Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 218 (18 Sep 2019)
Sequence version 4 (20 Apr 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Eukaryotic translation initiation factor 4 gamma 1

Gene

EIF4G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding, Translational shunt
Biological processHost-virus interaction, Protein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-166208 mTORC1-mediated signalling
R-HSA-429947 Deadenylation of mRNA
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q04637

Protein family/group databases

MoonProt database of moonlighting proteins

More...
MoonProti
Q04637

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 1
Short name:
eIF-4-gamma 1
Short name:
eIF-4G 1
Short name:
eIF-4G1
Alternative name(s):
p220
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4G1
Synonyms:EIF4F, EIF4G, EIF4GI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3296 EIF4G1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600495 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q04637

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parkinson disease 18 (PARK18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066573502A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar.1
Natural variantiVAR_0665791205R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi174 – 178KRERK → AAAAA: Loss of PABPC1 binding; when associated with 184-AAAA-187. 1 Publication5
Mutagenesisi180I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi182I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi184 – 187DPNQ → AAAA: Loss of PABPC1 binding; when associated with 174-AAAAA-178. 4
Mutagenesisi192I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi196I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi612Y → A or F: Abolishes binding to EIF4E. 1 Publication1
Mutagenesisi617 – 618LL → AA: Abolishes binding to EIF4E. 1 Publication2
Mutagenesisi682G → A, V, W, R or E: Reduced cleavage by protease 2A from human rhinovirus 2. 1 Publication1
Mutagenesisi768L → A: Abolishes binding to EIF4A; when associated with A-770 and A-775. 1 Publication1
Mutagenesisi771L → A: Abolishes binding to EIF4A; when associated with A-767 and A-775. 1 Publication1
Mutagenesisi776F → A: Abolishes binding to EIF4A; when associated with A-767 and A-770. 1 Publication1
Mutagenesisi842 – 843LL → AA: Abolishes binding to EIF4A; when associated with A-850 and K-851. 1 Publication2
Mutagenesisi851 – 852FE → AK: Abolishes binding to EIF4A; when associated with A-841 and A-842. 1 Publication2
Mutagenesisi896L → A: Abolishes binding to EIF4A; when associated with A-92 and A-95. 1 Publication1
Mutagenesisi902I → A: Abolishes binding to EIF4A; when associated with A-895 and A-95. 1 Publication1
Mutagenesisi905L → A: Abolishes binding to EIF4A; when associated with A-895 and A-92. 1 Publication1
Mutagenesisi974R → A: Abolishes binding to EIF4A; when associated with A-976. 1 Publication1
Mutagenesisi977F → A: Abolishes binding to EIF4A; when associated with A-973. 1 Publication1
Mutagenesisi985L → A: Slightly reduced binding to EIF4A; when associated with A-989. 1 Publication1
Mutagenesisi990W → A: Slightly reduced binding to EIF4A; when associated with A-984. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNET

More...
DisGeNETi
1981

MalaCards human disease database

More...
MalaCardsi
EIF4G1
MIMi614251 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000114867

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
411602 Hereditary late-onset Parkinson disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27722

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF4G1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862538

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000077861 – 1599Eukaryotic translation initiation factor 4 gamma 1Add BLAST1599
Isoform C (identifier: Q04637-4)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineBy similarity1
Modified residuei73Omega-N-methylarginineCombined sources1
Modified residuei110Omega-N-methylarginineCombined sources1
Modified residuei207PhosphothreonineCombined sources1
Modified residuei223PhosphothreonineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei602N6-acetyllysineBy similarity1
Modified residuei647PhosphothreonineCombined sources1
Modified residuei685Omega-N-methylarginineCombined sources1
Modified residuei694Omega-N-methylarginineCombined sources1
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1032Omega-N-methylarginineCombined sources1
Modified residuei1042Omega-N-methylarginineCombined sources1
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1
Modified residuei1095N6-acetyllysineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1185Phosphoserine; by PKC/PRKCACombined sources1 Publication1
Modified residuei1187PhosphoserineCombined sources1
Modified residuei1194PhosphoserineCombined sources1
Modified residuei1209PhosphoserineCombined sources1
Modified residuei1211PhosphothreonineCombined sources1
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1238PhosphoserineCombined sources1
Modified residuei1596PhosphoserineCombined sources1
Isoform C (identifier: Q04637-4)
Modified residuei2N-acetylmethionine1
Isoform 7 (identifier: Q04637-7)
Modified residuei489Omega-N-methylarginine1
Modified residuei498Omega-N-methylarginine1
Modified residuei509Phosphoserine1
Isoform 8 (identifier: Q04637-8)
Modified residuei685Omega-N-methylarginine1
Modified residuei694Omega-N-methylarginine1
Modified residuei705Phosphoserine1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.1 Publication
Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei674 – 675Cleavage; by foot-and-mouth disease virus leader protease2
Sitei681 – 682Cleavage; by enterovirus/rhinovirus protease 2A2

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q04637

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q04637

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q04637

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q04637

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q04637

PeptideAtlas

More...
PeptideAtlasi
Q04637

PRoteomics IDEntifications database

More...
PRIDEi
Q04637

ProteomicsDB human proteome resource

More...
ProteomicsDBi
20132
34026
58250 [Q04637-1]
58251 [Q04637-3]
58252 [Q04637-4]
58253 [Q04637-5]
58254 [Q04637-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q04637

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q04637

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q04637

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q04637

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114867 Expressed in 238 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q04637 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q04637 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB014774
HPA028487
HPA043866

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3.

Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1.

Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs.

Interacts with EIF4E3.

Interacts with CIRBP and MIF4GD.

Interacts with RBM4.

Interacts with HNRNPD/AUF1; the interaction requires RNA.

15 Publications

(Microbial infection)

Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis.

1 Publication

(Microbial infection)

Interacts with human adenovirus 5 protein 100K; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108296, 140 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q04637

Database of interacting proteins

More...
DIPi
DIP-1161N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q04637

Protein interaction database and analysis system

More...
IntActi
Q04637, 84 interactors

Molecular INTeraction database

More...
MINTi
Q04637

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000416255

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q04637

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q04637

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q04637

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini565 – 792MIF4GPROSITE-ProRule annotationAdd BLAST228
Domaini1241 – 1363MIPROSITE-ProRule annotationAdd BLAST123
Domaini1433 – 1599W2PROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni172 – 200PABPC1-bindingAdd BLAST29
Regioni607 – 618EIF4E-bindingAdd BLAST12
Regioni682 – 1085eIF3/EIF4A-bindingAdd BLAST404
Regioni1450 – 1599EIF4A-bindingAdd BLAST150
Regioni1585 – 1599Necessary but not sufficient for MKNK1-bindingAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi454 – 467Poly-GluAdd BLAST14
Compositional biasi501 – 504Poly-Ala4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0401 Eukaryota
ENOG410XS4P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154648

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231658

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q04637

KEGG Orthology (KO)

More...
KOi
K03260

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQPRGGP

Database of Orthologous Groups

More...
OrthoDBi
594395at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q04637

TreeFam database of animal gene trees

More...
TreeFami
TF101527

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23253:SF10 PTHR23253:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 8 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q04637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH
60 70 80 90 100
FYPSRAQPPS SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ
110 120 130 140 150
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQG
160 170 180 190 200
VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA
210 220 230 240 250
RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI IADRPGLPGP
260 270 280 290 300
EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM TTIQMSVEES
310 320 330 340 350
TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF SSSPLQAPTP
360 370 380 390 400
LASHTVEIHE PNGMVPSEDL EPEVESSPEL APPPACPSES PVPIAPTAQP
410 420 430 440 450
EELLNGAPSP PAVDLSPVSE PEEQAKEVTA SMAPPTIPSA TPATAPSATS
460 470 480 490 500
PAQEEEMEEE EEEEEGEAGE AGEAESEKGG EELLPPESTP IPANLSQNLE
510 520 530 540 550
AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA VPEVENQPPA
560 570 580 590 600
GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG EQKYEYKSDQ
610 620 630 640 650
WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV LDKANKTPLR
660 670 680 690 700
PLDPTRLQGI NCGPDFTPSF ANLGRTTLST RGPPRGGPGG ELPRGPAGLG
710 720 730 740 750
PRRSQQGPRK EPRKIIATVL MTEDIKLNKA EKAWKPSSKR TAADKDRGEE
760 770 780 790 800
DADGSKTQDL FRRVRSILNK LTPQMFQQLM KQVTQLAIDT EERLKGVIDL
810 820 830 840 850
IFEKAISEPN FSVAYANMCR CLMALKVPTT EKPTVTVNFR KLLLNRCQKE
860 870 880 890 900
FEKDKDDDEV FEKKQKEMDE AATAEERGRL KEELEEARDI ARRRSLGNIK
910 920 930 940 950
FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK
960 970 980 990 1000
AKPRMDQYFN QMEKIIKEKK TSSRIRFMLQ DVLDLRGSNW VPRRGDQGPK
1010 1020 1030 1040 1050
TIDQIHKEAE MEEHREHIKV QQLMAKGSDK RRGGPPGPPI SRGLPLVDDG
1060 1070 1080 1090 1100
GWNTVPISKG SRPIDTSRLT KITKPGSIDS NNQLFAPGGR LSWGKGSSGG
1110 1120 1130 1140 1150
SGAKPSDAAS EAARPATSTL NRFSALQQAV PTESTDNRRV VQRSSLSRER
1160 1170 1180 1190 1200
GEKAGDRGDR LERSERGGDR GDRLDRARTP ATKRSFSKEV EERSRERPSQ
1210 1220 1230 1240 1250
PEGLRKAASL TEDRDRGRDA VKREAALPPV SPLKAALSEE ELEKKSKAII
1260 1270 1280 1290 1300
EEYLHLNDMK EAVQCVQELA SPSLLFIFVR HGVESTLERS AIAREHMGQL
1310 1320 1330 1340 1350
LHQLLCAGHL STAQYYQGLY EILELAEDME IDIPHVWLYL AELVTPILQE
1360 1370 1380 1390 1400
GGVPMGELFR EITKPLRPLG KAASLLLEIL GLLCKSMGPK KVGTLWREAG
1410 1420 1430 1440 1450
LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS EELNRQLEKL
1460 1470 1480 1490 1500
LKEGSSNQRV FDWIEANLSE QQIVSNTLVR ALMTAVCYSA IIFETPLRVD
1510 1520 1530 1540 1550
VAVLKARAKL LQKYLCDEQK ELQALYALQA LVVTLEQPPN LLRMFFDALY
1560 1570 1580 1590
DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFKWLR EAEEESDHN
Length:1,599
Mass (Da):175,491
Last modified:April 20, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i324088B60863DA34
GO
Isoform B (identifier: Q04637-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: Produced by alternative initiation at Met-41 of isoform A.
Show »
Length:1,559
Mass (Da):171,514
Checksum:i22F62E219E629C0E
GO
Isoform C (identifier: Q04637-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: Produced by alternative initiation at Met-88 of isoform A.
Show »
Length:1,512
Mass (Da):166,619
Checksum:i09DD6DC263462CB6
GO
Isoform D (identifier: Q04637-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Note: Produced by alternative initiation at Met-165 of isoform A.
Show »
Length:1,435
Mass (Da):158,517
Checksum:i6F7E9DE4106E73B9
GO
Isoform E (identifier: Q04637-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: Produced by alternative initiation at Met-197 of isoform A.
Show »
Length:1,403
Mass (Da):154,805
Checksum:i3E93A66EE3DFDDA9
GO
Isoform 7 (identifier: Q04637-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.
     696-696: P → PQ

Note: Produced by alternative splicing.
Show »
Length:1,404
Mass (Da):154,933
Checksum:iE2CE3C54B5BB0A50
GO
Isoform 8 (identifier: Q04637-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     696-696: P → PQ

Note: Produced by alternative splicing.
Show »
Length:1,600
Mass (Da):175,619
Checksum:i2B32EF7A6D50B657
GO
Isoform 9 (identifier: Q04637-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-48: R → RQGGFRSL

Note: Produced by alternative splicing. Gene prediction based on EST data.
Show »
Length:1,606
Mass (Da):176,237
Checksum:iE4464821E0BA5FF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUU4E7EUU4_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,560Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGM1E9PGM1_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,513Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX73E7EX73_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,436Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J6B6C9J6B6_HUMAN
Eukaryotic translation initiation f...
EIF4G1
757Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF13C9JF13_HUMAN
Eukaryotic translation initiation f...
EIF4G1
903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K073C9K073_HUMAN
Eukaryotic translation initiation f...
EIF4G1
869Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2Z7C9J2Z7_HUMAN
Eukaryotic translation initiation f...
EIF4G1
833Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWW9C9JWW9_HUMAN
Eukaryotic translation initiation f...
EIF4G1
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C044H7C044_HUMAN
Eukaryotic translation initiation f...
EIF4G1
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J556C9J556_HUMAN
Eukaryotic translation initiation f...
EIF4G1
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC78444 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC82471 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA02185 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAD18554 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30P → R in AAC78443 (PubMed:9755181).Curated1
Sequence conflicti138F → L in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti138F → L in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti149Q → R in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti149Q → R in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti214G → S in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti462E → D in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti468A → V in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti474A → G in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti479G → R in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti604L → P in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti604L → P in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti604L → P in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti604L → P in AAC82471 (PubMed:9372926).Curated1
Sequence conflicti625 – 626AS → CQ in BAA02185 (PubMed:1429670).Curated2
Sequence conflicti693P → A in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti696P → A in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti764V → W in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti878G → E in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti894R → C in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1104K → Q in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1121N → I in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1185S → T in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1384C → Y in CAI46013 (PubMed:17974005).Curated1
Sequence conflicti1472Missing in BAA02185 (PubMed:1429670).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06657171P → S1 PublicationCorresponds to variant dbSNP:rs113810947Ensembl.1
Natural variantiVAR_061147161T → A5 PublicationsCorresponds to variant dbSNP:rs13319149Ensembl.1
Natural variantiVAR_079031201R → H Found in a patient with Rett syndrome-like phenotype; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs34838305Ensembl.1
Natural variantiVAR_055704311Y → C1 PublicationCorresponds to variant dbSNP:rs16858632Ensembl.1
Natural variantiVAR_063040432M → VCombined sources4 PublicationsCorresponds to variant dbSNP:rs2178403EnsemblClinVar.1
Natural variantiVAR_066572466 – 468Missing 1 Publication3
Natural variantiVAR_066573502A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar.1
Natural variantiVAR_066574686G → C Found in patients with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs112019125Ensembl.1
Natural variantiVAR_036117696P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754755344Ensembl.1
Natural variantiVAR_066575806I → V1 PublicationCorresponds to variant dbSNP:rs62287499Ensembl.1
Natural variantiVAR_066576829T → S1 PublicationCorresponds to variant dbSNP:rs111500185Ensembl.1
Natural variantiVAR_0665771164S → R Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113169049Ensembl.1
Natural variantiVAR_0665781197R → W Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113388242Ensembl.1
Natural variantiVAR_0665791205R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar.1
Natural variantiVAR_0611481229P → A1 PublicationCorresponds to variant dbSNP:rs35629949Ensembl.1
Natural variantiVAR_0557051233L → P1 PublicationCorresponds to variant dbSNP:rs2230570Ensembl.1
Natural variantiVAR_0665801257N → S1 PublicationCorresponds to variant dbSNP:rs73053766Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187231 – 196Missing in isoform E and isoform 7. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0187221 – 164Missing in isoform D. CuratedAdd BLAST164
Alternative sequenceiVSP_0187211 – 87Missing in isoform C. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_0187201 – 40Missing in isoform B. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_04739648R → RQGGFRSL in isoform 9. Curated1
Alternative sequenceiVSP_047397696P → PQ in isoform 7 and isoform 8. 4 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D12686 mRNA Translation: BAA02185.1 Frameshift.
AY082886 mRNA Translation: AAL92872.1
AF281070 mRNA Translation: AAM69365.1
AK131407 mRNA Translation: BAD18554.1 Sequence problems.
BX647812 mRNA Translation: CAI46013.1
AC078797 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78257.1
CH471052 Genomic DNA Translation: EAW78259.1
CH471052 Genomic DNA Translation: EAW78262.1
CH471052 Genomic DNA Translation: EAW78263.1
CH471052 Genomic DNA Translation: EAW78264.1
CH471052 Genomic DNA Translation: EAW78265.1
CH471052 Genomic DNA Translation: EAW78266.1
CH471052 Genomic DNA Translation: EAW78267.1
AF002816 mRNA Translation: AAC78443.1
AF004836 Genomic DNA Translation: AAC78444.1 Different initiation.
AF104913 mRNA Translation: AAC82471.1 Different initiation.
AJ001046 mRNA Translation: CAA04500.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3259.1 [Q04637-1]
CCDS3260.1 [Q04637-4]
CCDS3261.1 [Q04637-5]
CCDS46970.2 [Q04637-7]
CCDS54687.1 [Q04637-9]
CCDS54688.1 [Q04637-8]
CCDS77866.1 [Q04637-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A44453

NCBI Reference Sequences

More...
RefSeqi
NP_004944.3, NM_004953.4 [Q04637-7]
NP_886553.3, NM_182917.4
NP_937884.1, NM_198241.2 [Q04637-1]
NP_937885.1, NM_198242.2 [Q04637-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342981; ENSP00000343450; ENSG00000114867 [Q04637-8]
ENST00000346169; ENSP00000316879; ENSG00000114867 [Q04637-1]
ENST00000350481; ENSP00000317600; ENSG00000114867 [Q04637-5]
ENST00000352767; ENSP00000338020; ENSG00000114867 [Q04637-9]
ENST00000382330; ENSP00000371767; ENSG00000114867 [Q04637-9]
ENST00000392537; ENSP00000376320; ENSG00000114867 [Q04637-4]
ENST00000414031; ENSP00000391935; ENSG00000114867 [Q04637-3]
ENST00000424196; ENSP00000416255; ENSG00000114867 [Q04637-9]
ENST00000434061; ENSP00000411826; ENSG00000114867 [Q04637-7]
ENST00000435046; ENSP00000404754; ENSG00000114867 [Q04637-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1981

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1981

UCSC genome browser

More...
UCSCi
uc003fnp.4 human [Q04637-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12686 mRNA Translation: BAA02185.1 Frameshift.
AY082886 mRNA Translation: AAL92872.1
AF281070 mRNA Translation: AAM69365.1
AK131407 mRNA Translation: BAD18554.1 Sequence problems.
BX647812 mRNA Translation: CAI46013.1
AC078797 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78257.1
CH471052 Genomic DNA Translation: EAW78259.1
CH471052 Genomic DNA Translation: EAW78262.1
CH471052 Genomic DNA Translation: EAW78263.1
CH471052 Genomic DNA Translation: EAW78264.1
CH471052 Genomic DNA Translation: EAW78265.1
CH471052 Genomic DNA Translation: EAW78266.1
CH471052 Genomic DNA Translation: EAW78267.1
AF002816 mRNA Translation: AAC78443.1
AF004836 Genomic DNA Translation: AAC78444.1 Different initiation.
AF104913 mRNA Translation: AAC82471.1 Different initiation.
AJ001046 mRNA Translation: CAA04500.1
CCDSiCCDS3259.1 [Q04637-1]
CCDS3260.1 [Q04637-4]
CCDS3261.1 [Q04637-5]
CCDS46970.2 [Q04637-7]
CCDS54687.1 [Q04637-9]
CCDS54688.1 [Q04637-8]
CCDS77866.1 [Q04637-3]
PIRiA44453
RefSeqiNP_004944.3, NM_004953.4 [Q04637-7]
NP_886553.3, NM_182917.4
NP_937884.1, NM_198241.2 [Q04637-1]
NP_937885.1, NM_198242.2 [Q04637-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LJ2X-ray2.38C/D172-199[»]
1UG3X-ray2.24A/B1233-1571[»]
2W97X-ray2.29E/F609-622[»]
4AZAX-ray2.16B/D609-620[»]
4F02X-ray2.00C/F178-203[»]
5EHCX-ray2.40B609-622[»]
5EI3X-ray1.71B609-622[»]
5EIRX-ray2.69B609-622[»]
5T46X-ray1.53B/D592-653[»]
SMRiQ04637
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108296, 140 interactors
CORUMiQ04637
DIPiDIP-1161N
ELMiQ04637
IntActiQ04637, 84 interactors
MINTiQ04637
STRINGi9606.ENSP00000416255

Chemistry databases

BindingDBiQ04637

Protein family/group databases

MoonProtiQ04637

PTM databases

iPTMnetiQ04637
PhosphoSitePlusiQ04637
SwissPalmiQ04637

Polymorphism and mutation databases

BioMutaiEIF4G1
DMDMi294862538

Proteomic databases

EPDiQ04637
jPOSTiQ04637
MassIVEiQ04637
MaxQBiQ04637
PaxDbiQ04637
PeptideAtlasiQ04637
PRIDEiQ04637
ProteomicsDBi20132
34026
58250 [Q04637-1]
58251 [Q04637-3]
58252 [Q04637-4]
58253 [Q04637-5]
58254 [Q04637-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1981
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342981; ENSP00000343450; ENSG00000114867 [Q04637-8]
ENST00000346169; ENSP00000316879; ENSG00000114867 [Q04637-1]
ENST00000350481; ENSP00000317600; ENSG00000114867 [Q04637-5]
ENST00000352767; ENSP00000338020; ENSG00000114867 [Q04637-9]
ENST00000382330; ENSP00000371767; ENSG00000114867 [Q04637-9]
ENST00000392537; ENSP00000376320; ENSG00000114867 [Q04637-4]
ENST00000414031; ENSP00000391935; ENSG00000114867 [Q04637-3]
ENST00000424196; ENSP00000416255; ENSG00000114867 [Q04637-9]
ENST00000434061; ENSP00000411826; ENSG00000114867 [Q04637-7]
ENST00000435046; ENSP00000404754; ENSG00000114867 [Q04637-6]
GeneIDi1981
KEGGihsa:1981
UCSCiuc003fnp.4 human [Q04637-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1981
DisGeNETi1981

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EIF4G1
HGNCiHGNC:3296 EIF4G1
HPAiCAB014774
HPA028487
HPA043866
MalaCardsiEIF4G1
MIMi600495 gene
614251 phenotype
neXtProtiNX_Q04637
OpenTargetsiENSG00000114867
Orphaneti411602 Hereditary late-onset Parkinson disease
PharmGKBiPA27722

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0401 Eukaryota
ENOG410XS4P LUCA
GeneTreeiENSGT00940000154648
HOGENOMiHOG000231658
InParanoidiQ04637
KOiK03260
OMAiNQPRGGP
OrthoDBi594395at2759
PhylomeDBiQ04637
TreeFamiTF101527

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-166208 mTORC1-mediated signalling
R-HSA-429947 Deadenylation of mRNA
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiQ04637

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EIF4G1 human
EvolutionaryTraceiQ04637

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Eukaryotic_translation_initiation_factor_4_gamma

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1981

Pharos

More...
Pharosi
Q04637
PMAP-CutDBiQ04637

Protein Ontology

More...
PROi
PR:Q04637

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114867 Expressed in 238 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiQ04637 baseline and differential
GenevisibleiQ04637 HS

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain
PANTHERiPTHR23253:SF10 PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4G1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q04637
Secondary accession number(s): D3DNT2
, D3DNT4, D3DNT5, E9PFM1, G5E9S1, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 20, 2010
Last modified: September 18, 2019
This is version 218 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again