UniProtKB - Q04589 (FGFR1_RAT)
Fibroblast growth factor receptor 1
Fgfr1
Functioni
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).
By similarityCatalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotationBy similarityEC:2.7.10.1PROSITE-ProRule annotationBy similarity
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 514 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 568 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 623 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 627 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 641 | ATPPROSITE-ProRule annotation | 1 | |
Sitei | 766 | Mediates interaction with PLCG1 and SHBBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 484 – 490 | ATPPROSITE-ProRule annotation | 7 | |
Nucleotide bindingi | 562 – 564 | ATPPROSITE-ProRule annotation | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cell adhesion molecule binding Source: RGD
- fibroblast growth factor-activated receptor activity Source: UniProtKB
- fibroblast growth factor binding Source: UniProtKB
- heparin binding Source: UniProtKB
- identical protein binding Source: RGD
- protein-containing complex binding Source: RGD
- protein homodimerization activity Source: RGD
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: RGD
- receptor-receptor interaction Source: RGD
- SH2 domain binding Source: RGD
- signaling receptor binding Source: RGD
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- angiogenesis Source: RGD
- auditory receptor cell development Source: RGD
- blood vessel morphogenesis Source: RGD
- brain development Source: RGD
- branching involved in salivary gland morphogenesis Source: RGD
- cell maturation Source: RGD
- cellular response to histamine Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- cellular response to nerve growth factor stimulus Source: RGD
- central nervous system neuron development Source: RGD
- chondrocyte differentiation Source: RGD
- ear development Source: RGD
- embryonic limb morphogenesis Source: RGD
- epithelial to mesenchymal transition Source: RGD
- female pregnancy Source: RGD
- fibroblast growth factor receptor signaling pathway Source: UniProtKB
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development Source: RGD
- generation of neurons Source: RGD
- inner ear morphogenesis Source: RGD
- in utero embryonic development Source: RGD
- lung-associated mesenchyme development Source: RGD
- lung development Source: RGD
- mesenchymal cell differentiation Source: RGD
- midbrain development Source: RGD
- middle ear morphogenesis Source: RGD
- motogenic signaling involved in postnatal olfactory bulb interneuron migration Source: RGD
- negative regulation of fibroblast growth factor production Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of osteoblast differentiation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neuron projection development Source: RGD
- orbitofrontal cortex development Source: RGD
- organ induction Source: RGD
- outer ear morphogenesis Source: RGD
- paraxial mesoderm development Source: RGD
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of blood vessel endothelial cell migration Source: RGD
- positive regulation of cardiac muscle cell proliferation Source: RGD
- positive regulation of cell cycle Source: RGD
- positive regulation of cell differentiation Source: GO_Central
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of endothelial cell chemotaxis to fibroblast growth factor Source: RGD
- positive regulation of fibroblast migration Source: RGD
- positive regulation of hepatic stellate cell activation Source: RGD
- positive regulation of inflammatory response Source: RGD
- positive regulation of kinase activity Source: GO_Central
- positive regulation of MAPK cascade Source: RGD
- positive regulation of MAP kinase activity Source: UniProtKB
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: RGD
- positive regulation of mesenchymal cell proliferation Source: RGD
- positive regulation of mitotic cell cycle DNA replication Source: RGD
- positive regulation of neuron differentiation Source: UniProtKB
- positive regulation of neuron projection development Source: RGD
- positive regulation of parathyroid hormone secretion Source: RGD
- positive regulation of phospholipase C activity Source: UniProtKB
- positive regulation of protein kinase B signaling Source: RGD
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of vascular endothelial cell proliferation Source: RGD
- protein autophosphorylation Source: UniProtKB
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: RGD
- regulation of cell population proliferation Source: RGD
- regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
- regulation of gene expression Source: RGD
- regulation of lateral mesodermal cell fate specification Source: RGD
- regulation of phosphate transport Source: RGD
- regulation of phosphorus metabolic process Source: RGD
- regulation of sensory perception of pain Source: RGD
- regulation of stem cell proliferation Source: RGD
- response to ischemia Source: RGD
- response to nutrient levels Source: RGD
- salivary gland morphogenesis Source: RGD
- sensory perception of sound Source: RGD
- stem cell population maintenance Source: RGD
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- ureteric bud development Source: RGD
- ventricular zone neuroblast division Source: RGD
- vitamin D3 metabolic process Source: RGD
- wound healing Source: RGD
Keywordsi
Molecular function | Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 5301 |
Reactomei | R-RNO-109704, PI3K Cascade R-RNO-1257604, PIP3 activates AKT signaling R-RNO-190370, FGFR1b ligand binding and activation R-RNO-190373, FGFR1c ligand binding and activation R-RNO-190374, FGFR1c and Klotho ligand binding and activation R-RNO-445144, Signal transduction by L1 R-RNO-5654219, Phospholipase C-mediated cascade: FGFR1 R-RNO-5654687, Downstream signaling of activated FGFR1 R-RNO-5654688, SHC-mediated cascade:FGFR1 R-RNO-5654689, PI-3K cascade:FGFR1 R-RNO-5654693, FRS-mediated FGFR1 signaling R-RNO-5654726, Negative regulation of FGFR1 signaling R-RNO-5673001, RAF/MAP kinase cascade R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor receptor 1 (EC:2.7.10.1By similarity)Short name: FGFR-1 Short name: bFGF-R-1 Alternative name(s): Basic fibroblast growth factor receptor 1 MFR Proto-oncogene c-Fgr CD_antigen: CD331 |
Gene namesi | Name:Fgfr1 Synonyms:Flg |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620713, Fgfr1 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Cytoplasm and Cytosol
- cytosol 1 Publication
Other locations
- Cytoplasmic vesicle By similarity
Note: After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity).By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Nucleus
- nucleus Source: RGD
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: RGD
- cytoplasmic vesicle Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: RGD
- receptor complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 376 | ExtracellularSequence analysisAdd BLAST | 355 | |
Transmembranei | 377 – 397 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 398 – 822 | CytoplasmicSequence analysisAdd BLAST | 425 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000016782 | 22 – 822 | Fibroblast growth factor receptor 1Add BLAST | 801 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 55 ↔ 101 | PROSITE-ProRule annotation | ||
Glycosylationi | 77 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 178 ↔ 230 | PROSITE-ProRule annotation | ||
Glycosylationi | 227 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 240 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 264 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 277 ↔ 341 | PROSITE-ProRule annotation | ||
Glycosylationi | 296 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 317 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 330 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 463 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 583 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 585 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 653 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 654 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 730 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 766 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q04589 |
PaxDbi | Q04589 |
PRIDEi | Q04589 |
PTM databases
GlyGeni | Q04589, 8 sites |
iPTMneti | Q04589 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Monomer. Homodimer after ligand binding.
Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23.
Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains).
Interacts with FRS2.
Interacts (via C-terminus) with NEDD4 (via WW3 domain).
Interacts with RPS6KA1 (PubMed:15117958).
Interacts with KL (By similarity).
Interacts with SHB (via SH2 domain) and GRB10.
Interacts with ANOS1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2.
Interacts with SOX2 and SOX3 (By similarity).
Interacts with FLRT1, FLRT2 and FLRT3.
Found in a ternary complex with FGF1 and ITGAV:ITGB3 (By similarity).
By similarity1 PublicationBinary interactionsi
GO - Molecular functioni
- cell adhesion molecule binding Source: RGD
- fibroblast growth factor binding Source: UniProtKB
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
- receptor-receptor interaction Source: RGD
- SH2 domain binding Source: RGD
- signaling receptor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249399, 4 interactors |
CORUMi | Q04589 |
IntActi | Q04589, 3 interactors |
MINTi | Q04589 |
STRINGi | 10116.ENSRNOP00000036885 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 119 | Ig-like C2-type 1Add BLAST | 95 | |
Domaini | 158 – 246 | Ig-like C2-type 2Add BLAST | 89 | |
Domaini | 255 – 357 | Ig-like C2-type 3Add BLAST | 103 | |
Domaini | 478 – 767 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 290 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 120 – 162 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 160 – 177 | Heparin-bindingAdd BLAST | 18 | |
Regioni | 770 – 822 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 123 – 137 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 770 – 794 | Polar residuesSequence analysisAdd BLAST | 25 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
InParanoidi | Q04589 |
OMAi | RCLILWA |
PhylomeDBi | Q04589 |
Family and domain databases
CDDi | cd05098, PTKc_FGFR1, 1 hit |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR028174, FGF_rcpt_1 IPR016248, FGF_rcpt_fam IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF000628, FGFR, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MWGWRGLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL
60 70 80 90 100
LQLRCRLRDD VQSINWLRDG VQLAESNRTR ITGEEVEVRD SIPADSGLYA
110 120 130 140 150
CVTNSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP
160 170 180 190 200
VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS SGTPSPTLRW LKNGKEFKPD
210 220 230 240 250
HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN HTYQLDVVER
260 270 280 290 300
SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
310 320 330 340 350
GPDNLPYDQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS
360 370 380 390 400
HHSAWLTVLE ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIIYKMK
410 420 430 440 450
SGTKKSDFHS QMAVHKLAKS IPLRRQVTVS ADSSASMNSG VLLVRPSRLS
460 470 480 490 500
SSGTPMLAGV SEYELPEDPR WELPRDRLVL GKPLGEGCFG QVVLAEAIGL
510 520 530 540 550
DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK HKNIINLLGA
560 570 580 590 600
CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
610 620 630 640 650
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH
660 670 680 690 700
IDYYKKTTNG RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP
710 720 730 740 750
NPGVPVEELF KLLKEGHRMD KPSNCTNELY MMMRDCWNAV PSQRPTFKQL
760 770 780 790 800
VEDLDRIVAL TSNQEYLDLS MPLDQDSPSF PDTRSSTCSS GEDSVFSHEP
810 820
FPEEPCLPRH PTQLANGGLN RR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ63827 | Q63827_RAT | Fibroblast growth factor receptor | Fgfr1 | 729 | Annotation score: | ||
F1LM54 | F1LM54_RAT | Fibroblast growth factor receptor | Fgfr1 | 727 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12498 mRNA Translation: BAA02059.1 |
PIRi | S29840 |
RefSeqi | NP_077060.1, NM_024146.1 |
Genome annotation databases
GeneIDi | 79114 |
KEGGi | rno:79114 |
UCSCi | RGD:620713, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12498 mRNA Translation: BAA02059.1 |
PIRi | S29840 |
RefSeqi | NP_077060.1, NM_024146.1 |
3D structure databases
BMRBi | Q04589 |
SMRi | Q04589 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 249399, 4 interactors |
CORUMi | Q04589 |
IntActi | Q04589, 3 interactors |
MINTi | Q04589 |
STRINGi | 10116.ENSRNOP00000036885 |
Chemistry databases
ChEMBLi | CHEMBL4523276 |
PTM databases
GlyGeni | Q04589, 8 sites |
iPTMneti | Q04589 |
Proteomic databases
jPOSTi | Q04589 |
PaxDbi | Q04589 |
PRIDEi | Q04589 |
Genome annotation databases
GeneIDi | 79114 |
KEGGi | rno:79114 |
UCSCi | RGD:620713, rat |
Organism-specific databases
CTDi | 2260 |
RGDi | 620713, Fgfr1 |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
InParanoidi | Q04589 |
OMAi | RCLILWA |
PhylomeDBi | Q04589 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 5301 |
Reactomei | R-RNO-109704, PI3K Cascade R-RNO-1257604, PIP3 activates AKT signaling R-RNO-190370, FGFR1b ligand binding and activation R-RNO-190373, FGFR1c ligand binding and activation R-RNO-190374, FGFR1c and Klotho ligand binding and activation R-RNO-445144, Signal transduction by L1 R-RNO-5654219, Phospholipase C-mediated cascade: FGFR1 R-RNO-5654687, Downstream signaling of activated FGFR1 R-RNO-5654688, SHC-mediated cascade:FGFR1 R-RNO-5654689, PI-3K cascade:FGFR1 R-RNO-5654693, FRS-mediated FGFR1 signaling R-RNO-5654726, Negative regulation of FGFR1 signaling R-RNO-5673001, RAF/MAP kinase cascade R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Miscellaneous databases
PROi | PR:Q04589 |
Family and domain databases
CDDi | cd05098, PTKc_FGFR1, 1 hit |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR028174, FGF_rcpt_1 IPR016248, FGF_rcpt_fam IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF00047, ig, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF000628, FGFR, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FGFR1_RAT | |
Accessioni | Q04589Primary (citable) accession number: Q04589 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families