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Protein

Eukaryotic translation initiation factor 4 gamma 1

Gene

EIF4G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.

GO - Molecular functioni

  • ATP binding Source: ParkinsonsUK-UCL
  • eukaryotic initiation factor 4E binding Source: AgBase
  • identical protein binding Source: IntAct
  • mRNA binding Source: ParkinsonsUK-UCL
  • protein-containing complex scaffold activity Source: ParkinsonsUK-UCL
  • RNA binding Source: UniProtKB
  • translation factor activity, RNA binding Source: ParkinsonsUK-UCL
  • translation initiation factor activity Source: GO_Central
  • translation initiation factor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding, Translational shunt
Biological processHost-virus interaction, Protein biosynthesis, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-166208 mTORC1-mediated signalling
R-HSA-429947 Deadenylation of mRNA
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiQ04637

Protein family/group databases

MoonProtiQ04637

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 1
Short name:
eIF-4-gamma 1
Short name:
eIF-4G 1
Short name:
eIF-4G1
Alternative name(s):
p220
Gene namesi
Name:EIF4G1
Synonyms:EIF4F, EIF4G, EIF4GI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114867.19
HGNCiHGNC:3296 EIF4G1
MIMi600495 gene
neXtProtiNX_Q04637

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Parkinson disease 18 (PARK18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
See also OMIM:614251
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066573502A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar.1
Natural variantiVAR_0665791205R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi174 – 178KRERK → AAAAA: Loss of PABPC1 binding; when associated with 184-AAAA-187. 1 Publication5
Mutagenesisi180I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi182I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi184 – 187DPNQ → AAAA: Loss of PABPC1 binding; when associated with 174-AAAAA-178. 4
Mutagenesisi192I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi196I → A: Loss of PABPC1 binding. 1 Publication1
Mutagenesisi612Y → A or F: Abolishes binding to EIF4E. 1 Publication1
Mutagenesisi617 – 618LL → AA: Abolishes binding to EIF4E. 1 Publication2
Mutagenesisi682G → A, V, W, R or E: Reduced cleavage by protease 2A from human rhinovirus 2. 1 Publication1
Mutagenesisi768L → A: Abolishes binding to EIF4A; when associated with A-770 and A-775. 1 Publication1
Mutagenesisi771L → A: Abolishes binding to EIF4A; when associated with A-767 and A-775. 1 Publication1
Mutagenesisi776F → A: Abolishes binding to EIF4A; when associated with A-767 and A-770. 1 Publication1
Mutagenesisi842 – 843LL → AA: Abolishes binding to EIF4A; when associated with A-850 and K-851. 1 Publication2
Mutagenesisi851 – 852FE → AK: Abolishes binding to EIF4A; when associated with A-841 and A-842. 1 Publication2
Mutagenesisi896L → A: Abolishes binding to EIF4A; when associated with A-92 and A-95. 1 Publication1
Mutagenesisi902I → A: Abolishes binding to EIF4A; when associated with A-895 and A-95. 1 Publication1
Mutagenesisi905L → A: Abolishes binding to EIF4A; when associated with A-895 and A-92. 1 Publication1
Mutagenesisi974R → A: Abolishes binding to EIF4A; when associated with A-976. 1 Publication1
Mutagenesisi977F → A: Abolishes binding to EIF4A; when associated with A-973. 1 Publication1
Mutagenesisi985L → A: Slightly reduced binding to EIF4A; when associated with A-989. 1 Publication1
Mutagenesisi990W → A: Slightly reduced binding to EIF4A; when associated with A-984. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNETi1981
MalaCardsiEIF4G1
MIMi614251 phenotype
OpenTargetsiENSG00000114867
Orphaneti411602 Hereditary late-onset Parkinson disease
PharmGKBiPA27722

Polymorphism and mutation databases

BioMutaiEIF4G1
DMDMi294862538

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000077861 – 1599Eukaryotic translation initiation factor 4 gamma 1Add BLAST1599
Isoform C (identifier: Q04637-4)
Initiator methionineiRemoved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei73Omega-N-methylarginineCombined sources1
Modified residuei110Omega-N-methylarginineCombined sources1
Modified residuei207PhosphothreonineCombined sources1
Modified residuei223PhosphothreonineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei602N6-acetyllysineBy similarity1
Modified residuei647PhosphothreonineCombined sources1
Modified residuei685Omega-N-methylarginineCombined sources1
Modified residuei694Omega-N-methylarginineCombined sources1
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1032Omega-N-methylarginineCombined sources1
Modified residuei1042Omega-N-methylarginineCombined sources1
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1
Modified residuei1095N6-acetyllysineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1185Phosphoserine; by PKC/PRKCACombined sources1 Publication1
Modified residuei1187PhosphoserineCombined sources1
Modified residuei1194PhosphoserineCombined sources1
Modified residuei1209PhosphoserineCombined sources1
Modified residuei1211PhosphothreonineCombined sources1
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1238PhosphoserineCombined sources1
Modified residuei1596PhosphoserineCombined sources1
Isoform C (identifier: Q04637-4)
Modified residuei2N-acetylmethionine1
Isoform 7 (identifier: Q04637-7)
Modified residuei489Omega-N-methylarginine1
Modified residuei498Omega-N-methylarginine1
Modified residuei509Phosphoserine1
Isoform 8 (identifier: Q04637-8)
Modified residuei685Omega-N-methylarginine1
Modified residuei694Omega-N-methylarginine1
Modified residuei705Phosphoserine1

Post-translational modificationi

Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.1 Publication
Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei674 – 675Cleavage; by foot-and-mouth disease virus leader protease2
Sitei681 – 682Cleavage; by enterovirus/rhinovirus protease 2A2

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ04637
MaxQBiQ04637
PaxDbiQ04637
PeptideAtlasiQ04637
PRIDEiQ04637
ProteomicsDBi58250
58251 [Q04637-3]
58252 [Q04637-4]
58253 [Q04637-5]
58254 [Q04637-6]

PTM databases

iPTMnetiQ04637
PhosphoSitePlusiQ04637
SwissPalmiQ04637

Miscellaneous databases

PMAP-CutDBiQ04637

Expressioni

Gene expression databases

BgeeiENSG00000114867 Expressed in 238 organ(s), highest expression level in gastrocnemius
CleanExiHS_EIF4G1
ExpressionAtlasiQ04637 baseline and differential
GenevisibleiQ04637 HS

Organism-specific databases

HPAiCAB014774
HPA028487
HPA043866

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with RBM4. Interacts with HNRNPD/AUF1; the interaction requires RNA.15 Publications
(Microbial infection) Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis.1 Publication
(Microbial infection) Interacts with human adenovirus 5 protein 100K; this interaction promotes translational shunt in presence of polysomes containing viral tripartite leader mRNAs.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108296, 115 interactors
CORUMiQ04637
DIPiDIP-1161N
ELMiQ04637
IntActiQ04637, 71 interactors
MINTiQ04637
STRINGi9606.ENSP00000338020

Chemistry databases

BindingDBiQ04637

Structurei

Secondary structure

11599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ04637
SMRiQ04637
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ04637

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini565 – 792MIF4GPROSITE-ProRule annotationAdd BLAST228
Domaini1241 – 1363MIPROSITE-ProRule annotationAdd BLAST123
Domaini1433 – 1599W2PROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 200PABPC1-bindingAdd BLAST29
Regioni607 – 618EIF4E-bindingAdd BLAST12
Regioni682 – 1085eIF3/EIF4A-bindingAdd BLAST404
Regioni1450 – 1599EIF4A-bindingAdd BLAST150
Regioni1585 – 1599Necessary but not sufficient for MKNK1-bindingAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi454 – 467Poly-GluAdd BLAST14
Compositional biasi501 – 504Poly-Ala4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0401 Eukaryota
ENOG410XS4P LUCA
GeneTreeiENSGT00530000063038
HOGENOMiHOG000231658
HOVERGENiHBG052083
InParanoidiQ04637
KOiK03260
OMAiFDRISGQ
OrthoDBiEOG091G03ZW
PhylomeDBiQ04637
TreeFamiTF101527

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain
PANTHERiPTHR23253:SF10 PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 8 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q04637-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQH
60 70 80 90 100
FYPSRAQPPS SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ
110 120 130 140 150
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQG
160 170 180 190 200
VQQFPTGVAP TPVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA
210 220 230 240 250
RTASTPTPPQ TGGGLEPQAN GETPQVAVIV RPDDRSQGAI IADRPGLPGP
260 270 280 290 300
EHSPSESQPS SPSPTPSPSP VLEPGSEPNL AVLSIPGDTM TTIQMSVEES
310 320 330 340 350
TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF SSSPLQAPTP
360 370 380 390 400
LASHTVEIHE PNGMVPSEDL EPEVESSPEL APPPACPSES PVPIAPTAQP
410 420 430 440 450
EELLNGAPSP PAVDLSPVSE PEEQAKEVTA SMAPPTIPSA TPATAPSATS
460 470 480 490 500
PAQEEEMEEE EEEEEGEAGE AGEAESEKGG EELLPPESTP IPANLSQNLE
510 520 530 540 550
AAAATQVAVS VPKRRRKIKE LNKKEAVGDL LDAFKEANPA VPEVENQPPA
560 570 580 590 600
GSNPGPESEG SGVPPRPEEA DETWDSKEDK IHNAENIQPG EQKYEYKSDQ
610 620 630 640 650
WKPLNLEEKK RYDREFLLGF QFIFASMQKP EGLPHISDVV LDKANKTPLR
660 670 680 690 700
PLDPTRLQGI NCGPDFTPSF ANLGRTTLST RGPPRGGPGG ELPRGPAGLG
710 720 730 740 750
PRRSQQGPRK EPRKIIATVL MTEDIKLNKA EKAWKPSSKR TAADKDRGEE
760 770 780 790 800
DADGSKTQDL FRRVRSILNK LTPQMFQQLM KQVTQLAIDT EERLKGVIDL
810 820 830 840 850
IFEKAISEPN FSVAYANMCR CLMALKVPTT EKPTVTVNFR KLLLNRCQKE
860 870 880 890 900
FEKDKDDDEV FEKKQKEMDE AATAEERGRL KEELEEARDI ARRRSLGNIK
910 920 930 940 950
FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK
960 970 980 990 1000
AKPRMDQYFN QMEKIIKEKK TSSRIRFMLQ DVLDLRGSNW VPRRGDQGPK
1010 1020 1030 1040 1050
TIDQIHKEAE MEEHREHIKV QQLMAKGSDK RRGGPPGPPI SRGLPLVDDG
1060 1070 1080 1090 1100
GWNTVPISKG SRPIDTSRLT KITKPGSIDS NNQLFAPGGR LSWGKGSSGG
1110 1120 1130 1140 1150
SGAKPSDAAS EAARPATSTL NRFSALQQAV PTESTDNRRV VQRSSLSRER
1160 1170 1180 1190 1200
GEKAGDRGDR LERSERGGDR GDRLDRARTP ATKRSFSKEV EERSRERPSQ
1210 1220 1230 1240 1250
PEGLRKAASL TEDRDRGRDA VKREAALPPV SPLKAALSEE ELEKKSKAII
1260 1270 1280 1290 1300
EEYLHLNDMK EAVQCVQELA SPSLLFIFVR HGVESTLERS AIAREHMGQL
1310 1320 1330 1340 1350
LHQLLCAGHL STAQYYQGLY EILELAEDME IDIPHVWLYL AELVTPILQE
1360 1370 1380 1390 1400
GGVPMGELFR EITKPLRPLG KAASLLLEIL GLLCKSMGPK KVGTLWREAG
1410 1420 1430 1440 1450
LSWKEFLPEG QDIGAFVAEQ KVEYTLGEES EAPGQRALPS EELNRQLEKL
1460 1470 1480 1490 1500
LKEGSSNQRV FDWIEANLSE QQIVSNTLVR ALMTAVCYSA IIFETPLRVD
1510 1520 1530 1540 1550
VAVLKARAKL LQKYLCDEQK ELQALYALQA LVVTLEQPPN LLRMFFDALY
1560 1570 1580 1590
DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFKWLR EAEEESDHN
Length:1,599
Mass (Da):175,491
Last modified:April 20, 2010 - v4
Checksum:i324088B60863DA34
GO
Isoform B (identifier: Q04637-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: Missing.

Note: Produced by alternative initiation at Met-41 of isoform A.
Show »
Length:1,559
Mass (Da):171,514
Checksum:i22F62E219E629C0E
GO
Isoform C (identifier: Q04637-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: Produced by alternative initiation at Met-88 of isoform A.
Show »
Length:1,512
Mass (Da):166,619
Checksum:i09DD6DC263462CB6
GO
Isoform D (identifier: Q04637-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Note: Produced by alternative initiation at Met-165 of isoform A.
Show »
Length:1,435
Mass (Da):158,517
Checksum:i6F7E9DE4106E73B9
GO
Isoform E (identifier: Q04637-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: Produced by alternative initiation at Met-197 of isoform A.
Show »
Length:1,403
Mass (Da):154,805
Checksum:i3E93A66EE3DFDDA9
GO
Isoform 7 (identifier: Q04637-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.
     696-696: P → PQ

Note: Produced by alternative splicing.
Show »
Length:1,404
Mass (Da):154,933
Checksum:iE2CE3C54B5BB0A50
GO
Isoform 8 (identifier: Q04637-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     696-696: P → PQ

Note: Produced by alternative splicing.
Show »
Length:1,600
Mass (Da):175,619
Checksum:i2B32EF7A6D50B657
GO
Isoform 9 (identifier: Q04637-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-48: R → RQGGFRSL

Note: Produced by alternative splicing. Gene prediction based on EST data.
Show »
Length:1,606
Mass (Da):176,237
Checksum:iE4464821E0BA5FF6
GO

Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUU4E7EUU4_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,560Annotation score:
E9PGM1E9PGM1_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,513Annotation score:
E7EX73E7EX73_HUMAN
Eukaryotic translation initiation f...
EIF4G1
1,436Annotation score:
C9JF13C9JF13_HUMAN
Eukaryotic translation initiation f...
EIF4G1
903Annotation score:
C9J6B6C9J6B6_HUMAN
Eukaryotic translation initiation f...
EIF4G1
757Annotation score:
C9K073C9K073_HUMAN
Eukaryotic translation initiation f...
EIF4G1
869Annotation score:
C9J2Z7C9J2Z7_HUMAN
Eukaryotic translation initiation f...
EIF4G1
833Annotation score:
C9JWW9C9JWW9_HUMAN
Eukaryotic translation initiation f...
EIF4G1
285Annotation score:
H7C0V6H7C0V6_HUMAN
Eukaryotic translation initiation f...
EIF4G1
180Annotation score:
H7C044H7C044_HUMAN
Eukaryotic translation initiation f...
EIF4G1
226Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAC78444 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC82471 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA02185 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAD18554 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30P → R in AAC78443 (PubMed:9755181).Curated1
Sequence conflicti138F → L in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti138F → L in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti149Q → R in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti149Q → R in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti214G → S in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti462E → D in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti468A → V in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti474A → G in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti479G → R in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti604L → P in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti604L → P in AAL92872 (PubMed:14702039).Curated1
Sequence conflicti604L → P in AAM69365 (PubMed:14702039).Curated1
Sequence conflicti604L → P in AAC82471 (PubMed:9372926).Curated1
Sequence conflicti625 – 626AS → CQ in BAA02185 (PubMed:1429670).Curated2
Sequence conflicti693P → A in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti696P → A in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti764V → W in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti878G → E in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti894R → C in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1104K → Q in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1121N → I in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1185S → T in BAA02185 (PubMed:1429670).Curated1
Sequence conflicti1384C → Y in CAI46013 (PubMed:17974005).Curated1
Sequence conflicti1472Missing in BAA02185 (PubMed:1429670).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06657171P → S1 PublicationCorresponds to variant dbSNP:rs113810947Ensembl.1
Natural variantiVAR_061147161T → A5 PublicationsCorresponds to variant dbSNP:rs13319149Ensembl.1
Natural variantiVAR_079031201R → H Found in a patient with Rett syndrome-like phenotype; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs34838305Ensembl.1
Natural variantiVAR_055704311Y → C1 PublicationCorresponds to variant dbSNP:rs16858632Ensembl.1
Natural variantiVAR_063040432M → VCombined sources4 PublicationsCorresponds to variant dbSNP:rs2178403EnsemblClinVar.1
Natural variantiVAR_066572466 – 468Missing 1 Publication3
Natural variantiVAR_066573502A → V in PARK18. 1 PublicationCorresponds to variant dbSNP:rs111290936EnsemblClinVar.1
Natural variantiVAR_066574686G → C Found in patients with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs112019125Ensembl.1
Natural variantiVAR_036117696P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754755344Ensembl.1
Natural variantiVAR_066575806I → V1 PublicationCorresponds to variant dbSNP:rs62287499Ensembl.1
Natural variantiVAR_066576829T → S1 PublicationCorresponds to variant dbSNP:rs111500185Ensembl.1
Natural variantiVAR_0665771164S → R Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113169049Ensembl.1
Natural variantiVAR_0665781197R → W Found in a patient with Parkinson disease; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs113388242Ensembl.1
Natural variantiVAR_0665791205R → H in PARK18. 1 PublicationCorresponds to variant dbSNP:rs112176450EnsemblClinVar.1
Natural variantiVAR_0611481229P → A1 PublicationCorresponds to variant dbSNP:rs35629949Ensembl.1
Natural variantiVAR_0557051233L → P1 PublicationCorresponds to variant dbSNP:rs2230570Ensembl.1
Natural variantiVAR_0665801257N → S1 PublicationCorresponds to variant dbSNP:rs73053766Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0187231 – 196Missing in isoform E and isoform 7. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0187221 – 164Missing in isoform D. CuratedAdd BLAST164
Alternative sequenceiVSP_0187211 – 87Missing in isoform C. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_0187201 – 40Missing in isoform B. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_04739648R → RQGGFRSL in isoform 9. Curated1
Alternative sequenceiVSP_047397696P → PQ in isoform 7 and isoform 8. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12686 mRNA Translation: BAA02185.1 Frameshift.
AY082886 mRNA Translation: AAL92872.1
AF281070 mRNA Translation: AAM69365.1
AK131407 mRNA Translation: BAD18554.1 Sequence problems.
BX647812 mRNA Translation: CAI46013.1
AC078797 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78257.1
CH471052 Genomic DNA Translation: EAW78259.1
CH471052 Genomic DNA Translation: EAW78262.1
CH471052 Genomic DNA Translation: EAW78263.1
CH471052 Genomic DNA Translation: EAW78264.1
CH471052 Genomic DNA Translation: EAW78265.1
CH471052 Genomic DNA Translation: EAW78266.1
CH471052 Genomic DNA Translation: EAW78267.1
AF002816 mRNA Translation: AAC78443.1
AF004836 Genomic DNA Translation: AAC78444.1 Different initiation.
AF104913 mRNA Translation: AAC82471.1 Different initiation.
AJ001046 mRNA Translation: CAA04500.1
CCDSiCCDS3259.1 [Q04637-1]
CCDS3260.1 [Q04637-4]
CCDS3261.1 [Q04637-5]
CCDS46970.2 [Q04637-7]
CCDS54687.1 [Q04637-9]
CCDS54688.1 [Q04637-8]
CCDS77866.1 [Q04637-3]
PIRiA44453
RefSeqiNP_004944.3, NM_004953.4 [Q04637-7]
NP_886553.3, NM_182917.4
NP_937884.1, NM_198241.2
NP_937885.1, NM_198242.2 [Q04637-5]
UniGeneiHs.433750

Genome annotation databases

EnsembliENST00000342981; ENSP00000343450; ENSG00000114867 [Q04637-8]
ENST00000346169; ENSP00000316879; ENSG00000114867 [Q04637-1]
ENST00000350481; ENSP00000317600; ENSG00000114867 [Q04637-5]
ENST00000352767; ENSP00000338020; ENSG00000114867 [Q04637-9]
ENST00000382330; ENSP00000371767; ENSG00000114867 [Q04637-9]
ENST00000392537; ENSP00000376320; ENSG00000114867 [Q04637-4]
ENST00000414031; ENSP00000391935; ENSG00000114867 [Q04637-3]
ENST00000424196; ENSP00000416255; ENSG00000114867 [Q04637-9]
ENST00000434061; ENSP00000411826; ENSG00000114867 [Q04637-7]
ENST00000435046; ENSP00000404754; ENSG00000114867 [Q04637-6]
GeneIDi1981
KEGGihsa:1981
UCSCiuc003fnp.4 human [Q04637-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12686 mRNA Translation: BAA02185.1 Frameshift.
AY082886 mRNA Translation: AAL92872.1
AF281070 mRNA Translation: AAM69365.1
AK131407 mRNA Translation: BAD18554.1 Sequence problems.
BX647812 mRNA Translation: CAI46013.1
AC078797 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78257.1
CH471052 Genomic DNA Translation: EAW78259.1
CH471052 Genomic DNA Translation: EAW78262.1
CH471052 Genomic DNA Translation: EAW78263.1
CH471052 Genomic DNA Translation: EAW78264.1
CH471052 Genomic DNA Translation: EAW78265.1
CH471052 Genomic DNA Translation: EAW78266.1
CH471052 Genomic DNA Translation: EAW78267.1
AF002816 mRNA Translation: AAC78443.1
AF004836 Genomic DNA Translation: AAC78444.1 Different initiation.
AF104913 mRNA Translation: AAC82471.1 Different initiation.
AJ001046 mRNA Translation: CAA04500.1
CCDSiCCDS3259.1 [Q04637-1]
CCDS3260.1 [Q04637-4]
CCDS3261.1 [Q04637-5]
CCDS46970.2 [Q04637-7]
CCDS54687.1 [Q04637-9]
CCDS54688.1 [Q04637-8]
CCDS77866.1 [Q04637-3]
PIRiA44453
RefSeqiNP_004944.3, NM_004953.4 [Q04637-7]
NP_886553.3, NM_182917.4
NP_937884.1, NM_198241.2
NP_937885.1, NM_198242.2 [Q04637-5]
UniGeneiHs.433750

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LJ2X-ray2.38C/D172-199[»]
1UG3X-ray2.24A/B1233-1571[»]
2W97X-ray2.29E/F609-622[»]
4AZAX-ray2.16B/D609-620[»]
4F02X-ray2.00C/F178-203[»]
5EHCX-ray2.40B609-622[»]
5EI3X-ray1.71B609-622[»]
5EIRX-ray2.69B609-622[»]
5T46X-ray1.53B/D592-653[»]
ProteinModelPortaliQ04637
SMRiQ04637
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108296, 115 interactors
CORUMiQ04637
DIPiDIP-1161N
ELMiQ04637
IntActiQ04637, 71 interactors
MINTiQ04637
STRINGi9606.ENSP00000338020

Chemistry databases

BindingDBiQ04637

Protein family/group databases

MoonProtiQ04637

PTM databases

iPTMnetiQ04637
PhosphoSitePlusiQ04637
SwissPalmiQ04637

Polymorphism and mutation databases

BioMutaiEIF4G1
DMDMi294862538

Proteomic databases

EPDiQ04637
MaxQBiQ04637
PaxDbiQ04637
PeptideAtlasiQ04637
PRIDEiQ04637
ProteomicsDBi58250
58251 [Q04637-3]
58252 [Q04637-4]
58253 [Q04637-5]
58254 [Q04637-6]

Protocols and materials databases

DNASUi1981
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342981; ENSP00000343450; ENSG00000114867 [Q04637-8]
ENST00000346169; ENSP00000316879; ENSG00000114867 [Q04637-1]
ENST00000350481; ENSP00000317600; ENSG00000114867 [Q04637-5]
ENST00000352767; ENSP00000338020; ENSG00000114867 [Q04637-9]
ENST00000382330; ENSP00000371767; ENSG00000114867 [Q04637-9]
ENST00000392537; ENSP00000376320; ENSG00000114867 [Q04637-4]
ENST00000414031; ENSP00000391935; ENSG00000114867 [Q04637-3]
ENST00000424196; ENSP00000416255; ENSG00000114867 [Q04637-9]
ENST00000434061; ENSP00000411826; ENSG00000114867 [Q04637-7]
ENST00000435046; ENSP00000404754; ENSG00000114867 [Q04637-6]
GeneIDi1981
KEGGihsa:1981
UCSCiuc003fnp.4 human [Q04637-1]

Organism-specific databases

CTDi1981
DisGeNETi1981
EuPathDBiHostDB:ENSG00000114867.19
GeneCardsiEIF4G1
HGNCiHGNC:3296 EIF4G1
HPAiCAB014774
HPA028487
HPA043866
MalaCardsiEIF4G1
MIMi600495 gene
614251 phenotype
neXtProtiNX_Q04637
OpenTargetsiENSG00000114867
Orphaneti411602 Hereditary late-onset Parkinson disease
PharmGKBiPA27722
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0401 Eukaryota
ENOG410XS4P LUCA
GeneTreeiENSGT00530000063038
HOGENOMiHOG000231658
HOVERGENiHBG052083
InParanoidiQ04637
KOiK03260
OMAiFDRISGQ
OrthoDBiEOG091G03ZW
PhylomeDBiQ04637
TreeFamiTF101527

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-166208 mTORC1-mediated signalling
R-HSA-429947 Deadenylation of mRNA
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiQ04637

Miscellaneous databases

ChiTaRSiEIF4G1 human
EvolutionaryTraceiQ04637
GeneWikiiEukaryotic_translation_initiation_factor_4_gamma
GenomeRNAii1981
PMAP-CutDBiQ04637
PROiPR:Q04637
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114867 Expressed in 238 organ(s), highest expression level in gastrocnemius
CleanExiHS_EIF4G1
ExpressionAtlasiQ04637 baseline and differential
GenevisibleiQ04637 HS

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain
PANTHERiPTHR23253:SF10 PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIF4G1_HUMAN
AccessioniPrimary (citable) accession number: Q04637
Secondary accession number(s): D3DNT2
, D3DNT4, D3DNT5, E9PFM1, G5E9S1, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 209 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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