UniProtKB - Q04589 (FGFR1_RAT)

BLAST

>sp|Q04589|FGFR1_RAT Fibroblast growth factor receptor 1 OS=Rattus norvegicus OX=10116 GN=Fgfr1 PE=1 SV=1
MWGWRGLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLAESNRTRITGEEVEVRDSIPADSGLYACVTNSPSGSDTTYFSVNVSD
ALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYDQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSGTKKSDFHSQMAVHKLAKS
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMD
KPSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQDSPSF
PDTRSSTCSSGEDSVFSHEPFPEEPCLPRHPTQLANGGLNRR

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History
Entry version 165 (07 Nov 2018)
Sequence version 1 (01 Jun 1994)
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Protein

Fibroblast growth factor receptor 1

Gene

Fgfr1

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).By similarity

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotationBy similarity

Activity regulationⁱ

Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	514	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	568	ATPPROSITE-ProRule annotation	1
Active siteⁱ	623	Proton acceptorPROSITE-ProRule annotation	1
Binding siteⁱ	627	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	641	ATPPROSITE-ProRule annotation	1
Siteⁱ	766	Mediates interaction with PLCG1 and SHBBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	484 – 490	ATPPROSITE-ProRule annotation		7
Nucleotide bindingⁱ	562 – 564	ATPPROSITE-ProRule annotation		3

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cell adhesion molecule binding
Source: RGD
Inferred from physical interactionⁱ
- 19666467
fibroblast growth factor-activated receptor activity Source: UniProtKB
fibroblast growth factor binding Source: UniProtKB
heparin binding Source: UniProtKB
protein-containing complex binding
Source: RGD
Inferred from physical interactionⁱ
- 19339244
signaling receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 25485703
transmembrane receptor protein tyrosine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transmembrane signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to histamine
Source: RGD
Inferred from expression patternⁱ
- 23497494
cellular response to nerve growth factor stimulus
Source: RGD
Inferred from expression patternⁱ
- 9011767
central nervous system neuron development
Source: RGD
Inferred from mutant phenotypeⁱ
- 17314281
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 7789341
fibroblast growth factor receptor signaling pathway Source: UniProtKB
motogenic signaling involved in postnatal olfactory bulb interneuron migration
Source: RGD
Inferred from mutant phenotypeⁱ
- 20083104
negative regulation of apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of osteoblast differentiation
Source: RGD
Inferred from mutant phenotypeⁱ
- 18690792
negative regulation of signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuron projection development
Source: RGD
Inferred from direct assayⁱ
- 12791257
peptidyl-tyrosine phosphorylation Source: UniProtKB
positive regulation of cardiac muscle cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 18275970
positive regulation of cell proliferation Source: UniProtKB
positive regulation of ERK1 and ERK2 cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of fibroblast migration
Source: RGD
Inferred from mutant phenotypeⁱ
- 12176960
positive regulation of MAP kinase activity Source: UniProtKB
positive regulation of mesenchymal cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 18690792
positive regulation of neuron differentiation Source: UniProtKB
positive regulation of neuron projection development
Source: RGD
Inferred from direct assayⁱ
- 19952283
positive regulation of phospholipase C activity Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19229075
protein autophosphorylation Source: UniProtKB
regulation of cell proliferation
Source: RGD
Inferred from direct assayⁱ
- 9763444
regulation of sensory perception of pain
Source: RGD
Inferred from mutant phenotypeⁱ
- 17905520
regulation of stem cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 18690792
response to ischemia
Source: RGD
Inferred from expression patternⁱ
- 10521571
response to nutrient levels
Source: RGD
Inferred from expression patternⁱ
- 21430024
stem cell population maintenance
Source: RGD
Inferred from mutant phenotypeⁱ
- 19505325
wound healing
Source: RGD
Inferred from expression patternⁱ
- 9204964

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 5301

BRENDAⁱ

2.7.10.1 5301

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fibroblast growth factor receptor 1 (EC:2.7.10.1By similarity) Short name: FGFR-1 Short name: bFGF-R-1 Alternative name(s): Basic fibroblast growth factor receptor 1 MFR Proto-oncogene c-Fgr CD_antigen: CD331
Gene namesⁱ	Name:Fgfr1 Synonyms:Flg
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	620713 Fgfr1

RGDⁱ

620713 Fgfr1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 376	ExtracellularSequence analysisAdd BLAST	355
Transmembraneⁱ	377 – 397	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	398 – 822	CytoplasmicSequence analysisAdd BLAST	425

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000016782	22 – 822	Fibroblast growth factor receptor 1Add BLAST		801

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	55 ↔ 101	PROSITE-ProRule annotation
Glycosylationⁱ	77	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	117	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	178 ↔ 230	PROSITE-ProRule annotation
Glycosylationⁱ	227	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	240	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	264	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	277 ↔ 341	PROSITE-ProRule annotation
Glycosylationⁱ	296	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	317	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	330	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	463	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	583	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	585	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	653	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	654	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	730	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	766	Phosphotyrosine; by autocatalysisBy similarity	1

Post-translational modificationⁱ

Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer and proceeds in a highly ordered manner. Initial autophosphorylation at Tyr-653 increases the kinase activity by a factor of 50 to 100. After this, Tyr-583 becomes phosphorylated, followed by phosphorylation of Tyr-463, Tyr-766, Tyr-583 and Tyr-585. In a third stage, Tyr-654 is autophosphorylated, resulting in a further tenfold increase of kinase activity. Phosphotyrosine residues provide docking sites for interacting proteins and so are crucial for FGFR1 function and its regulation (By similarity).By similarity

Ubiquitinated. FGFR1 is rapidly ubiquitinated by NEDD4 after autophosphorylation, leading to internalization and lysosomal degradation. CBL is recruited to activated FGFR1 via FRS2 and GRB2, and mediates ubiquitination and subsequent degradation of FGFR1 (By similarity).By similarity

N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus (By similarity).By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q04589
PRIDEⁱ	Q04589

PTM databases

iPTMnetⁱ	Q04589

iPTMnetⁱ

Q04589

Expressionⁱ

Tissue specificityⁱ

Expressed in the parathyroid.1 Publication

Interactionⁱ

Subunit structureⁱ

Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23. Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains). Interacts with FRS2. Interacts (via C-terminus) with NEDD4 (via WW3 domain). Interacts with RPS6KA1 (PubMed:15117958). Interacts with KL (By similarity). Interacts with SHB (via SH2 domain) and GRB10. Interacts with ANOS1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2. Interacts with SOX2 and SOX3 (By similarity). Interacts with FLRT1, FLRT2 and FLRT3. Found in a ternary complex with FGF1 and ITGAV:ITGB3 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Htr1a	P19327	2	EBI-2480918,EBI-6570156
Plcg1	P10686	2	EBI-2480918,EBI-520788

GO - Molecular functionⁱ

cell adhesion molecule binding
Source: RGD
Inferred from physical interactionⁱ
- 19666467
fibroblast growth factor binding Source: UniProtKB
signaling receptor binding
Source: RGD
Inferred from physical interactionⁱ
- 25485703

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	249399, 3 interactors
CORUMⁱ	Q04589
IntActⁱ	Q04589, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q04589
STRINGⁱ	10116.ENSRNOP00000036885

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q04589
SMRⁱ	Q04589
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 119	Ig-like C2-type 1Add BLAST	95
Domainⁱ	158 – 246	Ig-like C2-type 2Add BLAST	89
Domainⁱ	255 – 357	Ig-like C2-type 3Add BLAST	103
Domainⁱ	478 – 767	Protein kinasePROSITE-ProRule annotationAdd BLAST	290

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	160 – 177	Heparin-bindingAdd BLAST		18

Domainⁱ

The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Isoforms lacking the first Ig-like domain have higher affinity for fibroblast growth factors (FGF) and heparan sulfate proteoglycans than isoforms with all three Ig-like domains (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0200 Eukaryota COG0515 LUCA
HOGENOMⁱ	HOG000263410
HOVERGENⁱ	HBG000345
InParanoidⁱ	Q04589
KEGG Orthology (KO) More...KOⁱ	K04362
PhylomeDBⁱ	Q04589

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05098 PTKc_FGFR1, 1 hit
Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR028174 FGF_rcpt_1 IPR016248 FGF_rcpt_fam IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013151 Immunoglobulin IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07679 I-set, 2 hits PF00047 ig, 1 hit PF07714 Pkinase_Tyr, 1 hit
PIRSFⁱ	PIRSF000628 FGFR, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00409 IG, 3 hits SM00408 IGc2, 3 hits SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q04589-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MWGWRGLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL 
        60         70         80         90        100
LQLRCRLRDD VQSINWLRDG VQLAESNRTR ITGEEVEVRD SIPADSGLYA 
       110        120        130        140        150
CVTNSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP 
       160        170        180        190        200
VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS SGTPSPTLRW LKNGKEFKPD 
       210        220        230        240        250
HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN HTYQLDVVER 
       260        270        280        290        300
SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI 
       310        320        330        340        350
GPDNLPYDQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS 
       360        370        380        390        400
HHSAWLTVLE ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIIYKMK 
       410        420        430        440        450
SGTKKSDFHS QMAVHKLAKS IPLRRQVTVS ADSSASMNSG VLLVRPSRLS 
       460        470        480        490        500
SSGTPMLAGV SEYELPEDPR WELPRDRLVL GKPLGEGCFG QVVLAEAIGL 
       510        520        530        540        550
DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK HKNIINLLGA 
       560        570        580        590        600
CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL 
       610        620        630        640        650
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH 
       660        670        680        690        700
IDYYKKTTNG RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP 
       710        720        730        740        750
NPGVPVEELF KLLKEGHRMD KPSNCTNELY MMMRDCWNAV PSQRPTFKQL 
       760        770        780        790        800
VEDLDRIVAL TSNQEYLDLS MPLDQDSPSF PDTRSSTCSS GEDSVFSHEP 
       810        820 
FPEEPCLPRH PTQLANGGLN RR

Length:822

Mass (Da):91,825

Last modified:June 1, 1994 - v1

Checksum:ⁱE59D924D0A1DE5C5

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q63827	Q63827_RAT	Fibroblast growth factor receptor Fibroblast growth factor receptor, EC 2.7.10.1	Fgfr1	729	Annotation score:
F1LM54	F1LM54_RAT	Fibroblast growth factor receptor Fibroblast growth factor receptor, EC 2.7.10.1	Fgfr1	727	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D12498 mRNA Translation: BAA02059.1
PIRⁱ	S29840
NCBI Reference Sequences More...RefSeqⁱ	NP_077060.1, NM_024146.1
UniGeneⁱ	Rn.207203 Rn.9797

Genome annotation databases

GeneIDⁱ	79114
KEGGⁱ	rno:79114
UCSC genome browser More...UCSCⁱ	RGD:620713 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q04589	Fibroblast growth factor receptor 1	)	HUMAN		822	UniRef90_P11362
Fibroblast growth factor receptor 1	)	MOUSE		822
Uncharacterized protein		AOTNA		962
Fibroblast growth factor receptor-1 (Fragment)		Rattus sp.		55
Fibroblast growth factor receptor		RHIRO		872
+331

Protein	Similar proteins		Species	Score	Length	Source
Q04589	Fibroblast growth factor receptor 1	)	HUMAN		822	UniRef50_P11362
Fibroblast growth factor receptor 1	)	MOUSE		822
S-adenosylhomocysteine hydrolase-like protein 1		RAT		483
Fibroblast growth factor receptor 3		CHICK		806
Uncharacterized protein		AOTNA		962
+533

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D12498 mRNA Translation: BAA02059.1
PIRⁱ	S29840
RefSeqⁱ	NP_077060.1, NM_024146.1
UniGeneⁱ	Rn.207203 Rn.9797

3D structure databases

ProteinModelPortalⁱ	Q04589
SMRⁱ	Q04589
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	249399, 3 interactors
CORUMⁱ	Q04589
IntActⁱ	Q04589, 3 interactors
MINTⁱ	Q04589
STRINGⁱ	10116.ENSRNOP00000036885

PTM databases

iPTMnetⁱ	Q04589

iPTMnetⁱ

Q04589

Proteomic databases

PaxDbⁱ	Q04589
PRIDEⁱ	Q04589

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	79114
KEGGⁱ	rno:79114
UCSCⁱ	RGD:620713 rat

Organism-specific databases

CTDⁱ	2260
RGDⁱ	620713 Fgfr1

Phylogenomic databases

eggNOGⁱ	KOG0200 Eukaryota COG0515 LUCA
HOGENOMⁱ	HOG000263410
HOVERGENⁱ	HBG000345
InParanoidⁱ	Q04589
KOⁱ	K04362
PhylomeDBⁱ	Q04589

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 5301

BRENDAⁱ

2.7.10.1 5301

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q04589

PROⁱ

PR:Q04589

Family and domain databases

CDDⁱ	cd05098 PTKc_FGFR1, 1 hit
Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR028174 FGF_rcpt_1 IPR016248 FGF_rcpt_fam IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013151 Immunoglobulin IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
Pfamⁱ	View protein in Pfam PF07679 I-set, 2 hits PF00047 ig, 1 hit PF07714 Pkinase_Tyr, 1 hit
PIRSFⁱ	PIRSF000628 FGFR, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00409 IG, 3 hits SM00408 IGc2, 3 hits SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FGFR1_RAT
Accessionⁱ	Q04589Primary (citable) accession number: Q04589
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - Q04589 (FGFR1_RAT)

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Fibroblast growth factor receptor 1

Fgfr1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ