UniProtKB - Q04637 (IF4G1_HUMAN)
Eukaryotic translation initiation factor 4 gamma 1
EIF4G1
Functioni
GO - Molecular functioni
- ATP binding Source: ParkinsonsUK-UCL
- eukaryotic initiation factor 4E binding Source: AgBase
- identical protein binding Source: IntAct
- molecular adaptor activity Source: ParkinsonsUK-UCL
- mRNA binding Source: ParkinsonsUK-UCL
- RNA binding Source: UniProtKB
- translation factor activity, RNA binding Source: ParkinsonsUK-UCL
- translation initiation factor activity Source: GO_Central
- translation initiation factor binding Source: ParkinsonsUK-UCL
GO - Biological processi
- behavioral fear response Source: Ensembl
- cap-dependent translational initiation Source: ParkinsonsUK-UCL
- cellular macromolecule biosynthetic process Source: ParkinsonsUK-UCL
- cellular response to nutrient levels Source: ParkinsonsUK-UCL
- developmental process Source: ParkinsonsUK-UCL
- energy homeostasis Source: ParkinsonsUK-UCL
- negative regulation of autophagy Source: ParkinsonsUK-UCL
- negative regulation of neuron death Source: ParkinsonsUK-UCL
- negative regulation of peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- positive regulation of cell death Source: ParkinsonsUK-UCL
- positive regulation of cell growth Source: ParkinsonsUK-UCL
- positive regulation of cellular protein metabolic process Source: ParkinsonsUK-UCL
- positive regulation of eukaryotic translation initiation factor 4F complex assembly Source: ParkinsonsUK-UCL
- positive regulation of G1/S transition of mitotic cell cycle Source: ParkinsonsUK-UCL
- positive regulation of miRNA mediated inhibition of translation Source: ParkinsonsUK-UCL
- positive regulation of mRNA cap binding Source: ParkinsonsUK-UCL
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of translation in response to endoplasmic reticulum stress Source: UniProtKB
- regulation of cellular response to stress Source: ParkinsonsUK-UCL
- regulation of gene silencing by miRNA Source: ParkinsonsUK-UCL
- regulation of mRNA stability Source: Reactome
- regulation of polysome binding Source: ParkinsonsUK-UCL
- regulation of presynapse assembly Source: ParkinsonsUK-UCL
- regulation of translational initiation Source: UniProtKB
- translation Source: ParkinsonsUK-UCL
- translational initiation Source: ParkinsonsUK-UCL
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Initiation factor, RNA-binding, Translational shunt |
Biological process | Host-virus interaction, Protein biosynthesis, Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | Q04637 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-166208, mTORC1-mediated signalling R-HSA-429947, Deadenylation of mRNA R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-72649, Translation initiation complex formation R-HSA-72662, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | Q04637 |
Protein family/group databases
MoonProti | Q04637 |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 4 gamma 1Short name: eIF-4-gamma 1 Short name: eIF-4G 1 Short name: eIF-4G1 Alternative name(s): p220 |
Gene namesi | Name:EIF4G1 Synonyms:EIF4F, EIF4G, EIF4GI |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3296, EIF4G1 |
MIMi | 600495, gene |
neXtProti | NX_Q04637 |
VEuPathDBi | HostDB:ENSG00000114867.19 |
Subcellular locationi
Other locations
- Stress granule 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: ParkinsonsUK-UCL
Other locations
- cytoplasm Source: AgBase
- cytoplasmic stress granule Source: UniProtKB-SubCell
- eukaryotic translation initiation factor 4F complex Source: ParkinsonsUK-UCL
- membrane Source: UniProtKB
- polysome Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Parkinson disease 18 (PARK18)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066573 | 502 | A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar. | 1 | |
Natural variantiVAR_066579 | 1205 | R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 174 – 178 | KRERK → AAAAA: Loss of PABPC1 binding; when associated with 184-AAAA-187. 1 Publication | 5 | |
Mutagenesisi | 180 | I → A: Loss of PABPC1 binding. 1 Publication | 1 | |
Mutagenesisi | 182 | I → A: Loss of PABPC1 binding. 1 Publication | 1 | |
Mutagenesisi | 184 – 187 | DPNQ → AAAA: Loss of PABPC1 binding; when associated with 174-AAAAA-178. | 4 | |
Mutagenesisi | 192 | I → A: Loss of PABPC1 binding. 1 Publication | 1 | |
Mutagenesisi | 196 | I → A: Loss of PABPC1 binding. 1 Publication | 1 | |
Mutagenesisi | 612 | Y → A or F: Abolishes binding to EIF4E. 1 Publication | 1 | |
Mutagenesisi | 617 – 618 | LL → AA: Abolishes binding to EIF4E. 1 Publication | 2 | |
Mutagenesisi | 682 | G → A, V, W, R or E: Reduced cleavage by protease 2A from human rhinovirus 2. 1 Publication | 1 | |
Mutagenesisi | 768 | L → A: Abolishes binding to EIF4A; when associated with A-770 and A-775. 1 Publication | 1 | |
Mutagenesisi | 771 | L → A: Abolishes binding to EIF4A; when associated with A-767 and A-775. 1 Publication | 1 | |
Mutagenesisi | 776 | F → A: Abolishes binding to EIF4A; when associated with A-767 and A-770. 1 Publication | 1 | |
Mutagenesisi | 842 – 843 | LL → AA: Abolishes binding to EIF4A; when associated with A-850 and K-851. 1 Publication | 2 | |
Mutagenesisi | 851 – 852 | FE → AK: Abolishes binding to EIF4A; when associated with A-841 and A-842. 1 Publication | 2 | |
Mutagenesisi | 896 | L → A: Abolishes binding to EIF4A; when associated with A-92 and A-95. 1 Publication | 1 | |
Mutagenesisi | 902 | I → A: Abolishes binding to EIF4A; when associated with A-895 and A-95. 1 Publication | 1 | |
Mutagenesisi | 905 | L → A: Abolishes binding to EIF4A; when associated with A-895 and A-92. 1 Publication | 1 | |
Mutagenesisi | 974 | R → A: Abolishes binding to EIF4A; when associated with A-976. 1 Publication | 1 | |
Mutagenesisi | 977 | F → A: Abolishes binding to EIF4A; when associated with A-973. 1 Publication | 1 | |
Mutagenesisi | 985 | L → A: Slightly reduced binding to EIF4A; when associated with A-989. 1 Publication | 1 | |
Mutagenesisi | 990 | W → A: Slightly reduced binding to EIF4A; when associated with A-984. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Neurodegeneration, Parkinson disease, ParkinsonismOrganism-specific databases
DisGeNETi | 1981 |
MalaCardsi | EIF4G1 |
MIMi | 614251, phenotype |
OpenTargetsi | ENSG00000114867 |
Orphaneti | 411602, Hereditary late-onset Parkinson disease |
PharmGKBi | PA27722 |
Miscellaneous databases
Pharosi | Q04637, Tbio |
Genetic variation databases
BioMutai | EIF4G1 |
DMDMi | 294862538 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
ChainiPRO_0000007786 | 1 – 1599 | Eukaryotic translation initiation factor 4 gamma 1Add BLAST | 1599 | ||
Isoform C (identifier: Q04637-4) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 15 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 73 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 110 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 207 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 223 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 314 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 602 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 647 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 685 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 694 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 1028 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1032 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 1042 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 1077 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1092 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1095 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 1145 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1147 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1185 | Phosphoserine; by PKC/PRKCACombined sources1 Publication | 1 | ||
Modified residuei | 1187 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1194 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1209 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1211 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 1231 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1238 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1596 | PhosphoserineCombined sources | 1 | ||
Isoform C (identifier: Q04637-4) | |||||
Modified residuei | 2 | N-acetylmethionineCombined sources | 1 | ||
Isoform 7 (identifier: Q04637-7) | |||||
Modified residuei | 489 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 498 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 509 | PhosphoserineCombined sources | 1 | ||
Isoform 8 (identifier: Q04637-8) | |||||
Modified residuei | 685 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 694 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 705 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 674 – 675 | Cleavage; by foot-and-mouth disease virus leader protease | 2 | |
Sitei | 681 – 682 | Cleavage; by enterovirus/rhinovirus protease 2A | 2 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | Q04637 |
jPOSTi | Q04637 |
MassIVEi | Q04637 |
MaxQBi | Q04637 |
PaxDbi | Q04637 |
PeptideAtlasi | Q04637 |
PRIDEi | Q04637 |
ProteomicsDBi | 20132 34026 58250 [Q04637-1] 58251 [Q04637-3] 58252 [Q04637-4] 58253 [Q04637-5] 58254 [Q04637-6] |
PTM databases
GlyConnecti | 2847, 1 O-Linked glycan (1 site) |
iPTMneti | Q04637 |
MetOSitei | Q04637 |
PhosphoSitePlusi | Q04637 |
SwissPalmi | Q04637 |
Expressioni
Gene expression databases
Bgeei | ENSG00000114867, Expressed in gastrocnemius and 249 other tissues |
ExpressionAtlasi | Q04637, baseline and differential |
Genevisiblei | Q04637, HS |
Organism-specific databases
HPAi | ENSG00000114867, Low tissue specificity |
Interactioni
Subunit structurei
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3.
Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1.
Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs.
Interacts with EIF4E3.
Interacts with CIRBP and MIF4GD.
Interacts with RBM4.
Interacts with HNRNPD/AUF1; the interaction requires RNA. Directly interacts with EIF4G1 in an RNA-independent manner (PubMed:22872150).
16 Publications(Microbial infection) Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis.
1 Publication(Microbial infection) Interacts with human adenovirus 5 protein 100K; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs.
1 PublicationBinary interactionsi
Hide detailsQ04637
Isoform A [Q04637-1]
With | #Exp. | IntAct |
---|---|---|
EIF4A1 [P60842] | 2 | EBI-5456295,EBI-73449 |
Isoform 9 [Q04637-9]
GO - Molecular functioni
- eukaryotic initiation factor 4E binding Source: AgBase
- identical protein binding Source: IntAct
- translation initiation factor binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 108296, 184 interactors |
ComplexPortali | CPX-2666, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G1 variant CPX-5634, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G1 variant |
CORUMi | Q04637 |
DIPi | DIP-1161N |
ELMi | Q04637 |
IntActi | Q04637, 87 interactors |
MINTi | Q04637 |
STRINGi | 9606.ENSP00000416255 |
Chemistry databases
BindingDBi | Q04637 |
Miscellaneous databases
RNActi | Q04637, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q04637 |
SMRi | Q04637 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q04637 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 565 – 792 | MIF4GPROSITE-ProRule annotationAdd BLAST | 228 | |
Domaini | 1241 – 1363 | MIPROSITE-ProRule annotationAdd BLAST | 123 | |
Domaini | 1433 – 1599 | W2PROSITE-ProRule annotationAdd BLAST | 167 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 172 – 200 | PABPC1-bindingAdd BLAST | 29 | |
Regioni | 607 – 618 | EIF4E-bindingAdd BLAST | 12 | |
Regioni | 682 – 1085 | eIF3/EIF4A-bindingAdd BLAST | 404 | |
Regioni | 1450 – 1599 | EIF4A-bindingAdd BLAST | 150 | |
Regioni | 1585 – 1599 | Necessary but not sufficient for MKNK1-bindingAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 454 – 467 | Poly-GluAdd BLAST | 14 | |
Compositional biasi | 501 – 504 | Poly-Ala | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0401, Eukaryota |
GeneTreei | ENSGT00940000154648 |
HOGENOMi | CLU_001519_2_0_1 |
InParanoidi | Q04637 |
OMAi | PRGGPNM |
PhylomeDBi | Q04637 |
TreeFami | TF101527 |
Family and domain databases
Gene3Di | 1.25.40.180, 3 hits |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR037584, EIF4G1 IPR003891, Initiation_fac_eIF4g_MI IPR016021, MIF4-like_sf IPR003890, MIF4G-like_typ-3 IPR003307, W2_domain |
PANTHERi | PTHR23253:SF10, PTHR23253:SF10, 1 hit |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 3 hits |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit PS51363, W2, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 8 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 8 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH
60 70 80 90 100
FYPSRAQPPS SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ
110 120 130 140 150
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQG
160 170 180 190 200
VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA
210 220 230 240 250
RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI IADRPGLPGP
260 270 280 290 300
EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM TTIQMSVEES
310 320 330 340 350
TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF SSSPLQAPTP
360 370 380 390 400
LASHTVEIHE PNGMVPSEDL EPEVESSPEL APPPACPSES PVPIAPTAQP
410 420 430 440 450
EELLNGAPSP PAVDLSPVSE PEEQAKEVTA SMAPPTIPSA TPATAPSATS
460 470 480 490 500
PAQEEEMEEE EEEEEGEAGE AGEAESEKGG EELLPPESTP IPANLSQNLE
510 520 530 540 550
AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA VPEVENQPPA
560 570 580 590 600
GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG EQKYEYKSDQ
610 620 630 640 650
WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV LDKANKTPLR
660 670 680 690 700
PLDPTRLQGI NCGPDFTPSF ANLGRTTLST RGPPRGGPGG ELPRGPAGLG
710 720 730 740 750
PRRSQQGPRK EPRKIIATVL MTEDIKLNKA EKAWKPSSKR TAADKDRGEE
760 770 780 790 800
DADGSKTQDL FRRVRSILNK LTPQMFQQLM KQVTQLAIDT EERLKGVIDL
810 820 830 840 850
IFEKAISEPN FSVAYANMCR CLMALKVPTT EKPTVTVNFR KLLLNRCQKE
860 870 880 890 900
FEKDKDDDEV FEKKQKEMDE AATAEERGRL KEELEEARDI ARRRSLGNIK
910 920 930 940 950
FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK
960 970 980 990 1000
AKPRMDQYFN QMEKIIKEKK TSSRIRFMLQ DVLDLRGSNW VPRRGDQGPK
1010 1020 1030 1040 1050
TIDQIHKEAE MEEHREHIKV QQLMAKGSDK RRGGPPGPPI SRGLPLVDDG
1060 1070 1080 1090 1100
GWNTVPISKG SRPIDTSRLT KITKPGSIDS NNQLFAPGGR LSWGKGSSGG
1110 1120 1130 1140 1150
SGAKPSDAAS EAARPATSTL NRFSALQQAV PTESTDNRRV VQRSSLSRER
1160 1170 1180 1190 1200
GEKAGDRGDR LERSERGGDR GDRLDRARTP ATKRSFSKEV EERSRERPSQ
1210 1220 1230 1240 1250
PEGLRKAASL TEDRDRGRDA VKREAALPPV SPLKAALSEE ELEKKSKAII
1260 1270 1280 1290 1300
EEYLHLNDMK EAVQCVQELA SPSLLFIFVR HGVESTLERS AIAREHMGQL
1310 1320 1330 1340 1350
LHQLLCAGHL STAQYYQGLY EILELAEDME IDIPHVWLYL AELVTPILQE
1360 1370 1380 1390 1400
GGVPMGELFR EITKPLRPLG KAASLLLEIL GLLCKSMGPK KVGTLWREAG
1410 1420 1430 1440 1450
LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS EELNRQLEKL
1460 1470 1480 1490 1500
LKEGSSNQRV FDWIEANLSE QQIVSNTLVR ALMTAVCYSA IIFETPLRVD
1510 1520 1530 1540 1550
VAVLKARAKL LQKYLCDEQK ELQALYALQA LVVTLEQPPN LLRMFFDALY
1560 1570 1580 1590
DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFKWLR EAEEESDHN
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PGM1 | E9PGM1_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 1,513 | Annotation score: | ||
E7EUU4 | E7EUU4_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 1,560 | Annotation score: | ||
E7EX73 | E7EX73_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 1,436 | Annotation score: | ||
C9JF13 | C9JF13_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 903 | Annotation score: | ||
C9J6B6 | C9J6B6_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 757 | Annotation score: | ||
C9J2Z7 | C9J2Z7_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 833 | Annotation score: | ||
C9K073 | C9K073_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 869 | Annotation score: | ||
C9JWW9 | C9JWW9_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 285 | Annotation score: | ||
H7C044 | H7C044_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 226 | Annotation score: | ||
C9JHW9 | C9JHW9_HUMAN | Eukaryotic translation initiation f... | EIF4G1 | 160 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | P → R in AAC78443 (PubMed:9755181).Curated | 1 | |
Sequence conflicti | 138 | F → L in AAL92872 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 138 | F → L in AAM69365 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 149 | Q → R in AAL92872 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 149 | Q → R in AAM69365 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 214 | G → S in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 462 | E → D in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 468 | A → V in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 474 | A → G in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 479 | G → R in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 604 | L → P in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 604 | L → P in AAL92872 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 604 | L → P in AAM69365 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 604 | L → P in AAC82471 (PubMed:9372926).Curated | 1 | |
Sequence conflicti | 625 – 626 | AS → CQ in BAA02185 (PubMed:1429670).Curated | 2 | |
Sequence conflicti | 693 | P → A in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 696 | P → A in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 764 | V → W in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 878 | G → E in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 894 | R → C in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 1104 | K → Q in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 1121 | N → I in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 1185 | S → T in BAA02185 (PubMed:1429670).Curated | 1 | |
Sequence conflicti | 1384 | C → Y in CAI46013 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1472 | Missing in BAA02185 (PubMed:1429670).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066571 | 71 | P → S1 PublicationCorresponds to variant dbSNP:rs113810947Ensembl. | 1 | |
Natural variantiVAR_061147 | 161 | T → A5 PublicationsCorresponds to variant dbSNP:rs13319149Ensembl. | 1 | |
Natural variantiVAR_079031 | 201 | R → H Found in a patient with Rett syndrome-like phenotype; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs34838305Ensembl. | 1 | |
Natural variantiVAR_055704 | 311 | Y → C1 PublicationCorresponds to variant dbSNP:rs16858632Ensembl. | 1 | |
Natural variantiVAR_063040 | 432 | M → VCombined sources4 PublicationsCorresponds to variant dbSNP:rs2178403EnsemblClinVar. | 1 | |
Natural variantiVAR_066572 | 466 – 468 | Missing 1 Publication | 3 | |
Natural variantiVAR_066573 | 502 | A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar. | 1 | |
Natural variantiVAR_066574 | 686 | G → C Found in patients with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs112019125Ensembl. | 1 | |
Natural variantiVAR_036117 | 696 | P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754755344Ensembl. | 1 | |
Natural variantiVAR_066575 | 806 | I → V1 PublicationCorresponds to variant dbSNP:rs62287499Ensembl. | 1 | |
Natural variantiVAR_066576 | 829 | T → S1 PublicationCorresponds to variant dbSNP:rs111500185Ensembl. | 1 | |
Natural variantiVAR_066577 | 1164 | S → R Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113169049Ensembl. | 1 | |
Natural variantiVAR_066578 | 1197 | R → W Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113388242Ensembl. | 1 | |
Natural variantiVAR_066579 | 1205 | R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar. | 1 | |
Natural variantiVAR_061148 | 1229 | P → A1 PublicationCorresponds to variant dbSNP:rs35629949EnsemblClinVar. | 1 | |
Natural variantiVAR_055705 | 1233 | L → P1 PublicationCorresponds to variant dbSNP:rs2230570Ensembl. | 1 | |
Natural variantiVAR_066580 | 1257 | N → S1 PublicationCorresponds to variant dbSNP:rs73053766Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018723 | 1 – 196 | Missing in isoform E and isoform 7. 1 PublicationAdd BLAST | 196 | |
Alternative sequenceiVSP_018722 | 1 – 164 | Missing in isoform D. CuratedAdd BLAST | 164 | |
Alternative sequenceiVSP_018721 | 1 – 87 | Missing in isoform C. 1 PublicationAdd BLAST | 87 | |
Alternative sequenceiVSP_018720 | 1 – 40 | Missing in isoform B. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_047396 | 48 | R → RQGGFRSL in isoform 9. Curated | 1 | |
Alternative sequenceiVSP_047397 | 696 | P → PQ in isoform 7 and isoform 8. 4 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12686 mRNA Translation: BAA02185.1 Frameshift. AY082886 mRNA Translation: AAL92872.1 AF281070 mRNA Translation: AAM69365.1 AK131407 mRNA Translation: BAD18554.1 Sequence problems. BX647812 mRNA Translation: CAI46013.1 AC078797 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78257.1 CH471052 Genomic DNA Translation: EAW78259.1 CH471052 Genomic DNA Translation: EAW78262.1 CH471052 Genomic DNA Translation: EAW78263.1 CH471052 Genomic DNA Translation: EAW78264.1 CH471052 Genomic DNA Translation: EAW78265.1 CH471052 Genomic DNA Translation: EAW78266.1 CH471052 Genomic DNA Translation: EAW78267.1 AF002816 mRNA Translation: AAC78443.1 AF004836 Genomic DNA Translation: AAC78444.1 Different initiation. AF104913 mRNA Translation: AAC82471.1 Different initiation. AJ001046 mRNA Translation: CAA04500.1 |
CCDSi | CCDS3259.1 [Q04637-1] CCDS3260.1 [Q04637-4] CCDS3261.1 [Q04637-5] CCDS46970.2 [Q04637-7] CCDS54687.1 [Q04637-9] CCDS54688.1 [Q04637-8] CCDS77866.1 [Q04637-3] |
PIRi | A44453 |
RefSeqi | NP_004944.3, NM_004953.4 [Q04637-7] NP_886553.3, NM_182917.4 NP_937884.1, NM_198241.2 [Q04637-1] NP_937885.1, NM_198242.2 [Q04637-5] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12686 mRNA Translation: BAA02185.1 Frameshift. AY082886 mRNA Translation: AAL92872.1 AF281070 mRNA Translation: AAM69365.1 AK131407 mRNA Translation: BAD18554.1 Sequence problems. BX647812 mRNA Translation: CAI46013.1 AC078797 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78257.1 CH471052 Genomic DNA Translation: EAW78259.1 CH471052 Genomic DNA Translation: EAW78262.1 CH471052 Genomic DNA Translation: EAW78263.1 CH471052 Genomic DNA Translation: EAW78264.1 CH471052 Genomic DNA Translation: EAW78265.1 CH471052 Genomic DNA Translation: EAW78266.1 CH471052 Genomic DNA Translation: EAW78267.1 AF002816 mRNA Translation: AAC78443.1 AF004836 Genomic DNA Translation: AAC78444.1 Different initiation. AF104913 mRNA Translation: AAC82471.1 Different initiation. AJ001046 mRNA Translation: CAA04500.1 |
CCDSi | CCDS3259.1 [Q04637-1] CCDS3260.1 [Q04637-4] CCDS3261.1 [Q04637-5] CCDS46970.2 [Q04637-7] CCDS54687.1 [Q04637-9] CCDS54688.1 [Q04637-8] CCDS77866.1 [Q04637-3] |
PIRi | A44453 |
RefSeqi | NP_004944.3, NM_004953.4 [Q04637-7] NP_886553.3, NM_182917.4 NP_937884.1, NM_198241.2 [Q04637-1] NP_937885.1, NM_198242.2 [Q04637-5] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LJ2 | X-ray | 2.38 | C/D | 172-199 | [»] | |
1UG3 | X-ray | 2.24 | A/B | 1233-1571 | [»] | |
2W97 | X-ray | 2.29 | E/F | 609-622 | [»] | |
4AZA | X-ray | 2.16 | B/D | 609-620 | [»] | |
4F02 | X-ray | 2.00 | C/F | 178-203 | [»] | |
5EHC | X-ray | 2.40 | B | 609-622 | [»] | |
5EI3 | X-ray | 1.71 | B | 609-622 | [»] | |
5EIR | X-ray | 2.69 | B | 609-622 | [»] | |
5T46 | X-ray | 1.53 | B/D | 592-653 | [»] | |
6ZMW | electron microscopy | 3.70 | g | 290-1599 | [»] | |
BMRBi | Q04637 | |||||
SMRi | Q04637 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108296, 184 interactors |
ComplexPortali | CPX-2666, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G1 variant CPX-5634, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G1 variant |
CORUMi | Q04637 |
DIPi | DIP-1161N |
ELMi | Q04637 |
IntActi | Q04637, 87 interactors |
MINTi | Q04637 |
STRINGi | 9606.ENSP00000416255 |
Chemistry databases
BindingDBi | Q04637 |
Protein family/group databases
MoonProti | Q04637 |
PTM databases
GlyConnecti | 2847, 1 O-Linked glycan (1 site) |
iPTMneti | Q04637 |
MetOSitei | Q04637 |
PhosphoSitePlusi | Q04637 |
SwissPalmi | Q04637 |
Genetic variation databases
BioMutai | EIF4G1 |
DMDMi | 294862538 |
Proteomic databases
EPDi | Q04637 |
jPOSTi | Q04637 |
MassIVEi | Q04637 |
MaxQBi | Q04637 |
PaxDbi | Q04637 |
PeptideAtlasi | Q04637 |
PRIDEi | Q04637 |
ProteomicsDBi | 20132 34026 58250 [Q04637-1] 58251 [Q04637-3] 58252 [Q04637-4] 58253 [Q04637-5] 58254 [Q04637-6] |
Protocols and materials databases
Antibodypediai | 3406, 577 antibodies |
DNASUi | 1981 |
Genome annotation databases
Organism-specific databases
CTDi | 1981 |
DisGeNETi | 1981 |
GeneCardsi | EIF4G1 |
HGNCi | HGNC:3296, EIF4G1 |
HPAi | ENSG00000114867, Low tissue specificity |
MalaCardsi | EIF4G1 |
MIMi | 600495, gene 614251, phenotype |
neXtProti | NX_Q04637 |
OpenTargetsi | ENSG00000114867 |
Orphaneti | 411602, Hereditary late-onset Parkinson disease |
PharmGKBi | PA27722 |
VEuPathDBi | HostDB:ENSG00000114867.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0401, Eukaryota |
GeneTreei | ENSGT00940000154648 |
HOGENOMi | CLU_001519_2_0_1 |
InParanoidi | Q04637 |
OMAi | PRGGPNM |
PhylomeDBi | Q04637 |
TreeFami | TF101527 |
Enzyme and pathway databases
PathwayCommonsi | Q04637 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-166208, mTORC1-mediated signalling R-HSA-429947, Deadenylation of mRNA R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-72649, Translation initiation complex formation R-HSA-72662, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | Q04637 |
Miscellaneous databases
BioGRID-ORCSi | 1981, 557 hits in 882 CRISPR screens |
ChiTaRSi | EIF4G1, human |
EvolutionaryTracei | Q04637 |
GeneWikii | Eukaryotic_translation_initiation_factor_4_gamma |
GenomeRNAii | 1981 |
Pharosi | Q04637, Tbio |
PROi | PR:Q04637 |
RNActi | Q04637, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114867, Expressed in gastrocnemius and 249 other tissues |
ExpressionAtlasi | Q04637, baseline and differential |
Genevisiblei | Q04637, HS |
Family and domain databases
Gene3Di | 1.25.40.180, 3 hits |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR037584, EIF4G1 IPR003891, Initiation_fac_eIF4g_MI IPR016021, MIF4-like_sf IPR003890, MIF4G-like_typ-3 IPR003307, W2_domain |
PANTHERi | PTHR23253:SF10, PTHR23253:SF10, 1 hit |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 3 hits |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit PS51363, W2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IF4G1_HUMAN | |
Accessioni | Q04637Primary (citable) accession number: Q04637 Secondary accession number(s): D3DNT2 Q8N102 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 228 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families