Eukaryotic translation initiation factor 4 gamma 1

Protein family/group databases

MoonProtⁱ	Q04637

MoonProtⁱ

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 4 gamma 1 Short name: eIF-4-gamma 1 Short name: eIF-4G 1 Short name: eIF-4G1 Alternative name(s): p220
Gene namesⁱ	Name:EIF4G1 Synonyms:EIF4F, EIF4G, EIF4GI
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114867.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3296 EIF4G1
MIMⁱ	600495 gene
neXtProtⁱ	NX_Q04637

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Parkinson disease 18 (PARK18)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_066573	502	A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar.		1
Natural variantⁱVAR_066579	1205	R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	174 – 178	KRERK → AAAAA: Loss of PABPC1 binding; when associated with 184-AAAA-187. 1 Publication	5
Mutagenesisⁱ	180	I → A: Loss of PABPC1 binding. 1 Publication	1
Mutagenesisⁱ	182	I → A: Loss of PABPC1 binding. 1 Publication	1
Mutagenesisⁱ	184 – 187	DPNQ → AAAA: Loss of PABPC1 binding; when associated with 174-AAAAA-178.	4
Mutagenesisⁱ	192	I → A: Loss of PABPC1 binding. 1 Publication	1
Mutagenesisⁱ	196	I → A: Loss of PABPC1 binding. 1 Publication	1
Mutagenesisⁱ	612	Y → A or F: Abolishes binding to EIF4E. 1 Publication	1
Mutagenesisⁱ	617 – 618	LL → AA: Abolishes binding to EIF4E. 1 Publication	2
Mutagenesisⁱ	682	G → A, V, W, R or E: Reduced cleavage by protease 2A from human rhinovirus 2. 1 Publication	1
Mutagenesisⁱ	768	L → A: Abolishes binding to EIF4A; when associated with A-770 and A-775. 1 Publication	1
Mutagenesisⁱ	771	L → A: Abolishes binding to EIF4A; when associated with A-767 and A-775. 1 Publication	1
Mutagenesisⁱ	776	F → A: Abolishes binding to EIF4A; when associated with A-767 and A-770. 1 Publication	1
Mutagenesisⁱ	842 – 843	LL → AA: Abolishes binding to EIF4A; when associated with A-850 and K-851. 1 Publication	2
Mutagenesisⁱ	851 – 852	FE → AK: Abolishes binding to EIF4A; when associated with A-841 and A-842. 1 Publication	2
Mutagenesisⁱ	896	L → A: Abolishes binding to EIF4A; when associated with A-92 and A-95. 1 Publication	1
Mutagenesisⁱ	902	I → A: Abolishes binding to EIF4A; when associated with A-895 and A-95. 1 Publication	1
Mutagenesisⁱ	905	L → A: Abolishes binding to EIF4A; when associated with A-895 and A-92. 1 Publication	1
Mutagenesisⁱ	974	R → A: Abolishes binding to EIF4A; when associated with A-976. 1 Publication	1
Mutagenesisⁱ	977	F → A: Abolishes binding to EIF4A; when associated with A-973. 1 Publication	1
Mutagenesisⁱ	985	L → A: Slightly reduced binding to EIF4A; when associated with A-989. 1 Publication	1
Mutagenesisⁱ	990	W → A: Slightly reduced binding to EIF4A; when associated with A-984. 1 Publication	1

Keywords - Diseaseⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1981
MalaCards human disease database More...MalaCardsⁱ	EIF4G1
MIMⁱ	614251 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000114867
Orphanetⁱ	411602 Hereditary late-onset Parkinson disease
PharmGKBⁱ	PA27722

Polymorphism and mutation databases

BioMutaⁱ	EIF4G1
DMDMⁱ	294862538

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000007786	1 – 1599	Eukaryotic translation initiation factor 4 gamma 1Add BLAST	1599
Isoform C (identifier: Q04637-4)
Initiator methionineⁱ		Removed

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	15	PhosphoserineBy similarity	1
Modified residueⁱ	73	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	110	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	207	PhosphothreonineCombined sources	1
Modified residueⁱ	223	PhosphothreonineCombined sources	1
Modified residueⁱ	314	PhosphoserineCombined sources	1
Modified residueⁱ	602	N6-acetyllysineBy similarity	1
Modified residueⁱ	647	PhosphothreonineCombined sources	1
Modified residueⁱ	685	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	694	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1028	PhosphoserineCombined sources	1
Modified residueⁱ	1032	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1042	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	1077	PhosphoserineCombined sources	1
Modified residueⁱ	1092	PhosphoserineCombined sources	1
Modified residueⁱ	1095	N6-acetyllysineCombined sources	1
Modified residueⁱ	1145	PhosphoserineCombined sources	1
Modified residueⁱ	1147	PhosphoserineCombined sources	1
Modified residueⁱ	1185	Phosphoserine; by PKC/PRKCACombined sources1 Publication	1
Modified residueⁱ	1187	PhosphoserineCombined sources	1
Modified residueⁱ	1194	PhosphoserineCombined sources	1
Modified residueⁱ	1209	PhosphoserineCombined sources	1
Modified residueⁱ	1211	PhosphothreonineCombined sources	1
Modified residueⁱ	1231	PhosphoserineCombined sources	1
Modified residueⁱ	1238	PhosphoserineCombined sources	1
Modified residueⁱ	1596	PhosphoserineCombined sources	1
Isoform C (identifier: Q04637-4)
Modified residueⁱ	2	N-acetylmethionine	1
Isoform 7 (identifier: Q04637-7)
Modified residueⁱ	489	Omega-N-methylarginine	1
Modified residueⁱ	498	Omega-N-methylarginine	1
Modified residueⁱ	509	Phosphoserine	1
Isoform 8 (identifier: Q04637-8)
Modified residueⁱ	685	Omega-N-methylarginine	1
Modified residueⁱ	694	Omega-N-methylarginine	1
Modified residueⁱ	705	Phosphoserine	1

Post-translational modificationⁱ

Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.1 Publication

Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	674 – 675	Cleavage; by foot-and-mouth disease virus leader protease		2
Siteⁱ	681 – 682	Cleavage; by enterovirus/rhinovirus protease 2A		2

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q04637
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q04637
PaxDbⁱ	Q04637
PeptideAtlas More...PeptideAtlasⁱ	Q04637
PRIDEⁱ	Q04637
ProteomicsDBⁱ	58250 58251 [Q04637-3] 58252 [Q04637-4] 58253 [Q04637-5] 58254 [Q04637-6]

PTM databases

iPTMnetⁱ	Q04637
PhosphoSitePlusⁱ	Q04637
SwissPalmⁱ	Q04637

Miscellaneous databases

PMAP-CutDBⁱ	Q04637

PMAP-CutDBⁱ

CAB014774
HPA028487
HPA043866

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000114867 Expressed in 238 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_EIF4G1
ExpressionAtlasⁱ	Q04637 baseline and differential
Genevisibleⁱ	Q04637 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB014774 HPA028487 HPA043866

HPAⁱ

Interactionⁱ

Subunit structureⁱ

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with RBM4. Interacts with HNRNPD/AUF1; the interaction requires RNA.15 Publications

(Microbial infection) Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis.1 Publication

(Microbial infection) Interacts with human adenovirus 5 protein 100K; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-73711,EBI-73711
DDX3X	O00571	3	EBI-73711,EBI-353779
EIF3J	O75822	2	EBI-73711,EBI-366647
EIF4A1	P60842	11	EBI-73711,EBI-73449
EIF4E	P06730	9	EBI-73711,EBI-73440
HNRNPD	Q14103-4	3	EBI-73711,EBI-432545
PABPC1	P11940	4	EBI-73711,EBI-81531
RBM4	Q9BWF3-1	4	EBI-73711,EBI-15621561
UL54	Q9J0X9	3	EBI-73711,EBI-7967856	From Human herpesvirus 1.

GO - Molecular functionⁱ

eukaryotic initiation factor 4E binding
Source: AgBase
Inferred from direct assayⁱ
- 23814182
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16698552
protein-containing complex scaffold activity
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 25255371
translation initiation factor binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 25765080

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108296, 115 interactors
CORUMⁱ	Q04637
Database of interacting proteins More...DIPⁱ	DIP-1161N
ELMⁱ	Q04637
IntActⁱ	Q04637, 71 interactors
Molecular INTeraction database More...MINTⁱ	Q04637
STRINGⁱ	9606.ENSP00000338020

Chemistry databases

BindingDBⁱ	Q04637

BindingDBⁱ

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	181 – 183	Combined sources	3
Helixⁱ	185 – 187	Combined sources	3
Helixⁱ	193 – 197	Combined sources	5
Helixⁱ	614 – 618	Combined sources	5
Turnⁱ	619 – 622	Combined sources	4
Helixⁱ	624 – 627	Combined sources	4
Turnⁱ	637 – 639	Combined sources	3
Helixⁱ	1234 – 1256	Combined sources	23
Helixⁱ	1259 – 1267	Combined sources	9
Helixⁱ	1272 – 1274	Combined sources	3
Helixⁱ	1275 – 1286	Combined sources	12
Turnⁱ	1287 – 1289	Combined sources	3
Helixⁱ	1291 – 1306	Combined sources	16
Helixⁱ	1312 – 1329	Combined sources	18
Turnⁱ	1330 – 1332	Combined sources	3
Helixⁱ	1336 – 1344	Combined sources	9
Helixⁱ	1345 – 1348	Combined sources	4
Helixⁱ	1355 – 1362	Combined sources	8
Turnⁱ	1363 – 1365	Combined sources	3
Helixⁱ	1366 – 1369	Combined sources	4
Helixⁱ	1372 – 1387	Combined sources	16
Helixⁱ	1389 – 1398	Combined sources	10
Helixⁱ	1403 – 1405	Combined sources	3
Helixⁱ	1413 – 1419	Combined sources	7
Helixⁱ	1423 – 1425	Combined sources	3
Helixⁱ	1439 – 1452	Combined sources	14
Helixⁱ	1457 – 1467	Combined sources	11
Helixⁱ	1470 – 1473	Combined sources	4
Helixⁱ	1476 – 1489	Combined sources	14
Beta strandⁱ	1494 – 1496	Combined sources	3
Helixⁱ	1501 – 1514	Combined sources	14
Helixⁱ	1518 – 1534	Combined sources	17
Helixⁱ	1541 – 1551	Combined sources	11
Helixⁱ	1557 – 1563	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q04637
SMRⁱ	Q04637
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q04637

EvolutionaryTraceⁱ

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	565 – 792	MIF4GPROSITE-ProRule annotationAdd BLAST	228
Domainⁱ	1241 – 1363	MIPROSITE-ProRule annotationAdd BLAST	123
Domainⁱ	1433 – 1599	W2PROSITE-ProRule annotationAdd BLAST	167

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	172 – 200	PABPC1-bindingAdd BLAST	29
Regionⁱ	607 – 618	EIF4E-bindingAdd BLAST	12
Regionⁱ	682 – 1085	eIF3/EIF4A-bindingAdd BLAST	404
Regionⁱ	1450 – 1599	EIF4A-bindingAdd BLAST	150
Regionⁱ	1585 – 1599	Necessary but not sufficient for MKNK1-bindingAdd BLAST	15

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	454 – 467	Poly-GluAdd BLAST		14
Compositional biasⁱ	501 – 504	Poly-Ala		4

Sequence similaritiesⁱ

Belongs to the eukaryotic initiation factor 4G family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0401 Eukaryota ENOG410XS4P LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063038
HOGENOMⁱ	HOG000231658
HOVERGENⁱ	HBG052083
InParanoidⁱ	Q04637
KEGG Orthology (KO) More...KOⁱ	K03260
OMAⁱ	FDRISGQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03ZW
PhylomeDBⁱ	Q04637
TreeFamⁱ	TF101527

Family and domain databases

Gene3Dⁱ	1.25.40.180, 3 hits
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR037584 EIF4G1 IPR003891 Initiation_fac_eIF4g_MI IPR016021 MIF4-like_sf IPR003890 MIF4G-like_typ-3 IPR003307 W2_domain
PANTHERⁱ	PTHR23253:SF10 PTHR23253:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02847 MA3, 1 hit PF02854 MIF4G, 1 hit PF02020 W2, 1 hit
SMARTⁱ	View protein in SMART SM00515 eIF5C, 1 hit SM00544 MA3, 1 hit SM00543 MIF4G, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 3 hits
PROSITEⁱ	View protein in PROSITE PS51366 MI, 1 hit PS51363 W2, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsⁱ produced by alternative splicing and alternative initiation. Align Add to basket

This entry has 8 described isoforms and 19 potential isoforms that are computationally mapped.Show all Align All

Isoform A (identifier: Q04637-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH 
        60         70         80         90        100
FYPSRAQPPS SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ 
       110        120        130        140        150
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQG 
       160        170        180        190        200
VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA 
       210        220        230        240        250
RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI IADRPGLPGP 
       260        270        280        290        300
EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM TTIQMSVEES 
       310        320        330        340        350
TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF SSSPLQAPTP 
       360        370        380        390        400
LASHTVEIHE PNGMVPSEDL EPEVESSPEL APPPACPSES PVPIAPTAQP 
       410        420        430        440        450
EELLNGAPSP PAVDLSPVSE PEEQAKEVTA SMAPPTIPSA TPATAPSATS 
       460        470        480        490        500
PAQEEEMEEE EEEEEGEAGE AGEAESEKGG EELLPPESTP IPANLSQNLE 
       510        520        530        540        550
AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA VPEVENQPPA 
       560        570        580        590        600
GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG EQKYEYKSDQ 
       610        620        630        640        650
WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV LDKANKTPLR 
       660        670        680        690        700
PLDPTRLQGI NCGPDFTPSF ANLGRTTLST RGPPRGGPGG ELPRGPAGLG 
       710        720        730        740        750
PRRSQQGPRK EPRKIIATVL MTEDIKLNKA EKAWKPSSKR TAADKDRGEE 
       760        770        780        790        800
DADGSKTQDL FRRVRSILNK LTPQMFQQLM KQVTQLAIDT EERLKGVIDL 
       810        820        830        840        850
IFEKAISEPN FSVAYANMCR CLMALKVPTT EKPTVTVNFR KLLLNRCQKE 
       860        870        880        890        900
FEKDKDDDEV FEKKQKEMDE AATAEERGRL KEELEEARDI ARRRSLGNIK 
       910        920        930        940        950
FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK 
       960        970        980        990       1000
AKPRMDQYFN QMEKIIKEKK TSSRIRFMLQ DVLDLRGSNW VPRRGDQGPK 
      1010       1020       1030       1040       1050
TIDQIHKEAE MEEHREHIKV QQLMAKGSDK RRGGPPGPPI SRGLPLVDDG 
      1060       1070       1080       1090       1100
GWNTVPISKG SRPIDTSRLT KITKPGSIDS NNQLFAPGGR LSWGKGSSGG 
      1110       1120       1130       1140       1150
SGAKPSDAAS EAARPATSTL NRFSALQQAV PTESTDNRRV VQRSSLSRER 
      1160       1170       1180       1190       1200
GEKAGDRGDR LERSERGGDR GDRLDRARTP ATKRSFSKEV EERSRERPSQ 
      1210       1220       1230       1240       1250
PEGLRKAASL TEDRDRGRDA VKREAALPPV SPLKAALSEE ELEKKSKAII 
      1260       1270       1280       1290       1300
EEYLHLNDMK EAVQCVQELA SPSLLFIFVR HGVESTLERS AIAREHMGQL 
      1310       1320       1330       1340       1350
LHQLLCAGHL STAQYYQGLY EILELAEDME IDIPHVWLYL AELVTPILQE 
      1360       1370       1380       1390       1400
GGVPMGELFR EITKPLRPLG KAASLLLEIL GLLCKSMGPK KVGTLWREAG 
      1410       1420       1430       1440       1450
LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS EELNRQLEKL 
      1460       1470       1480       1490       1500
LKEGSSNQRV FDWIEANLSE QQIVSNTLVR ALMTAVCYSA IIFETPLRVD 
      1510       1520       1530       1540       1550
VAVLKARAKL LQKYLCDEQK ELQALYALQA LVVTLEQPPN LLRMFFDALY 
      1560       1570       1580       1590 
DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFKWLR EAEEESDHN

Length:1,599

Mass (Da):175,491

Last modified:April 20, 2010 - v4

Checksum:ⁱ324088B60863DA34

Isoform B (identifier: Q04637-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-40: Missing.

        10         20         30         40         50
MNTPSQPRQH FYPSRAQPPS SAASRVQSAA PARPGPAAHV YPAGSQVMMI 
        60         70         80         90        100
PSQISYPASQ GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT 
       110        120        130        140        150
YAGAYYPAQG VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI RIRDPNQGGK 
       160        170        180        190        200
DITEEIMSGA RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI 
       210        220        230        240        250
IADRPGLPGP EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM 
       260        270        280        290        300
TTIQMSVEES TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF 
       310        320        330        340        350
SSSPLQAPTP LASHTVEIHE PNGMVPSEDL EPEVESSPEL APPPACPSES 
       360        370        380        390        400
PVPIAPTAQP EELLNGAPSP PAVDLSPVSE PEEQAKEVTA SMAPPTIPSA 
       410        420        430        440        450
TPATAPSATS PAQEEEMEEE EEEEEGEAGE AGEAESEKGG EELLPPESTP 
       460        470        480        490        500
IPANLSQNLE AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA 
       510        520        530        540        550
VPEVENQPPA GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG 
       560        570        580        590        600
EQKYEYKSDQ WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV 
       610        620        630        640        650
LDKANKTPLR PLDPTRLQGI NCGPDFTPSF ANLGRTTLST RGPPRGGPGG 
       660        670        680        690        700
ELPRGPAGLG PRRSQQGPRK EPRKIIATVL MTEDIKLNKA EKAWKPSSKR 
       710        720        730        740        750
TAADKDRGEE DADGSKTQDL FRRVRSILNK LTPQMFQQLM KQVTQLAIDT 
       760        770        780        790        800
EERLKGVIDL IFEKAISEPN FSVAYANMCR CLMALKVPTT EKPTVTVNFR 
       810        820        830        840        850
KLLLNRCQKE FEKDKDDDEV FEKKQKEMDE AATAEERGRL KEELEEARDI 
       860        870        880        890        900
ARRRSLGNIK FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT 
       910        920        930        940        950
TIGKDLDFEK AKPRMDQYFN QMEKIIKEKK TSSRIRFMLQ DVLDLRGSNW 
       960        970        980        990       1000
VPRRGDQGPK TIDQIHKEAE MEEHREHIKV QQLMAKGSDK RRGGPPGPPI 
      1010       1020       1030       1040       1050
SRGLPLVDDG GWNTVPISKG SRPIDTSRLT KITKPGSIDS NNQLFAPGGR 
      1060       1070       1080       1090       1100
LSWGKGSSGG SGAKPSDAAS EAARPATSTL NRFSALQQAV PTESTDNRRV 
      1110       1120       1130       1140       1150
VQRSSLSRER GEKAGDRGDR LERSERGGDR GDRLDRARTP ATKRSFSKEV 
      1160       1170       1180       1190       1200
EERSRERPSQ PEGLRKAASL TEDRDRGRDA VKREAALPPV SPLKAALSEE 
      1210       1220       1230       1240       1250
ELEKKSKAII EEYLHLNDMK EAVQCVQELA SPSLLFIFVR HGVESTLERS 
      1260       1270       1280       1290       1300
AIAREHMGQL LHQLLCAGHL STAQYYQGLY EILELAEDME IDIPHVWLYL 
      1310       1320       1330       1340       1350
AELVTPILQE GGVPMGELFR EITKPLRPLG KAASLLLEIL GLLCKSMGPK 
      1360       1370       1380       1390       1400
KVGTLWREAG LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS 
      1410       1420       1430       1440       1450
EELNRQLEKL LKEGSSNQRV FDWIEANLSE QQIVSNTLVR ALMTAVCYSA 
      1460       1470       1480       1490       1500
IIFETPLRVD VAVLKARAKL LQKYLCDEQK ELQALYALQA LVVTLEQPPN 
      1510       1520       1530       1540       1550
LLRMFFDALY DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFKWLR 

EAEEESDHN

Note: Produced by alternative initiation at Met-41 of isoform A.

Length:1,559

Mass (Da):171,514

Checksum:ⁱ22F62E219E629C0E

Isoform C (identifier: Q04637-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-87: Missing.

        10         20         30         40         50
MMIPSQISYP ASQGAYYIPG QGRSTYVVPT QQYPVQPGAP GFYPGASPTE 
        60         70         80         90        100
FGTYAGAYYP AQGVQQFPTG VAPTPVLMNQ PPQIAPKRER KTIRIRDPNQ 
       110        120        130        140        150
GGKDITEEIM SGARTASTPT PPQTGGGLEP QANGETPQVA VIVRPDDRSQ 
       160        170        180        190        200
GAIIADRPGL PGPEHSPSES QPSSPSPTPS PSPVLEPGSE PNLAVLSIPG 
       210        220        230        240        250
DTMTTIQMSV EESTPISRET GEPYRLSPEP TPLAEPILEV EVTLSKPVPE 
       260        270        280        290        300
SEFSSSPLQA PTPLASHTVE IHEPNGMVPS EDLEPEVESS PELAPPPACP 
       310        320        330        340        350
SESPVPIAPT AQPEELLNGA PSPPAVDLSP VSEPEEQAKE VTASMAPPTI 
       360        370        380        390        400
PSATPATAPS ATSPAQEEEM EEEEEEEEGE AGEAGEAESE KGGEELLPPE 
       410        420        430        440        450
STPIPANLSQ NLEAAAATQV AVSVPKRRRK IKELNKKEAV GDLLDAFKEA 
       460        470        480        490        500
NPAVPEVENQ PPAGSNPGPE SEGSGVPPRP EEADETWDSK EDKIHNAENI 
       510        520        530        540        550
QPGEQKYEYK SDQWKPLNLE EKKRYDREFL LGFQFIFASM QKPEGLPHIS 
       560        570        580        590        600
DVVLDKANKT PLRPLDPTRL QGINCGPDFT PSFANLGRTT LSTRGPPRGG 
       610        620        630        640        650
PGGELPRGPA GLGPRRSQQG PRKEPRKIIA TVLMTEDIKL NKAEKAWKPS 
       660        670        680        690        700
SKRTAADKDR GEEDADGSKT QDLFRRVRSI LNKLTPQMFQ QLMKQVTQLA 
       710        720        730        740        750
IDTEERLKGV IDLIFEKAIS EPNFSVAYAN MCRCLMALKV PTTEKPTVTV 
       760        770        780        790        800
NFRKLLLNRC QKEFEKDKDD DEVFEKKQKE MDEAATAEER GRLKEELEEA 
       810        820        830        840        850
RDIARRRSLG NIKFIGELFK LKMLTEAIMH DCVVKLLKNH DEESLECLCR 
       860        870        880        890        900
LLTTIGKDLD FEKAKPRMDQ YFNQMEKIIK EKKTSSRIRF MLQDVLDLRG 
       910        920        930        940        950
SNWVPRRGDQ GPKTIDQIHK EAEMEEHREH IKVQQLMAKG SDKRRGGPPG 
       960        970        980        990       1000
PPISRGLPLV DDGGWNTVPI SKGSRPIDTS RLTKITKPGS IDSNNQLFAP 
      1010       1020       1030       1040       1050
GGRLSWGKGS SGGSGAKPSD AASEAARPAT STLNRFSALQ QAVPTESTDN 
      1060       1070       1080       1090       1100
RRVVQRSSLS RERGEKAGDR GDRLERSERG GDRGDRLDRA RTPATKRSFS 
      1110       1120       1130       1140       1150
KEVEERSRER PSQPEGLRKA ASLTEDRDRG RDAVKREAAL PPVSPLKAAL 
      1160       1170       1180       1190       1200
SEEELEKKSK AIIEEYLHLN DMKEAVQCVQ ELASPSLLFI FVRHGVESTL 
      1210       1220       1230       1240       1250
ERSAIAREHM GQLLHQLLCA GHLSTAQYYQ GLYEILELAE DMEIDIPHVW 
      1260       1270       1280       1290       1300
LYLAELVTPI LQEGGVPMGE LFREITKPLR PLGKAASLLL EILGLLCKSM 
      1310       1320       1330       1340       1350
GPKKVGTLWR EAGLSWKEFL PEGQDIGAFV AEQKVEYTLG EESEAPGQRA 
      1360       1370       1380       1390       1400
LPSEELNRQL EKLLKEGSSN QRVFDWIEAN LSEQQIVSNT LVRALMTAVC 
      1410       1420       1430       1440       1450
YSAIIFETPL RVDVAVLKAR AKLLQKYLCD EQKELQALYA LQALVVTLEQ 
      1460       1470       1480       1490       1500
PPNLLRMFFD ALYDEDVVKE DAFYSWESSK DPAEQQGKGV ALKSVTAFFK 
      1510 
WLREAEEESD HN

Note: Produced by alternative initiation at Met-88 of isoform A.

Length:1,512

Mass (Da):166,619

Checksum:ⁱ09DD6DC263462CB6

Isoform D (identifier: Q04637-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-164: Missing.

        10         20         30         40         50
MNQPPQIAPK RERKTIRIRD PNQGGKDITE EIMSGARTAS TPTPPQTGGG 
        60         70         80         90        100
LEPQANGETP QVAVIVRPDD RSQGAIIADR PGLPGPEHSP SESQPSSPSP 
       110        120        130        140        150
TPSPSPVLEP GSEPNLAVLS IPGDTMTTIQ MSVEESTPIS RETGEPYRLS 
       160        170        180        190        200
PEPTPLAEPI LEVEVTLSKP VPESEFSSSP LQAPTPLASH TVEIHEPNGM 
       210        220        230        240        250
VPSEDLEPEV ESSPELAPPP ACPSESPVPI APTAQPEELL NGAPSPPAVD 
       260        270        280        290        300
LSPVSEPEEQ AKEVTASMAP PTIPSATPAT APSATSPAQE EEMEEEEEEE 
       310        320        330        340        350
EGEAGEAGEA ESEKGGEELL PPESTPIPAN LSQNLEAAAA TQVAVSVPKR 
       360        370        380        390        400
RRKIKELNKK EAVGDLLDAF KEANPAVPEV ENQPPAGSNP GPESEGSGVP 
       410        420        430        440        450
PRPEEADETW DSKEDKIHNA ENIQPGEQKY EYKSDQWKPL NLEEKKRYDR 
       460        470        480        490        500
EFLLGFQFIF ASMQKPEGLP HISDVVLDKA NKTPLRPLDP TRLQGINCGP 
       510        520        530        540        550
DFTPSFANLG RTTLSTRGPP RGGPGGELPR GPAGLGPRRS QQGPRKEPRK 
       560        570        580        590        600
IIATVLMTED IKLNKAEKAW KPSSKRTAAD KDRGEEDADG SKTQDLFRRV 
       610        620        630        640        650
RSILNKLTPQ MFQQLMKQVT QLAIDTEERL KGVIDLIFEK AISEPNFSVA 
       660        670        680        690        700
YANMCRCLMA LKVPTTEKPT VTVNFRKLLL NRCQKEFEKD KDDDEVFEKK 
       710        720        730        740        750
QKEMDEAATA EERGRLKEEL EEARDIARRR SLGNIKFIGE LFKLKMLTEA 
       760        770        780        790        800
IMHDCVVKLL KNHDEESLEC LCRLLTTIGK DLDFEKAKPR MDQYFNQMEK 
       810        820        830        840        850
IIKEKKTSSR IRFMLQDVLD LRGSNWVPRR GDQGPKTIDQ IHKEAEMEEH 
       860        870        880        890        900
REHIKVQQLM AKGSDKRRGG PPGPPISRGL PLVDDGGWNT VPISKGSRPI 
       910        920        930        940        950
DTSRLTKITK PGSIDSNNQL FAPGGRLSWG KGSSGGSGAK PSDAASEAAR 
       960        970        980        990       1000
PATSTLNRFS ALQQAVPTES TDNRRVVQRS SLSRERGEKA GDRGDRLERS 
      1010       1020       1030       1040       1050
ERGGDRGDRL DRARTPATKR SFSKEVEERS RERPSQPEGL RKAASLTEDR 
      1060       1070       1080       1090       1100
DRGRDAVKRE AALPPVSPLK AALSEEELEK KSKAIIEEYL HLNDMKEAVQ 
      1110       1120       1130       1140       1150
CVQELASPSL LFIFVRHGVE STLERSAIAR EHMGQLLHQL LCAGHLSTAQ 
      1160       1170       1180       1190       1200
YYQGLYEILE LAEDMEIDIP HVWLYLAELV TPILQEGGVP MGELFREITK 
      1210       1220       1230       1240       1250
PLRPLGKAAS LLLEILGLLC KSMGPKKVGT LWREAGLSWK EFLPEGQDIG 
      1260       1270       1280       1290       1300
AFVAEQKVEY TLGEESEAPG QRALPSEELN RQLEKLLKEG SSNQRVFDWI 
      1310       1320       1330       1340       1350
EANLSEQQIV SNTLVRALMT AVCYSAIIFE TPLRVDVAVL KARAKLLQKY 
      1360       1370       1380       1390       1400
LCDEQKELQA LYALQALVVT LEQPPNLLRM FFDALYDEDV VKEDAFYSWE 
      1410       1420       1430 
SSKDPAEQQG KGVALKSVTA FFKWLREAEE ESDHN

Note: Produced by alternative initiation at Met-165 of isoform A.

Length:1,435

Mass (Da):158,517

Checksum:ⁱ6F7E9DE4106E73B9

Isoform E (identifier: Q04637-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-196: Missing.

        10         20         30         40         50
MSGARTASTP TPPQTGGGLE PQANGETPQV AVIVRPDDRS QGAIIADRPG 
        60         70         80         90        100
LPGPEHSPSE SQPSSPSPTP SPSPVLEPGS EPNLAVLSIP GDTMTTIQMS 
       110        120        130        140        150
VEESTPISRE TGEPYRLSPE PTPLAEPILE VEVTLSKPVP ESEFSSSPLQ 
       160        170        180        190        200
APTPLASHTV EIHEPNGMVP SEDLEPEVES SPELAPPPAC PSESPVPIAP 
       210        220        230        240        250
TAQPEELLNG APSPPAVDLS PVSEPEEQAK EVTASMAPPT IPSATPATAP 
       260        270        280        290        300
SATSPAQEEE MEEEEEEEEG EAGEAGEAES EKGGEELLPP ESTPIPANLS 
       310        320        330        340        350
QNLEAAAATQ VAVSVPKRRR KIKELNKKEA VGDLLDAFKE ANPAVPEVEN 
       360        370        380        390        400
QPPAGSNPGP ESEGSGVPPR PEEADETWDS KEDKIHNAEN IQPGEQKYEY 
       410        420        430        440        450
KSDQWKPLNL EEKKRYDREF LLGFQFIFAS MQKPEGLPHI SDVVLDKANK 
       460        470        480        490        500
TPLRPLDPTR LQGINCGPDF TPSFANLGRT TLSTRGPPRG GPGGELPRGP 
       510        520        530        540        550
AGLGPRRSQQ GPRKEPRKII ATVLMTEDIK LNKAEKAWKP SSKRTAADKD 
       560        570        580        590        600
RGEEDADGSK TQDLFRRVRS ILNKLTPQMF QQLMKQVTQL AIDTEERLKG 
       610        620        630        640        650
VIDLIFEKAI SEPNFSVAYA NMCRCLMALK VPTTEKPTVT VNFRKLLLNR 
       660        670        680        690        700
CQKEFEKDKD DDEVFEKKQK EMDEAATAEE RGRLKEELEE ARDIARRRSL 
       710        720        730        740        750
GNIKFIGELF KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL 
       760        770        780        790        800
DFEKAKPRMD QYFNQMEKII KEKKTSSRIR FMLQDVLDLR GSNWVPRRGD 
       810        820        830        840        850
QGPKTIDQIH KEAEMEEHRE HIKVQQLMAK GSDKRRGGPP GPPISRGLPL 
       860        870        880        890        900
VDDGGWNTVP ISKGSRPIDT SRLTKITKPG SIDSNNQLFA PGGRLSWGKG 
       910        920        930        940        950
SSGGSGAKPS DAASEAARPA TSTLNRFSAL QQAVPTESTD NRRVVQRSSL 
       960        970        980        990       1000
SRERGEKAGD RGDRLERSER GGDRGDRLDR ARTPATKRSF SKEVEERSRE 
      1010       1020       1030       1040       1050
RPSQPEGLRK AASLTEDRDR GRDAVKREAA LPPVSPLKAA LSEEELEKKS 
      1060       1070       1080       1090       1100
KAIIEEYLHL NDMKEAVQCV QELASPSLLF IFVRHGVEST LERSAIAREH 
      1110       1120       1130       1140       1150
MGQLLHQLLC AGHLSTAQYY QGLYEILELA EDMEIDIPHV WLYLAELVTP 
      1160       1170       1180       1190       1200
ILQEGGVPMG ELFREITKPL RPLGKAASLL LEILGLLCKS MGPKKVGTLW 
      1210       1220       1230       1240       1250
REAGLSWKEF LPEGQDIGAF VAEQKVEYTL GEESEAPGQR ALPSEELNRQ 
      1260       1270       1280       1290       1300
LEKLLKEGSS NQRVFDWIEA NLSEQQIVSN TLVRALMTAV CYSAIIFETP 
      1310       1320       1330       1340       1350
LRVDVAVLKA RAKLLQKYLC DEQKELQALY ALQALVVTLE QPPNLLRMFF 
      1360       1370       1380       1390       1400
DALYDEDVVK EDAFYSWESS KDPAEQQGKG VALKSVTAFF KWLREAEEES 

DHN

Note: Produced by alternative initiation at Met-197 of isoform A.

Length:1,403

Mass (Da):154,805

Checksum:ⁱ3E93A66EE3DFDDA9

Isoform 7 (identifier: Q04637-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-196: Missing.
696-696: P → PQ

        10         20         30         40         50
MSGARTASTP TPPQTGGGLE PQANGETPQV AVIVRPDDRS QGAIIADRPG 
        60         70         80         90        100
LPGPEHSPSE SQPSSPSPTP SPSPVLEPGS EPNLAVLSIP GDTMTTIQMS 
       110        120        130        140        150
VEESTPISRE TGEPYRLSPE PTPLAEPILE VEVTLSKPVP ESEFSSSPLQ 
       160        170        180        190        200
APTPLASHTV EIHEPNGMVP SEDLEPEVES SPELAPPPAC PSESPVPIAP 
       210        220        230        240        250
TAQPEELLNG APSPPAVDLS PVSEPEEQAK EVTASMAPPT IPSATPATAP 
       260        270        280        290        300
SATSPAQEEE MEEEEEEEEG EAGEAGEAES EKGGEELLPP ESTPIPANLS 
       310        320        330        340        350
QNLEAAAATQ VAVSVPKRRR KIKELNKKEA VGDLLDAFKE ANPAVPEVEN 
       360        370        380        390        400
QPPAGSNPGP ESEGSGVPPR PEEADETWDS KEDKIHNAEN IQPGEQKYEY 
       410        420        430        440        450
KSDQWKPLNL EEKKRYDREF LLGFQFIFAS MQKPEGLPHI SDVVLDKANK 
       460        470        480        490        500
TPLRPLDPTR LQGINCGPDF TPSFANLGRT TLSTRGPPRG GPGGELPRGP 
       510        520        530        540        550
QAGLGPRRSQ QGPRKEPRKI IATVLMTEDI KLNKAEKAWK PSSKRTAADK 
       560        570        580        590        600
DRGEEDADGS KTQDLFRRVR SILNKLTPQM FQQLMKQVTQ LAIDTEERLK 
       610        620        630        640        650
GVIDLIFEKA ISEPNFSVAY ANMCRCLMAL KVPTTEKPTV TVNFRKLLLN 
       660        670        680        690        700
RCQKEFEKDK DDDEVFEKKQ KEMDEAATAE ERGRLKEELE EARDIARRRS 
       710        720        730        740        750
LGNIKFIGEL FKLKMLTEAI MHDCVVKLLK NHDEESLECL CRLLTTIGKD 
       760        770        780        790        800
LDFEKAKPRM DQYFNQMEKI IKEKKTSSRI RFMLQDVLDL RGSNWVPRRG 
       810        820        830        840        850
DQGPKTIDQI HKEAEMEEHR EHIKVQQLMA KGSDKRRGGP PGPPISRGLP 
       860        870        880        890        900
LVDDGGWNTV PISKGSRPID TSRLTKITKP GSIDSNNQLF APGGRLSWGK 
       910        920        930        940        950
GSSGGSGAKP SDAASEAARP ATSTLNRFSA LQQAVPTEST DNRRVVQRSS 
       960        970        980        990       1000
LSRERGEKAG DRGDRLERSE RGGDRGDRLD RARTPATKRS FSKEVEERSR 
      1010       1020       1030       1040       1050
ERPSQPEGLR KAASLTEDRD RGRDAVKREA ALPPVSPLKA ALSEEELEKK 
      1060       1070       1080       1090       1100
SKAIIEEYLH LNDMKEAVQC VQELASPSLL FIFVRHGVES TLERSAIARE 
      1110       1120       1130       1140       1150
HMGQLLHQLL CAGHLSTAQY YQGLYEILEL AEDMEIDIPH VWLYLAELVT 
      1160       1170       1180       1190       1200
PILQEGGVPM GELFREITKP LRPLGKAASL LLEILGLLCK SMGPKKVGTL 
      1210       1220       1230       1240       1250
WREAGLSWKE FLPEGQDIGA FVAEQKVEYT LGEESEAPGQ RALPSEELNR 
      1260       1270       1280       1290       1300
QLEKLLKEGS SNQRVFDWIE ANLSEQQIVS NTLVRALMTA VCYSAIIFET 
      1310       1320       1330       1340       1350
PLRVDVAVLK ARAKLLQKYL CDEQKELQAL YALQALVVTL EQPPNLLRMF 
      1360       1370       1380       1390       1400
FDALYDEDVV KEDAFYSWES SKDPAEQQGK GVALKSVTAF FKWLREAEEE 

SDHN

Note: Produced by alternative splicing.

Length:1,404

Mass (Da):154,933

Checksum:ⁱE2CE3C54B5BB0A50

Isoform 8 (identifier: Q04637-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
696-696: P → PQ

        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH 
        60         70         80         90        100
FYPSRAQPPS SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ 
       110        120        130        140        150
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQG 
       160        170        180        190        200
VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA 
       210        220        230        240        250
RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI IADRPGLPGP 
       260        270        280        290        300
EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM TTIQMSVEES 
       310        320        330        340        350
TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF SSSPLQAPTP 
       360        370        380        390        400
LASHTVEIHE PNGMVPSEDL EPEVESSPEL APPPACPSES PVPIAPTAQP 
       410        420        430        440        450
EELLNGAPSP PAVDLSPVSE PEEQAKEVTA SMAPPTIPSA TPATAPSATS 
       460        470        480        490        500
PAQEEEMEEE EEEEEGEAGE AGEAESEKGG EELLPPESTP IPANLSQNLE 
       510        520        530        540        550
AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA VPEVENQPPA 
       560        570        580        590        600
GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG EQKYEYKSDQ 
       610        620        630        640        650
WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV LDKANKTPLR 
       660        670        680        690        700
PLDPTRLQGI NCGPDFTPSF ANLGRTTLST RGPPRGGPGG ELPRGPQAGL 
       710        720        730        740        750
GPRRSQQGPR KEPRKIIATV LMTEDIKLNK AEKAWKPSSK RTAADKDRGE 
       760        770        780        790        800
EDADGSKTQD LFRRVRSILN KLTPQMFQQL MKQVTQLAID TEERLKGVID 
       810        820        830        840        850
LIFEKAISEP NFSVAYANMC RCLMALKVPT TEKPTVTVNF RKLLLNRCQK 
       860        870        880        890        900
EFEKDKDDDE VFEKKQKEMD EAATAEERGR LKEELEEARD IARRRSLGNI 
       910        920        930        940        950
KFIGELFKLK MLTEAIMHDC VVKLLKNHDE ESLECLCRLL TTIGKDLDFE 
       960        970        980        990       1000
KAKPRMDQYF NQMEKIIKEK KTSSRIRFML QDVLDLRGSN WVPRRGDQGP 
      1010       1020       1030       1040       1050
KTIDQIHKEA EMEEHREHIK VQQLMAKGSD KRRGGPPGPP ISRGLPLVDD 
      1060       1070       1080       1090       1100
GGWNTVPISK GSRPIDTSRL TKITKPGSID SNNQLFAPGG RLSWGKGSSG 
      1110       1120       1130       1140       1150
GSGAKPSDAA SEAARPATST LNRFSALQQA VPTESTDNRR VVQRSSLSRE 
      1160       1170       1180       1190       1200
RGEKAGDRGD RLERSERGGD RGDRLDRART PATKRSFSKE VEERSRERPS 
      1210       1220       1230       1240       1250
QPEGLRKAAS LTEDRDRGRD AVKREAALPP VSPLKAALSE EELEKKSKAI 
      1260       1270       1280       1290       1300
IEEYLHLNDM KEAVQCVQEL ASPSLLFIFV RHGVESTLER SAIAREHMGQ 
      1310       1320       1330       1340       1350
LLHQLLCAGH LSTAQYYQGL YEILELAEDM EIDIPHVWLY LAELVTPILQ 
      1360       1370       1380       1390       1400
EGGVPMGELF REITKPLRPL GKAASLLLEI LGLLCKSMGP KKVGTLWREA 
      1410       1420       1430       1440       1450
GLSWKEFLPE GQDIGAFVAE QKVEYTLGEE SEAPGQRALP SEELNRQLEK 
      1460       1470       1480       1490       1500
LLKEGSSNQR VFDWIEANLS EQQIVSNTLV RALMTAVCYS AIIFETPLRV 
      1510       1520       1530       1540       1550
DVAVLKARAK LLQKYLCDEQ KELQALYALQ ALVVTLEQPP NLLRMFFDAL 
      1560       1570       1580       1590       1600
YDEDVVKEDA FYSWESSKDP AEQQGKGVAL KSVTAFFKWL REAEEESDHN

Note: Produced by alternative splicing.

Length:1,600

Mass (Da):175,619

Checksum:ⁱ2B32EF7A6D50B657

Isoform 9 (identifier: Q04637-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
48-48: R → RQGGFRSL

        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG 
        60         70         80         90        100
GFRSLQHFYP SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ 
       110        120        130        140        150
ISYPASQGAY YIPGQGRSTY VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG 
       160        170        180        190        200
AYYPAQGVQQ FPTGVAPTPV LMNQPPQIAP KRERKTIRIR DPNQGGKDIT 
       210        220        230        240        250
EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD DRSQGAIIAD 
       260        270        280        290        300
RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI 
       310        320        330        340        350
QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS 
       360        370        380        390        400
PLQAPTPLAS HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP 
       410        420        430        440        450
IAPTAQPEEL LNGAPSPPAV DLSPVSEPEE QAKEVTASMA PPTIPSATPA 
       460        470        480        490        500
TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE AESEKGGEEL LPPESTPIPA 
       510        520        530        540        550
NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA FKEANPAVPE 
       560        570        580        590        600
VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK 
       610        620        630        640        650
YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK 
       660        670        680        690        700
ANKTPLRPLD PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP 
       710        720        730        740        750
RGPAGLGPRR SQQGPRKEPR KIIATVLMTE DIKLNKAEKA WKPSSKRTAA 
       760        770        780        790        800
DKDRGEEDAD GSKTQDLFRR VRSILNKLTP QMFQQLMKQV TQLAIDTEER 
       810        820        830        840        850
LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP TVTVNFRKLL 
       860        870        880        890        900
LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR 
       910        920        930        940        950
RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG 
       960        970        980        990       1000
KDLDFEKAKP RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR 
      1010       1020       1030       1040       1050
RGDQGPKTID QIHKEAEMEE HREHIKVQQL MAKGSDKRRG GPPGPPISRG 
      1060       1070       1080       1090       1100
LPLVDDGGWN TVPISKGSRP IDTSRLTKIT KPGSIDSNNQ LFAPGGRLSW 
      1110       1120       1130       1140       1150
GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE STDNRRVVQR 
      1160       1170       1180       1190       1200
SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER 
      1210       1220       1230       1240       1250
SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE 
      1260       1270       1280       1290       1300
KKSKAIIEEY LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA 
      1310       1320       1330       1340       1350
REHMGQLLHQ LLCAGHLSTA QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL 
      1360       1370       1380       1390       1400
VTPILQEGGV PMGELFREIT KPLRPLGKAA SLLLEILGLL CKSMGPKKVG 
      1410       1420       1430       1440       1450
TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP GQRALPSEEL 
      1460       1470       1480       1490       1500
NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF 
      1510       1520       1530       1540       1550
ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR 
      1560       1570       1580       1590       1600
MFFDALYDED VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE 

EESDHN

Note: Produced by alternative splicing. Gene prediction based on EST data.

Length:1,606

Mass (Da):176,237

Checksum:ⁱE4464821E0BA5FF6

Alternative initiation, Alternative splicing, Polymorphism

Computationally mapped potential isoform sequencesⁱ

There are 19 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	E7EUU4	E7EUU4_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	1,560	Annotation score:
	E9PGM1	E9PGM1_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	1,513	Annotation score:
	E7EX73	E7EX73_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	1,436	Annotation score:
	C9JF13	C9JF13_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	903	Annotation score:
	C9J6B6	C9J6B6_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	757	Annotation score:
	C9K073	C9K073_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	869	Annotation score:
	C9J2Z7	C9J2Z7_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	833	Annotation score:
	C9JWW9	C9JWW9_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	285	Annotation score:
	H7C0V6	H7C0V6_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	180	Annotation score:
	H7C044	H7C044_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4 gamma 1	EIF4G1	226	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAC78444 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAC82471 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAA02185 differs from that shown. Reason: Frameshift at several positions.Curated

The sequence BAD18554 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30	P → R in AAC78443 (PubMed:9755181).Curated	1
Sequence conflictⁱ	138	F → L in AAL92872 (PubMed:14702039).Curated	1
Sequence conflictⁱ	138	F → L in AAM69365 (PubMed:14702039).Curated	1
Sequence conflictⁱ	149	Q → R in AAL92872 (PubMed:14702039).Curated	1
Sequence conflictⁱ	149	Q → R in AAM69365 (PubMed:14702039).Curated	1
Sequence conflictⁱ	214	G → S in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	462	E → D in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	468	A → V in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	474	A → G in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	479	G → R in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	604	L → P in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	604	L → P in AAL92872 (PubMed:14702039).Curated	1
Sequence conflictⁱ	604	L → P in AAM69365 (PubMed:14702039).Curated	1
Sequence conflictⁱ	604	L → P in AAC82471 (PubMed:9372926).Curated	1
Sequence conflictⁱ	625 – 626	AS → CQ in BAA02185 (PubMed:1429670).Curated	2
Sequence conflictⁱ	693	P → A in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	696	P → A in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	764	V → W in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	878	G → E in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	894	R → C in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	1104	K → Q in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	1121	N → I in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	1185	S → T in BAA02185 (PubMed:1429670).Curated	1
Sequence conflictⁱ	1384	C → Y in CAI46013 (PubMed:17974005).Curated	1
Sequence conflictⁱ	1472	Missing in BAA02185 (PubMed:1429670).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_066571	71	P → S1 PublicationCorresponds to variant dbSNP:rs113810947Ensembl.	1
Natural variantⁱVAR_061147	161	T → A5 PublicationsCorresponds to variant dbSNP:rs13319149Ensembl.	1
Natural variantⁱVAR_079031	201	R → H Found in a patient with Rett syndrome-like phenotype; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs34838305Ensembl.	1
Natural variantⁱVAR_055704	311	Y → C1 PublicationCorresponds to variant dbSNP:rs16858632Ensembl.	1
Natural variantⁱVAR_063040	432	M → VCombined sources4 PublicationsCorresponds to variant dbSNP:rs2178403EnsemblClinVar.	1
Natural variantⁱVAR_066572	466 – 468	Missing 1 Publication	3
Natural variantⁱVAR_066573	502	A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar.	1
Natural variantⁱVAR_066574	686	G → C Found in patients with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs112019125Ensembl.	1
Natural variantⁱVAR_036117	696	P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754755344Ensembl.	1
Natural variantⁱVAR_066575	806	I → V1 PublicationCorresponds to variant dbSNP:rs62287499Ensembl.	1
Natural variantⁱVAR_066576	829	T → S1 PublicationCorresponds to variant dbSNP:rs111500185Ensembl.	1
Natural variantⁱVAR_066577	1164	S → R Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113169049Ensembl.	1
Natural variantⁱVAR_066578	1197	R → W Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113388242Ensembl.	1
Natural variantⁱVAR_066579	1205	R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar.	1
Natural variantⁱVAR_061148	1229	P → A1 PublicationCorresponds to variant dbSNP:rs35629949Ensembl.	1
Natural variantⁱVAR_055705	1233	L → P1 PublicationCorresponds to variant dbSNP:rs2230570Ensembl.	1
Natural variantⁱVAR_066580	1257	N → S1 PublicationCorresponds to variant dbSNP:rs73053766Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_018723	1 – 196	Missing in isoform E and isoform 7. 1 PublicationAdd BLAST	196
Alternative sequenceⁱVSP_018722	1 – 164	Missing in isoform D. CuratedAdd BLAST	164
Alternative sequenceⁱVSP_018721	1 – 87	Missing in isoform C. 1 PublicationAdd BLAST	87
Alternative sequenceⁱVSP_018720	1 – 40	Missing in isoform B. 1 PublicationAdd BLAST	40
Alternative sequenceⁱVSP_047396	48	R → RQGGFRSL in isoform 9. Curated	1
Alternative sequenceⁱVSP_047397	696	P → PQ in isoform 7 and isoform 8. 4 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D12686 mRNA Translation: BAA02185.1 Frameshift. AY082886 mRNA Translation: AAL92872.1 AF281070 mRNA Translation: AAM69365.1 AK131407 mRNA Translation: BAD18554.1 Sequence problems. BX647812 mRNA Translation: CAI46013.1 AC078797 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78257.1 CH471052 Genomic DNA Translation: EAW78259.1 CH471052 Genomic DNA Translation: EAW78262.1 CH471052 Genomic DNA Translation: EAW78263.1 CH471052 Genomic DNA Translation: EAW78264.1 CH471052 Genomic DNA Translation: EAW78265.1 CH471052 Genomic DNA Translation: EAW78266.1 CH471052 Genomic DNA Translation: EAW78267.1 AF002816 mRNA Translation: AAC78443.1 AF004836 Genomic DNA Translation: AAC78444.1 Different initiation. AF104913 mRNA Translation: AAC82471.1 Different initiation. AJ001046 mRNA Translation: CAA04500.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3259.1 [Q04637-1] CCDS3260.1 [Q04637-4] CCDS3261.1 [Q04637-5] CCDS46970.2 [Q04637-7] CCDS54687.1 [Q04637-9] CCDS54688.1 [Q04637-8] CCDS77866.1 [Q04637-3]
PIRⁱ	A44453
NCBI Reference Sequences More...RefSeqⁱ	NP_004944.3, NM_004953.4 [Q04637-7] NP_886553.3, NM_182917.4 NP_937884.1, NM_198241.2 NP_937885.1, NM_198242.2 [Q04637-5]
UniGeneⁱ	Hs.433750

Genome annotation databases

Ensemblⁱ	ENST00000342981; ENSP00000343450; ENSG00000114867 [Q04637-8] ENST00000346169; ENSP00000316879; ENSG00000114867 [Q04637-1] ENST00000350481; ENSP00000317600; ENSG00000114867 [Q04637-5] ENST00000352767; ENSP00000338020; ENSG00000114867 [Q04637-9] ENST00000382330; ENSP00000371767; ENSG00000114867 [Q04637-9] ENST00000392537; ENSP00000376320; ENSG00000114867 [Q04637-4] ENST00000414031; ENSP00000391935; ENSG00000114867 [Q04637-3] ENST00000424196; ENSP00000416255; ENSG00000114867 [Q04637-9] ENST00000434061; ENSP00000411826; ENSG00000114867 [Q04637-7] ENST00000435046; ENSP00000404754; ENSG00000114867 [Q04637-6]
GeneIDⁱ	1981
KEGGⁱ	hsa:1981
UCSC genome browser More...UCSCⁱ	uc003fnp.4 human [Q04637-1]

Keywords - Coding sequence diversityⁱ

Protein	Similar proteins		Species	Score	Length	Source
Q04637-4	Isoform 9 of Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1606	UniRef100_Q04637-4
Eukaryotic translation initiation factor 4 gamma 1 (Fragment)		HUMAN		92
Q04637-5	eIF4G1 protein		HUMAN		1606	UniRef100_B2RU10
Isoform E of Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1403
Eukaryotic translation initiation factor 4 gamma 1 (Fragment)		HUMAN		757
Eukaryotic translation initiation factor 4 gamma 1 (Fragment)		HUMAN		285
UPI000021BFB0		HUMAN		1512
Q04637-6	eIF4G1 protein		HUMAN		1606	UniRef100_B2RU10
Isoform D of Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1435
Eukaryotic translation initiation factor 4 gamma 1 (Fragment)		HUMAN		757
Eukaryotic translation initiation factor 4 gamma 1 (Fragment)		HUMAN		285
UPI000021BFB0		HUMAN		1512
Q04637-7	Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1560	UniRef100_E7EUU4
Isoform 8 of Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1600
Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1513
Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1436
Eukaryotic translation initiation factor 4 gamma 1 (Fragment)		HUMAN		833
Q04637-8	Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1560	UniRef100_E7EUU4
Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1513
Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1436
Isoform 7 of Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1404
Eukaryotic translation initiation factor 4 gamma 1 (Fragment)		HUMAN		833
Q04637-9	Isoform C of Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1512	UniRef100_Q04637-4
Eukaryotic translation initiation factor 4 gamma 1 (Fragment)		HUMAN		92

Protein	Similar proteins		Species	Score	Length	Source
Q04637	Isoform B of Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1559	UniRef90_Q04637
eukaryotic translation initiation factor 4 gamma 1 isoform X1		PHYCD		1876
protein FAM131A isoform X2		DELLE		281
protein FAM131A isoform X2		Yangtze finless porpoise		281
Protein FAM131A (Fragment)		MOUSE		37
+520

Protein	Similar proteins		Species	Score	Length	Source
Q04637	Eukaryotic translation initiation factor 4 gamma 1		MOUSE		1600	UniRef50_Q04637
Eukaryotic translation initiation factor 4 gamma 1		RABIT		1402
Isoform B of Eukaryotic translation initiation factor 4 gamma 1		HUMAN		1559
eukaryotic translation initiation factor 4 gamma 1 isoform X1		PHYCD		1876
protein FAM131A isoform X2		DELLE		281
+979

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D12686 mRNA Translation: BAA02185.1 Frameshift. AY082886 mRNA Translation: AAL92872.1 AF281070 mRNA Translation: AAM69365.1 AK131407 mRNA Translation: BAD18554.1 Sequence problems. BX647812 mRNA Translation: CAI46013.1 AC078797 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78257.1 CH471052 Genomic DNA Translation: EAW78259.1 CH471052 Genomic DNA Translation: EAW78262.1 CH471052 Genomic DNA Translation: EAW78263.1 CH471052 Genomic DNA Translation: EAW78264.1 CH471052 Genomic DNA Translation: EAW78265.1 CH471052 Genomic DNA Translation: EAW78266.1 CH471052 Genomic DNA Translation: EAW78267.1 AF002816 mRNA Translation: AAC78443.1 AF004836 Genomic DNA Translation: AAC78444.1 Different initiation. AF104913 mRNA Translation: AAC82471.1 Different initiation. AJ001046 mRNA Translation: CAA04500.1
CCDSⁱ	CCDS3259.1 [Q04637-1] CCDS3260.1 [Q04637-4] CCDS3261.1 [Q04637-5] CCDS46970.2 [Q04637-7] CCDS54687.1 [Q04637-9] CCDS54688.1 [Q04637-8] CCDS77866.1 [Q04637-3]
PIRⁱ	A44453
RefSeqⁱ	NP_004944.3, NM_004953.4 [Q04637-7] NP_886553.3, NM_182917.4 NP_937884.1, NM_198241.2 NP_937885.1, NM_198242.2 [Q04637-5]
UniGeneⁱ	Hs.433750

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LJ2	X-ray	2.38	C/D	172-199	[»]
	1UG3	X-ray	2.24	A/B	1233-1571	[»]
	2W97	X-ray	2.29	E/F	609-622	[»]
	4AZA	X-ray	2.16	B/D	609-620	[»]
	4F02	X-ray	2.00	C/F	178-203	[»]
	5EHC	X-ray	2.40	B	609-622	[»]
	5EI3	X-ray	1.71	B	609-622	[»]
	5EIR	X-ray	2.69	B	609-622	[»]
	5T46	X-ray	1.53	B/D	592-653	[»]
ProteinModelPortalⁱ	Q04637
SMRⁱ	Q04637
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108296, 115 interactors
CORUMⁱ	Q04637
DIPⁱ	DIP-1161N
ELMⁱ	Q04637
IntActⁱ	Q04637, 71 interactors
MINTⁱ	Q04637
STRINGⁱ	9606.ENSP00000338020

Chemistry databases

BindingDBⁱ	Q04637

BindingDBⁱ

Protein family/group databases

MoonProtⁱ	Q04637

MoonProtⁱ

PTM databases

iPTMnetⁱ	Q04637
PhosphoSitePlusⁱ	Q04637
SwissPalmⁱ	Q04637

Polymorphism and mutation databases

BioMutaⁱ	EIF4G1
DMDMⁱ	294862538

Proteomic databases

EPDⁱ	Q04637
MaxQBⁱ	Q04637
PaxDbⁱ	Q04637
PeptideAtlasⁱ	Q04637
PRIDEⁱ	Q04637
ProteomicsDBⁱ	58250 58251 [Q04637-3] 58252 [Q04637-4] 58253 [Q04637-5] 58254 [Q04637-6]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1981
Structural Biology Knowledgebase	Search...

Genome annotation databases

Organism-specific databases

CTDⁱ	1981
DisGeNETⁱ	1981
EuPathDBⁱ	HostDB:ENSG00000114867.19
GeneCardsⁱ	EIF4G1
HGNCⁱ	HGNC:3296 EIF4G1
HPAⁱ	CAB014774 HPA028487 HPA043866
MalaCardsⁱ	EIF4G1
MIMⁱ	600495 gene 614251 phenotype
neXtProtⁱ	NX_Q04637
OpenTargetsⁱ	ENSG00000114867
Orphanetⁱ	411602 Hereditary late-onset Parkinson disease
PharmGKBⁱ	PA27722
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0401 Eukaryota ENOG410XS4P LUCA
GeneTreeⁱ	ENSGT00530000063038
HOGENOMⁱ	HOG000231658
HOVERGENⁱ	HBG052083
InParanoidⁱ	Q04637
KOⁱ	K03260
OMAⁱ	FDRISGQ
OrthoDBⁱ	EOG091G03ZW
PhylomeDBⁱ	Q04637
TreeFamⁱ	TF101527

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-166208 mTORC1-mediated signalling R-HSA-429947 Deadenylation of mRNA R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-72649 Translation initiation complex formation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORⁱ	Q04637

Reactomeⁱ

R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-166208 mTORC1-mediated signalling
R-HSA-429947 Deadenylation of mRNA
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNORⁱ