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Protein

Envelope glycoprotein M

Gene

gM

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein MUniRule annotation
Short name:
gMUniRule annotation
Gene namesi
Name:gMUniRule annotation
ORF Names:18L, U72
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12IntravirionUniRule annotationAdd BLAST12
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Topological domaini34 – 76Virion surfaceUniRule annotationAdd BLAST43
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Topological domaini98 – 125IntravirionUniRule annotationAdd BLAST28
Transmembranei126 – 146HelicalUniRule annotationAdd BLAST21
Topological domaini147Virion surfaceUniRule annotation1
Transmembranei148 – 168HelicalUniRule annotationAdd BLAST21
Topological domaini169 – 203IntravirionUniRule annotationAdd BLAST35
Transmembranei204 – 224HelicalUniRule annotationAdd BLAST21
Topological domaini225 – 238Virion surfaceUniRule annotationAdd BLAST14
Transmembranei239 – 259HelicalUniRule annotationAdd BLAST21
Topological domaini260 – 263IntravirionUniRule annotation4
Transmembranei264 – 284HelicalUniRule annotationAdd BLAST21
Topological domaini285 – 293Virion surfaceUniRule annotation9
Transmembranei294 – 314HelicalUniRule annotationAdd BLAST21
Topological domaini315 – 344IntravirionUniRule annotationAdd BLAST30

GO - Cellular componenti

Keywords - Cellular componenti

Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157791 – 344Envelope glycoprotein MAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44Interchain (with gN)UniRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ04630

Interactioni

Subunit structurei

Interacts (via N-terminus) with gN (via N-terminus). The gM-gN heterodimer forms the gCII complex.UniRule annotation

Structurei

3D structure databases

SMRiQ04630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein M family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK19257
OrthoDBiVOG090000D2

Family and domain databases

HAMAPiMF_04035 HSV_GM, 1 hit
InterProiView protein in InterPro
IPR000785 Herpes_glycop_M
PfamiView protein in Pfam
PF01528 Herpes_glycop, 1 hit
PRINTSiPR00333 HSVINTEGRLMP

Sequencei

Sequence statusi: Complete.

Q04630-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSRVDTIN LRIWLVSIIC AALSFINVTV YLIAINFPNL GFPCAYFEIN
60 70 80 90 100
DLKAVNLSAN NQIYQMTHQL YINPVQIICY VLIMAMLFLL IIIYYIVCCA
110 120 130 140 150
KVFSSNKTSN VNQTTRDITW MGDTSSCFQF ILIMDTFQLF VTALSFRLVA
160 170 180 190 200
LGAFAYCIFF VCFTTFNVTL ITQFQSADKS FFAFQKIHPN LKGTVQFKTV
210 220 230 240 250
VINLTELMLG YSTMFLGITT CLGVGNSIYI RSITVAYSSI NTFLVMACIY
260 270 280 290 300
SIVIEAVLVR YVKPLFGYYV GMFCGAVGLS FPILQYETFF ESEWSTGLII
310 320 330 340
NLAVIAIISI GFIICRLVRY LVKKKRRYKQ LVNTESSSLM DENE
Length:344
Mass (Da):38,992
Last modified:October 1, 1996 - v1
Checksum:i7EF1394AF4A12254
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68963 Genomic DNA Translation: AAA65580.1
X83413 Genomic DNA Translation: CAA58364.1
RefSeqiNP_042965.1, NC_001664.2

Genome annotation databases

GeneIDi1487953
KEGGivg:1487953

Similar proteinsi

Entry informationi

Entry nameiGM_HHV6U
AccessioniPrimary (citable) accession number: Q04630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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