UniProtKB - Q04511 (UFO1_YEAST)
Protein
Ubiquitin ligase complex F-box protein UFO1
Gene
UFO1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).By similarity1 Publication
Miscellaneous
Present with 639 molecules/cell in log phase SD medium.1 Publication
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- protein-macromolecule adaptor activity Source: SGD
GO - Biological processi
- cellular response to DNA damage stimulus Source: SGD
- cellular response to methylmercury Source: SGD
- protein ubiquitination Source: UniProtKB-UniPathway
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: SGD
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-SCE-8951664, Neddylation R-SCE-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin ligase complex F-box protein UFO1 |
Gene namesi | Name:UFO1 Ordered Locus Names:YML088W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004553, UFO1 |
VEuPathDBi | FungiDB:YML088W |
Subcellular locationi
Nucleus
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
- SCF ubiquitin ligase complex Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119970 | 1 – 668 | Ubiquitin ligase complex F-box protein UFO1Add BLAST | 668 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 511 | PhosphoserineCombined sources | 1 | |
Modified residuei | 514 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q04511 |
PaxDbi | Q04511 |
PRIDEi | Q04511 |
PTM databases
iPTMneti | Q04511 |
Interactioni
Subunit structurei
Interacts with SKP1.
Component of the probable SCF(UFO1) complex containing CDC53, SKP1, RBX1 and UFO1.
2 PublicationsBinary interactionsi
Q04511
With | #Exp. | IntAct |
---|---|---|
SKP1 [P52286] | 6 | EBI-20020,EBI-4090 |
Protein-protein interaction databases
BioGRIDi | 35053, 180 interactors |
ComplexPortali | CPX-3243, SCF-Ufo1 ubiquitin ligase complex |
DIPi | DIP-1953N |
IntActi | Q04511, 5 interactors |
MINTi | Q04511 |
STRINGi | 4932.YML088W |
Miscellaneous databases
RNActi | Q04511, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 51 | F-boxPROSITE-ProRule annotationAdd BLAST | 47 | |
Domaini | 547 – 566 | UIM 1PROSITE-ProRule annotationAdd BLAST | 20 | |
Domaini | 583 – 602 | UIM 2PROSITE-ProRule annotationAdd BLAST | 20 | |
Domaini | 651 – 668 | UIM 3PROSITE-ProRule annotationAdd BLAST | 18 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0274, Eukaryota |
HOGENOMi | CLU_425266_0_0_1 |
InParanoidi | Q04511 |
OMAi | CTTPQGC |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR003903, UIM_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit SM00726, UIM, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS50330, UIM, 3 hits |
i Sequence
Sequence statusi: Complete.
Q04511-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPGLVLQD LPPEILINIF SHLDEKDLFT LQELSTHFRN LIHDEELWKN
60 70 80 90 100
LFKSRVHTTH FPTFSQSSKF SVEYIERTRG LHHWQHNKAI RTKYTIIPTR
110 120 130 140 150
NWDQPSIERI VFDYPRVAAY NDGTITILQL QNHKRQKKFK KLIYIPCTTP
160 170 180 190 200
QGCSTMDFNI NAAVFGRFDG RVFGKLLSNK SYLTPVMEFT GRHSAGVTAI
210 220 230 240 250
CNSESWDTSR EDWSVSGSEN GEIIWWCENK LVKMWKVSNR VIWKLAFFKD
260 270 280 290 300
WTLIMDDEKL YIIHQMQELH SIDIPKDLDE QPMRVRFFKM DFGSMTLVLA
310 320 330 340 350
DLNNVYTISV NPNGNFGNLR KLEMPEQICA VEIDEKTSQR EQNWQFAGDD
360 370 380 390 400
GCYISLLTTQ NTLYIINIRD LSSSGLKVQC KISFDEQVYV SQVTNLIVVV
410 420 430 440 450
ALPNVLQILN AMTGELIKTV LKTEKFPEFL KVSQDKIIMG SGNVLNYLKF
460 470 480 490 500
VSSDSKKHHH STKGKNTVSN KWNETLNTEL QYYDEDEDLR RKRQSEISRL
510 520 530 540 550
IDAYGGDLEL SGDTDEENDI QLRIALLESQ EAQARNQAEA GEPVGDDEDE
560 570 580 590 600
QLRRALEESQ LIYETQTNSS ANHGNNTNDE IDEDDEEFLR AIRQSRVEDE
610 620 630 640 650
RRRHLRNHTT GRRNGPLSDD NFATYGAAES SERTSTENTI GSSVGVDASN
660
NVDEDLQLAI ALSLSEIN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46660 Genomic DNA Translation: CAA86650.1 BK006946 Genomic DNA Translation: DAA09809.1 |
PIRi | S49639 |
RefSeqi | NP_013622.1, NM_001182447.1 |
Genome annotation databases
EnsemblFungii | YML088W_mRNA; YML088W; YML088W |
GeneIDi | 854886 |
KEGGi | sce:YML088W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z46660 Genomic DNA Translation: CAA86650.1 BK006946 Genomic DNA Translation: DAA09809.1 |
PIRi | S49639 |
RefSeqi | NP_013622.1, NM_001182447.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 35053, 180 interactors |
ComplexPortali | CPX-3243, SCF-Ufo1 ubiquitin ligase complex |
DIPi | DIP-1953N |
IntActi | Q04511, 5 interactors |
MINTi | Q04511 |
STRINGi | 4932.YML088W |
PTM databases
iPTMneti | Q04511 |
Proteomic databases
MaxQBi | Q04511 |
PaxDbi | Q04511 |
PRIDEi | Q04511 |
Genome annotation databases
EnsemblFungii | YML088W_mRNA; YML088W; YML088W |
GeneIDi | 854886 |
KEGGi | sce:YML088W |
Organism-specific databases
SGDi | S000004553, UFO1 |
VEuPathDBi | FungiDB:YML088W |
Phylogenomic databases
eggNOGi | KOG0274, Eukaryota |
HOGENOMi | CLU_425266_0_0_1 |
InParanoidi | Q04511 |
OMAi | CTTPQGC |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-SCE-8951664, Neddylation R-SCE-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
PROi | PR:Q04511 |
RNActi | Q04511, protein |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR003903, UIM_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit SM00726, UIM, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS50330, UIM, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UFO1_YEAST | |
Accessioni | Q04511Primary (citable) accession number: Q04511 Secondary accession number(s): D6W0J5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways