UniProtKB - Q04539 (RPE2_CUPNH)
Protein
Ribulose-phosphate 3-epimerase 2
Gene
rpe2
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
Status
Functioni
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.UniRule annotation
Catalytic activityi
- EC:5.1.3.1UniRule annotation
Cofactori
a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation
: Carbohydrate degradation Pathwayi
This protein is involved in Carbohydrate degradation.UniRule annotationView all proteins of this organism that are known to be involved in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 21 | SubstrateUniRule annotation | 1 | |
Metal bindingi | 46 | Divalent metal cation; via tele nitrogenUniRule annotation | 1 | |
Active sitei | 48 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 48 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 79 | Divalent metal cation; via pros nitrogenUniRule annotation | 1 | |
Binding sitei | 79 | SubstrateUniRule annotation | 1 | |
Active sitei | 192 | Proton donorUniRule annotation | 1 | |
Metal bindingi | 192 | Divalent metal cationUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-UniRule
- ribulose-phosphate 3-epimerase activity Source: UniProtKB-UniRule
GO - Biological processi
- pentose catabolic process Source: UniProtKB-UniRule
- pentose-phosphate shunt Source: InterPro
- reductive pentose-phosphate cycle Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase |
Biological process | Calvin cycle, Carbohydrate metabolism |
Ligand | Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:rpe2UniRule annotation Synonyms:cbbEP, cfxE Ordered Locus Names:PHG423 |
Encoded oni | Plasmid megaplasmid pHG1 |
Organismi | Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) |
Taxonomic identifieri | 381666 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171557 | 1 – 241 | Ribulose-phosphate 3-epimerase 2Add BLAST | 241 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 155 – 158 | Substrate bindingUniRule annotation | 4 | |
Regioni | 192 – 194 | Substrate bindingUniRule annotation | 3 | |
Regioni | 214 – 215 | Substrate bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the ribulose-phosphate 3-epimerase family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0036, Bacteria |
HOGENOMi | CLU_054856_1_0_4 |
OrthoDBi | 1697639at2 |
Family and domain databases
CDDi | cd00429, RPE, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_02227, RPE, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR026019, Ribul_P_3_epim IPR000056, Ribul_P_3_epim-like IPR011060, RibuloseP-bd_barrel |
PANTHERi | PTHR11749, PTHR11749, 1 hit |
Pfami | View protein in Pfam PF00834, Ribul_P_3_epim, 1 hit |
PIRSFi | PIRSF001461, RPE, 1 hit |
SUPFAMi | SSF51366, SSF51366, 1 hit |
TIGRFAMsi | TIGR01163, rpe, 1 hit |
PROSITEi | View protein in PROSITE PS01085, RIBUL_P_3_EPIMER_1, 1 hit PS01086, RIBUL_P_3_EPIMER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q04539-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHATEPNTGH GSQRAIRLAP SILSADFARL GEEVCAIEAG GADLVHFDVM
60 70 80 90 100
DNHYVSNLTI GPLVCEAIRP LVSIPIDVHL MVEPVDALIP MFAKAGANLI
110 120 130 140 150
SFHPEASRHV DRTIGLIRDH GCKAGLVLNP ATPLSWLDHT LDKLDLVLLM
160 170 180 190 200
SVNPGFGGQA FIPGVLDKVR QARARIDRQV AAGGRPVWLE IDGGVKADNI
210 220 230 240
TEIARAGADT FVAGSAVFGA PDADGGYRGI LHRLREAATI T
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64172 Genomic DNA Translation: AAA98231.1 AY305378 Genomic DNA Translation: AAP86172.1 |
RefSeqi | WP_011154335.1, NZ_CP039289.1 |
Genome annotation databases
EnsemblBacteriai | AAP86172; AAP86172; PHG423 |
KEGGi | reh:PHG423 |
PATRICi | fig|381666.6.peg.351 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64172 Genomic DNA Translation: AAA98231.1 AY305378 Genomic DNA Translation: AAP86172.1 |
RefSeqi | WP_011154335.1, NZ_CP039289.1 |
3D structure databases
SMRi | Q04539 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 381666.PHG423 |
Genome annotation databases
EnsemblBacteriai | AAP86172; AAP86172; PHG423 |
KEGGi | reh:PHG423 |
PATRICi | fig|381666.6.peg.351 |
Phylogenomic databases
eggNOGi | COG0036, Bacteria |
HOGENOMi | CLU_054856_1_0_4 |
OrthoDBi | 1697639at2 |
Family and domain databases
CDDi | cd00429, RPE, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_02227, RPE, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR026019, Ribul_P_3_epim IPR000056, Ribul_P_3_epim-like IPR011060, RibuloseP-bd_barrel |
PANTHERi | PTHR11749, PTHR11749, 1 hit |
Pfami | View protein in Pfam PF00834, Ribul_P_3_epim, 1 hit |
PIRSFi | PIRSF001461, RPE, 1 hit |
SUPFAMi | SSF51366, SSF51366, 1 hit |
TIGRFAMsi | TIGR01163, rpe, 1 hit |
PROSITEi | View protein in PROSITE PS01085, RIBUL_P_3_EPIMER_1, 1 hit PS01086, RIBUL_P_3_EPIMER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPE2_CUPNH | |
Accessioni | Q04539Primary (citable) accession number: Q04539 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1995 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Plasmid, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families