFMLQ DVLDLRGSNW VPRRGDQGPK 
      1010       1020       1030       1040       1050
TIDQIHKEAE MEEHREHIKV QQLMAKGSDK RRGGPPGPPI SRGLPLVDDG 
      1060       1070       1080       1090       1100
GWNTVPISKG SRPIDTSRLT KITKPGSIDS NNQLFAPGGR LSWGKGSSGG 
      1110       1120       1130       1140       1150
SGAKPSDAAS EAARPATSTL NRFSALQQAV PTESTDNRRV VQRSSLSRER 
      1160       1170       1180       1190       1200
GEKAGDRGDR LERSERGGDR GDRLDRARTP ATKRSFSKEV EERSRERPSQ 
      1210       1220       1230       1240       1250
PEGLRKAASL TEDRDRGRDA VKREAALPPV SPLKAALSEE ELEKKSKAII 
      1260       1270       1280       1290       1300
EEYLHLNDMK EAVQCVQELA SPSLLFIFVR HGVESTLERS AIAREHMGQL 
      1310       1320       1330       1340       1350
LHQLLCAGHL STAQYYQGLY EILELAEDME IDIPHVWLYL AELVTPILQE 
      1360       1370       1380       1390       1400
GGVPMGELFR EITKPLRPLG KAASLLLEIL GLLCKSMGPK KVGTLWREAG 
      1410       1420       1430       1440       1450
LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS EELNRQLEKL 
      1460       1470       1480       1490       1500
LKEGSSNQRV FDWIEANLSE QQIVSNTLVR ALMTAVCYSA IIFETPLRVD 
      1510       1520       1530       1540       1550
VAVLKARAKL LQKYLCDEQK ELQALYALQA LVVTLEQPPN LLRMFFDALY 
      1560       1570       1580       1590 
DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFKWLR EAEEESDHN
Length:1,599
Mass (Da):175,491
Last modified:April 20, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i324088B60863DA34
GO
Isoform B (identifier: Q04637-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: Produced by alternative initiation at Met-41 of isoform A.Curated
Show »
Length:1,559
Mass (Da):171,514
Checksum:i22F62E219E629C0E
GO
Isoform C (identifier: Q04637-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: Produced by alternative initiation at Met-88 of isoform A.Curated
Show »
Length:1,512
Mass (Da):166,619
Checksum:i09DD6DC263462CB6
GO
Isoform D (identifier: Q04637-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Note: Produced by alternative initiation at Met-165 of isoform A.Curated
Show »
Length:1,435
Mass (Da):158,517
Checksum:i6F7E9DE4106E73B9
GO
Isoform E (identifier: Q04637-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: Produced by alternative initiation at Met-197 of isoform A.Curated
Show »
Length:1,403
Mass (Da):154,805
Checksum:i3E93A66EE3DFDDA9
GO
Isoform 7 (identifier: Q04637-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.
     696-696: P → PQ

Note: Produced by alternative splicing.Curated
Show »
Length:1,404
Mass (Da):154,933
Checksum:iE2CE3C54B5BB0A50
GO
Isoform 8 (identifier: Q04637-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     696-696: P → PQ

Note: Produced by alternative splicing.Curated
Show »
Length:1,600
Mass (Da):175,619
Checksum:i2B32EF7A6D50B657
GO
Isoform 9 (identifier: Q04637-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-48: R → RQGGFRSL

Note: Produced by alternative splicing.Curated
Show »
Length:1,606
Mass (Da):176,237
Checksum:iE4464821E0BA5FF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGM1E9PGM1_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,513Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUU4E7EUU4_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,560Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX73E7EX73_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,436Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6B6C9J6B6_HUMAN
Eukaryotic translation initiation f...
EIF4G1
757Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF13C9JF13_HUMAN
Eukaryotic translation initiation f...
EIF4G1
903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2Z7C9J2Z7_HUMAN
Eukaryotic translation initiation f...
EIF4G1
833Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K073C9K073_HUMAN
Eukaryotic translation initiation f...
EIF4G1
869Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWW9C9JWW9_HUMAN
Eukaryotic translation initiation f...
EIF4G1
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2Y1C3A0A7I2Y1C3_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,577Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C044H7C044_HUMAN
Eukaryotic translation initiation f...
EIF4G1
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC78444 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAC82471 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA02185 differs from that shown. Reason: Frameshift.Curated
The sequence BAD18554 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30P → R in AAC78443 (PubMed:9755181).Curated1
Sequence conflicti138F → L in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti138F → L in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti149Q → R in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti149Q → R in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti214G → S in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti462E → D in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti468A → V in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti474A → G in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti479G → R in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti604L → P in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti604L → P in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti604L → P in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti604L → P in AAC82471 (PubMed:9372926).Curated1
Sequence conflicti625 – 626AS → CQ in BAA02185 (PubMed:1429670).Curated2
Sequence conflicti693P → A in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti696P → A in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti764V → W in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti878G → E in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti894R → C in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1104K → Q in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1121N → I in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1185S → T in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1384C → Y in CAI46013 (PubMed:17974005).Curated1
Sequence conflicti1472Missing in BAA02185 (PubMed:1429670).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06657171P → S1 PublicationCorresponds to variant dbSNP:rs113810947Ensembl.1
Natural variantiVAR_061147161T → A5 PublicationsCorresponds to variant dbSNP:rs13319149Ensembl.1
Natural variantiVAR_079031201R → H Found in a patient with Rett syndrome-like phenotype; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs34838305Ensembl.1
Natural variantiVAR_055704311Y → C1 PublicationCorresponds to variant dbSNP:rs16858632Ensembl.1
Natural variantiVAR_063040432M → VCombined sources4 PublicationsCorresponds to variant dbSNP:rs2178403EnsemblClinVar.1
Natural variantiVAR_066572466 – 468Missing 1 Publication3
Natural variantiVAR_066573502A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar.1
Natural variantiVAR_066574686G → C Found in patients with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs112019125Ensembl.1
Natural variantiVAR_036117696P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754755344Ensembl.1
Natural variantiVAR_066575806I → V1 PublicationCorresponds to variant dbSNP:rs62287499Ensembl.1
Natural variantiVAR_066576829T → S1 PublicationCorresponds to variant dbSNP:rs111500185Ensembl.1
Natural variantiVAR_0665771164S → R Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113169049Ensembl.1
Natural variantiVAR_0665781197R → W Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113388242Ensembl.1
Natural variantiVAR_0665791205R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar.1
Natural variantiVAR_0611481229P → A1 PublicationCorresponds to variant dbSNP:rs35629949EnsemblClinVar.1
Natural variantiVAR_0557051233L → P1 PublicationCorresponds to variant dbSNP:rs2230570Ensembl.1
Natural variantiVAR_0665801257N → S1 PublicationCorresponds to variant dbSNP:rs73053766Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187231 – 196Missing in isoform E and isoform 7. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0187221 – 164Missing in isoform D. CuratedAdd BLAST164
Alternative sequenceiVSP_0187211 – 87Missing in isoform C. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_0187201 – 40Missing in isoform B. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_04739648R → RQGGFRSL in isoform 9. Curated1
Alternative sequenceiVSP_047397696P → PQ in isoform 7 and isoform 8. 4 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D12686 mRNA Translation: BAA02185.1 Frameshift.
AY082886 mRNA Translation: AAL92872.1
AF281070 mRNA Translation: AAM69365.1
AK131407 mRNA Translation: BAD18554.1 Sequence problems.
BX647812 mRNA Translation: CAI46013.1
AC078797 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78257.1
CH471052 Genomic DNA Translation: EAW78259.1
CH471052 Genomic DNA Translation: EAW78262.1
CH471052 Genomic DNA Translation: EAW78263.1
CH471052 Genomic DNA Translation: EAW78264.1
CH471052 Genomic DNA Translation: EAW78265.1
CH471052 Genomic DNA Translation: EAW78266.1
CH471052 Genomic DNA Translation: EAW78267.1
AF002816 mRNA Translation: AAC78443.1
AF004836 Genomic DNA Translation: AAC78444.1 Different initiation.
AF104913 mRNA Translation: AAC82471.1 Different initiation.
AJ001046 mRNA Translation: CAA04500.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3259.1 [Q04637-1]
CCDS3260.1 [Q04637-4]
CCDS3261.1 [Q04637-5]
CCDS46970.2 [Q04637-7]
CCDS54687.1 [Q04637-9]
CCDS54688.1 [Q04637-8]
CCDS77866.1 [Q04637-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A44453

NCBI Reference Sequences

More...RefSeqi		NP_004944.3, NM_004953.4 [Q04637-7]
NP_886553.3, NM_182917.4
NP_937884.1, NM_198241.2 [Q04637-1]
NP_937885.1, NM_198242.2 [Q04637-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342981; ENSP00000343450; ENSG00000114867 [Q04637-8]
ENST00000346169; ENSP00000316879; ENSG00000114867 [Q04637-1]
ENST00000350481; ENSP00000317600; ENSG00000114867 [Q04637-5]
ENST00000352767; ENSP00000338020; ENSG00000114867 [Q04637-9]
ENST00000382330; ENSP00000371767; ENSG00000114867 [Q04637-9]
ENST00000392537; ENSP00000376320; ENSG00000114867 [Q04637-4]
ENST00000414031; ENSP00000391935; ENSG00000114867 [Q04637-3]
ENST00000424196; ENSP00000416255; ENSG00000114867 [Q04637-9]
ENST00000434061; ENSP00000411826; ENSG00000114867 [Q04637-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1981

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1981

UCSC genome browser

More...UCSCi		uc003fnp.4, human [Q04637-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12686 mRNA Translation: BAA02185.1 Frameshift.
AY082886 mRNA Translation: AAL92872.1
AF281070 mRNA Translation: AAM69365.1
AK131407 mRNA Translation: BAD18554.1 Sequence problems.
BX647812 mRNA Translation: CAI46013.1
AC078797 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78257.1
CH471052 Genomic DNA Translation: EAW78259.1
CH471052 Genomic DNA Translation: EAW78262.1
CH471052 Genomic DNA Translation: EAW78263.1
CH471052 Genomic DNA Translation: EAW78264.1
CH471052 Genomic DNA Translation: EAW78265.1
CH471052 Genomic DNA Translation: EAW78266.1
CH471052 Genomic DNA Translation: EAW78267.1
AF002816 mRNA Translation: AAC78443.1
AF004836 Genomic DNA Translation: AAC78444.1 Different initiation.
AF104913 mRNA Translation: AAC82471.1 Different initiation.
AJ001046 mRNA Translation: CAA04500.1
CCDSiCCDS3259.1 [Q04637-1]
CCDS3260.1 [Q04637-4]
CCDS3261.1 [Q04637-5]
CCDS46970.2 [Q04637-7]
CCDS54687.1 [Q04637-9]
CCDS54688.1 [Q04637-8]
CCDS77866.1 [Q04637-3]
PIRiA44453
RefSeqiNP_004944.3, NM_004953.4 [Q04637-7]
NP_886553.3, NM_182917.4
NP_937884.1, NM_198241.2 [Q04637-1]
NP_937885.1, NM_198242.2 [Q04637-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LJ2X-ray2.38C/D172-199[»]
1UG3X-ray2.24A/B1233-1571[»]
2W97X-ray2.29E/F609-622[»]
4AZAX-ray2.16B/D609-620[»]
4F02X-ray2.00C/F178-203[»]
5EHCX-ray2.40B609-622[»]
5EI3X-ray1.71B609-622[»]
5EIRX-ray2.69B609-622[»]
5T46X-ray1.53B/D592-653[»]
6ZMWelectron microscopy3.70g290-1599[»]
BMRBiQ04637
SMRiQ04637
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108296, 209 interactors
ComplexPortaliCPX-2666, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G1 variant
CPX-5634, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G1 variant
CORUMiQ04637
DIPiDIP-1161N
ELMiQ04637
IntActiQ04637, 91 interactors
MINTiQ04637
STRINGi9606.ENSP00000416255

Chemistry databases

BindingDBiQ04637
ChEMBLiCHEMBL4523621

Protein family/group databases

MoonProtiQ04637

PTM databases

GlyConnecti2847, 1 O-Linked glycan (1 site)
GlyGeniQ04637, 6 sites, 1 O-linked glycan (6 sites)
iPTMnetiQ04637
MetOSiteiQ04637
PhosphoSitePlusiQ04637
SwissPalmiQ04637

Genetic variation databases

BioMutaiEIF4G1
DMDMi294862538

Proteomic databases

EPDiQ04637
jPOSTiQ04637
MassIVEiQ04637
MaxQBiQ04637
PaxDbiQ04637
PeptideAtlasiQ04637
PRIDEiQ04637
ProteomicsDBi20132
34026
58250 [Q04637-1]
58251 [Q04637-3]
58252 [Q04637-4]
58253 [Q04637-5]
58254 [Q04637-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3406, 601 antibodies

The DNASU plasmid repository

More...DNASUi		1981

Genome annotation databases

EnsembliENST00000342981; ENSP00000343450; ENSG00000114867 [Q04637-8]
ENST00000346169; ENSP00000316879; ENSG00000114867 [Q04637-1]
ENST00000350481; ENSP00000317600; ENSG00000114867 [Q04637-5]
ENST00000352767; ENSP00000338020; ENSG00000114867 [Q04637-9]
ENST00000382330; ENSP00000371767; ENSG00000114867 [Q04637-9]
ENST00000392537; ENSP00000376320; ENSG00000114867 [Q04637-4]
ENST00000414031; ENSP00000391935; ENSG00000114867 [Q04637-3]
ENST00000424196; ENSP00000416255; ENSG00000114867 [Q04637-9]
ENST00000434061; ENSP00000411826; ENSG00000114867 [Q04637-7]
GeneIDi1981
KEGGihsa:1981
UCSCiuc003fnp.4, human [Q04637-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1981
DisGeNETi1981

GeneCards: human genes, protein and diseases

More...GeneCardsi		EIF4G1
HGNCiHGNC:3296, EIF4G1
HPAiENSG00000114867, Low tissue specificity
MalaCardsiEIF4G1
MIMi600495, gene
614251, phenotype
neXtProtiNX_Q04637
OpenTargetsiENSG00000114867
Orphaneti411602, Hereditary late-onset Parkinson disease
PharmGKBiPA27722
VEuPathDBiHostDB:ENSG00000114867

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0401, Eukaryota
GeneTreeiENSGT00940000154648
HOGENOMiCLU_001519_2_0_1
InParanoidiQ04637
OMAiPRGGPNM
PhylomeDBiQ04637
TreeFamiTF101527

Enzyme and pathway databases

PathwayCommonsiQ04637
ReactomeiR-HSA-1169408, ISG15 antiviral mechanism
R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-166208, mTORC1-mediated signalling
R-HSA-429947, Deadenylation of mRNA
R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649, Translation initiation complex formation
R-HSA-72662, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiQ04637

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1981, 574 hits in 1025 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EIF4G1, human
EvolutionaryTraceiQ04637

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Eukaryotic_translation_initiation_factor_4_gamma

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1981
PharosiQ04637, Tbio

Protein Ontology

More...PROi		PR:Q04637
RNActiQ04637, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114867, Expressed in gastrocnemius and 250 other tissues
ExpressionAtlasiQ04637, baseline and differential
GenevisibleiQ04637, HS

Family and domain databases

DisProtiDP02398
Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037584, EIF4G1
IPR003891, Initiation_fac_eIF4g_MI
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain
PANTHERiPTHR23253:SF10, PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit
SMARTiView protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4G1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04637
Secondary accession number(s): D3DNT2
, D3DNT4, D3DNT5, E9PFM1, G5E9S1, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 231 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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