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Protein

5-aminolevulinate synthase 1

Gene

hemA

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-aminolevulinate from glycine.
Proteins known to be involved in this subpathway in this organism are:
  1. 5-aminolevulinate synthase 1 (hemA), 5-aminolevulinate synthase 2 (hemT)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from glycine, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21SubstrateBy similarity1
Binding sitei137SubstrateBy similarity1
Binding sitei156SubstrateBy similarity1
Binding sitei189Pyridoxal phosphateBy similarity1
Binding sitei217Pyridoxal phosphateBy similarity1
Binding sitei245Pyridoxal phosphateBy similarity1
Active sitei248By similarity1
Binding sitei277Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei278Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei363SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processHeme biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase 1 (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:hemA
Ordered Locus Names:RHOS4_15770
ORF Names:RSP_2984
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001638291 – 4075-aminolevulinate synthase 1Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ04512

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272943.RSP_2984

Structurei

3D structure databases

ProteinModelPortaliQ04512
SMRiQ04512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107EEK Bacteria
COG0156 LUCA
HOGENOMiHOG000221020
KOiK00643
OMAiATPINYP
OrthoDBiPOG091H024U
PhylomeDBiQ04512

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR010961 4pyrrol_synth_NH2levulA_synth
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01821 5aminolev_synth, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q04512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYNLALDTA LNRLHTEGRY RTFIDIERRK GAFPKAMWRK PDGSEKEITV
60 70 80 90 100
WCGNDYLGMG QHPVVLGAMH EALDSTGAGS GGTRNISGTT LYHKRLEAEL
110 120 130 140 150
ADLHGKEAAL VFSSAYIAND ATLSTLPQLI PGLVIVSDKL NHASMIEGIR
160 170 180 190 200
RSGTEKHIFK HNDLDDLRRI LTSIGKDRPI LVAFESVYSM DGDFGRIEEI
210 220 230 240 250
CDIADEFGAL KYIDEVHAVG MYGPRGGGVA ERDGLMDRID IINGTLGKAY
260 270 280 290 300
GVFGGYIAAS SKMCDAVRSY APGFIFSTSL PPVVAAGAAA SVRHLKGDVE
310 320 330 340 350
LREKHQTQAR ILKMRLKGLG LPIIDHGSHI VPVHVGDPVH CKMISDMLLE
360 370 380 390 400
HFGIYVQPIN FPTVPRGTER LRFTPSPVHD SGMIDHLVKA MDVLWQHCAL

NRAEVVA
Length:407
Mass (Da):44,616
Last modified:October 1, 1993 - v1
Checksum:iDCDE2484BFACC7F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07490 Genomic DNA Translation: AAA72325.1
CP000143 Genomic DNA Translation: ABA79145.1
RefSeqiWP_011337894.1, NZ_AKVW01000001.1
YP_353046.1, NC_007493.2

Genome annotation databases

EnsemblBacteriaiABA79145; ABA79145; RSP_2984
GeneIDi3720398
KEGGirsp:RSP_2984
PATRICifig|272943.9.peg.1924

Similar proteinsi

Entry informationi

Entry nameiHEM1_RHOS4
AccessioniPrimary (citable) accession number: Q04512
Secondary accession number(s): Q3J239
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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